Pancreatic Cancer: What the Oncologist Can Offer for Palliation by Malcolm J Moore

“…Some novel biological agents, including angiogenesis inhibitors, matrix metalloproteinase inhibitors, antisense compounds, inhibitors of cell signalling such as epidermal growth factor and vascular endothelial growth factor, and inhibitors of oncogene activation, are undergoing phase II and III trials in patients with pancreatic cancer. …”
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An Unusual Cause of Coma by Sujith Ovallath, R. S. Raj, Abdu Rahman, A. S. Girija

“…The patient developed a recurrent hypoglycemia possibly secondary to the insulin-like growth factor secreted from the fibroid. The hypoglycemic symptoms disappeared on removal of the fibroid. …”
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Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients by Fernando G. Zampieri, Vanessa Jacob, Hermes V. Barbeiro, Fabiano Pinheiro da Silva, Heraldo P. de Souza

“…We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity. …”
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Small spheroids for head and neck cartilage tissue engineering by Sven Reutter, Johann Kern, Yvonne Jakob, Nicole Rotter, David Gvaramia

“…Furthermore, we evaluated the influence of key chondrogenic cytokines, such as transforming growth factor (TGF)-β, connective tissue growth factor (CTGF), and insulin-like growth factor (IGF)-1, on spheroid morphology and the production of cartilage extracellular matrix (ECM) components. …”
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Decreased plasma gelsolin in the COVID-19-related acute respiratory distress syndrome by Gunturk Inayet, Seydel Gonul Seyda, Yazici Cevat, Topaloglu Ulas Serkan, Eren Esma, Yuksel Recep Civan

“…The aim of this study was to evaluate the potential roles of plasma gelsolin (pGSN), transforming growth factor-beta1 (TGF-β1), and lysophosphatidic acid (LPA) as profibrotic and immune modulatory markers in patients with acute respiratory distress syndrome (ARDS) and patients with mild to moderate disease.…”
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Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…Insulin, insulin-like growth factor I (IGF-I), and epidermal growth factor receptor (EGFR) may mediate interactions between these two hormones. …”
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Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET by Camilla Ruffilli, Sascha Röth, Noam Zelcer, Kevin Moreau

“…Here we compare orthogonal antibody based approaches, i.e. immunoblotting, flow cytometry and immunofluorescence, to measure PROTAC mediated degradation of two established, endogenous targets, epidermal growth factor receptor (EGFR) and hepatocyte growth-factor receptor (c-MET). …”
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Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment by Bassel Alsaed, Linh Lin, Jieun Son, Jiaqi Li, Johannes Smolander, Timothy Lopez, Pinar Ö. Eser, Atsuko Ogino, Chiara Ambrogio, Yoonji Eum, Tran Thai, Haiyun Wang, Eva Sutinen, Hilma Mutanen, Hanna Duàn, Nina Bobik, Kristian Borenius, William W. Feng, Behnam Nabet, Satu Mustjoki, Sanna Laaksonen, Benjamin K. Eschle, Michael J. Poitras, David Barbie, Ilkka Ilonen, Prafulla Gokhale, Pasi A. Jänne, Heidi M. Haikala

“…Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are commonly used to treat non-small cell lung cancers with EGFR mutations, but drug resistance often emerges. …”
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Molecular Imaging of IGF-1R in Cancer by Yingying Sun PhD, Xilin Sun PhD, Baozhong Shen MD, PhD

“…The important role of insulin-like growth factor 1 receptor (IGF-1R) in malignant tumors has been well established. …”
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Analysis of Progress and Challenges of EGFR-Targeted Molecular Imaging in Cancer With a Focus on Affibody Molecules by Weizhi Chen MD, Baozhong Shen MD, PhD, Xilin Sun PhD

