Radiation Induces Pulmonary Fibrosis by Promoting the Fibrogenic Differentiation of Alveolar Stem Cells by Lu-Kai Wang, Tsai-Jung Wu, Ji-Hong Hong, Fang-Hsin Chen, John Yu, Chun-Chieh Wang

“…Moreover, radiation drove LSCs to fibrosis as shown with the elevated levels of markers for epithelial-mesenchymal transition and myofibroblast (α-smooth muscle actin (α-SMA)) differentiation in in vitro and ex vivo studies. Increased gene expressions of connective tissue growth factor and α-SMA were found in both irradiated LSCs and alveolar cells, suggesting that radiation could induce the fibrogenic differentiation of LSCs. …”
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Evolutionary origins of synchronization for integrating information in neurons by Takashi Shibata, Takashi Shibata, Noriaki Hattori, Hisao Nishijo, Tsutomu Takahashi, Tsutomu Takahashi, Yuko Higuchi, Yuko Higuchi, Satoshi Kuroda, Kaoru Takakusaki

“…The evolution of brain-expressed genes is notably slower than that of genes expressed in other tissues, a phenomenon likely due to high-level functional constraints. …”
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Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice by Yangchen Dhondup, Ivar Sjaastad, Øystein Sandanger, Jan Magnus Aronsen, Muhammad Shakil Ahmed, Håvard Attramadal, Alexandra Vanessa Finsen, Lili Zhang, Trine Ranheim, Katrine Alfsnes, Pål Aukrust, Geir Christensen, Arne Yndestad, Leif Erik Vinge

“…Both HF groups displayed increased left atrium size, lung weight, fetal gene expressions, monocyte/macrophage infiltration, and fibrosis. …”
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Enhanced Proliferation of Porcine Bone Marrow Mesenchymal Stem Cells Induced by Extracellular Calcium is Associated with the Activation of the Calcium-Sensing Receptor and ERK Sign... by Jingjing Ye, Wei Ai, Fenglin Zhang, Xiaotong Zhu, Gang Shu, Lina Wang, Ping Gao, Qianyun Xi, YongLiang Zhang, Qingyan Jiang, Songbo Wang

“…Moreover, Ca2+o-induced promotion of pBMSCs proliferation, the changes of proliferative genes expression levels, and the activation of ERK1/2 signaling pathway were effectively blocked by U0126, a selective ERK kinase inhibitor. …”
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NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects by Walter Toscanelli, Matteo Fracella, Marta De Angelis, Carolina Scagnolari, Leonardo Sorrentino, Elena Piselli, Maria Elena Marcocci, Fabio Midulla, Enrica Mancino, Raffaella Nenna, Laura Petrarca, Anna Teresa Palamara, Guido Antonelli, Alessandra Pierangeli, Lucia Nencioni

“…Methods The NRF2 and redox‐related genes expression was examined in nasopharyngeal swabs from children attending the pediatric hospital for SARS‐CoV‐2 molecular testing. …”
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Platelet-rich fibrin and silver nano-particles loaded chitosan treatment for post- laminectomy epidural scar adhesions: in vivo rats study model by Samah Fouad, Awad Rizk, Esam Mosbah, Mostafa M. Nabeeh, Walaa Awadin, Ayman S. Elmezayyen, Ekramy Elmorsy, Adel Zaghloul

“…Results Data revealed that epidural scar adhesion, scaring, arachnoid involvement, dural thickness, as well as inflammation and TGFβ-1and IL-6 coding genes expression were significantly reduced in PRF group, Chi/Ag-NPs group, and combined group compared to the laminectomy group. …”
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Renin-angiotensin-aldosterone system in ISIAH rats with stressinduced arterial hypertension by A. D. Dubinina, E. V. Antonov, L. A. Fedoseeva, E. N. Pivovarova, A. L. Markel, L. N. Ivanova

“…By contrast, a significant increase of RAS genes expression was found in the brain tissues. The mRNA of the Ren gene was increased in the hypothalamus, and the mRNA of Ace gene was increased in the brain stem of the ISIAH rats. …”
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Decreased Breg/Th17 Ratio Improved the Prognosis of Patients with Ulcerative Colitis by Xue Bing, Liang Linlang, Chen Keyan

