Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone significantly reduced pro-inflammatory cytokines including interleukin-6, interleukin-1β, transforming growth factor-β, tumor necrosis factor- α, high-mobility group box-1, and toll-like receptor-4, elevated gamma-aminobutyric acid, decreased glutamate levels, modulated aspartate aminotransferase and alanine aminotransferase levels. …”
Get full text

Cardiovascular Development and the Colonizing Cardiac Neural Crest Lineage by Paige Snider, Michael Olaopa, Anthony B. Firulli, Simon J. Conway

“…Combined, this suggests that either the cardiac neural crest secrete factor/s that regulate myocardial proliferation, can signal to the epicardium to subsequently secrete a growth factor/s, or may even contribute directly to the heart. …”
Get full text

Tumor Microenvironment Responsive Key Nanomicelles for Effective Against Invasion and Metastasis in Ovarian Cancer Using Mice Model by Liu Y, Kong L, Yu Y, Zang J, Zhang L, Guo RB, Li ST, Cheng L, Li XT, Chen YQ

“…In addition, by regulating the expression levels of E-Cadherin, N-Cadherin, matrix metalloproteinases (MMPs), hypoxia-inducible factor 1-alpha (HIF-1α), and vascular endothelial growth factor (VEGF), it exhibited an inhibitory effect on epithelial-mesenchymal transformation (EMT) and tumor cell angiogenesis, and effectively inhibited the invasion and metastasis of ovarian cancer cells.Conclusion: PVGLIG-MTX-D/T-NMs achieved passive targeting of tumor sites by enhancing permeability and retention (EPR) effects. …”
Get full text

The Optimum Dietary Phenylalanine Requirement of Hybrid Grouper (Epinephelusfuscoguttatus ♀ × Epinepheluslanceolatus ♂) Juveniles: Effects on Growth Performance, Gut Micromorpholog... by Pinxian Yang, Haijiao Wang, Lei Ma, Haoran Yin, Zhanying Zhu, Cong Liu, Wei Huang, Zhiyu Zhou, Xiaoyi Wu, Sehrish Taj

“…Expression of hepatic insulin-like growth factor-1 (IGF-1) and growth hormone receptor 1 (GHR1) displayed a similar pattern of variation to that of GH. …”
Get full text

Clinical Effect of MOTOmed Intelligent Motion Feedback Training Combined with Refined Rehabilitation Training on Patients with Hemiplegia after Cerebral Infarction by WANG Bin, GAO Songnian, LIU Qiaoyun, DONG Xinchun

“…Blood flow velocity changes of the middle cerebral artery (MCA) and anterior cerebral artery (ACA), levels of serum nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were compared.ResultsCompared with that before treatment, NIHSS score of the control group and the observation group after treatment decreased significantly, while FMA score of the upper or lower limbs, BBS score, MBI score, WHOQOL-BREF score, MAC and ACA blood flow velocity and serum NGF and BDNF level increased significantly, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
Get full text

3,5,6,7,8,3’,4’- Heptamethoxyflavonoid inhibits TGF-β1-induced epithelial–mesenchymal transition by regulating oxidative stress and autophagy through MEK/ERK/PI3K/AKT/mTOR signalin... by Yiting Wang, Zhiheng Ma, Weiwen Peng, Qinglian Yu, Wenjie Liang, Liu Cao, Zhuqiang Wang

“…However, it remains unclear whether and how HMF alleviates transforming growth factor-β1 (TGF-β1)-induced EMT. The objective of this study was to investigate the impact of HMF on TGF-β1-induced EMT in human alveolar Type II epithelial cells (A549) and its underlying mechanism. …”
Get full text

