Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…Several therapeutic monoclonal antibodies (mAbs), including those targeting epidermal growth factor receptor, human epidermal growth factor receptor 2 (HER2), and CD20, mediate fragment crystallizable gamma receptor (FcγR)–dependent activities as part of their mechanism of action. …”
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Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retro... by Ha Young Jo, Hyun Ji Jang, Chong Kun Cheon, Ju Young Yoon, Sukdong Yoo, Jung Hyun Lee, Jeong Eun Lee, Ye Jin Kim, Sejin Kim, Hyun-Ji Kim, Im Jeong Choi, Min Jung Kwak

“…The SDS for insulin-like growth factor-1 (IGF-1) was lower among boys without GHD than among boys with GHD, while the SDS for insulin-like growth factor-binding protein-3 (IGFBP-3) was higher among girls without GHD than among girls with GHD; however, there was no significant difference when comparing all children with GHD to those without GHD. …”
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Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy by Enzo D’Ambrosio, Paolo Tortorella, Ludovico Iannetti

“…Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization. …”
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Effects of physical activity on brain function: Mechanisms, adaptations and clinical implications by Dariusz Fabian, Klaudia Maria Kufel, Mateusz Teofilak, Natalia Maria Smyl, Olga Śpiołek, Jan Siwiec, Aleksandra Słowikowska, Julia Szatkowska, Marcelina Paula Sztyler-Krąkowska, Agnieszka Alicja Wąsowicz, Franciszek Kędziora

“…The article identifies key neurotrophic factors, such as BDNF (brain-derived neurotrophic factor) and VEGF (vascular endothelial growth factor), which are regulated by physical activity and contribute to improved cognitive function and mental health. …”
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EGFR T790M-Positive Lung Adenocarcinoma Metastases to the Pituitary Gland Causing Adrenal Insufficiency: A Case Report by Michael L. Adashek, Kenneth Miller, Arit A. Silpasuvan

“…A 64-year-old man, with history of micropapillary thyroid cancer and epidermal growth factor receptor-positive lung adenocarcinoma with no evidence of active disease for 3 years after chemotherapy and radiation on erlotinib, presented with fatigue, nausea, lack of appetite, and xeroderma. …”
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The Role of the TGF-β Coreceptor Endoglin in Cancer by Eduardo Pérez-Gómez, Gaelle del Castillo, Juan Francisco Santibáñez, Jose Miguel Lêpez-Novoa, Carmelo Bernabéu, Miguel Quintanilla

“…Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling. …”
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Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis by Linlin Chen, Yiyou Zou, Jie Peng, Fanggen Lu, Yani Yin, Fujun Li, Junwen Yang

“…The expression of interleukin- (IL-) 17, tumor necrosis factor α (TNFα), IL-23, transforming growth factor β1 (TGFβ1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. …”
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Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article by Syed Faizan Mehdi, Muhammad Hamza Qureshi, Salman Pervaiz, Karishma Kumari, Edwin Saji, Mahnoor Shah, Ahmad Abdullah, Kamran Zahoor, Hafiza Amna Qadeer, Disha Kumari Katari, Christine Metz, Lopa Mishra, Derek LeRoith, Kevin Tracey, Michael J. Brownstein, Jesse Roth

“…Increased cortisol or cortisolemia is evident throughout the acute phase, along with changes in the hypothalamic pituitary thyroid (HPT) axis, growth hormone-IGF-1 axis, insulin-glucose axis, leptin, catecholamines, renin angiotensin aldosterone axis, ghrelin, glucagon, hypothalamic pituitary gonadal (HGA) axis, and fibroblast growth factor-21. These changes and metabolic alterations constitute the overall response to infection in sepsis. …”
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3D-QSAR Study on a Series of VEGFR-2 Kinase Inhibitors: 3-Pyrrole Substituted Indolin-2-Ones Compounds by Shunlai Li, Rutao Zhang, Hongguang Du

“…The vascular endothelial growth factor receptor-2 kinases (VEGFR-2) are attractive targets for the development of anticancer agents. …”
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Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions by Kerry L. Hull, Steve Harvey

“…The somatotropic axis, consisting of growth hormone (GH), hepatic insulin-like growth factor I (IGF-I), and assorted releasing factors, regulates growth and body composition. …”
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Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish by Hui Lv, Bo Liu, Yongwen Qin

