Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis by Haiyan Wu, Yayun Fan, Yuanyuan Bao, Qing Zhou, Lei Xu, Yao Xu

“…Drug prediction analysis showed that bevacizumab and cisplatin were related to vascular endothelial growth factor A. Risk score, as an independent prognostic factor of cervical cancer, had a good survival prediction effect. …”
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Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases by Aristeidis Hristos Zibis, Apostolos Haralampos Fyllos, Sophia Havaki, Sotirios Sotiriou, Georgios Kotakidis, Dimitrios Leonidas Arvanitis

“…Immunohistochemistry showed positivity for Gross Cystic Disease Fluid Protein-15 (GCDFP-15), androgen receptors, and score 3+ for the Human Epidermal growth factor Receptor-2 (HER2). The aggressive behavior of the present tumor goes along with previous reports showing that HER2 high score cases exhibit a worse prognosis.…”
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Protein kinase inhibitors as targeted therapy for glioblastoma: a meta-analysis of randomized controlled clinical trials by José Pinto-Fraga, Celia García-Chico, Simone Lista, Pedro Miguel Lacal, Giuseppe Carpenzano, Maurizio Salvati, Alejandro Santos-Lozano, Grazia Graziani, Claudia Ceci

“…Upon disease progression, the anti-vascular endothelial growth factor-A (VEGF-A) monoclonal antibody bevacizumab, can be considered.Given the limited efficacy of pharmacological treatments, particularly for the recurrent disease, several molecularly targeted interventions have been explored, such as small-molecule protein kinase inhibitors (PKIs), inhibiting tyrosine kinase growth factor receptors and downstream signaling pathways involved in GBM angiogenesis and infiltrative behavior.This meta-analysis, based on searches in PubMed and Web Of Science, evaluated 12 randomized controlled trials (RCTs) examining PKIs in patients with newly diagnosed or recurrent GBM. …”
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Effect of Shangke Zhitong Ointment Kinesio Tape on Ankle Sprain by WANG Qiang, LIU Zhiyang, JU Shaohua, LI Xiaodong, HUANG Jichao, XIANG Ning

“…Before treatment and after two weeks of treatment, visual analogue score (VAS), swelling degree measurement, American orthopedic foot and ankle society-ankle hindfood scale (AOFAS-AHS), traditional Chinese medicine (TCM) syndrome score (local tenderness, local swelling, local blood stasis, limited activity) were evaluated, and laboratory index test [interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), malondialdehyde (MDA), fibroblast growth factor-2 (FGF-2), transforming growth factor-β1 (TGF-β1) , matrix metalloproteinase (MMP-9)] were performed and skin adverse reactions were observed.Results(1) VAS score, swelling degree of ankle joint and AOFAS-AHS score: compared with before treatment, VAS score and swelling degree in the three groups decreased significantly after treatment, while AOFAS-AHS score increased significantly after treatment (<italic>P</italic>&lt;0.05). …”
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Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway by Yue He, Chao Huang, Jingjing Chen, Weizeng Shen

“…Subsequently, our study verified the target-regulatory relationship between miR-126 and vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells (HUVECs) by using the “TargetScan” website and dual-luciferase reporter assay. …”
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A Review of Age-related Macular Degeneration and Current Concepts in Management by Sahebaan Sethi

“…Pharmacological interventions, particularly anti-vascular endothelial growth factor (anti-VEGF) agents, are extensively reviewed as the mainstay of treatment for wet AMD. …”
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Obesity as a Major Risk Factor for Cancer by Giovanni De Pergola, Franco Silvestris

“…Four main systems have been identified as potential producers of cancer in obesity: insulin, insulin-like growth factor-I, sex steroids, and adipokines. Various novel candidate mechanisms have been proposed: chronic inflammation, oxidative stress, crosstalk between tumour cells and surrounding adipocytes, migrating adipose stromal cells, obesity-induced hypoxia, shared genetic susceptibility, and the functional defeat of immune function. …”
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High FGF18 expression levels predict poor prognosis in endometrial carcinoma patients and promote tumor growth and metastasis by Zheng-Yao Lei, Jian Wu, Bao-Hua Zhang, Wei Xiang, Min Wang, Bin-bin Li, Ming-Cheng Dai