不同剂量苯那普利对自发性高血压大鼠肾小球硬化的影响

“…【目的】 观察超大剂量血管紧张素转化酶抑制剂干预能否进一步抑制肾小球硬化65377;【方法】 30只8周龄雄性自发性高血压大鼠随机分为模型对照组(M组),大剂量(10 mg·kg-1·d-1)苯那普利治疗组(LT组),超大剂量(50 mg·kg-1·d-1)苯那普利治疗组(HT组),以10只Wistar-Kyoto大鼠(Wistar-Kyoto rats,WKY)为正常对照组(N组)65377;检测各组大鼠的血压65380;血清肌酐及24 h尿蛋白;RT-PCR和免疫组织化学方法分别检测肾组织转化生长因子-β1(transforming growth factor,TGF-β1)和纤溶酶原激活物抑制因子(Plasminogen Activator Inhibitor,PAI-1)的mRNA和蛋白表达;肾组织石蜡切片评估肾小球胶原沉积程度,采用MASSON染色65377; 【结果】 1)TGF-β1和PAI-1的mRNA和蛋白表达:LT组和HT组的TGF-β1和PAI-1 的mRNA和蛋白表达被抑制(P < 0.01);两治疗组间无统计学差异(P > 0.05)65377;2)肾小球胶原沉积:LT组和HT组的胶原面积/肾小球面积比值均明显减低(0.17 ± 0.15, 0.18 ± 0.11 vs 0.30 ± 0.28; P = 0.001);两治疗组间无统计学差异(0.17 ± 0.15 vs 0.18 ± 0.11; P=0.404)65377;【结论】 大剂量与超大剂量血管紧张素转化酶抑制剂均能降低血压,减少蛋白尿,抑制肾组织TGF-β1和PAI-1的mRNA和蛋白表达,延缓肾小球硬化;但超大剂量血管紧张素转化酶抑制剂不能进一步的抑制肾小球硬化65377;…”
Get full text

Knowledge and attitudes of primary care physicians regarding acromegaly: a survey study with multinational participation by Aysen Kutan Fenercioglu, Ebru Unur Demircan, Gunay Can, Cem Sulu, Nurver Turfaner Sipahioglu, Hande Mefkure Ozkaya, Pinar Kadioglu

“…Only 36.1% of the Turkish physicians, 29.8% of the European physicians, and 31.3% of the Asian/African physicians knew that serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels were diagnostic indicators for acromegaly. …”
Get full text

LIN28A-dependent lncRNA NEAT1 aggravates sepsis-induced acute respiratory distress syndrome through destabilizing ACE2 mRNA by RNA methylation by Jun Liu, Xiang Li, Peng Yang, Yufeng He, Weilong Hong, Yawei Feng, Zhiqiang Ye

“…Moreover, lin-28 homolog A (LIN28A) improved NEAT1 stability whereas insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) augmented NEAT1 destabilization by associating with LIN28A to disrupt the combination of LIN28A and NEAT1 in LPS-treated AT-II cells. …”
Get full text

Non-cancerous CT findings as predictors of survival outcome in advanced non-small cell lung cancer patients treated with first-generation EGFR-TKIs. by Pakorn Prakaikietikul, Pattraporn Tajarenmuang, Phumiphat Losuriya, Natee Ina, Thanika Ketpueak, Thanat Kanthawang

“…<h4>Purpose</h4>To identify non-cancerous factors from baseline CT chest affecting survival in advanced non-small cell lung cancer (NSCLC) treated with first-generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (EGFR-TKIs).…”
Get full text

Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab by Settimio Rossi, Carlo Gesualdo, Ernesto Marano, Raffaele Perrotta, Maria Consiglia Trotta, Antonio Del Giudice, Francesca Simonelli

“…Intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents have transformed nAMD treatment, with Brolucizumab emerging as a promising therapy. …”
Get full text

Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

“…The concentrations of 13 complement proteins and vascular endothelial growth factor A (VEGF-A) were measured using Luminex® × MAP® technology.Results: During ranibizumab treatment, a reduction in the levels of C1q (p < 0.001), C2 (p = 0.030), C4 (p = 0.001), C4b (p = 0.026), C3b/iC3b (p < 0.001), C5 (p = 0.007), C5a (p = 0.005), CFD (p = 0.022), CFH (p < 0.001), and CFI (p < 0.001) in AH was observed. …”
Get full text

Preoperative prediction of multiple biological characteristics in colorectal cancer using MRI and machine learning by Qiao-yi Huang, Hui-da Zheng, Bin Xiong, Qi-ming Huang, Kai Ye, Shu Lin, Jian-hua Xu