“…We found that 6 drugs including isosorbide mononitrate, amlodipine, bisoprolol fumarate, carvedilol, irbesartan, and rosuvastatin calcium may affect angiogenesis by vascular endothelial growth factor (VEGF) signaling pathway. Conclusion. These new findings of some cardiovascular drugs should improve the treatment of cardiovascular diseases.…”
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Comprehensive review of angioid streaks by Sindhuja Kandasamy, Nawazish Shaikh, Abhidnya Surve, Somya Kumari, Amber A. Bhayana, Pradeep Kumar, Rohan Chawla, Vinod Kumar

“…Treatment consists of management of the choroidal neovascular membrane commonly through intravitreal antivascular endothelial growth factor injections. In this review, we provide an overview of angioid streaks right from their epidemiology to their management.…”
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Third Swiss Annual Meeting on HER2-Positive Breast Cancer: Recent Advances and New Challenges by Marcus Vetter, Christian Kurzeder

“…The development of antibody-based therapies has transformed the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. …”
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Modeling of chemo-radiotherapy targeting growing vascular tumors: A continuum-level approach. by Ioannis Lampropoulos, Marina Koutsi, Michail E Kavousanakis

“…Our model integrates the impact of chemical species on tumor dynamics, and we model -through reaction-diffusion equations- the spatio-temporal evolution of oxygen, vascular endothelial growth factor (VEGF) and chemotherapeutic agents. Simulations of a growing tumor exposed to external radiation showcase the rapid impact of radiotherapy on tumor suppression, however this effect diminishes over time. …”
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Phototherapy in vitiligo by Anuradha Bishnoi, Iltefat Hamzavi

“…Additionally, combination therapies involving phototherapy and topical and systemic agents (such as psoralens, corticosteroids, calcineurin inhibitors, azathioprine, and other systemic immunomodulators, basic fibroblast growth factor/decapeptide and Janus kinase inhibitors) and surgical management have demonstrated enhanced repigmentation outcomes. …”
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Diagnosing Growth Hormone Deficiency in Adults by Nigel Glynn, Amar Agha

“…Although multiple diagnostic modalities are available including a 24-hour serum GH profile, stimulated GH levels, and insulin-like growth factor-1 (IGF-1) levels, the use of dynamic tests for GH reserves is required in most cases. …”
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miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? by Agata Michalak, Małgorzata Guz, Joanna Kozicka, Marek Cybulski, Witold Jeleniewicz, Ilona Telejko, Karolina Szczygieł, Ewa Tywanek, Halina Cichoż-Lach

“…Direct indices of liver fibrosis [procollagen I carboxyterminal propeptide (PICP), procollagen III aminoterminal propeptide (PIIINP), platelet-derived growth factor AB (PDGF-AB), transforming growth factor-α (TGF-α) and laminin] together with indirect markers (AAR, APRI, FIB-4 and GPR) were also evaluated. …”
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The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach by Irena Markova, Denisa Miklankova, Martina Hüttl, Petr Kacer, Jelena Skibova, Jan Kucera, Radislav Sedlacek, Tereza Kacerova, Ludmila Kazdova, Hana Malinska

“…Assessing urinary secretion of proinflammatory cytokines and epidermal growth factor can help in detecting early development of metabolic syndrome-associated renal dysfunction.…”
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Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects by Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Jakub Kurasz, Wojciech Maj, Wiktoria Tomaszewska, Wiktoria Podlasiewicz, Katarzyna Pala, Piotr Dudziak, Anna Nowak, Maria Golińska

“…These processes are mediated through the modulation of insulin-like growth factor-1 (IGF-1) and the inhibition of glucocorticoid-induced catabolism. …”
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Mesenchymal Stem Cells and Tissue Bioengineering Applications in Sheep as Ideal Model by Talita D’Paula Tavares Pereira Muniz, Mariana Correa Rossi, Vânia Maria de Vasconcelos Machado, Ana Liz Garcia Alves

“…The most common technologies in tissue engineering include growth factor therapies; metal implants, such as titanium; 3D bioprinting; nanoimprinting for ceramic/polymer scaffolds; and cell therapies, such as mesenchymal stem cells (MSCs). …”
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