Mitigating moral distress by enhancing healthcare workers’ understanding of challenges faced by carers of children with disabilities in low-resource settings in Kenya by Anne Geniets, Jarim Omogi, Laura Hakimi, Alice Lakati, Niall Winters

“…Consequently, improved training of healthcare- and community health workers in the field of childhood disability is needed to strengthen health systems, and to support these caregivers and their children.…”
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Prediction of Type 2 Diabetes Mellitus using a Logistic Regression Model by Olivia Altamirano Guerrero, Ronelsys Martínez Martínez, Jhonny Alejandro Rodríguez Gutiérrez

“…<strong>Foundation:</strong> type 2 diabetes mellitus constitutes a growing epidemic and represents a substantial economic burden for health systems. Detecting the disease at an early stage helps reduce medical costs and the risk of patients having more complicated health problems. …”
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The community as an active part in the implementation of interventions for the prevention and care of tuberculosis: A scoping review. by Lesly Chavez-Rimache, César Ugarte-Gil, Maria J Brunette

“…Community participation not only strengthens the capacities of health systems for the prevention and care of tuberculosis, but also allows a better understanding of the disease from the perspective of the patient and the affected community by identifying barriers and difficulties through of the tuberculosis care cascade. …”
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The global health and economic burden of chikungunya from 2011 to 2020: a model-driven analysis on the impact of an emerging vector-borne disease by Adrianne Marije de Roo, Gerard Timmy Vondeling, Martijn Boer, Kristy Murray, Maarten Jacobus Postma

“…Especially in combination with its unpredictable nature, chikungunya could significantly impact local health systems. Insights from this study could inform decision makers on the impact of chikungunya on population health and help them to appropriately allocate resources to protect vulnerable populations from this debilitating disease.…”
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Cost‐of‐illness analysis of chronic urticaria clinical management in five countries of Latin America by Jorge Sánchez, Leidy Álvarez, José Ignacio Larco, Luis Ensina, Guillermo Guidos‐Fogelbach, Cesar A. Reyes‐López, German D. Ramon, Karla Robles‐Velasco, Ivan Cherrez‐Ojeda

“…Strengthening national health systems, as well as following the recommendations of international guidelines, seems to reduce the cost of CSU and improve the quality of patients.…”
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Characterization of Patients with Acute Myocardial Infarction Treated at the General University Hospital Dr. Gustavo Aldereguía Lima by Edislaimy Suárez Rosales, Rodolfo Javier Rivero Morey, Lourdes María Roca Surí, Francisco de Jesús Valladares Carvajal, Evelyn Delgado Rodríguez, Lourdes María Fernández García

“…<strong>Background:</strong> ST-segment elevation acute myocardial infarction poses a great challenge to health systems, therefore its diagnosis and management are important. …”
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Critical appraisal and comparison of recommendations of clinical practice guidelines for treatment of schizophrenia in children and adolescents: a methodological survey protocol by Cristiane de Cássia Bergamaschi, Silvio Barberato-Filho, Izabela Fulone, Maíra Ramos Alves, Flávia Blaseck Sorrilha, Rejane Coan Ferretti Mayer, Daniela Oliveira de Melo, Luciane Lopes

“…The aim of this study will be to assess the quality of the development of CPGs for the treatment and management of schizophrenia in children and adolescents over time using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to compare the recommendations and interventions described in these documents.Methods and analysis CPGs will be identified using a prospective protocol through a systematic search of multiple databases (Medline, Embase, Health Systems Evidence, Epistemonikos, Lilacs, etc) and guideline websites from 2004 to December 2020. …”
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Improving the provision of clinical pharmacy services in low- and middle-income countries: a qualitative study in tertiary health facilities in Tanzania by Fredrick Kalokola, Dorkasi L Mwakawanga, Ritah F Mutagonda, Hamu J Mlyuka, Wigilya P Mikomangwa, Manase Kilonzi, Wema A Kibanga, Alphonce Ignace Marealle, Bertha Mallya, Deogratias Katabalo, Sofia Sanga, John Rwegasha, Rose Magambo, John Mmassy, Sungwa Kabissi, Josephine A Balati, Peter Maduki, Omary Mashiku Minzi, Appolinary A R Kamuhabwa

“…The latter calls for multifaceted engagement from pharmacists, training institutions, policymakers, regulatory bodies and health systems for sustainable progress.…”
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Patient education and follow-up units in Iran: A quality improvement project by Elham Almassi Ghaleh, Susan Jamshidi Farsani, Parastoo Ariamloo, Nasrin Mehrnoosh, Maryam Rassouli, Abbas Ebadi

“… Background & Aim: The rising prevalence of chronic and non-communicable diseases, presents significant challenges to health systems. This study aims to empower patients and their families by establishing patient education and follow-up units, thereby improving readmission rates, reducing unplanned referrals to emergency departments, and enhancing patient satisfaction, which are key nursing-sensitive indicators. …”
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Barriers and facilitators for healthcare access among immigrants in Japan: a mixed methods systematic review and meta-synthesisResearch in context by Yu Par Khin, Floret Maame Owusu, Nobutoshi Nawa, Pamela J. Surkan, Takeo Fujiwara

“…Interpretation: Findings highlight the critical importance of a multidimensional approach to support immigrants in Japan, ranging from improving healthcare information access to creating immigrant-friendly health systems. More research is needed on the healthcare access among vulnerable immigrants, such as undocumented and low-skilled labor immigrants and children. …”
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Defining national research priorities for prostate cancer in Zambia: using the Delphi process for comprehensive cancer policy setting in sub-Saharan Africa by Ajay Aggarwal, Janet Seeley, Virginia Bond, Kennedy Lishimpi, John Kachimba, Musonda Simwinga, Andrew Sentoogo Ssemata, Susan Msadabwe, Dorothy Chilambe Lombe, Monde Mwamba, Richard Muhumuza, Victor Mapulanga

