Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways by Randa Ismail, Heba A. Habib, Aliaa F. Anter, Amr Amin, Gehan H. Heeba

Subjects: Get full text

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins by Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

“…Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. …”
Get full text

It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma by Christin Knickmeier, Gaetan Aime Noubissi Nzeteu, Bernhard F. Gibbs, Frederik J. H. Hoogwater, Maarten W. Nijkamp, Maximilian Bockhorn, N. Helge Meyer

Subjects: Get full text

The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease by Xueyan Liu, Wei Wu, Xuejuan Li, Chengyan Wang, Ke Chai, Fanru Yuan, Huijuan Zheng, Yuxing Yao, Chenlu Li, Zu-Cheng Ye, Daijun Zha

Subjects: Get full text

Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new ent... by Zeliha Çelik, Naile Kökbudak, Fahriye Kilinç, Pembe Oltulu

“…Three groups, in which CD44, p53, Ki-67, p27, HBME-1, galectin-3, cytokeratin-19, CD56 were used as markers, were evaluated. …”
Get full text

Differential impact of TIM-3 ligands on NK cell function by Xin Zhang, Lazar Vujanovic, Riyue Bao, Robert L Ferris, Tullia C Bruno, Aditi Kulkarni, Hridesh Banerjee, Housaiyin Li, Juncheng Wang, Lawrence P Kane, Pragati Upadhyay, Jennifer L Anderson, Onyedikachi Victor Onyekachi, Lidia M R B Arantes

“…Among the four putative TIM-3 ligands, galectin-9 most consistently suppresses NK cell-mediated cytotoxicity and proliferation through TIM-3 and CD44 signaling, respectively, but promotes IFN-γ release in a TIM-3-dependent manner. …”
Get full text

Left ventricular hypertrophy in young hypertensives: the possible crosstalk of mTOR and angiotensin-II -a case-control study by Busayo Onafowoke Oguntola, Stephen Olawale Oguntola, Opeyemi Ezekiel Ojo, Pauleen Ayomide Ukpabio, Adams Olalekan Omoaghe, Kehinde Samuel Olaniyi

“…Venous blood was obtained to estimate mTOR, Ang II, Chemerin, lipids – triglyceride (TG), high-density lipoprotein (HDL), total cholesterol (TC), troponin-T, NF-Kβ, and Galectin-3 using enzyme-linked immunosorbent assay. …”
Get full text

Immunohistochemical Expression of HBME-1 in a Spectrum of Thyroid Neoplasms by Archi A. Chawla, Reeta Dhar, Shilpi Sahu

“…However, using a panel of markers comprising Galectin-3 and Ck-19 along with HBME-1 increases the accuracy and specificity for the correct diagnosis of thyroid neoplasms.…”
Get full text

Uncovering NK cell sabotage in gut diseases via single cell transcriptomics. by Hansong Lee, Dai Sik Ko, Hye Jin Heo, Seung Eun Baek, Eun Kyoung Kim, Eun Jung Kwon, Junho Kang, Yeuni Yu, Ninib Baryawno, Kihun Kim, Dongjun Lee, Yun Hak Kim

“…In the context of colorectal cancer (CRC), both NK cells and CD8+ T cells exhibited significant changes in cytotoxicity and exhaustion. The GALECTIN-9 (LGALS9)-HAVCR2 axis was identified as one of the CRC-specific pathways. …”
Get full text

Early Detection of Pancreatic Cancer: Opportunities Provided by Cancer-induced Paraneoplastic Phenomena and Artificial Intelligence by Wei-Chih Liao

“…Paraneoplastic syndromes, including pancreatic cancer-associated diabetes and cachexia, are prevalent in PDAC patients and may provide windows of opportunity for early detection. S100A9 and galectin-3 are novel PDAC-derived factors mediating pancreatic cancer-associated diabetes and have shown promise in facilitating the early detection of PDAC. …”
Get full text

Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells by Elisa Persiani, Antonella Cecchettini, Sofia Amato, Elisa Ceccherini, Ilaria Gisone, Agnese Sgalippa, Chiara Ippolito, Valter Castelvetro, Tommaso Lomonaco, Federico Vozzi

“…Key markers like RUNX-2 and galectin-3, which regulate cardiovascular pathology, were activated, alongside the inflammasome complex. …”
Get full text

