Brain Reward System and Its Volumetric Investigations in Alcohol Addiction by Muhammed Fatih Tabara, Murad Atmaca, Hanefi Yıldırım, Onur Solmaz, Muhammed Amir Essibayi, Mehmet Gürkan Gurok

“…The group with alcohol use disorder exhibited a significant decrease in the volume of the right hippocampus. No differences were found between the two groups in terms of other brain regions. …”
Get full text

Diffusion Tensor Imaging in Alzheimer’s Disease and Mild Cognitive Impairment by G. T. Stebbins, C. M. Murphy

“…Structural magnetic resonance imaging (MRI) studies of Alzheimer’s disease and mild cognitive impairment (MCI) have focused on the hippocampus and entorhinal cortex; gray matter structures in the medial temporal lobe. …”
Get full text

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats by Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill

“…Herein, we examined the effects of an acute psychological stress (120 min restraint) on gene expression patterns of enzymes along the kynurenine pathway over a protracted time-course (1–24 h post-stress termination) within the amygdala, hippocampus, hypothalamus, and medial prefrontal cortex. …”
Get full text

Abnormal Amygdala Subregion Functional Connectivity in Patients with Crohn’s Disease with or without Anxiety and Depression by Jingwen Sun, Wei Sun, Kecen Yue, Yin Zhang, Xintong Wu, Wenjia Liu, Ling Zou, Haifeng Shi

“…Compared with the HC group, the CDad group demonstrated decreased rsFC between the right laterobasal subregion and the left hippocampus (P<.001) and right middle frontal gyrus (P<.001) and between the left superficial subregion and the left insula (P<.001). …”
Get full text

Alterations of Amino Acids and Monoamine Metabolism in Male Fmr1 Knockout Mice: A Putative Animal Model of the Human Fragile X Mental Retardation Syndrome by Michael Gruss, Katharina Braun

“…In juvenile knockout mice, aspartate and taurine were especially increased in cortical regions, striatum, hippocampus, cerebellum, and brainstem. In addition, juveniles showed an altered balance between excitatory and inhibitory amino acids in the caudal cortex, hippocampus, and brainstem. …”
Get full text

Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation by Karla Salgado-Puga, Roberto A. Prado-Alcalá, Fernando Peña-Ortega

“…One typical rodent behavior that has been proposed as a hippocampus-dependent assessment model of ADL in mice and rats is burrowing. …”
Get full text

Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model by Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee

“…To test this possibility, full-length type I or type III NRG1 was overexpressed via lentiviral vectors in the hippocampus of line 41 AD mouse. Both type I and type III NRG1 improves deficits in the Morris water-maze behavioral task. …”
Get full text

Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study by Zhao Qing, Weiping Li, Zuzana Nedelska, Wenbo Wu, Fangfang Wang, Renyuan Liu, Hui Zhao, Weibo Chen, Queenie Chan, Bin Zhu, Yun Xu, Jakub Hort, Bing Zhang

“…We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F=4.44, p=0.05), pallidum (F=8.97, p=0.005), and thalamus (F=5.95, p=0.02), which were negative in NC (right hippocampus, r=−0.49; right pallidum, r=−0.50; right thalamus, r=−0.45; all p<0.05) but absent in MCI (right hippocampus, r=0.21; right pallidum, r=0.32; right thalamus r=0.28; all p>0.2). …”
Get full text

The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post‐Traumatic Stress Disorder by Fernando Hinostroza, Michele M. Mahr

“…Results Findings demonstrate that chronic PTSD is associated with progressive dysfunction in the amygdala, hippocampus, prefrontal cortex, hypothalamic–pituitary–adrenal axis, and white matter pathways. …”
Get full text

Evaluation of L-carnitine's protective properties against AlCl3-induced brain, liver, and renal toxicity in rats. by Haifa Ali Alqhtani

“…Furthermore, the histological structure of the cortex, hippocampus, and hepatic renal tissues appeared to change in response to AlCl3. …”
Get full text

Dendritic Spines in Depression: What We Learned from Animal Models by Hui Qiao, Ming-Xing Li, Chang Xu, Hui-Bin Chen, Shu-Cheng An, Xin-Ming Ma

“…Generally, chronic stress causes dendritic atrophy and spine loss in the neurons of the hippocampus and prefrontal cortex. Meanwhile, neurons of the amygdala and nucleus accumbens exhibit an increase in spine density. …”
Get full text

Involvement of transposable elements in neurogenesis by R. N. Mustafin, E. K. Khusnutdinova

“…Significant activity of long non-coding RNA was detected in the hippocampus, which confirms the role of transposons in the regulation of brain function. …”
Get full text

MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury by Barbara Pijet, Marzena Stefaniuk, Leszek Kaczmarek

“…Decreased spine density was also observed in the dentate gyrus of the hippocampus; however, in contrast to the cerebral cortex, spines in the DG became more filopodia-like. …”
Get full text

Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice by Alessandro Ieraci, Alessandra Mallei, Maurizio Popoli

“…SI showed lower mRNA levels of the BDNF-7 splice variant, c-Fos, Arc, and Egr-1 in both hippocampus and prefrontal cortex compared to GH mice. …”
Get full text

Unveiling the functional connectivity of astrocytic networks with AstroNet, a graph reconstruction algorithm coupled to image processing by L. Zonca, F. C. Bellier, G. Milior, P. Aymard, J. Visser, A. Rancillac, N. Rouach, D. Holcman

“…Applied to the CA1 hippocampus and motor cortex, AstroNet reveals notable differences: astrocytes in the hippocampus display stronger connectivity, while cortical astrocytes form sparser networks. …”
Get full text

Brain aquaporin-4 expression in the rat septic model (immunohistochemical study) by T.V.  Shulyatnikova, V.O. Tumanskiy

“…The immunohistochemical study of aquaporin-4 was carried out in the sensorimotor cortex, white matter, hippocampus, thalamus and caudate nucleus/putamen regions between 20 and 38 h after CLP. …”
Get full text

Shenfu Injection Protects Brain Injury in Rats with Cardiac Arrest through Nogo/NgR Pathway by Haixia Deng, Zhanhong Tang, Peng Tuo, Ruihua Wu, Si Jia, Xuan Zhao, Deqing Huang, Yuguang Gao, Zhou Lan

“…The ultrastructure of the brain and hippocampus was observed by electron microscopy. Real-time quantitative polymerase chain reaction (PCR), western blotting, and immunohistochemistry were used to detect Nogo receptor (NgR) expression in the hippocampus and cerebral cortex, and Nogo–NgR expression in CA/CPR model. …”
Get full text

Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness by Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty

“…CysLT and LTB4 concentrations were elevated in the hippocampus and the cerebral cortex, along with enhanced 5-LOX expression in neurons and microglia. …”
Get full text

Supralinear dendritic integration in murine dendrite-targeting interneurons by Simonas Griesius, Amy Richardson, Dimitri Michael Kullmann

“…Dendritic boosting of spatially clustered synaptic signals argues for previously unappreciated computational complexity in dendrite-projecting inhibitory cells of the hippocampus.…”
Get full text

A Comprehensive Evaluation of Radiomic Features in Normal Brain Magnetic Resonance Imaging: Investigating Robustness and Region Variations by Mahsa Shakeri, Ahmad Mostaar, Arash Zare Sadeghi, Seyyed Mohammad Hosseini, Ali Yaghobi Joybari, Hossein Ghadiri

“…Seven patches located in the thalamus, putamen, hippocampus and brain stem were selected as volume of interest (VOI). …”
Get full text