Showing 421 - 440 results of 1,902 for search '"fatty acid"', query time: 0.09s Refine Results
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    Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway by Jiaochen Luan, Mengchi Yu, Qi Gu, Xuan Zhou, Yunqiang Shao, Tong Chen, Jiayi Zhang, Zheng Zhu, Ninghong Song, Jie Yang

    Published 2025-01-01
    “…BackgroundErectile dysfunction (ED) is a prevalent male sexual disorder, commonly associated with hypertension, though the underlying mechanisms remain poorly understood.ObjectiveThis study aims to explore the role of Fatty acid synthase (Fasn) in hypertension-induced ED and evaluate the therapeutic potential of the Fasn inhibitor C75.Materials and methodsErectile function was assessed by determining the intracavernous pressure/mean arterial pressure (ICP/MAP) ratio, followed by the collection of cavernous tissue for transcriptomic and non-targeted metabolomic analyses. …”
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  8. 428

    Polysaccharide-rich extract of Potentilla anserina ameliorates nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/sugar diet-fed mice by Xiujun Lin, Yimei Zheng, Yingying Yan, Hongting Deng, Shunxin Wang, Yuanju He, Yuting Tian, Wenhui Zhang, Hui Teng

    Published 2024-11-01
    “…Moreover, PAP increased the mRNA levels of CPT-1 and PPARα, which were involved in fatty acid oxidation. The present results indicated the PAP could alleviate the damage of liver associated with obesity and PAP treatment might provide a dietary therapeutic option for the treatment of hyperlipidemia.…”
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    Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved] by Jose Miguel Rizo, Theresa Steeb, Johanna Eiblwieser, Pedro Antonio Regidor

    Published 2024-12-01
    Subjects: “…pregnancy; specialized pro-resolving mediators; polyunsaturated fatty acids; chronic inflammation; preterm birth; preeclampsia; amniotic inflammation; chorioamnionitis…”
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