双向凝胶电泳－飞行时问质谱法分析促癌剂TPA诱导NIH3T3细胞表达变化的蛋白质 by 江培洲

“…（结果l软件分析显示TPA处理后的NIH3T3细胞中有明显的差异表达蛋白质， 质谱鉴定表明TPA处理后，表达上调的蛋白质有线粒体基质蛋白Pl前体、微管蛋白beta-5链；TPA处理后明显 表达下调的蛋白质有galectin-1、N-myc下游调节基因l蛋白。【结论】TPA刺激NIH3T3细胞后可以下调生长抑 制基因的表达，同时上调与细胞增生相关基因的表达。…”
Get full text

Biomarkers as Diagnostic and Prognostic Tools in Cardiac Disorders: A Comprehensive Review by Rabinarayan Parhi, Goutam Kumar Jena, Chinam Niranjan Patra, Sruti Jammula

“…Emerging biomarkers, such as galectin-3, suppression of tumorigenicity 2, and microRNAs, show promise in enhancing the prediction of heart failure, assessment of myocardial stress, and detection of cardiac conditions in early stages. …”
Get full text

Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection. by Jacques Augenstreich, Anna T Phan, Charles N S Allen, Anushka Poddar, Hanzhang Chen, Lalitha Srinivasan, Volker Briken

“…The LC3 recruitment was associated with galectin-3 and oxysterol-binding protein 1 staining, indicating a correlation with membrane damage and repair mechanisms. …”
Get full text

Does quercetin affect tendon healing? An experimental study in a rat model of Achilles tendon injury by Ahmet Yurteri, Numan Mercan, Zeliha Esin Çelik, Hakan Yaykaşlı, Ahmet Yıldırım

“…In the immunohistochemical analysis, type I collagen, type III collagen, alpha smooth muscle actin (SMA), and Galectin-3 were evaluated, and it was observed that quercetin increased tendon healing (p-values = 0.0166, 0.0036, 0.0323, 0.0295, respectively). …”
Get full text

半乳糖凝集素－３与β－Ｃａｔｅｎｉｎ在上皮性卵巢癌中的表达和 临床指标及预后关系

“…摘 要： 【目的】 探讨半乳糖凝集素－３（Ｇａｌｅｃｔｉｎ－３ Ｇａｌ－３）和β－Ｃａｔｅｎｉｎ在上皮性卵巢癌组织中的表达情况及临床意义。【方法】 采用免疫组织化学方法，检测７７例上皮性卵巢癌患者肿瘤组织中Ｇａｌ－３和β－Ｃａｔｅｎｉｎ蛋白表达的情况，并分析其与患者临床病理特征、治疗效果及预后的关系。 …”
Get full text

Characterization of squash polysaccharide and the anti-diabetic effect on type 2 diabetic rat revealed by urine metabolomics analysis by Li Liang, Fuming Zhang, Quanhong Li, Baoguo Sun, Yuyu Zhang, Robert J. Linhardt

“…Study of surface plasmon resonance revealed the binding kinetics with galectin-3 (Gal-3) and fibroblast growth factor 2 (FGF2). …”
Get full text

H₂S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins by Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam

“…SG-1002 also decreased the expression of hypertrophic/HF protein markers such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), galectin-3, TIMP1, collagen type III, and TGF-β1 in stressed HL-1 cells. …”
Get full text

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation by Holger A. Russ, Limor Landsman, Christopher L. Moss, Roger Higdon, Renee L. Greer, Kelly Kaihara, Randy Salamon, Eugene Kolker, Matthias Hebrok

“…Expression analysis of pancreata confirmed the presence of three potentially important factors in cell differentiation: Galectin-1 (LGALS1), Neuroplastin (NPTN), and the Laminin α-2 subunit (LAMA2). …”
Get full text

Carrageenan-Free Diet Shows Improved Glucose Tolerance and Insulin Signaling in Prediabetes: A Randomized, Pilot Clinical Trial by Leo Feferman, Sumit Bhattacharyya, Erin Oates, Nicole Haggerty, Tianxiu Wang, Krista Varady, Joanne K. Tobacman

“…They had increases in C-peptide (p=0.029) and Matsuda Index (2.1±0.7 to 4.8±2.3; p=0.052) and declines in serum IL-8, serum galectin-3, and neutrophil phospho-(Ser307/312)-IRS1 (p=0.049, p=0.003, and p=0.006; paired t-tests, two tailed). …”
Get full text