Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma by Xiong SS

“…Then, DCFH-DA probe detection and NAC intervention experiments were used to detect ROS levels. The ferroptosis inhibitor (Liproxstatin-1) was used to study the effect of compound 6c in inducing ferroptosis. …”
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Effect of eicosapentaenoic acid on innate immune responses in Atlantic salmon cells infected with infectious salmon anemia virus by Ingrid Holmlund, Samira Ahmadi, Bente Ruyter, Tone-Kari Østbye, Marta Bou, Tor Gjøen

“…Several biological pathways were affected, including protein synthesis (ribosomal transcripts), peroxisome proliferator activated receptor (PPAR) signaling, and ferroptosis. Cells exposed to both increasing concentrations of EPA and virus displayed gene expression patterns indicating increased formation of oxygen radicals and that cell death via ferroptosis was activated. …”
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Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome by Arturs Zemitis, Arturs Zemitis, Juris Vanags, Juris Vanags, Theresa Schiemer, Theresa Schiemer, Kristaps Klavins, Kristaps Klavins, Guna Laganovska, Guna Laganovska

“…These results suggest a potential link to ferroptosis.ConclusionFerroptosis is a form of programmed cell death characterized by iron-dependent LPO. …”
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Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation by Shiwen Fan, Kaixin Wang, Tianhao Zhang, Daling Deng, Jiwei Shen, Bowen Zhao, Daan Fu, Xiangdong Chen

“…Specifically, the focus includes GPX4’s physiological roles, antioxidant defense mechanisms, regulation of ferroptosis, involvement in signal transduction pathways, and metabolic regulation. …”
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Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology by Emile Youssef, Brandon Fletcher, Dannelle Palmer

“…Additionally, emerging approaches target ferroptosis—a regulated, iron-dependent form of cell death—offering new possibilities for selectively inducing tumor cell death in resistant cancers. …”
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Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis by Xing-Yue Chen, Li-Jia Zhi, Jun Chen, Rong Li, Kun-Lan Long

“…Recent high-frequency keywords in this field include “septic AKI,” “mitochondrial dysfunction,” “inflammasome,” “ferroptosis,” and “macrophage.” The terms “mitochondrial dysfunction,” “inflammasome,” “ferroptosis,” and “macrophage” represent current research hotspots and potential targets in this area.ConclusionThis is the first comprehensive bibliometric study to summarize the trends and advancements in SA-AKI research in recent years. …”
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MUC5B regulates alterations in the immune microenvironment in nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway by Hongming Wang

“…In vitro, increased expression of elevated mucin 5B, oligomeric mucus/gel-forming activates nasopharyngeal carcinoma cell activity and immune escape and inhibits ferroptosis. In terms of pathways, upregulating mucin 5B, oligomeric mucus/gel-forming expression could activate the Wnt/β-catenin pathway. …”
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Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress by Yuwei Han, Guangzhi Hao, Song Han, Tingzhun Zhu, Yushu Dong, Ligang Chen, Xinyu Yang, Xiaoming Li, Hai Jin, Guobiao Liang

“…The protective effects of PD are mediated through SIRT1, which inhibits ER stress and reduces neuronal apoptosis and ferroptosis.…”
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METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression by Chen Zhang, Tianpeng Yang, Hanbin Chen, Xiaofeng Ding, Huajian Chen, Zhenzhen Liang, Yinlong Zhao, Shumei Ma, Xiaodong Liu

“…Abstract Radiotherapy is one of the main treatment modalities for advanced hepatocellular carcinoma (HCC). Ferroptosis has been shown to promote the radiosensitivity of HCC cells, but it remains unclear whether epigenetic regulations function in this process. …”
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Superoxide dismutase promotes gastric tumorigenesis mediated by Helicobacter pylori and enhances resistance to 5-fluorouracil in gastric cancer by Hongbing Fu, Yu Zhang, Yantao Duan, Xin Zhang, Jun Yao, Dejun Yang, Ziran Wei, Zhenxin Zhu, Jiapeng Xu, Zunqi Hu, Qing You, Ronglin Yan, Weijun Wang