“…Objective To investigate if fibroblast growth factor 18 (FGF18) expression plays an important role in endometrial carcinoma (EC). …”
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Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway by Chao Chen, Qiwu Wang, Jiwen Liu

“…Expression levels of insulin-like growth factor 1 receptor (IGF-1R) were determined by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blotting. …”
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Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application by Kaichun Li, Jin Li

“…Trastuzumab, an antibody targeting human epidermal growth factor receptor 2 (HER2), can significantly improve survival in advanced gastric cancer patients with HER2 overexpression. …”
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Using cortical organoids to understand the pathogenesis of malformations of cortical development by Kellen D. Winden, Isabel Gisser, Mustafa Sahin

“…Several genetic pathways have been associated with these disorders from control of cell cycle and cytoskeletal dynamics in global malformations to variants in growth factor signaling pathways, especially those interacting with the mechanistic target of rapamycin (mTOR), in FCDs. …”
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Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance by Ji Won Han, Su-Hyung Park

“…The liver’s distinct immunological microenvironment, characterized by tolerogenic antigen-presenting cells and high levels of interleukin (IL)-10 and transforming growth factor-β, positions this organ as an ideal setting for Treg-mediated tolerance. …”
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EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration by Alexandra Collin de l'Hortet, Hélène Gilgenkrantz, Jacques-Emmanuel Guidotti

“…The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. …”
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Update on New Antigens in the Pathogenesis of Membranous Nephropathy by Maurizio Salvadori, Aris Tsalouchos

“…Through these techniques, four new antigens were first detected, including neural epidermal growth factor 1 and semaphorin 3B in the so-called primary membranous nephropathy, and exostosin 1 and 2 and neural cell adhesion molecule 1 in lupus membranous nephropathy. …”
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Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study by Guang-Jun Du, Si-Yan Xing, Ning Wu, Tong Wang, Yue-Hui Jiang, Tao Song, Bai-Bing Yang, Yu-Tian Dai

“…In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming growth factor-β1 (TGF-β1), fibrin, sodium tetradecyl sulfate (STS) combined with TGF-β1, and polidocanol (POL) combined with TGF-β1. …”
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Combined Application of Bevacizumab and Mitomycin C or Bevacizumab and 5-Fluorouracil in Experimental Glaucoma Filtration Surgery by Lei Zuo, Jianhong Zhang, Xun Xu

“…The inhibitory effect of combined BVZ and 5-Fu in retinal pigment epithelial cells on vascular endothelial growth factor (VEGF) levels was demonstrated through in vitro experiments. …”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…Clinical data are currently available for sodium channel isoform-specific antagonists, anti-nerve growth factor molecules, and fatty acid amide hydrolase inhibitors.…”
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Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1 by Simone Maria Kluth, Teja Falk Radke, Gesine Kögler

“…Compared to CB MSC, USSC lead to a higher expansion of haematopoietic cells and in addition express significantly higher levels of insulin-like growth factor binding protein 1 (IGFBP1), but lower levels of IGF2. …”
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Diagnostic accuracy of high-resolution melting curve analysis for discrimination of oncology-associated mutations: a systematic review and meta-analysis by Shu Yu, Yan Cheng, Chen-Cheng Tang, Yue-Ping Liu

“…Objective To investigate the diagnostic value of high-resolution melting (HRM) analysis for oncology-associated epidermal growth factor receptor ( EGFR) gene mutations. Methods We systematically searched Embase, PubMed, and Web of Science for HRM and EGFR mutation detection studies published through September 2024. …”
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Thiazolidinedione-Induced Fluid Retention: Recent Insights into the Molecular Mechanisms by Jerzy Bełtowski, Jolanta Rachańczyk, Mirosław Włodarczyk

“…These effects are mediated by PPARγ-induced nongenomic transactivation of the epidermal growth factor receptor and downstream extracellular signal-regulated kinases (ERK).…”
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