Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Datasets (GSE25101 and GSE73754) and ELISA to assess the expression levels of the five genes and their corresponding proteins.Results: Seven cuproptosis-related DEGs and four immune cell types were identified, revealing significant immune heterogeneity in the immune cell infiltration between the two cuproptosis-related molecular clusters in AS. The eXtreme Gradient Boosting (XGB) model showed the highest predictive accuracy, achieving an area under the receiver operating characteristic curve (AUC) of 0.725, and 5-gene prediction models were established. …”
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Implementation of a Cost and Variation Reduction Program for Hemostasis Products at a Large Academic Medical Center: A Multi-Stakeholder Perspective by Shah T, Brethauer S, Danker III WA, Doshi I, O'Hara M, Silber A, Vasileff WK

“…Survey respondents noted overall satisfaction with conversion, including the level of input they provided in the decision-making process (75% were somewhat to extremely satisfied), availability of hemostatic agents during the conversion process (87%), and the vendor-supported HOP (100%). …”
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Picometre-level surface control of a closed-loop, adaptive X-ray mirror with integrated real-time interferometric feedback by Ioana-Theodora Nistea, Simon G. Alcock, Andrew Foster, Vivek Badami, Riccardo Signorato, Matteo Fusco

“…Aside from demonstrating the extreme sensitivity of the interferometer sensors, this study also highlights the voltage repeatability and stability of the programmable high-voltage power supply, the accuracy of the correction-calculation algorithms and the almost instantaneous response of the bimorph mirror to command voltage pulses. …”
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Therapeutic Efficacy of Ultrasound-Guided High-Voltage Long-Duration Pulsed Radiofrequency for Pudendal Neuralgia by Feng Ji, Shuzhuan Zhou, Caixia Li, Yongyan Zhang, Hua Xu

“…Only short-term ipsilateral involuntary convulsion of the lower extremity was reported in one patient, who recovered within 12 h. …”
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Ethical education: Ways of moral consciousness development (understanding experience through Tyumen ethical and philosophical tradition) by E. N. Yarkova, A. G. Ivanov, Ya. V. Maltsev

“…This is due to the fact that the person’s moral consciousness is an extremely subtle matter; the ways of its development are complex and non-linear. …”
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Females have Lower Knee Strength and Vertical Ground Reaction Forces During Landing than Males Following Anterior Cruciate Ligament Reconstruction at the Time of Return to Sport by Zachary B. Sullivan, Barrie S. Sugarman, Mallory S. Faherty, Carrie Killelea, Dean C. Taylor, Daniel Le, Alison P. Toth, Jonathan C. Riboh, Lee H. Diehl, Jocelyn R. Wittstein, Annunziato Amendola, Timothy C. Sell

“…Performance in lower extremity isokinetic and isometric strength testing, static and dynamic postural stability testing, and a single leg stop-jump task was compared between the sexes…”
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Development and validation of a biomarker-based prediction model for metastasis in patients with colorectal cancer: Application of machine learning algorithms by Erfan Ayubi, Sajjad Farashi, Leili Tapak, Saeid Afshar

“…Subsequently, the prediction model was developed and internally validated using five machine learning (ML) algorithms including lasso and elastic-net regularized generalized linear model (glmnet), k-nearest neighbors (kNN), support vector machine (SVM) with Radial Basis Function Kernel, random forest (RF), and eXtreme Gradient Boosting (XGBoost). The predictive performance of the algorithm with the highest accuracy was then externally validated on the GSE41568 dataset. …”
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The Landbound Chicken and the Deliberate Chameleon yet have their Uses: Yorùbá Art History, Language, and Interpretation. by Kathy Curnow

“… Rowland Abiodun’s Yorùbá Art and Language contains many extremely valuable features, wrapped around a question he raises in its introduction: can foreign scholars ever truly understand a work the way its Yorùbá makers and users do? …”
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Supervised vs. Self-Managed Exercise Therapy for Improving Shoulder Function After Traumatic Dislocation and Sprain: A Systematic Review and Meta-Analysis by Daniel Koska, Robert Zetzsche, Tobias A. Mayer, Christian Maiwald

“…Trauma-induced shoulder dislocations and sprains rank among the most common upper extremity injuries, with contact sports accounting for the majority of cases. …”
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Retrospective analysis of trauma patients transported by dispatch monitored type B ambulances to Dhulikhel Hospital, Kavre, Nepal, 2019–2023 by Maxwell L. Mantych, Shiva Neupane, Machchendra Sapkota, Laura D. Cassidy, Sarah C. Young, Ronald Anguzu, Samjhana Basnet

“…Approximately one-third of patients admitted to the hospital after evaluation in the emergency department experienced multiple injuries, and the most prevalent diagnosis of admitted cases were extremity fractures (52%). Conclusion Trauma cases accounted for 15% (227/1541) of all patients who received transport and prehospital care services from a Type B ambulance monitored by the Dispatch Center between 2019 and 2023. …”
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Comparative analysis of Sentinel-2 and PlanetScope imagery for chlorophyll-a prediction using machine learning models by Eden T. Wasehun, Leila Hashemi Beni, Courtney A. Di Vittorio, Christopher M. Zarzar, Kyana R.L. Young