“…Our research demonstrates that SOD2 can serve as an inhibitor of ferroptosis by activating AKT, and stabilizing GPX4 protein, which subsequently induces 5-fluorouracil resistance. …”
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Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

“…While apoptosis, necroptosis and ferroptosis were clearly involved in cell death of T-24 cells, cytotoxicity in RT-112 cells was probably provoked by apoptosis, ferroptosis and pyroptosis. …”
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Ginger protects against vein graft remodeling by precisely modulating ferroptotic stress in vascular smooth muscle cell dedifferentiation by Xiaoyu Yu, Weiwei Wu, Jingjun Hao, Yuxin Zhou, Deyang Yu, Wei Ding, Xuejuan Zhang, Gaoli Liu, Jianxun Wang

“…In addition, Nox1 is a ferroptosis-promoting gene that encourages ferroptotic stress production, indirectly leading to VSMC dedifferentiation. …”
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Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets by Yuepeng An, Fu Zhao, Hongling Jia, Siyu Meng, Ziwei Zhang, Shuxiao Li, Jiusi Zhao

“…Meanwhile, the induction of ferroptosis and pyroptosis was thought to trigger immune responses that helped suppress melanoma dissemination. …”
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Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control by Yun Gao, Xiushan Yin, Xiaomeng Ren

“…They alleviate liver diseases by differentiating to hepatocyte-like cells, immunomodulation, homing to the injured site, regulating cell ferroptosis, regulating cell autophagy, paracrine effects, and MSC-mitochondrial transfer. …”
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The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…Six coexpression pathways related to transcription and metabolism, including the citrate cycle, ascorbate and aldarate metabolism, proximal tubule bicarbonate reclamation, glycolysis/gluconeogenesis, ferroptosis, and drug metabolism–cytochrome P450, were identified. …”
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Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy by Mingyue Wu, Zixia Huang, Lijin Zeng, Chunfei Wang, Deming Wang

“…In recent years, different types of programmed cell death such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy have been described and found to be linked with cardiovascular diseases such as myocardial infarction, heart failure, and myocarditis. …”
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Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications by Yating Cong, Na Li, Zixin Zhang, Yan Shang, Hailong Zhao

“…Abstract Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms and signaling pathways. …”
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铁死亡：心肌缺血再灌注损伤分子机制和药物治疗研究新靶点 by 刘思齐, 杨正飞

“…心肌缺血/再灌注损伤（I/R）是再灌注治疗的重要并发症，也是心血管疾病和急危重症患者死亡的主要原因之一，其发病机制复杂，目前临床上尚缺乏有效的防治措施。铁死亡（ferroptosis）是近年来发现的一种全新的调节性细胞死亡方式，是各类疾病发病机理及治疗靶点的热点研究领域。…”
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Identification of hub genes and pathogenesis in Kawasaki disease based on bioinformatics analysis by Min Cao, Zhenhu Zhang, Qian Liu, Yuda Zhang

“…Results: In this study, 32 Co-DEGs were identified, and these genes mainly participated in neutrophil degranulation, neutrophil activation involved in immune response, and negative regulation of cytokine production involved in immune response; meanwhile, they were primarily enriched in starch and sucrose metabolism, fatty acid metabolism, autophagy and apoptosis, ferroptosis, and other pathways. Combined with the results of PPI and CytoHubba, 13 key genes were selected as follows: S100A12, HK3, HP, MMP9, MCEMP1, PYGL, ARG1, HIST2H2AA, ANXA3, HIST2H2AC, HIST2H2AA3, GYG1, DYSF. …”
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Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases by Xiya Ren, Limei Zhao, Yajie Hao, Xiu Huang, Guangna Lv, Xiaoshuang Zhou

“…When copper metabolism is disordered and mitochondrial dysfunction is impaired, programmed cell death such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis, autophagy and necroptosis can be induced. …”
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