Beyond identification of familial hypercholesterolemia: Improving downstream visits and treatments in a large health care system by Harin Lee, Tarun Kadaru, Ruth Schneider, Taylor Triana, Carol Tujardon, Colby Ayers, Mujeeb Basit, Zahid Ahmad, Amit Khera

“…Conclusions: Approximately 1 in 5 individuals in a large healthcare system who were contacted for a recorded LDL-C ≥ 190 mg/dL had a meaningful improvement in the management of severe hypercholesterolemia and diagnosis of FH. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Abstract Introduction Validated patient-reported outcome measures (PROMs) are crucial for assessing patients’ experiences in the healthcare system. Both clinically and theoretically, patient-centered consultations are essential in patient-care, and are often suggested as the optimal strategy in caring for patients with multimorbidity. …”
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Explainable AI in Diagnostic Radiology for Neurological Disorders: A Systematic Review, and What Doctors Think About It by Yasir Hafeez, Khuhed Memon, Maged S. AL-Quraishi, Norashikin Yahya, Sami Elferik, Syed Saad Azhar Ali

“…Although data scientists, researchers, and medical experts have been working in the direction of designing and developing computer aided diagnosis (CAD) tools to serve as assistants to doctors, their large-scale adoption and integration into the healthcare system still seems far-fetched. Diagnostic radiology is no exception. …”
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Physicians’ Perceptions of the Quality of Palliative Care and of the Importance of Collaboration in Interdisciplinary Teams in Norwegian Nursing Homes by Skomakerstuen Ødbehr L, Hov R, Sanaker H, Sandsdalen T

“…Also, important for maintaining good quality were different aspects of the healthcare system, and a suitable physical environment that made patients and relatives feel cared for. …”
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Is training policy for general practitioners in China charting the right path forward? a mixed methods analysis by Li Luo, Chen Chen, Wenya Yu, Qian Liu, Chunhua Chi, Yan Yang, Rui Liu, Jianwei Shi, Dehua Yu, Hua Jin, Zhaoxin Wang, Qingfeng Du, Xin Gong, Jiaoling Huang, Ning Chen

“…Objectives Since 2010, the Chinese government has gradually increased its investment in the training of general practitioners (GPs) to support their role as ‘gatekeepers’ in the healthcare system. However, this training is still organised from the perspective of specialist care. …”
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Botulinum toxin type A for the treatment of patients with post-stroke spasticity in Thailand: cost-utility and budget impact analysis by Phorntida Hadnorntun, Pattara Leelahavarong, Tanawan Kongmalai, Varalak Srinonprasert, Juthamas Prawjaeng, Phakamas Tanvijit, Chuenchom Chueluecha, Nawarat Jintakul, Tipyarat Saringcarinkul, Witsanu Kumthornthip

“…Integrating BoNT-A treatment delivery into the healthcare system would require a budget outlay of approximately US$413 246–US$966 103 that may vary annually by an additional US$50 260–US$335 064.Conclusion BoNT-A effectively reduces focal spasticity and improves quality of life in post-stroke patients. …”
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Is first-line treatment with polatuzumab vedotin–rituximab–cyclophosphamide, doxorubicin and prednisone (pola-R-CHP) for previously untreated diffuse large B-cell lymphoma cost-eff... by Lin Yang, Ting Chen, Qiuling Zhao, Liangliang Dong, Wanfu Zhong, Wenbin Liu, Xiuliang Qiu, Ruyi Huang, Shengqiang Huang, Ruixiang Xie

