nD-PointCloud Data Management by Haicheng Liu

“…By contrast, state-of-the-art DataBase Management Systems (DBMSs) avoid these issues, because they are initially devised for generic use of data. However, DBMSs still present limitations on efficiently indexing non-uniformly distributed points, supporting continuous LoI, and operating high dimensional data. …”
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Ion-exchange chromatography, capillary isoelectric focusing, and capillary zone electrophoresis coupled to mass spectrometry for charge variant analysis of monoclonal antibodies by Jasmin Schairer, Alisa Höchsmann, Benedikt Bauer, Volker Höfer, Jennifer Römer, Christian Neusüß

“…Each method was tested for generic use by measuring 10 mAbs with an isoelectric point (pI) of 7.3 to 8.7 without individually adjusting the method parameters for each mAb. …”
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Quantitative characterisation of extracellular vesicles designed to decoy or compete with SARS-CoV-2 reveals differential mode of action across variants of concern and highlights t... by Melanie Schürz, Isabel Pagani, Eva Klinglmayr, Heloisa Melo Benirschke, Martin Mayora Neto, Luis J. V. Galietta, Arianna Venturini, Nicoletta Pedemonte, Valeria Capurro, Sandra Laner-Plamberger, Christoph Grabmer, Essi Emminger, Martin Wolf, Marianne Steiner, Cyrus Kohlmetz, Niklas Mayr, Liliia Paniushkina, Katharina Schallmoser, Dirk Strunk, Hans Brandstetter, Martin Hintersteiner, Nigel Temperton, Elisa Vicenzi, Nicole Meisner-Kober

“…Following the recent COVID-19 pandemic, EVs engineered with either the ACE2-receptor or Spike-protein have been proposed as strategy to either decoy SARS-CoV-2, or to compete with its cell entry. For generic use as a platform for future pandemic preparedness, a systematic and quantitative comparison of both strategies is required to assess their limitations and benefits across different variants of concern. …”
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