Acceptability, feasibility, and effectiveness of internet-based cognitive behavior therapy for obsessive–compulsive disorder (OCD-NET): a naturalistic pilot trial during the COVID-... by Elisabeth Kohls, Sabrina Baldofski, Julia Scholl, Oskar Flygare, Lina Lundström, Ursula Beyrich-Kolbus, Marc Steinbrecher, Christian Rück, Christine Rummel-Kluge

“…Abstract Background Cognitive behavior therapy (CBT) is the gold-standard treatment for obsessive–compulsive disorder (OCD). …”
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Identification of a novel heterozygous GPD1 missense variant in a Chinese adult patient with recurrent HTG-AP consuming a high-fat diet and heavy smoking by Xiao-Yao Li, Bei-Yuan Zhang, Xin-Ran Liang, Yan-Yu Han, Min-Hua Cheng, Mei Wei, Ke Cao, Xian-Cheng Chen, Ming Chen, Jian-Feng Duan, Wen-Kui Yu

“…It was found that there was a new variant of GPD1 gene-p.K327N, which was verified by gold standard-sanger sequencing method. In vitro, the corresponding plasmid was constructed and transfected into human renal HEK-293T cells, and GPD1 protein levels were detected. …”
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Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson’s disease? by Maaike Goris, Pieter Ginis, Clint Hansen, Christian Schlenstedt, Christian Schlenstedt, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Nicholas D’Cruz, Wim Vandenberghe, Wim Vandenberghe, Walter Maetzler, Alice Nieuwboer, Moran Gilat

“…Despite that, the FOG-index’s classification performance and criterion validity is not tested against the gold standard (i.e., video-rated time spent freezing). …”
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Ambulatory Surgery for Perianal Crohn’s Disease: Study of Feasibility by S. Sibio, A. Di Giorgio, M. Campanelli, S. Di Carlo, A. Divizia, C. Fiorani, R. Scaramuzzo, C. Arcudi, G. Del Vecchio Blanco, L. Biancone, G. Sica

“…One-third of Crohn’s disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA). …”
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Strategies of physiological, morpho-anatomical and biochemical adaptation in seedlings of native species exposed to mining waste by Belén Heredia, Pablo Diaz Recio, Brian Jonathan Young, Pablo Pacheco, Franco Barcelo Zungre, Silvina Hruby, Maria Andreína Acevedo, María Inés Mercado, Gonzalo Roqueiro

“…Seeds of four native species of trees and shrubs (Larrea cuneifolia, Bulnesia retama, Plectrocarpa tetracantha and Prosopis flexuosa) were exposed to soil contaminated with As, Cu, Cd, and Zn from an abandoned gold mine to identify adaptation strategies. Several physiological, morpho-anatomical, and biochemical parameters were determined. …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Methadone maintenance treatment is the gold standard of medication-based treatment for OUD, but high-dose methadone is associated with cardiotoxicity and respiratory complications, among other side effects. …”
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Indocyanine Green Fluorescence Plus Blue Dye for Sentinel Lymph Node Biopsy in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter, Prospective Cohort Stu... by Miao Liu, Yang Yang, Bin Hua, Rui Feng, Tianyu Xu, Mengyuan Wang, Xiaowei Qi, Yingming Cao, Bo Zhou, Fuzhong Tong, Peng Liu, Hongjun Liu, Lin Cheng, Houpu Yang, Fei Xie, Siyuan Wang, Chaobin Wang, Yuan Peng, Danhua Shen, Lei Chen, Jun Jiang, Shu Wang

“…ABSTRACT Background Sentinel lymph node biopsy (SLNB) using radioisotope tracer plus blue dye is the gold standard after neoadjuvant chemotherapy (NAC) in initially cN1 breast cancer patients, but clinical use still has limitations. …”
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Mineralization and metallogenic model of the Laurani high-sulfidation epithermal deposit in northeastern Bolivian Altiplano by Fei Liu, Runsheng Han, Shuming Wen, Dong Zhao, Wenyao Li, Li Lei, Chaojian Qin, Yuxinyue Guo

