The accuracy of ultrasensitive PSA in predicting disease progression after radical prostatectomy by Heikki Seikkula, Jaakko Hyysalo, Mikael Högerman, Peter J. Boström, Otto Ettala

“…This strategic approach optimizes resource allocation in busy urological outpatient clinics, especially valuable in publicly reimbursed healthcare systems like Finland.…”
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Rotavirus Vaccination Protects Against Diabetes Mellitus Type 1 in Children in Developed Countries: A Systematic Review and Meta-Analysis by Chrysoula Kosmeri, Achilleas Klapas, Nikolas Evripidou, Evanthia Kantza, Anastasios Serbis, Ekaterini Siomou, Fani Ladomenou

“…While these findings are promising, they may not be generalizable to settings outside similar advanced healthcare systems. Further research is needed to confirm the protective effects of rotavirus vaccination against T1D across diverse populations.…”
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Model systems of human immunodef iciency virus (HIV-1) for in vitro eff icacy assessment of candidate vaccines and drugs against HIV-1 by N. B. Rudometova, D. N. Shcherbakov, A. P. Rudometov, A. A. Ilyichev, L. I. Karpenko

“…HIV infection still remains a major challenge for healthcare systems of the world. There are several aspects on counteracting the HIV/AIDS epidemic. …”
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The Recent Progress and Applications of Digital Technologies in Healthcare: A Review by Maksut Senbekov, Timur Saliev, Zhanar Bukeyeva, Aigul Almabayeva, Marina Zhanaliyeva, Nazym Aitenova, Yerzhan Toishibekov, Ildar Fakhradiyev

“…In this regard, the use of telemedicine and other e-health technologies might help to lessen the pressure on healthcare systems. Summary. Digital platforms can help optimize diagnosis, consulting, and treatment of patients. …”
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The PainSMART project: Protocol for a research program on effectiveness, mechanisms of effect and patient-practitioner experiences of the PainSMART-strategy as an adjunct to usual... by Richard Thompson, Maria Fors, Ann-Sofi Kammerlind, Pia Tingström, Allan Abbott, Kajsa Johansson

“…<h4>Background</h4>Musculoskeletal pain (MSKP) disorders entail a significant burden for individuals and healthcare systems. The PainSMART-strategy has been developed aiming to reduce divergences between patients and healthcare practitioners in their understanding of MSKP by providing a shared basis for communication and to facilitate patients' self-management of MSKP. …”
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First-line glaucoma monotherapy medication patterns in Finland during 1995-2019 based on a population-based study. by Petri K M Purola, Seppo V P Koskinen, Hannu M T Uusitalo

“…Exploring these in longitudinal and population-based settings would provide information for the healthcare systems to plan glaucoma care accordingly.<h4>Objective</h4>To evaluate patterns in first-line glaucoma monotherapy in Finland during 1995-2019 based on nationwide survey and register data.…”
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Home intravenous diuretic administration for heart failure management: A scoping review. by Morgan B Krauter, Katherine S McGilton, Stuti S Patel, Karen Harkness, Tracey J F Colella

“…<h4>Background</h4>Heart failure (HF) significantly impacts healthcare systems due to high rates of hospital bed utilization and readmission rates. …”
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Securing fog computing in healthcare with a zero-trust approach and blockchain by Navjeet Kaur, Ayush Mittal, Umesh Kumar Lilhore, Sarita Simaiya, Surjeet Dalal, Kashif Saleem, Ehab Seif Ghith

“…Abstract As healthcare systems increasingly adopt fog computing to improve responsiveness and real-time data processing at the edge, significant security challenges emerge due to the decentralized architecture. …”
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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…These disorders, ranging from neurodegenerative diseases to psychiatric conditions, not only impact individuals but also place a substantial burden on healthcare systems and society. A major obstacle in treating these conditions is the blood-brain barrier (BBB), which restricts the passage of therapeutic agents to the brain. …”
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Prediction models used in the progression of chronic kidney disease: A scoping review. by David K E Lim, James H Boyd, Elizabeth Thomas, Aron Chakera, Sawitchaya Tippaya, Ashley Irish, Justin Manuel, Kim Betts, Suzanne Robinson

“…The study populations across the studies were heterogenous and data acquired by the studies were sourced from different levels and locations of healthcare systems. 31 studies implemented supervised models, and 2 studies included unsupervised models. …”
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Near-mortality Scenarios in Obstetrics: Case Studies of Severe Complications and their Management by Jayshree P Kulkarni, Swapnali Sansare, Sneha

“…These cases underscore the critical need for timely medical interventions and improved maternal healthcare systems to manage life-threatening obstetric emergencies effectively.…”
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Prevalence and influencing factors of occupational burnout among healthcare workers in the Chinese mainland during the late 2022 Omicron COVID-19 outbreak: a multicenter cross-sect... by Shu Jing, Zhenwei Dai, Yijin Wu, Xin Liu, Ling Zhang, Xiaoyang Liu, Tianrui Ren, Jiaqi Fu, Xu Chen, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Zhili Han, Xiaoyou Su, Youlin Qiao

