Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury by Haitao Ren, Qiang Zhang, Jinfu Wang, Ruolang Pan

“…Furthermore, we found that UCMSCs secreted higher levels of anti-inflammatory cytokines (interleukin-10 and keratinocyte growth factor) in ALI-related conditions, which may be due to the greater therapeutic capacity of UCMSCs compared with MBMSCs. …”
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The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications by Chi-Yuan Chen, Kuo-Yen Huang, Chin-Chuan Chen, Ya-Hsuan Chang, Hsin-Jung Li, Tong-Hong Wang, Pan-Chyr Yang

“…PM2.5 can increase oxidative stress and inflammation, induce genetic alterations and activation of oncogenes (including the epidermal growth factor receptor, EGFR), and contribute to lung cancer progression. …”
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Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy by Luwei Zhang, Jinhang Zhang, Xinnong Liu, Shengli Liu, Jun Tian

“…To reveal the expression and possible role of tribbles homolog 3 (TRB3) in the incidence of type 2 diabetic nephropathy, we used immunohistochemistry, real-time quantitative PCR, western blot analysis, and enzyme-linked immunosorbent assay (ELISA) to study the expression of TRB3, extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase (ERK1/2 MAPK), transforming growth factor β1 (TGF-β1), and collagen type IV in kidneys of db/db diabetic mice and in murine renal mesangial cells stimulated with high glucose. …”
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TGF‐β regulates the release of breast cancer cell‐derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression by Chao Li, Agustin Enciso‐Martinez, Roman I. Koning, Mona Shahsavari, Peter ten Dijke

“…The cytokine transforming growth factor‐β (TGF‐β) facilitates cancer progression via EVs secreted by cancer cells, which act on recipient cells in the tumour microenvironment. …”
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Update Review and Clinical Presentation in Congenital Insensitivity to Pain and Anhidrosis by L. M. Pérez-López, M. Cabrera-González, D. Gutiérrez-de la Iglesia, S. Ricart, G. Knörr-Giménez

“…This pathology is caused by a genetic mutation in the NTRK1 gene, which encodes a tyrosine receptor (TrkA) for nerve growth factor (NGF). Methods. The consultation of a child female in our center with CIPA and a tibia fracture in pseudoarthrosis encouraged us to carefully review literature and examine the therapeutic possibilities. …”
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Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy by I Nyoman Bayu Mahendra, I Gde Sastra Winata, William Alexander Setiawan, Ida Bagus Agung Widnyana Putra, Putu Bagus Darmayasa

“…Key tumor angiogenesis markers, such as vascular endothelial growth factor (VEGF) and its receptor (VEGFR), are critical in driving tumor progression in advanced cervical cancer. …”
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Targeted microbiome metabolomics reveals flaxseed oil supplementation regulated the gut microbiota and farnesoid X receptor pathway in high-fat diet mice by Chen Yang, Zhenxia Xu, Qingde Huang, Xu Wang, Fenghong Huang, Qianchun Deng

“…FSO reduced the concentrations of conjugated BAs, such as cholic acid, tauro-α-murocholic acid, and tauro-ursodesoxycholic acid in feces, which in turn inhibit the intestinal farnesoid X receptor (FXR)-fibroblast growth factor (FGF) 15 signaling pathway. Further analysis revealed that FSO activated FXR in the liver and regulated downstream gene expression (SHP, SREBP-1c, and CPT-1a), which promoted lipolysis and inhibited lipogenesis. …”
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Amygdalin Promotes Fracture Healing through TGF-β/Smad Signaling in Mesenchymal Stem Cells by Jun Ying, Qinwen Ge, Songfeng Hu, Cheng Luo, Fengyi Lu, Yikang Yu, Taotao Xu, Shuaijie Lv, Lei Zhang, Jie Shen, Di Chen, Peijian Tong, Luwei Xiao, Ju Li, Hongting Jin, Pinger Wang

“…Further experiments using MSC-specific transforming growth factor- (TGF-) β receptor 2 conditional knockout (KO) mice (Tgfbr2Gli1-Cre) and C3H10 T1/2 murine mesenchymal progenitor cells showed that this effect was mediated through TGF-β/Smad signaling. …”
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Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? by Stefania Gonfloni, Emiliano Maiani, Claudia Di Bartolomeo, Marc Diederich, Gianni Cesareni

“…The c-Abl tyrosine kinase is implicated in diverse cellular activities including growth factor signaling, cell adhesion, oxidative stress, and DNA damage response. …”
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Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape by Silke De Vriendt, Emma Laporte, Berkehür Abaylı, Julie Hoekx, Florian Hermans, Diether Lambrechts, Hugo Vankelecom

“…Importantly, we functionally validated transcriptomic findings using pituitary stem cell organoids, revealing roles for Krüppel-like transcription factor 5 (KLF5), activator protein-1 (AP-1) complex and epidermal growth factor (EGF) pathways in pituitary stem cell regulation. …”
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PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

