Tumor Reduction with Pazopanib in a Patient with Recurrent Lumbar Chordoma by Maurício Fernando Silva Almeida Ribeiro, Micelange Carvalho de Sousa, Samir Abdallah Hanna, Marcos Vinicius Calfat Maldaun, Ceci Obara Kurimori, Luiz Guilherme Cernaglia Aureliano de Lima, Romulo Loss Mattedi, Rodrigo Ramella Munhoz

“…A large proportion of these tumors express stem-cell factor receptor (c-KIT) and platelet-derived growth factor receptors (PDGFRs), providing a rationale for the use of tyrosine-kinase inhibitors (TKIs). …”
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Osteoblast‐Derived ECM1 Promotes Anti‐Androgen Resistance in Bone Metastatic Prostate Cancer by Xinwen Wang, Min Wang, Qijun Lin, Lixin He, Baolin Zhang, Xin Chen, Guanhong Chen, Hong Du, Chuandong Lang, Xinsheng Peng, Yuhu Dai

“…This event further recruits adapter proteins including growth factor receptor‐bound protein 2 (GRB2) and son of sevenless homolog 1 (SOS1), which activates the downstream mitogen‐activated protein kinase (MAPK) signaling pathway to induce anti‐androgen resistance. …”
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Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry by Michael J. Greig, Sherry Niessen, Scott L. Weinrich, Jun Li Feng, Manli Shi, Ted O. Johnson

“…Utilizing SILAC MS, we measured the cellular turnover rates of an important non-small cell lung cancer target, epidermal growth factor receptor (EGFR). Wild-type (WT) EGFR, EGFR with a single activating mutant (Del 746–750 or L858R), and the drug-resistant double mutant (L858R/T790M) EGFR were analyzed. …”
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Tetramethylpyrazine and paeoniflorin combination (TMP-PF) alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathw... by Rong Yuan, Qiqi Xin, Weili Shi, Yu Miao, Zhengchuan Zhu, Yahui Yuan, Ying Chen, Xiaoning Chen, Sean Xiao Leng, Keji Chen, Weihong Cong

“…Results showed that TMP and high-dose TMP-PF decreased serum triglyceride and low-density lipoprotein cholesterol levels, suppressed vascular endothelial growth factor receptor 2 (VEGFR2) and nuclear receptor subfamily 4 group A member 1 (NR4A1) expression in aortic tissues, inhibited plaque angiogenesis, reduced plaque areas, and alleviated atherosclerosis in ApoE-/- mice. …”
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Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish by Anqi Dong, Wenqian Lei, Weiqi Zhou, Wenwen Li, Jianghua Wang

“…Additionally, a notable reduction in protein level in eggs and the gene expression of both the hormone/insulin-like growth factor (GH/IGF) and hypothalamic-pituitary-thyroid (HPT) pathways were observed. …”
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Evaluation of the Effects of STZ-Induced Diabetes on In Vitro Fertilization and Early Embryogenesis Processes by Hüseyin Aktuğ, Vildan Bozok Çetintaş, Ayşegül Uysal, Fatih Oltulu, Altuğ Yavaşoğlu, Saadet Özen Akarca, Buket Kosova

“…Connective tissue growth factor expression increased in groups that included sperm cells isolated from diabetic male rats, whereas mucin-1 expression increased in the group that included oocytes isolated from diabetic female rats paired with sperm cells isolated from healthy male rats. …”
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Relevance of the GH-VEGFB/VEGFA axis in liver grafts from brain-dead donors with alcohol-associated liver disease by Marc Micó-Carnero, Marc Micó-Carnero, Carlos Rojano-Alfonso, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Cristina Maroto-Serrat, Juan Carlos Cutrin, Araní Casillas-Ramírez, Araní Casillas-Ramírez, Carmen Peralta

“…Here, we investigated the role of growth hormone (GH) in livers with ALD from DBDs and its relationship with vascular endothelial growth factor A (VEGFA) and VEGFB.MethodsLivers from rats fed ethanol for 6 weeks and with brain death (BD) were cold stored for 24 h and subjected to ex vivo reperfusion. …”
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The influence of follicular fluid on the regulation of apoptosis and related genes during IVM of camel oocytes by A.A. Ammari, AR. Alhimaidi, K.N. Yaseen, B.O. Almutairi, R.A. Amran, A. AL-juaimlan, A. Rady

“…Acta2 and Tagln genes that relate to cytoskeletal protein “actin” in transforming growth factor beta (TGFβ) pathway were also modulated. …”
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Panretinal Photocoagulation Using Short-Pulse Laser Induces Less Inflammation and Macular Thickening in Patients with Diabetic Retinopathy by Yoshihiro Takamura, Shogo Arimura, Seiji Miyake, Takehiro Matsumura, Makoto Gozawa, Kentaro Iwasaki, Masaru Inatani