“…The number of Breg cells and Th17 cells, the gene expressions of IL-10 and RORγT, and serum levels of IL-10 and IL-17 all increased in peripheral blood. …”
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Dietary Supplemental Glutamine Enhances the Percentage of Circulating Endothelial Progenitor Cells in Mice with High-Fat Diet-Induced Obesity Subjected to Hind Limb Ischemia by Chi-Hsuan Ko, Sung-Ling Yeh, Chiu-Li Yeh

“…The HG group had higher circulating EPCs on day 1 while muscle vascular endothelial growth factor, matrix metalloproteinase-9, and hypoxia-inducible factor-1 gene expressions were higher on day 7 postischemia than those of the HI group. …”
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Inhibition of Androgen Receptor Expression with Small Interfering RNA Enhances Cancer Cell Apoptosis by Suppressing Survival Factors in Androgen Insensitive, Late Stage LNCaP Cells by Sang Soo Kim, Hee Joo Cho, Jung Yoon Kang, Hee Kyu Kang, Tag Keun Yoo

“…However, in si-LNCaP cell line, protein expressions were reversed to the level of es-LNCaP cell lines (25, 102, 109, 98, and 101%), and gene expressions on real-time PCR were also reversed to the expression level of es-LNCaP (ls-LNCaP: 179, 156, 133, 123, and 167%; si-LNCaP: 22, 93, 103, 112, and 107%). …”
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Integrated Single-Cell and RNA Sequencing Analysis Identifies Key Immune Cell and Dendritic Cells Associated Genes Participated in Myocarditis by Qiang Gong, Jianfeng Huang, Qicai Wu

“…The purpose of our study was to investigate the gene and single-cell signature to explore the involvement of immune cells in myocarditis. Gene expressions merged from GSE35182 and GSE35182 datasets were subjected to differential expression gene (DEG) analysis and PPI network construction. …”
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Comparison of the Effect of Extracted Bacteriocin and Lytic Bacteriophage on the Expression of Biofilm Associated Genes in Streptococcus mutans by Zahra Rajabi, Mohammad Mehdi Soltan Dallal, Mohammad Reza Afradi, Yousef Erfani, Donya Alinejad, Reza Ranjbar, Rouha Kasra-Kermanshahi

“…Finally, the effect of isolated bacteriocin and bacteriophage on gtfs genes expression level was measured by real-time PCR. Out of 81 dental plaque samples, 32 (39.5%) Streptococcus mutans strains were isolated. …”
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Cutibacterium acnes biofilm formation is influenced by bone microenvironment, implant surfaces and bacterial internalization by Jennifer Varin-Simon, Marius Colin, Frédéric Velard, Min Tang-Fichaux, Xavier Ohl, Céline Mongaret, Sophie C. Gangloff, Fany Reffuveille

“…After internalization, one of the non-PJI-related strains biofilm characteristics were affected: (i) a lower quantity of adhered bacteria (80.3-fold decrease), (ii) an increase of polysaccharides signal in biofilm and (iii) an activation of biofilm gene expressions on textured titanium disk. Conclusion Taken together, these results evidenced the versatility of C. acnes biofilm, depending on the support used, the bone environment and the strain.…”
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Interleukin-1β Accelerates the Onset of Stroke in Stroke-Prone Spontaneously Hypertensive Rats by Tsuyoshi Chiba, Tatsuki Itoh, Masaki Tabuchi, Toru Nakazawa, Takao Satou

“…Stimulated IL-1β signal was also observed in cerebrovascular endothelial cells of SHRSP. Gene expressions of IL-1β, IL-1 receptors, caspase-1, and downstream genes (MCP-1 and ICAM-1), which associated with immune cell recruitment, were significantly greater in SHRSP than in WKY or SHR, coincident with greater NFκB protein levels in SHRSP compared to WKY or SHR. …”
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Inhibition of Viability, Proliferation, Cytokines Secretion, Surface Antigen Expression, and Adipogenic and Osteogenic Differentiation of Adipose-Derived Stem Cells by Seven-Day Ex... by Jian Wang, Bo Xiang, Jixian Deng, Darren H. Freed, Rakesh C. Arora, Ganghong Tian