“…Abstract Anti-epidermal growth factor receptor (EGFR) therapy (cetuximab) shows a limited clinical benefit for patients with locally advanced or recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), due to the frequent occurrence of secondary resistance mechanisms. …”
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Efficiency to Discovery Transgenic Loci in GM Rice Using Next Generation Sequencing Whole Genome Re-sequencing by Doori Park, Dongin Kim, Green Jang, Jongsung Lim, Yun-Ji Shin, Jina Kim, Mi-Seong Seo, Su-Hyun Park, Ju-Kon Kim, Tae-Ho Kwon, Ik-Young Choi

“…In the present study, we applied NGS to insert transgenic loci, specifically the epidermal growth factor (EGF) in genetically modified rice cells. …”
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Effects of bFGF on the Modulation of Apoptosis in Gingival Fibroblasts with Different Host Ages by Kotaro Tanimoto, Satoru Ohkuma, Yuki Tanne, Ryo Kunimatsu, Naoto Hirose, Tomomi Mitsuyoshi, Yuki Yoshimi, Shaoching Su, Kazuo Tanne

“…The purpose of this study was to investigate the effects of basic fibroblast growth factor (bFGF) treatment on the proliferation and apoptosis of cultured gingival fibroblasts (GFs). …”
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Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation by Shi-Qing Mu, Jia-Jie Lin, Yu Wang, Li-Yun Yang, Sen Wang, Zhao-Yi Wang, An-Qi Zhao, Wen-Jun Luo, Zi-Qi Dong, Yu-Guang Cao, Ze-An Jiang, Si-Fan Wang, Shan-Hu Cao, Li Meng, Yang Li, Shu-Yan Yang, Shao-Guang Sun

“…Abstract Aberrant autophagy in vascular smooth muscle cells (VSMCs) is associated with the progression of vascular remodeling diseases caused by neointimal hyperplasia. Platelet-derived growth factor-BB (PDGF-BB)-induced vascular remodeling is accompanied by autophagy activation, however, the involvement of circular RNAs (circRNAs) remains unclear. …”
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Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization by Peng-Chao Wang, Jie Liu, Yue-Fang Liu, Yang Wu, Lin-Li Xue, Zhen-Shan Yang

“…PGE2-mediated upregulation of insulin growth factor binding protein 1 (IGFBP1) was significantly inhibited by Valdecoxib and MK886. …”
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NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression by Wenchao Xu, Jianzhou Liu, Qiaofei Liu, Jia Xu, Li Zhou, Zhiyong Liang, Haoran Huang, Bowen Huang, Gary Guishan Xiao, Junchao Guo

“…Metastatic tumors produce transforming growth factor β to activate the SMAD3 pathway within neutrophils, inducing NFE2-driven polarization. …”
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RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study by Yanju Li, Xu Yang, Feiqing Wang, Feiqing Wang, Jianing Zhao, Chike Zhang, Dan Wu, Bo Yang, Rui Gao, Peng Zhao, Yun Zan, Min Su, Zhixu He, Yang Liu, Yang Liu, Yang Liu, Jishi Wang, Dongxin Tang

“…According to the top-10 core genes and targets of the PPI pathway, AKT1, interleukin (IL)-6, vascular endothelial growth factor (VEGF)A, MYC, and epidermal growth factor receptor (EGFR) were selected for molecular docking. …”
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SPDEF ameliorates UUO-induced renal fibrosis by transcriptional activation of NR4A1 by Hongshuang Wang, Ziheng Wei, Chang Xu, Fang Fang, Zheng Wang, Yan Zhong, Xiangting Wang

“…Our results showed that the knockdown of NR4A1 can accelerate unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice, and overexpression of NR4A1 can significantly reduce transforming growth factor-β1-induced (TGF-β1) fibrosis in HK-2 cells. …”
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Immune Privilege and Eye-Derived T-Regulatory Cells by Hiroshi Keino, Shintaro Horie, Sunao Sugita

“…Furthermore, we examined the therapeutic potential of Tregs generated by RPE cells that express transforming growth factor beta (TGF-β), cytotoxic T lymphocyte-associated antigen-2 alpha (CTLA-2α), and retinoic acid for autoimmune uveoretinitis and evaluated a new strategy using human RPE-induced Tregs for clinical application in inflammatory ocular disease. …”
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Early growth response 1 transcription factor and its context-dependent functions in glioblastoma by Saleh Rasras, Esma’il Akade, Seyed Ehsan Mohammadianinejad, Maedeh Barahman, Mohammad Bahadoram

“…Early growth response 1 regulatory roles extend to angiogenesis, cell adhesion, and resistance to chemotherapy, notably influencing pathways like hypoxia-inducible factor 1 and vascular endothelial growth factor A. Early growth response 1 can also induce cell adhesion, migration, chemoresistance against temozolomide, stemness, and self-renewal in glioblastoma cells. …”
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