Case Report: Efficacy and safety of recombinant growth hormone therapy in a girl with Loeys–Dietz syndrome by Kamil Dyrka, Aleksander Jamsheer, Michal Bartecki, Waldemar Bobkowski, Malgorzata Pawelec-Wojtalik, Justyna Rajewska-Tabor, Andzelika Tomaszewska, Justyna Balcerzak, Zuzanna Aniol, Marek Niedziela, Monika Obara-Moszynska

“…We present the case of a 16.5-year-old girl with LDS type 2 (LDS2) caused by a heterozygous pathogenic variant, c.1582C>T (p.Arg528Cys), in the transforming growth factor-beta receptor type 2 (TGFBR2) gene who was treated with recombinant growth hormone (rGH) due to coexisting GH deficiency (GHD). …”
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Role of the TGF-β cytokine and its gene polymorphisms in asthma etiopathogenesis by Jacek Plichta, Michał Panek

“…Transforming growth factor beta (TGF-β) is a pluripotent cytokine expressed by all cells of the human body which plays important roles in maintaining homeostasis and allowing for proper individual development. …”
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Tracking Tumor Cells in Lymphatics in a Mice Xenograft Model by Magnetic Resonance Imaging by Ting Liu, Haijun Zhou, Rui Xia, Jichun Liao, Changqiang Wu, Hui Wang, Hua Ai, Feng Bi, Fabao Gao

“…Histologic findings confirmed the in vivo MRI results and revealed lymphangiogenesis, angiogenesis, infiltration of macrophages, and expression of vascular endothelial growth factor C in tumor and draining lymph nodes as well. …”
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Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians by Pearse A. Keane, Srinivas R. Sadda

“…By the early 1990s, it had become clear that the recently discovered “vascular endothelial growth factor” (VEGF) was a powerful mediator of angiogenesis. …”
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Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer by Qingqing Meng, Zheng Li

“…Hormone receptors, growth factor receptor, and angiogenic factors, such as ER, PR, HER2, and VEGFR, have been adopted as imaging targets to detect and stage the breast cancer and to monitor the treatment efficacy. …”
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T Helper 17 Cells in Autoimmune Liver Diseases by Masanori Abe, Yoichi Hiasa, Morikazu Onji

“…Because the liver is known to be an important source of transforming growth factor-β and IL-6, which are cytokines that are crucial for Th17 differentiation, it is very likely that Th17 cells contribute to liver inflammation and autoimmunity. …”
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Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns by Maria Portelli, Byron Baron

“…The clinical presentation of PE and data gathered for the biochemical markers placental growth factor (PlGF), soluble Feline McDonough Sarcoma- (fms-) like tyrosine kinase-1 (sFlt-1), asymmetric dimethylarginine (ADMA), and methyl-lysine is being reviewed with the aim of providing both a clinical and biochemical understanding of how these biomarkers might assist in the diagnosis of PE or indicate its severity.…”
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Acromegaloid Facial Appearance: Case Report and Literature Review by Adline Ghazi, Shikha Khosla, Kenneth Becker

“…It encompasses a spectrum of acromegaloid physical findings, normal growth hormone (GH) and insulin-like growth factor one (IGF-1) levels, and variable mode of inheritance. …”
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Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy by Soichi Furukawa, Takashi Kobayashi, Saori Shiono, Shuta Nishinakagawa

“…Immunostaining of the primary tumor was positive for alpha-fetoprotein and negative for human epidermal growth factor receptor 2. Serum alpha-fetoprotein levels decreased to within normal limits after eight courses of S-1 monotherapy; however, levels started to increase, and a hypovascular nodule in segment 5/6 of the liver was detected 3.5 years later. …”
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Planning for signal linking at 3 intersection in Sukabumi City by Wulandari Firdawati, Hidayat Muhammad, Damas Permadi Dio

“…According to the calculation of the road capacity, it produces a total of 1,595 pcu/hour, according to the calculation of the maximum road capacity it produces 4,787 pcu/hour, so in anticipation of this reduction to 85% of the total percent of its maximum capacity, to 4,070, and from the calculation of Growth Factor it produces 3,978 in the year 2034, that means planning for implementing signal linking at its 3 intersections, namely in 2034.…”
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Recent advances of antibody-drug conjugates in treating breast cancer with different HER2 status by Yue Qiu, Yaqin Shi, Zhujun Chao, Xinyu Zhu, Yan Chen, Linlin Lu

“…The identification of human epidermal growth factor receptor 2 (HER2) as an oncogenic driver in a subset of breast cancers, alongside the development of HER2-targeted therapies, has significantly improved the prognosis of HER2-amplified breast cancers. …”
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Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy by Niamh Donnellan, Anne M Friel

“…It interacts with various biological signalling pathways which suppress tumour cells, notably, the Hypoxia-Inducible Factor-1, Vascular Endothelial Growth Factor and the Nuclear Factor Kappa B pathways. …”
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Enhancing Akt Imaging through Targeted Reporter Expression by Limin Zhang, Mahaveer S. Bhojani, Brian D. Ross, Alnawaz Rehemtulla

“…In addition, inhibition of upstream signaling kinases such as epidermal growth factor receptor and phosphatidylinositol 3-kinase activity resulted in changes in Akt activity that were quantitatively monitored by bioluminescence imaging. …”
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A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence by Shoja Rahimian, Timothy Johnson, Ronald Herb

“…Comparison of the pathological features of the renal biopsies within the cases noted mesangial proliferation as a common finding, which has been described to be potentiated by platelet-derived growth factor (PDGF). This commonality may represent a link between ET and glomerular disease which deserves further attention in future cases. …”
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Functional Expression Study of Igf2 Antisense Transcript in Mouse by Carolina Duart-Garcia, Martin H. Braunschweig

“…Insulin-like growth factor antisense gene (Igf2as) expression was investigated in different mouse tissues during development, in differentiating C2C12 cells and in a ΔDMR1-U2 knockout mouse model. …”
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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease by Emma V. Jones, David S. Bouvier

“…Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. …”
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Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain by Edoardo Parrella, Valter D. Longo

“…Mutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. …”
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Navigating the Evolving Treatment Paradigm for _EGFR_-Mutant NSCLC by Sebastian Kraus

“…In non-small cell lung cancer (NSCLC), the most prevalent driver mutations in epidermal growth factor receptor (_EGFR_) are deletions in exon 19 (Ex19del) and L858R mutations in exon 21, which comprise approximately 90% of all _EGFR_ mutations. …”
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Anti-Arthritic Effect of the Hydroethanolic Root Extract of Psydrax subcordata in Rats by Phyllis Annan, Newman Osafo, Paul Poku Sampene Ossei, Wonder Kofi Mensah Abotsi

“…The effect of PSRE on oxidative markers and serum transforming growth factor (TGF) beta 1 was also determined via chemical assays. …”
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Comparison between the Express Implant and Transscleral Diode Laser in Neovascular Glaucoma by Faried Mohammed Wagdy, Adel Galal Zaky

“…The eyes had NVG with intraocular pressure (IOP) more than 21 mmHg of the maximally tolerated medication treatment after previous panretinal photocoagulation and antivascular endothelial growth factor (anti-VEGF) injection, with no previous history of a cyclodestruction procedure or glaucoma surgery, were randomized either for Ex-PRESS glaucoma filtration device or TSCP. …”
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