“…After seven-day exposure to 0.5-Tesla Static Magnetic Field (SMF), Adipose-derived Stem Cells (ASCs) and those labeled by superparamagnetic iron oxide (SPIO) nanoparticles were examined for viability by methyl thiazol tetrazolium (MTT) assay, proliferation by cell counting and bromodeoxyuridine (BrdU) incorporation, DNA integrity by single cell gel electrophoresis, surface antigen by flow cytometry analysis, and the expression of cytokines and genetic markers by reverse transcription-PCR and underwent adipogenic and osteogenic differentiation assessed by quantifying related specific genes expression. The SMF slightly reduced cell viability and proliferation and inhibited the expression of CD49d, CD54, and CD73 but did not damage DNA integrity. …”
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Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue by Nozomi Nishida, Satoru Sugimoto, Satoshi Miyagaki, Chiharu Cho, Madoka Konishi, Takeshi Goda, Mihoko Yamaguchi, Yasuhiro Kawabe, Hidechika Morimoto, Joji Kusuyama, Takuro Okamura, Masahide Hamaguchi, Jun Mori, Hisakazu Nakajima, Michiaki Fukui, Tomoko Iehara

“…We found that Ang 1–7 reduced MCP-1 and TNF-α gene expressions and the number of crown-like structures, which are histological hallmarks of the pro-inflammatory process, in visceral epididymal WAT (eWAT) and reduced circulating MCP-1 and TNF-α levels, accompanied by improvement in insulin resistance, in dietary-induced obese mice. …”
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Programmed cell death-related gene IL20RA facilitates tumor progression and remodels tumor microenvironment in thyroid cancer by Yuqi Wang, Yunlong Zhang, Min Liu, Yu Liu, Yu Zeng, Wei Zhang, Shuping Wu, Linfei Hu, Xianhui Ruan, Xiangqian Zheng, Ming Gao, Jingzhu Zhao

“…This study aimed to explore the relationship between PCD-related genes expression and prognosis in thyroid cancer (THCA), especially IL20RA, as a potential prognostic marker for THCA. …”
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Developmental changes of skin quality from breast, back, and thigh of Pekin ducks from 1 to 6 weeks of age by Hao Li, Wenxuan Zheng, Shuo Xin, Ye Hui, Yijun Zhu, Xi Lin, Huaqi Zhang, Yongwen Zhu

“…The skin strength, skin thickness, and collagen content as well as the related gene expressions were determined for the evaluation of skin quality. …”
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Integration of ATAC-seq and RNA-seq reveals signal regulation during post-molt and inter-molt stages in muscle of Eriocheir sinensis by Bin Wang, Bin Wang, Jingjing Li, Mingzhi Zhang, Mingzhi Zhang, Anqi Li, Zhentao Song, Zhentao Song, Zhen He, Zhen He, Ruiqi Zhang, Ruiqi Zhang, Tong Hao, Tong Hao, Jinsheng Sun, Jinsheng Sun

“…However, the signal regulation mechanisms involved in muscle during molting remain unexplored.MethodsIn this work, a comprehensive analysis of the gene expressions in E. sinensis muscle between post-molt and inter-molt stages were performed by integrating the ATAC-seq and RNA-seq techniques.ResultsThe integration analysis identified 446 up-regulated and 21 down-regulated genes in the two stages. …”
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Effect of the gut core microbiota Cetobacterium on the growth, physiology, and nutritional metabolism of Nile tilapia (Oreochromis niloticus) by Miao Wang, Chenglin Tang, Ziyue Zhang, Zijian Fan, Lijin Jiang, Zhigang Liu, Jianmeng Cao, Zhang Wang, Maixin Lu, Mengmeng Yi, Xiaoli Ke

“…Furthermore, analysis of the liver transcriptome and RT-qPCR data indicated a decrease of genes expression of fatty acid synthesis (SREB 1c, ACCα, and FAS) with NK01 supplementation feeding group. …”
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