“…The scenario analyses were also conducted.Setting Chinese healthcare system perspective.Participants A hypothetical cohort of adult patients presenting with CD20-positive, patients with previously untreated DLBCL.Interventions Pola-R-CHP versus R-CHOP.Main outcome measures The main outcomes of the study were QALYs, incremental cost-effectiveness ratio (ICER) and incremental net-health benefit (INHB).Results In China, the ICER and INHB of pola-R-CHP compared with R-CHOP were US$77 036.33/QALY and −1.11 QALYs, respectively. …”
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Cost-savings and health impact of strategies for prevention of Respiratory Syncytial Virus with nirsevimab in Chile based on the integrated analysis of 2019–2023 national databases... by Denis Sauré, Miguel O’Ryan, Juan Pablo Torres, Natalia Trigo, Gonzalo Diaz, Marcel Goic, Charles Thraves, Jorge Pacheco, Patricio Aguilera, Andrea Caro, Leonardo J. Basso

“…This strategy would have significantly decreased the strain on the healthcare system during the seasonal surge, reducing 13,533 ICU (77·81/1000 live newborns) and 27,465 hospital bed requirements (157·91/1000 live newborns), alongside 46,886 emergency room visits (269·58/1000 live newborns). …”
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Cost-effectiveness analysis of three surgical approaches for parathyroidectomy in secondary hyperparathyroidism patients by Qila Sa, Qila Sa, Yinghui Zhou, Guangming Cheng, Boyuan Nan, Yingnan Feng, Yingnan Feng, Ningyuan Zhang, Ningyuan Zhang, Wantao Xie, Wantao Xie, Wei Zhang

“…Sensitivity analysis results indicate that varying any parameter within a certain range over the given time interval will not cause the ICER to exceed the WTP threshold and will not reverse the primary analysis results.ConclusionIn the Chinese healthcare system, tPTX is considered the most cost-effective treatment for refractory hyperparathyroidism, when compared to tPTX+AT and sPTX.…”
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Retrospective analysis of the occurrence, potential risk factors and medical significance of pulmonary complications after total shoulder arthroplasty from the National Inpatient S... by Mengning Dong, Huitong Liang, Jinlang Fu, Zeying Guo, Hao Xie, Qinfeng Yang, Qingmei Yu, Xiaomin Hou

“…As a result, the healthcare system in USA could face a considerable financial strain due to the emergence of subsequent pulmonary problems. …”
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Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland by Elina Peltola, Päivi Hannula, Heini Huhtala, Saara Metso, Ulla Kiviniemi, Martine Vornanen, Juhani Sand, Johanna Laukkarinen, Mirja Tiikkainen, Camilla Schalin-Jäntti, Johanna Arola, Jukka Sirén, Antti Piiroinen, Minna Soinio, Pirjo Nuutila, Mirva Söderström, Hanna Hämäläinen, Leena Moilanen, David Laaksonen, Elina Pirinen, Fia Sundelin, Tapani Ebeling, Pasi Salmela, Markus J. Mäkinen, Pia Jaatinen

“…To shorten the delay, clinicians should be informed and alert to consider the possibility of hypoglycemia and insulinoma, when symptomatic attacks are investigated in different sectors of the healthcare system. Developing the surgical treatment is another major target, in order to lower the overall complication rate, without compromising the high cure rate of insulinomas.…”
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Observational cohort study of a group-based VR program to improve mental health and wellbeing in people with life-threatening illnesses by Hannes Kettner, Hannes Kettner, David R. Glowacki, David R. Glowacki, Justin Wall, Justin Wall, Justin Wall, Robin L. Carhart-Harris, Robin L. Carhart-Harris, Leor Roseman, Leor Roseman, Joseph L. Hardy, Joseph L. Hardy

“…Relatively few interventions are available to address the existential concerns of individuals facing LTI, while treatment of the underlying physical ailment typically remains the priority of the healthcare system. Research has shown that psychedelic-assisted psychotherapy (PAT) holds promise for supporting mental health in people with LTIs. …”
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Kidney failure-related excess mortality during the first three years of the COVID-19 pandemic in the United States: a nation-wide, population-based analysis by Zhenhu Chen, Pingping Jia, Di Xie, Jingyu Xie, Juan Liu, Wangnan Cao, Lefei Han, Jinjun Ran, Shengzhi Sun, Shi Zhao, Yang Ge, Leonardo Martinez, Xin Chen, Peihua Cao