“…During this period, medical crowding and enormous pressure on the healthcare systems occurred, which might result in the occurrence of occupational burnout among healthcare workers (HCWs). …”
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Interpretable machine learning-based prediction of 28-day mortality in ICU patients with sepsis: a multicenter retrospective study by Li Shen, Li Shen, Jiaqiang Wu, Jianger Lan, Chao Chen, Yi Wang, Zhiping Li

“…BackgroundSepsis is a major cause of mortality in intensive care units (ICUs) and continues to pose a significant global health challenge, with sepsis-related deaths contributing substantially to the overall burden on healthcare systems worldwide. The primary objective was to construct and evaluate a machine learning (ML) model for forecasting 28-day all-cause mortality among ICU sepsis patients.MethodsData for the study was sourced from the eICU Collaborative Research Database (eICU-CRD) (version 2.0). …”
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Implicit bias in referrals to relational psychological therapies: review and recommendations for mental health services by Chenai Mandangu, Anne Millicent Ramos, Mohona Sengupta, Rosslyn Bender, Reem El-Hayani, Ifrah Hasan, Hannah Okechukwu, Shafeena Anas, Dominik Havsteen-Franklin

“…IntroductionTimely and appropriate psychological treatment is an essential element required to address the growing burden of mental health issues, which has significant implications for individuals, society, and healthcare systems. However, research indicates that implicit biases among mental health professionals may influence referral decisions, potentially leading to disparities in access to relational psychological therapies. …”
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Nursing-Related Barriers to Children’s Pain Management at Selected Hospitals in Ghana: A Descriptive Qualitative Study by Abigail Kusi Amponsah, Evans Frimpong Kyei, John Bright Agyemang, Hanson Boakye, Joana Kyei-Dompim, Collins Kwadwo Ahoto, Evans Oduro

“…Nurses should be educated, empowered, and supported with the requisite material resources to effectively manage children’s pain and improve outcomes for families, healthcare systems, and the nation. Future studies should explore the facilitators and barriers from other stakeholders involved in pediatric pain management.…”
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Differential effects of clary sage (Salvia sclarea L.) oil and linalyl acetate on depression levels in diabetic foot ulcer patients with T2DM: a randomized blinded controlled trial by Ji Won Son, Purum Kang, Sun Seek Min, Geun Hee Seol, Geun Hee Seol

“…BackgroundDiabetic foot ulcer (DFU) is a significant global health concern due to its substantial burden on individuals and healthcare systems. In addition to its physical impact, DFU has emotional effects on patients. …”
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A Study on Diagnostic Accuracy of Dipsi Method Over Traditional Oral Glucose Tolerance Test Among Antenatal Women by Vijayadevi Shanmugam, Dharani Sudha Gopalraj, Shruthi Nanjudappan, Rajeswari Ravindran

“…Failure to identify true positive cases could have significant clinical implications, impacting maternal and neonatal outcomes and overburdening healthcare systems. Further research with larger and diverse populations is needed to establish more accurate diagnostic thresholds for GDM using the DIPSI method or alternative criteria.…”
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COVID-19 and children with congenital anomalies: a European survey of parents’ experiences of healthcare services by Ingeborg Barisic, Carlos Matias Dias, Amanda Neville, Anna Pierini, Anke Rissmann, Joan K Morris, Judith Rankin, Ester Garne, Anna Latos-Bielenska, Elena Marcus, Anna Jamry-Dziurla, Ljubica Odak, Clara Cavero- Carbonell, Elly Den Hond, Lucas Genard, Ana João Santos, L Renée Lutke, Christina Neergaard Pedersen, Annika Niemann, Lucía Páramo-Rodríguez

“…Regional differences in disruptions raise questions about the competence of certain healthcare systems to meet the needs of this vulnerable group of patients and indicate improvements should be strived for in some regions.…”
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Genetic markers of children asthma: predisposition to disease course variants by M. V. Smolnikova, Ed. W. Kasparov, M. A. Malinchik, K. V. Kopylova

“…Asthma is a heterogeneous and often difficult to treat condition that results in a disproportionate cost to healthcare systems. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life. …”
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Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study by Jing Wang, Chen Chen, Xiaoying Hu, Yi Fan, Yaping Wang, Yu Qiu, Qiujiao Yang, Mingming Xu, Yanfeng Weng, Yanni Li, Lisong Lin, Fa Chen, Baochang He, Fengqiong Liu

“…Path analysis revealed that neck dissection had the highest total effect on hospitalisation expenses (β=0.307), while surgery exerted an indirect effect on expenses via LOS (β=0.021).Conclusion This study highlights the significant economic burden imposed by OC on patients and healthcare systems. While prevention and early diagnosis remain critical, our findings underscore several modifiable factors, including improving oral hygiene and optimising surgical protocols, such as chemotherapy and lymph node dissection, that present opportunities to reduce costs and enhance cost-effectiveness. …”
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