“…Utilizing five machine learning models, namely linear regression (LR), least absolute shrinkage and selection operator (LASSO), extreme gradient boosting (XGBoost), random forest (RF), and support vector regression (SVR), we constructed inversion models. …”
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Continuous overnight monitoring of body temperature during embryo transfer cycles as a proxy for establishing progesterone fluctuations by comparison with P4 blood progesterone res... by T.G. Knowles, J.A. García-Velasco, M. Toribio, N. Garrido, A.I. Barrio Pedraza, C. Colomé Rakosnik, A. Salazar Vera, R. Milnes

“…Conclusions The results provide extremely strong evidence of a linear relationship between LnP4 and Smooth Temperature (ST) measured the day before blood sampling (Z = 15.6, p < 0.0001, 2 sided). …”
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Experimental Study on Well Placement Optimization for Steam-Assisted Gravity Drainage to Enhance Recovery of Thin Layer Oil Sand Reservoirs by Lei Tao, Xiao Yuan, Hao Cheng, Bingchao Li, Sen Huang, Na Zhang

“…However, when making use of the traditional SAGD technique (the production and injection well are located on the same axis with the horizontal well spacing of 0 m), the steam chamber development is usually insufficient because of the high longitudinal sweep rate of steam, which seriously influences the SAGD performance for developing thin layer oil sand reservoirs especially. It is extremely important to find an economical and practicable method to promote the steam chamber development in thin oil sand reservoirs in the process of SAGD production; optimizing well placement is a reliable method. …”
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Cytotoxic and cytostatic activity of five new imidazotetrazine derivatives on breast cancer cell cultures MDAMB231, BT474, and MCF-7 by Ahmed Hamid Al-Humairi, Svetlana E. Sitnikova, Valery V Novochadov

“…These two derivatives were classified as the compounds with an extremely low CTA. Imidazotetrazine 1 and iminothiotriazine 5 showed cytotoxic activity higher than that of the comparison drug and we classified these compounds as the ones with a moderate CTA. …”
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Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity by Velid Unsal, Erkan Oner, Reşit Yıldız, Başak Doğru Mert

“…Since drug development is an extremely risky, costly and time-consuming process, the data obtained in this study will facilitate and guide future studies. …”
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The performance of a machine learning model in predicting accelerometer-derived walking speed by Aleksej Logacjov, Tonje Pedersen Ludvigsen, Kerstin Bach, Atle Kongsvold, Mats Flaaten, Tom Ivar Lund Nilsen, Paul Jarle Mork

“…The video recordings were labelled and used as ground truth for training an eXtreme Gradient Boosting (XGBoost) machine learning classifier. …”
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Deep learning of noncontrast CT for fast prediction of hemorrhagic transformation of acute ischemic stroke: a multicenter study by Huanhuan Ren, Haojie Song, Shaoguo Cui, Hua Xiong, Bangyuan Long, Yongmei Li

“…A clinical model was developed using eXtreme Gradient Boosting, an NCCT-based imaging model was created using deep learning, and an ensemble model integrated both models. …”
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Construction of a prognostic prediction model for colorectal cancer based on 5-year clinical follow-up data by Boao Xiao, Min Yang, Yao Meng, Weimin Wang, Yuan Chen, Chenglong Yu, Longlong Bai, Lishun Xiao, Yansu Chen

“…Decision tree, random forest, support vector machine, and extreme gradient boosting (XGBoost) models were selected for modeling based on the features identified through recursive feature elimination (RFE). …”
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Unusual hypertrophic cardiomyopathy: case report of an early onset wild-type ATTR amyloidosis accompanied by a chromosomal duplication involving the MYH6 and MYH7 gene by Jassin Hamidi, Yvonne Hanel, Sven Dittmann, Wanda Maria Gerding, Huu Phuc Nguyen, Karin Klingel, Eric Schulze-Bahr

“…Consequently, two distinct and rare disease entities co-occurred in this patient, both ultimately leading to HCM.DiscussionTo date, no other case featuring wild-type transthyretin amyloidosis (wtATTR) concurrently with a chromosomal duplication affecting both cardiac myosin heavy chain genes has been reported in the literature. This highlights the extreme rarity of this condition, making it challenging to ascertain the extent to which a presumably mutated hybrid myosin gene construct or the TTR amyloid fibrils contribute to stiffness, tissue fibrosis, and cardiac dysfunction. …”
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ŽINOJIMO SOCIALUMO PROBLEMA ŠIUOLAIKINĖJE SOCIALINĖJE EPISTEMOLOGIJOJE: DU POŽIŪRIAI by Audronė Rimkutė

“…So contemporary social epistemology vacillates meantime between two extremities: the individualistic concept of knowledge, which doesn’t help to solve the problems of collective knowledge production, and sociologistic one, which reduces knowledge seeking to social actions and therefore can’t provide base for the adequate knowledge and science policy. …”
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