“…Immunohistochemistry analysis was performed to detect the expression levels of p53, synaptophysin (Syn), human epidermal growth factor receptor 2 (HER2), perineural invasion (PNI), and vascular invasion (VI) expression levels in CRC tissues. …”
Get full text

Effects of kelp phlorotannins on the growth, immunity, intestinal health and disease resistance against Vibrio splendidus of sea cucumber Apostichopus japonicus by Zhikai Zhang, Yan Chi, Yongheng Du, Feng Li, Ning Ma, Song Qin

“…The intestinal health of sea cucumbers was also enhanced by phlorotannins, as expressed by the higher intestine fold height, up-regulation of tight junction genes (ZO-1 and occludin) and down-regulation of two proinflammatory genes (interleukin 17 and transforming growth factor - beta). In conclusion, the present work reported the promoting effects of phlorotannins on growth and disease resistance of sea cucumbers, which could be attributed to the abilities to improve the immunity, redox homeostasis and intestinal healthy condition. …”
Get full text

Predictive factors for axillary pathological complete response to neoadjuvant therapy in elderly breast cancer patients by Yuying Wang, Rui Wang, Di Lu, Yaling Zeng, Xihui Tu, Shiwei Liu, Purong Zhang

“…The univariate analysis results showed that the initial clinical lymph nodes negative(cN0) stage, Human Epidermal Growth Factor Receptor 2(HER2) positivity and breast pathological complete response(bpCR) were significantly correlated with high apCR rates(all P < 0.05). …”
Get full text

TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Background: Despite treatment advances for patients with early-stage triple-negative breast cancer (TNBC) and hormone receptor (HR)-low/human epidermal growth factor receptor 2-negative (HER2−) breast cancer, treatments that improve clinical outcomes while mitigating toxicity are needed. …”
Get full text

Aplikasi Pertimbangan Wisata di Pulau Lombok dengan Metode Fuzzy Mamdani & Algoritma Genetika by Zainul Harir, Ida Bagus Ketut Widiartha, Royana Afwani

“…Abstract Tourism in Lombok has an interesting culture, it makes Lombok got three awards at the 2016 World Halal Tourism Awards and became a growth factor for tourist visits by 13% that year. An application that can help tourists in determining travel decision is mandatory.The application developed with Mamdani Fuzzy Logic and Genetic Algorithm to provide tourism recommendations. …”
Get full text

HGF-Modified Dental Pulp Stem Cells Mitigate the Inflammatory and Fibrotic Responses in Paraquat-Induced Acute Respiratory Distress Syndrome by Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang

“…Mesenchymal stem cells (MSCs) and hepatocyte growth factor (HGF) have been shown to partially reverse this damage. …”
Get full text

Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study by Matthew A. Lee, Kate L. Burley, Emma L. Hazelwood, Sally Moore, Sarah J. Lewis, Lucy J. Goudswaard

“…Seven proteins had 95% confidence intervals (CIs) that did not overlap the null in both forward MR analyses and did not have evidence for an effect in the reverse direction: higher levels of dermatopontin (DPT), beta-crystallin B1 (CRYBB1), interleukin-18-binding protein (IL18BP) and vascular endothelial growth factor receptor 2 (KDR) and lower levels of odorant-binding protein 2b (OBP2B), glutamate-cysteine ligase regulatory subunit (GCLM) and gamma-crystallin D (CRYGD) were implicated in increasing MM risk. …”
Get full text

CircRNA-miRNA-mRNA regulatory network in high-altitude hypobaric hypoxia-induced hearing impairment and hearing acclimatization by Danzeng Awang, Kanzi Danzeng, Tianheng Wang, Quzong Deji, Mengting Huang, Hailong Ren, Xinzhu Liu, Binghan Zhao, Lanzi Gongga

“…Anterograde trans-synaptic signaling (GO:0098916) and negative regulation of cellular response to growth factor stimulus (GO:0090288) were regulated by hearing impairment ceRNA networks, and embryonic organ development (GO:0048568) was regulated by hearing acclimatization ceRNA networks. …”
Get full text