“…Abstract Background The onset of the COVID-19 pandemic has had a detrimental impact on the healthcare system. Patients with kidney failure and related kidney disease are notably vulnerable to the COVID-19 pandemic. …”
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Genomic characteristics of ST6115 carbapenem-resistant Klebsiella pneumoniae coharboring blaNDM-1 and blaIMP-4 by Xiaofang Xie, Xiaofang Xie, Yaxuan Zhai, Zhichen Zhu, Feinan Qian, Feinan Qian, Jie Zhu, Qizhao Gao, Hong Du, Hong Du

“…Our study indicates that the healthcare system and services should remain vigilant regarding the spread and prevalence of ST6115.…”
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Similar Survival Between Non-Western Immigrant Patients and Danish-Born Patients with Lymphoma: A Danish Population-Based Study by Simonsen MR, Maksten EF, Jakobsen LH, Severinsen MT, Dann EJ, Frederiksen H, Niemann CU, Jørgensen JM, Clausen MR, Starklint J, Johnsen SP, El-Galaly TC, Baech J

“…This study investigated whether the Danish tax-based healthcare system has overcome these challenges and delivered non-Western immigrant patients quality care on the same levels as that of the Danish-born patients.Therefore, using available population based Danish registries, survival between these groups were compared, while adjusting for important clinical differences, and no significant effect of immigration status on survival was found even though non-Western immigrant patients generally had lower socioeconomic status.Keywords: epidemiology, socioeconomics, causal inference, mediation analysis…”
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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

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Predictors of Colorectal Cancer Screening and Screening Modalities among Patients seen at Federally Qualified Health Centers Funded by the United States Health Resources and Servic... by Megan R.M. Aaronson, Nadereh Pourat, Connie Lu, Jayraan Badiee, Helen Yu-Lefler, Benjamin Picillo, Hank Hoang, Folasade P. May

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Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies by Giulia Mammone, Simona Borghesi, Nicolò Borsellino, Anna Caliò, Roberta Ceccarelli, Alessia Cimadamore, Giario Natale Conti, Laura Cortesi, Rolando Maria D’Angelillo, Gaetano Facchini, Lorena Incorvaia, Alberto Lapini, Luigi Mearini, Giovanni Pappagallo, Paolo Prontera, Daniela Turchetti, Grazia Sirgiovanni, Sergio Bracarda, on behalf of the Italian Society of Uro-Oncology (SIUrO)

“…In conclusion, the proposed care pathway represents a critical step towards integrating BRCA testing into routine PCa care, aiming to optimize patient management and familial risk assessment within the constraints of the Italian healthcare system.…”
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Diagnosis, treatment, surgical practices and review of the literature in rare coagulation factor deficiencies by Hüseyin Avni Solgun

“…Conclusions We believe that data-based service is required in every clinic and healthcare system for early diagnosis and follow-up of RBDs. …”
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Emerging burden of post-cancer therapy complications on unplanned hospitalisation and costs among Australian cancer patients: a retrospective cohort study over 14 years by Rashidul Alam Mahumud, Md. Shahjalal, Padam Kanta Dahal, Md. Parvez Mosharaf, Sabuj Kanti Mistry, Kamrun Nahar Koly, Sujana Haque Chowdhury, Andre M. N. Renzaho, Jeff Gow, Khorshed Alam, Olivia Wawryk

“…A retrospective cohort study was conducted among 8,633 cancer patients (1.03 million emergency hospital admissions) in Victoria, Australia from July 2006 to June 2020, from the Australian healthcare system perspective. Multivariate generalised linear regression models were employed to estimate the adjusted association between post-therapy complications and clinical characteristics with hospital LOS and associated hospitalisation medical costs. …”
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