“…Abstract The Laurani high-sulfidation epithermal deposit, located in the northeastern Altiplano of Bolivia, is a representative gold-polymetallic deposit linked to the late Miocene volcanic rocks that were formed approximately at about 7.5 Ma. …”
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What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells? by R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz

“…MSCs derived from the umbilical cord tissue, termed UCX, were investigated for their immunomodulatory properties and compared to bone marrow-derived MSCs (BM-MSCs), the gold-standard in immunotherapy. Immunogenicity and immunosuppression were assessed by mixed lymphocyte reactions, suppression of lymphocyte proliferation and induction of regulatory T cells. …”
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Multiresidue Pesticides Analysis of Vegetables in Vietnam by Ultrahigh-Performance Liquid Chromatography in Combination with High-Resolution Mass Spectrometry (UPLC-Orbitrap MS) by Nam Vu-Duc, Trung Nguyen-Quang, Thuy Le-Minh, Xuyen Nguyen-Thi, Tri Manh Tran, Hai Anh Vu, Lan-Anh Nguyen, Tien Doan-Duy, Bui Van Hoi, Cam-Tu Vu, Dung Le-Van, Lan-Anh Phung-Thi, Hong-An Vu-Thi, Dinh Binh Chu

“…Multiclass pesticides were separated on the Thermo Hypersil Gold PFP column utilizing a gradient of the mobile phase consisting of 5 mM ammonium formate, 0.1% formic acid in deionized water, and methanol. …”
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Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome by Federica Tiberio, Martina Salvati, Luca Polito, Giada Tisci, Alessia Vita, Ornella Parolini, Luca Massimi, Lorena Di Pietro, Pierpaolo Ceci, Gianpiero Tamburrini, Alessandro Arcovito, Elisabetta Falvo, Wanda Lattanzi

“…The resulting constitutive activation of the FGFR2 signaling causes the premature osteogenic differentiation of calvarial mesenchymal stromal cells in skull sutures, leading to early suture ossification. Craniectomy is the gold standard treatment, being invasive and burdened by complications. …”
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Temporal trends in characteristics and outcome of heart failure patients with and without significant coronary artery disease by Entela Bollano, Björn Redfors, Araz Rawshani, Dimitrios Venetsanos, Sebastian Völz, Oskar Angerås, Charlotta Ljungman, Joakim Alfredsson, Tomas Jernberg, Truls Råmunddal, Petur Petursson, J. Gustav Smith, Oscar Braun, Henrik Hagström, Ole Fröbert, David Erlinge, Elmir Omerovic

“…Invasive coronary angiography (CAG) is the gold standard for evaluating the presence and severity of CAD. …”
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A modified screening protocol for ARDS in patients with respiratory support based on SpO2 and FiO2: A single-center prospective, observational study by Yan Xia, Qiancheng Xu, Zhiyuan Guo, Huijuan Zhang, Yingya Cao, Yupeng Qi, Qun Chen, Weihua Lu

“…Then, a new diagnostic process was established, and the reliability was verified with the Berlin definition set as the gold standard for diagnosis and classification. Results: There were 341 patients were included. …”
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Extended depth-of-field microscopic imaging for intact histological samples via self-calibrated diplane network by Yuezhi He, Xu Yang, Shiwei Ye, Zonghua Wen, Peng Liu, Hui Li, Feng Xiang, Jiuling Liao, Yizhou Tan, Haoyong Ning, Junjie Zou, Guilu He, Long Zeng, Yanwu Guo, Hui Li, Ying Gu, Bo Wang, Wei Zheng

