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Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies
Published 2025-01-01“…Methods We compared the PRS prediction accuracy in ADNI (N = 568) and BioFINDER (N = 766) cohorts using five disease risk modelling approaches, three PRS derivation methods, two AD genome-wide association study (GWAS) statistics and two sets of SNPs: the whole genome and microglia-selective regions only. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting
Published 2025-02-01“…Purpose: We aimed to characterize genomic alterations with potential prognostic or predictive significance in patients with metastatic triple-negative breast cancer (mTNBC) treated with chemotherapy in a real-world setting. …”
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Chromosome-level genome reference of the Caucasian dwarf goby Knipowitschia cf. caucasica, a new alien Gobiidae invading the River Rhine
Published 2024-11-01Subjects: Get full text
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Multi-ancestry genome-wide association analyses: a comparison of meta- and mega-analyses in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
Published 2025-01-01Subjects: “…Genome-wide association analysis…”
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1349
Genomic analysis and replication kinetics of the closely related EHV-1 neuropathogenic 21P40 and abortigenic 97P70 strains
Published 2025-01-01“…The genome and replication kinetics of the Belgian EHM isolate 21P40, associated with the Valencia outbreak, and the well-characterized abortigenic strain 97P70 were compared. …”
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Evaluating Community Engagement Strategies to Manage Stigma in Two African Genomics Studies Involving People Living with Schizophrenia or Rheumatic Heart Disease
Published 2021-01-01“…Global Health, Epidemiology and Genomics…”
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DPV pUL15 possesses a potential NLS, which is important for the location of the terminase complex and for viral proliferation and genome cleavage
Published 2025-01-01Subjects: Get full text
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CRISPR-Cas9-based one-step multiplexed genome editing through optimizing guide RNA processing strategies in Pichia pastoris
Published 2025-06-01Subjects: Get full text
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1354
Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.
Published 2010-07-01“…Schizosaccharomyces pombe Rad3 checkpoint kinase and its human ortholog ATR are essential for maintaining genome integrity in cells treated with genotoxins that damage DNA or arrest replication forks. …”
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Genome-wide analyses of the NAC transcription factor gene family in Acer palmatum provide valuable insights into the natural process of leaf senescence
Published 2025-01-01“…This study revealed 116 ApNAC genes within the genome of A. palmatum. These genes are unevenly distributed on the 13 chromosomes of A. palmatum. …”
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Protocol for genetic analysis of population-scale ultra-low-depth sequencing data
Published 2025-03-01Subjects: Get full text
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Elegant and Innovative Recoding Strategies for Advancing Vaccine Development
Published 2025-01-01Subjects: “…genome…”
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1358
Acral Melanoma: A Review of Its Pathogenesis, Progression, and Management
Published 2025-01-01Subjects: Get full text
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Novel bacteriophages targeting wheat phyllosphere bacteria carry DNA modifications and single-strand breaks
Published 2025-02-01Subjects: Get full text
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Human migration from the Levant and Arabia into Yemen since Last Glacial Maximum
Published 2024-12-01Subjects: “…Genomics…”
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