A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes. by Victoria Gillan, Kerry O'Neill, Kirsty Maitland, Francis M Sverdrup, Eileen Devaney

“…Novel drugs are required for the elimination of infections caused by filarial worms, as most commonly used drugs largely target the microfilariae or first stage larvae of these infections. …”
Get full text

Aktualne kierunki zmian we wspólnej polityce rolnej Unii Europejskiej by Mieczysław Adamowicz

Subjects: Get full text

Microgeographical Variation in <i>Dirofilaria immitis</i> Prevalence in Dogs in Suburban and Urban Areas of Rio De Janeiro, Brazil by Marianna Laura Elis Chocobar, Elizabeth Moreira dos Santos Schmidt, Ângelo Joel Ferreira Mendes, Paul Christopher Duncan Johnson, William Weir, Rossella Panarese

Subjects: Get full text

Vulval Elephantiasis: A Case Report by Harsh Mohan, Bhumika Bisht, Poonam Goel, Geeta Garg

“…Females have lower incidence of filarial infection. Vulval elephantiasis due to filariasis is still rarer. …”
Get full text

Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to Brugia malayi Wolbachia Surface Protein by Chantima Porksakorn, Surang Nuchprayoon, Kiwon Park, Alan L. Scott

“…Wolbachia, an endosymbiotic bacterium found in most species of filarial parasites, is thought to play a significant role in inducing innate inflammatory responses in lymphatic filariasis patients. …”
Get full text

Integrating post-validation surveillance of lymphatic filariasis with the WHO STEPwise approach to non-communicable disease risk factor surveillance in Niue, a study protocol. by Adam T Craig, Harriet Lawford, Grizelda Mokoia, Minerva Ikimau, Peter Fetaui, Tonia Marqardt, Colleen L Lau

“…<h4>Background</h4>Lymphatic filariasis (LF), a mosquito-borne parasitic disease caused by three species of filarial worms, was first detected in Niue, a small Pacific Island nation of approximately 1,600 people, in 1954. …”
Get full text

Retroperitoneal Cyst: An Uncommon Presentation of Filariasis by Senthil Ganesan, Saurabh Galodha, Rajan Saxena

“…After surgical resection due to diagnostic uncertainty, at histopathology, it turned out be a filarial cyst. After receiving a course of diethylcarbamazine, the patient is asymptomatic at 4 months’ follow-up.…”
Get full text

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline by Alexander Yaw Debrah, Sabine Mand, Yeboah Marfo-Debrekyei, Linda Batsa, Anna Albers, Sabine Specht, Ute Klarmann, Kenneth Pfarr, Ohene Adjei, Achim Hoerauf

“…Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. …”
Get full text

Clinical Aspects of Dermatitis Associated with Dirofilaria repens in Pets: A Review of 100 Canine and 31 Feline Cases (1990–2010) and a Report of a New Clinic Case Imported from It... by Walter Tarello

“…Cutaneous dirofilariasis is a parasitic disease caused by the mosquito-borne filarial nematodes Dirofilaria (Nochtiella) repens, living in the subcutaneous tissue of dogs, cats, wild carnivores, and humans. …”
Get full text

Lethal Effects of Aspergillus niger against Mosquitoes Vector of Filaria, Malaria, and Dengue: A Liquid Mycoadulticide by Gavendra Singh, Soam Prakash

“…This liquid spray of fungal culture isolate of A. niger can reduce malaria, dengue, and filarial transmission. These results significantly support broadening the current vector control paradigm beyond chemical adulticides.…”
Get full text

Role of Oxidants in Interstitial Lung Diseases: Pneumoconioses, Constrictive Bronchiolitis, and Chronic Tropical Pulmonary Eosinophilia by William N. Rom

“…Inorganic dusts target alveolar macrophages, World Trade Center dust targets bronchial epithelial cells, and eosinophils characterize tropical pulmonary eosinophilia (TPE) caused by filarial organisms. The technique of bronchoalveolar lavage in humans has recovered alveolar macrophages (AMs) in dust diseases and eosinophils in TPE that release increased amounts of oxidants in vitro. …”
Get full text

Implication of the endogenous midgut microbiota on cell genotoxicity and biological fitness of Culex pipiens complex (Diptera: Culicidae) by Alaa Fouaad, Nagwa A. Rashdan, Refaat M. Gabre, Emtithal M. Abdel-Samie

“…Abstract Background Culex pipiens is one of the most important mosquito transmitter of diseases that attains its greatest impact as a vector through spreading out several serious arboviral, protozoal and filarial diseases. Furthermore, it is a native in Europe, Asia and Africa. …”
Get full text

Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway by Alexandra Ehrens, Benjamin Lenz, Celia Nieto-Pérez, Eicke Latz, Florian I. Schmidt, Achim Hoerauf, Marc P. Hübner

“…The current study demonstrates that microfilariae (MF) of the rodent filarial nematode Litomosoides sigmodontis induce eosinophil ETosis via the canonical inflammasome pathway. …”
Get full text

The Effect of Lymphoedema Exercises and Foot Elevation on the Quality of Life of Patients with Elephantiasis by Emirensiana Watu, Supargiyono, Haryani

“…Filariasis is a chronic infectious disease caused by filarial worms. Swelling in the legs in patients with filariasis can result in a significantly lower quality of life. …”
Get full text

MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity. by Hailey Johnson, Stephanie Banakis, Matthew Chung, Elodie Ghedin, Denis Voronin

“…From a broader perspective, the miRNAs secreted by filarial parasites could potentially be used in the future for diagnosing and monitoring disease progression or treatment efficacy.…”
Get full text

IDENTIFICATION OF MICROFILARIAE USING CONVENTIONAL POLYMERASE CHAIN REACTION AND QPCR-HRM by Bagus Muhammad Ihsan, Widyana Lakshmi Puspita, Linda Triana, Wahdaniah, Khayan, Cecep Dani Sucipto

“…Background: The presence of filarial worms in the lymph nodes can result in acute symptoms, such as inflammation of the lymph nodes and ducts, particularly in the groin region. …”
Get full text

Exploiting venom toxins in paratransgenesis to prevent mosquito-borne disease by Stephanie French, Rachael Da Silva, Janet Storm, Christida E. Wastika, India Cullen, Martijn ten Have, Grant L. Hughes, Cassandra M. Modahl

“…Abstract Mosquitoes are responsible for the transmission of numerous pathogens, including Plasmodium parasites, arboviruses and filarial worms. They pose a significant risk to public health with over 200 million cases of malaria per annum and approximately 4 billion people at risk of arthropod-borne viruses (arboviruses). …”
Get full text

Optimization of a Loop-Mediated Isothermal Amplification Assay as a Point-of-Care Tool for the Detection of Wuchereria bancrofti in Human Blood in Tana River Delta, Kenya by Kinyatta Nancy, Wambua Lillian, Mutahi Wilkinson, Mugasa Claire, Kamau Luna, Wachira Dorcas, Githae Rosemary, Lusweti Japheth, Ichugu Christine, Waigi Emily, Kagai Jim

“…Accurate detection of filarial parasites in humans and vectors is essential for the implementation and evaluation of Global and National Programs to eliminate lymphatic filariasis. …”
Get full text

Large-scale production of Mansonella perstans infective larvae from engorged Culicoides milnei by Chi Anizette Kien, Chi Anizette Kien, Rene Ebai, Rene Ebai, Fanny Fri Fombad, Fanny Fri Fombad, Frederick Esofi, Frederick Esofi, Anna Ning Ntuh, Anna Ning Ntuh, Emmanuel Ouam, Emmanuel Ouam, Narcisse Victor Tchamatchoua Gandjui, Narcisse Victor Tchamatchoua Gandjui, Valerine Chawa Chunda, Valerine Chawa Chunda, Relindis Ekanya, Relindis Ekanya, Franck Noel Nietcho, Franck Noel Nietcho, Juluis Visnel Foyet, Juluis Visnel Foyet, Lucy Cho Nchang, Lucy Cho Nchang, Chefor Magha, Chefor Magha, Abdel Jelil Njouendou, Abdel Jelil Njouendou, Peter Enyong, Peter Enyong, Achim Hoerauf, Achim Hoerauf, Achim Hoerauf, Manuel Ritter, Manuel Ritter, Samuel Wanji, Samuel Wanji

“…However, research about novel drugs against this filarial nematode is missing because of the lack of parasite material. …”
Get full text

Alternative approaches for monitoring and evaluation of lymphatic filariasis following mass drug treatment with ivermectin, diethylcarbamazine and albendazole in East New Britain P... by Krufinta Bun, Benedict Mode, Melinda Susapu, Joyceline Salo, Catherine Bjerum, Michael Payne, Daniel Tisch, Makoto Sekihara, Emanuele Giorgi, Gary J Weil, Peter U Fischer, Leanne Robinson, Moses Laman, Christopher L King

“…<h4>Methods and findings</h4>Two cross-sectional studies were conducted at baseline (N = 49 clusters or villages) and 12 months after mass drug administration (MDA) with IDA (N = 47 villages) to assess lymphatic filariasis (LF) by circulating filarial antigenemia (CFA) and microfilariae (Mf). …”
Get full text