“…The aim of this project was to develop a research agenda for national cancer control planning, using a nationally driven approach, focused on barriers to diagnosis and high-quality treatment for prostate cancer in Zambia.Methods and analysis This was a Delphi process. 29 stakeholders were scored barriers on feasibility, the proportion of patients affected, the impact on patient outcomes and if there was a potential to address health systems barriers meaningfully. There were three rounds (R) to the process: (R1 and R2) by electronic survey and (R3) in-person meeting. …”
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Multidisciplinary stakeholder engagement in a type 2 diabetes comparative effectiveness study utilizing real-world data by Elizabeth H. Golembiewski, Mindy M. Mickelson, Juan P. Brito, Victor M. Montori, Rozalina G. McCoy

“…The PSAG (n = 12) included individuals with T2D, clinicians, health systems leaders, professional society representatives, and a payer representative. …”
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Applied pharmacogenetics to predict response to treatment of first psychotic episode: study protocol by Sergi Mas, Sergi Mas, Sergi Mas, Laura Julià, Manuel J. Cuesta, Manuel J. Cuesta, Manuel J. Cuesta, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Carlos Spuch, Carlos Spuch, Ana Gonzalez-Pinto, Ana Gonzalez-Pinto, Angela Ibañez, Angela Ibañez, Judith Usall, Judith Usall, Cristina Romero-López-Alberca, Cristina Romero-López-Alberca, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Anna Mané, Anna Mané, Anna Mané, Anna Mané, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo

“…The global reach of the FarmaPRED-PEP project is to facilitate the effective deployment of precision medicine in national health systems.…”
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Protocol for a systematic review and individual participant data meta-analysis for risk factors for lung cancer in individuals with lung nodules identified by low-dose CT screening by Matthew Callister, Harry J de Koning, Robert C Rintoul, Carolyn Horst, Arjun Nair, John K Field, Christine D Berg, Samantha Quaife, Rhian Gabe, Stephen Duffy, Sam Janes, Philip AJ Crosbie, Mark M Hammer, Panos Alexandris, Michael PA Davies

“…Consequently, many individuals receive extra imaging and/or unnecessary procedures, which can have a negative physical and psychological impact, as well as placing a financial burden on health systems. Therefore, there is a need to identify individuals who need no interval CT between screening rounds.Methods and analysis The aim of this study is to identify risk factors predictive of LC, which are known at the time of the scan, in patients with LDCT screen-detected lung nodules. …”
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Users’ views on the use of a smartwatch app to collect daily symptom data in individuals with multiple long-term conditions (Multimorbidity): A qualitative study by Cassandra Kenning, Peter Bower, Nicola Small, Syed Mustafa Ali, Benjamin Brown, Katherine Dempsey, Elaine Mackey, Brian McMillan, Caroline Sanders, Ilina Serafimova, Sabine N Van der Veer, William G Dixon, John McBeth

“…Introduction Long-term conditions are a major burden on health systems. One way to facilitate more research and better clinical care among patients with long-term conditions is to collect accurate data on their daily symptoms (patient-generated health data) using wearable technologies. …”
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Chronic-Care-Management Programs for Multimorbid Patients with Diabetes in Europe: A Scoping Review with the Aim to Identify the Best Practice by Julia Heike Brettel, Ulf Manuwald, Henriette Hornstein, Joachim Kugler, Ulrike Rothe

“…Nevertheless, the review shows that CCM was successfully implemented in various care situations and also can be useful in single practices, which often dominate the primary care sector in many European health systems. The present review was able to provide a comprehensive overview of the current care situation of chronically ill patients with multimorbidities. …”
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Impact of diabetes on mental and functional well-being of older adults in Kerala by A. Anjana, P. Bindu

“…Due to its high prevalence, imposed costs on health systems, and various adverse effects on patients, this disease is receiving more attention today. …”
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Personal and professional experiences related to Sars-Cov-2 infection and attitudes to vaccination against COVID-19: the case of medical workers in the Republic of Moldova Experie... by RUSNAC Svetlana

“…The global COVID-19 pandemic has presented huge challenges for health systems worldwide, but also for the entire population, leading to about 545 millions of infections and over 6.3 million of deaths so far. …”
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Bayesian polygenic risk estimation approach to nuclear families with discordant sib-pairs for myelomeningocele. by Adolfo Aguayo-Gómez, Leonora Luna-Muñoz, Yevgeniya Svyryd, Luis Ángel Muñoz-Téllez, Osvaldo M Mutchinick

“…Myelomeningocele (MMC) is the most severe and disabling form of spina bifida with chronic health multisystem complications and social and economic family and health systems burden. In the present study, we aimed to investigate the genetic risk estimate for MMC in a cohort of 203 Mexican nuclear families with discordant siblings for the defect. …”
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The impact of the Lesotho health reform in the re-structuring of the village health workers program by Afom T. Andom, Hannah N. Gilbert, Courtney M. Yuen, Mapoho Mokoroane, Melino Ndayizigiye, Mpopo Tsoele, Masebeo Koto, Retsepile Tlali, Makena Ratsiu, Joia S. Mukherjee

“…Abstract Background Community Health Workers locally known as Village Health Workers (VHW) in Lesotho are key members of the primary health workforce, and has been playing a significant role in building primary health systems in many countries and they can fill significant gaps in human resources as low and middle income countries work towards universal health coverage in the era of Sustainable Development Goals (SDGs). …”
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