“…Pathological imaging of surgically excised specimens is the gold standard in clinical practice for diagnosing diseases and making treatment decisions. …”
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Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment by Koichi Egashira, Daisuke Sueta, Masafumi Kidoh, Mai Tomiguchi, Seitaro Oda, Hiroki Usuku, Kaori Hidaka, Lisa Goto‐Yamaguchi, Aiko Sueta, Takashi Komorita, Fumi Oike, Koichiro Fujisue, Eiichiro Yamamoto, Shinsuke Hanatani, Seiji Takashio, Satoshi Araki, Kenichi Matsushita, Yutaka Yamamoto, Toshinori Hirai, Kenichi Tsujita

“…Although cardiac magnetic resonance and echocardiography are recognized as the ‘gold standard’ for detecting cardiotoxicity, they have many shortcomings. …”
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[Translated article] Surgical treatment of ipsilateral bifocal tibial fractures: A challenge for the surgeon by A. Ortega-Yago, M. Barrés-Carsí, A. Balfagón-Ferrer

“…Currently there is no gold standard regarding the ideal surgical treatment.The objective of this study is to analyze the surgical treatment and the radiographic and functional results, as well as the associated complication rate of ipsilateral bifocal tibia fractures. …”
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Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy by Anna De Lucia, Lucia Mazzotti, Lucia Mazzotti, Anna Gaimari, Anna Gaimari, Matteo Zurlo, Roberta Maltoni, Claudio Cerchione, Sara Bravaccini, Angelo Delmonte, Lucio Crinò, Patricia Borges de Souza, Luigi Pasini, Fabio Nicolini, Fabrizio Bianchi, Manel Juan, Hugo Calderon, Chiara Magnoni, Chiara Magnoni, Luca Gazzola, Luca Gazzola, Paola Ulivi, Massimiliano Mazza

“…Nowadays, targeted therapies remain the gold standard for many patients, but still they suffer from many adverse effects, including unexpected toxicity and intrinsic acquired resistance mutations, which lead to relapse. …”
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Diagnosis and management of de novo non-specific spinal infections: European Association of Neurosurgical Societies (EANS) Spine Section Delphi consensus recommendations by Andreas Kramer, Santhosh G. Thavarajasingam, Jonathan Neuhoff, Benjamin Davies, Giuseppe Barbagallo, Bertrand Debono, Bart Depreitere, Sven O. Eicker, Nikolay Gabrovsky, Marisa L. Gandia-Gonzalez, Marcel Ivanov, Radek Kaiser, Stanislav Kaprovoy, Nikolay Konovalov, Jesus Lafuente, Andrzej Maciejczak, Bernhard Meyer, Paulo Pereira, Yana Petrova, Wilco C. Peul, Carla Reizinho, Yu-Mi Ryang, Nico Sampron, Ralph Schär, Enrico Tessitore, Claudius Thomé, Jake Timothy, Carmen Vleggeert-Lankamp, Andreas K. Demetriades, Ehab Shiban, Florian Ringel

“…MRI was confirmed as the gold standard for diagnosis. Regarding surgical indications, the panel agreed that any new neurological deficit, even subtle, warrants surgical consideration. …”
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Tratamiento quirúrgico de las fracturas bifocales ipsilaterales de tibia: un reto para el cirujano by A. Ortega-Yago, M. Barrés-Carsí, A. Balfagón-Ferrer

“…Currently there is no gold standard regarding the ideal surgical treatment.The objective of this study is to analyze the surgical treatment and the radiographic and functional results, as well as the associated complication rate of ipsilateral bifocal tibia fractures. …”
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Rome à la campagne : les décors en pierre de la villa de la Grande Boussue à Nouvelles (Mons, Belgique) by Catherine Coquelet, Roland Dreesen, Éric Goemaere, Éric Leblois, Marie-Thérèse Raepsaet-Charlier

“…These are associated with a wall mosaic made of glass paste including 1570 tesserae of various colours, some of which are enhanced with gold leaf.Between these two rooms, a tank and a service room of about 20 m2 were discovered. …”
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