“…Epidermal growth factor receptor (EGFR)-targeted cancer therapy requires an accurate estimation of EGFR expression in tumors to identify responsive patients, monitor therapeutic effect, and estimate prognosis. …”
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In Vivo Detection of c-MET Expression in a Rat Hepatocarcinogenesis Model Using Molecularly Targeted Magnetic Resonance Imaging by Rheal A. Towner, Nataliya Smith, Yasvir A. Tesiram, Andrew Abbott, Debbie Saunders, Rebecca Blindauer, Oana Herlea, Robert Silasi-Mansat, Florea Lupu

“…The multifunctional growth factor scatter factor/hepatocyte growth factor and its tyrosine kinase receptor, c-MET, have been implicated in the genesis and malignant progression of numerous human malignancies, including hepatocellular carcinomas. …”
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Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside by Jacopo Olivieri, Sabrina Coluzzi, Imma Attolico, Attilio Olivieri

“…In many inflammatory fibrotic diseases, such as Systemic Scleroderma (SSc) and cGVHD with fibrotic features, an abnormal activation of transforming growth factor (TGFβ) and platelet-derived growth factor receptor (PDGF-R) pathways have been observed. …”
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Long non-coding RNA CAR10 promotes angiogenesis of lung adenocarcinoma by mediating nuclear LDHA to epigenetically regulate VEGFA/C by Xiaolu Ge, Chao Du, Li Fang, Wei Xu, Juanjuan Xiang, Jiheng Liu, Ming Zhou, Yuejun Chen, Ziyao Wang, Zheng Li

“…Mechanistically, CAR10 could bind to Lactate Dehydrogenase A (LDHA) protein to regulate the phosphorylation and acetylation of LDHA and increase the dimerization of LDHA to promote its nuclear translocation, which increased the H3K79 methylation in Vascular Endothelial Growth Factor A (VEGFA) and Vascular Endothelial Growth Factor C (VEGFC) gene interval. …”
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Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model by Juan Sebastian Yakisich, Neelam Azad, Rajkumar Venkatadri, Yogesh Kulkarni, Clayton Wright, Vivek Kaushik, Anand Krishnan V. Iyer

“…Methods to isolate LTSs are usually performed in serum-free media supplemented with specific additives such as epidermal growth factor and basic fibroblast growth factor. In this study, we report the generation of LTSs without the addition of any external mitogenic stimulation. …”
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Anti-VEGF Treatment Strategies for Wet AMD by Jaclyn L. Kovach, Stephen G. Schwartz, Harry W. Flynn, Ingrid U. Scott

“…Over the past few years, antivascular endothelial growth factor (VEGF) therapy has become a standard treatment for neovascular age-related macular degeneration (AMD). …”
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NGF-TrkA Axis Enhances PDGF-C-Mediated Angiogenesis in Osteosarcoma via miR-29b-3p Suppression: A Potential Therapeutic Strategy Using Larotrectinib by Sheng-Mou Hou, Ching-Yuan Cheng, Wei-Li Chen, En-Ming Chang, Chih-Yang Lin

“…Angiogenesis plays a critical role in osteosarcoma (OS) growth and metastasis. While nerve growth factor (NGF) is implicated in cancer progression, its role in OS angiogenesis remains unclear. …”
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Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide Synthase-Knockout Mouse by Takashi Kitano, Hiroshi Yamada, Maki Kida, Yuka Okada, Shizuya Saika, Munehito Yoshida

“…Population of granulation tissue-related cell types, that is, myofibroblasts and macrophages, growth factor expression, and reepithelialization were evaluated. …”
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Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women by Kishiko Ogawa, Kiyoshi Sanada, Shuichi Machida, Mitsuharu Okutsu, Katsuhiko Suzuki

“…Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. …”
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Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways by Li Gong, Shixue Yang, Junli Huang, Yongsheng Li

“…Key oncogenic targets, including epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and kirsten rat sarcoma viral oncogene homologue (KRAS), have emerged as focal points in the development of targeted agents. …”
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Intravitreal Therapy for Diabetic Macular Edema: An Update by Claudio Furino, Francesco Boscia, Michele Reibaldi, Giovanni Alessio

“…Although laser has been considered as the gold standard for many years, over the past several years vascular endothelial growth factor inhibitors (anti-VEGFs) have become first-line therapy. …”
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