“…Vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemotactic protein-1 (MCP-1) levels in vitreous humor were measured using an immunoassay. …”
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Interfacial cfDNA Enrichment and Amplification with On‐Chip Thermoplasmonics for Highly Sensitive Cancerous Liquid Biopsy by Danhua Wang, Linlin Liu, Wenjing Chi, Zhenping Liu, Jiayun Wu, Yirou Liang, Fei He, Ruixiang Zhang, Pengxin Huang, Yunbo Li, Guangyu Qiu

“…Typical cfDNA biomarkers, including epidermal growth factor receptor (EGFR), tumor protein 53 (TP53), phosphatase and tensin homologue deleted on chromosome 10 (PTEN), and cyclin‐dependent kinase inhibitor (CDKN2A), are quantified with detection limits down to femtomolar‐level. …”
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Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse by Kishio Furuya, Kishio Furuya, Hiroaki Hirata, Hiroaki Hirata, Takeshi Kobayashi, Hiroshi Ishiguro, Masahiro Sokabe, Masahiro Sokabe

“…The diffuse ATP release pattern changed to a transient-sharp pattern by cholera toxin treatment and the reverse change was induced by transforming growth factor (TGF) β treatment. DCPIB, an inhibitor of volume-regulated anion channels (VRACs), suppressed the diffuse pattern. …”
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…Metformin, an antidiabetic drug, is effective for endometrial cancer through inhibition of the PI3K-Akt-mTOR pathway by activating LKB1-AMPK and reduction of insulin and insulin-like growth factor-1 due to AMPK activation. COX-2 inhibitors for cervical cancer may also be examples of drug repositioning. …”
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Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Ce... by Koichi Takayama, Shunichi Sugawara, Yasuo Saijo, Makoto Maemondo, Atsushi Sato, Shinzo Takamori, Taishi Harada, Tetsuro Sasada, Tatsuyuki Kakuma, Junji Kishimoto, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Yoichi Nakanishi

“…Previously treated PS0-1 patients with IIIB/IV EGFR (epidermal growth factor receptor) wild genotype NSCLC were randomly assigned to docetaxel (60 mg/m2 on Day 1) plus PPV based on preexisting host immunity or docetaxel plus placebo. …”
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Involvement of the TGF-β pathway in epithelialmesenchymal transition promoted by the pulmonary microenvironment in Mycoplasma pneumoniae pneumonia by Fan Lu, Wang Huixia, Xu Nuo, Guo Yun, Li Ling

“…Transcriptome sequencing revealed significant upregulation of pathways including transforming growth factor beta (TGF-β), tumor protein 53 (P53), protein kinase Hippo, Ras-proximate-1 or Ras-related protein 1 (Rap1), and members of class O forkhead box proteins (FoxO) in cells exposed to bronchoalveolar lavage fluid (BALF) from MPP patients with atelectasis. …”
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The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology by Bart Krist, Urszula Florczyk, Katarzyna Pietraszek-Gremplewicz, Alicja Józkowicz, Jozef Dulak

“…On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors. …”
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Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors by Gabriela Placoná Diniz, Marcela Sorelli Carneiro-Ramos, Maria Luiza Morais Barreto-Chaves

“…TH-induced cardiac hypertrophy in vivo is accompanied by increased cardiac Transforming Growth Factor-β1 (TGF-β1) levels, which is mediated by Angiotensin II type 1 receptors (AT1R) and type 2 receptors (AT2R). …”
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Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFβ3 and Induces a Myofibroblast-Like Genotype by Luisa Marilena Schäck, Manuela Buettner, Alexander Wirth, Claudia Neunaber, Christian Krettek, Andrea Hoffmann, Sandra Noack

“…We demonstrate that CD24 is an important modulator in transforming growth factor beta 3 (TGFβ3) signaling with a reciprocal regulatory relationship between these two proteins.…”
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Thrombospondin and VEGF-R: Is There a Correlation in Inflammatory Bowel Disease? by Jaroslaw Wejman, Michal Pyzlak, Dariusz Szukiewicz, Dorota Jarosz, Wieslaw Tarnowski, Grzegorz Szewczyk

“…The purpose of our study was to evaluate the relationship between vascular density and expression of thrombospondin-1 (TSP-1) and vascular endothelial growth factor receptor 1 (VEGFR-1) in full-thickness tissue fragments of intestinal wall taken from patients after colectomy, comparing those with IBD to non-IBD control group. …”
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低能量氦氖激光照射促进体外培养神经元的突起生长和RNA合成 by 周汉城

“…培养物分为激光照射组与对照组,两组均在含有神经生长因子(nerve growth factor)的培养液中生长。激光照射组每隔2小时用4毫瓦氦氖激光(Helium-Neon laser)照射一次,每次5分钟,直至终止培养。…”
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Similarity of Fibroglandular Breast Tissue Content Measured from Magnetic Resonance and Mammographic Images and by a Mathematical Algorithm by Fatima Nayeem, Hyunsu Ju, Donald G. Brunder, Manubai Nagamani, Karl E. Anderson, Tuenchit Khamapirad, Lee-Jane W. Lu

“…We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were more strongly associated with amounts of glandular tissue than adipose tissue, while fat body mass, alanine aminotransferase, and insulin like growth factor-II appear to be more associated with the amount of breast adipose tissue. …”
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