Pembrolizumab with external radiation therapy effectively controlled TMB-high unresectable recurrent parathyroid cancer: a case report with review of literature by Hiroshi Katoh, Tomoya Mitsuma, Riku Okamoto, Kanako Naito, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai

“…Parathyroid cancer (PC) is extremely resistant to chemotherapy and radiotherapy (RT), but hormonally functional by producing excessive parathyroid hormone (PTH), causing remarkable hypercalcemia even in biochemical disease recurrence. …”
Get full text

Appendicular Skeletal Muscle Index Is Positively Related to Mediterranean Diet Adherence in University Students by Paraskevi Detopoulou, Olga Magni, Ioanna Pylarinou, Despoina Levidi, Vassilios Dedes, Milia Tzoutzou, Konstantina Argyri, Evangelia Fappa, Aristea Gioxari, George Panoutsopoulos

“…The aSMI was calculated as the sum of the upper and lower extremity muscle masses divided by height squared. …”
Get full text

The Use of Digital Microscopy to Compare the Thicknesses of Normal Corneas and Ex Vivo Rejected Corneal Grafts with a Focus on the Descemet’s Membrane by Taíse Tognon, Sabrina Bergeron, Christina Mastromonaco, Kleyton Barella, Adriano Pasqualotti, Laura Nunez, Francisco Murta, Luciene Barbosa de Sousa, Mauro Campos, Miguel Noel Nascentes Burnier

“…There were differences between the normal and FGR groups in the mean central thickness of the epithelium (p<0.001), the nasal and temporal stromal regions (p<0.001), and of the DM in the nasal and temporal regions (p<0.001). Compared with the extremities of the sample (nasal and temporal), the mean thickness of the DM in normal corneas was lower in the central region (p<0.001), and this difference was not found in the FGR group. …”
Get full text

<i>Clostridium difficile</i>-associated disease by V. T. Ivashkin, O. S. Shifrin, A. S. Tertycnhy, Ye. A. Poluektova, T. L. Lapina, O. S. Lyashenko, K. V. Ivashkin

“…This disease is the most frequent cause of intrahospital diarrhea resulting in significant mortality. This is why it is extremely important to be able to diagnose, treat in due terms this disease and to carry out prophylactic procedures.…”
Get full text

Transforming monosaccharides: Recent advances in rare sugar production and future exploration by Shin-ichi Nakakita, Jun Hirabayashi

“…Rare sugars are defined as monosaccharides and their derivatives that do not exist in nature at all or that exist in extremely limited amounts despite being theoretically possible. …”
Get full text

Probabilistic Forecasting of Ground Magnetic Perturbation Spikes at Mid‐Latitude Stations by Michael Coughlan, Amy Keesee, Victor Pinto, Raman Mukundan, José Paulo Marchezi, Jeremiah Johnson, Hyunju Connor, Don Hampton

“…Directly forecasting these fluctuations has proven difficult, but accurately determining the risk of extreme events can allow for the worst of the damage to be prevented. …”
Get full text

A Synoptic- and Remote Sensing-based Analysis of a Severe Dust Storm Event over Central Asia by Parya Broomandi, Kaveh Mohammadpour, Dimitris G. Kaskaoutis, Aram Fathian, Sabur F. Abdullaev, Vladimir A. Maslov, Amirhossein Nikfal, Ali Jahanbakhshi, Bakhyt Aubakirova, Jong Ryeol Kim, Alfrendo Satyanaga, Alireza Rashki, Nick Middleton

“…Meteorological measurements and HYSPLIT back-trajectories at selected sites in Central Asia (Turkmenabat, Khujand and Tashkent) showed a remarkable dust impact that reduced temperature (by 2–4°C) and visibility to below 1 km at different periods, as the thick dust plume expanded in various directions. The extremely high PM concentrations (PM10 > 10,000 µg m−3 in Tashkent) could endanger both human health and the environment, especially in a region suffering from high susceptibility to wind erosion and significant land degradation and desertification. …”
Get full text

Multiscale Attention Feature Fusion Based on Improved Transformer for Hyperspectral Image and LiDAR Data Classification by Aili Wang, Guilong Lei, Shiyu Dai, Haibin Wu, Yuji Iwahori

“…However, the complexity of urban areas and their surrounding structures makes it extremely difficult to capture correlations between features. …”
Get full text

Anatomic characteristics of the lacrimal sac and adjacent bony structures–a computed tomographic-dacryocystography research by Xin-Han Cui, Yan-Wen Fang, Li-Min Zhang, Ji-Ni Qiu, Chao-Ran Zhang, Yan Wang

“…The obstructions were generally located around the entrance of the NLD, but some extreme individual variations strongly implies the importance of CT-DCG scanning before surgery.…”
Get full text

Performance analysis of PCM-based lithium-ion battery module thermal management system under mechanical vibration by Jiebo Yang, Qinghua Yu, Wenjie Ye, Yang Yu, Sheng Chen

“…The findings indicate that, under mechanical vibration condition, mechanical vibration's influence on the performance of the BTMS is negligible at lower discharge rates, but becomes significant when the discharge rate surpasses a certain threshold, particularly at extremely fast discharge level, resulting in a decrease of 2.28 K in the LIB module’s maximum temperature and a more uniform temperature distribution upon completion of an 8 C discharge in contrast to its stationary equivalent. …”
Get full text

Excess costs of post-traumatic stress disorder related to child maltreatment in Germany by Thomas Grochtdreis, Hans-Helmut König, Falk Leichsenring, Manfred E. Beutel, Lila Feix, Harald Gündel, Andrea Hermann, Melissa Hitzler, Christine Knaevelsrud, Iris-Tatjana Kolassa, Johannes Kruse, Helen Niemeyer, Fatima Nöske, Simone Salzer, Karoline Sophie Sauer, Patrick Schuster, Christiane Steinert, Kerstin Weidner, Jörn von Wietersheim, Jürgen Hoyer, Judith Dams

“…Individuals with mild to moderate PTSD symptoms incurred total excess costs of €6038 (95% CI: €3879 to €8197), while those with severe to extreme symptoms faced €11,433 (95% CI: €8220 to €14,646). …”
Get full text

Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study by Yanfei Chen, Bing Wang, Yankai Shi, Wenhao Qi, Shihua Cao, Bingsheng Wang, Ruihan Xie, Jiani Yao, Xiajing Lou, Chaoqun Dong, Xiaohong Zhu, Danni He

“…The study utilised Random Forest and Extreme Gradient Boosting (XGBoost) algorithms alongside traditional logistic regression for modelling. …”
Get full text

Prediction of sentiment polarity in restaurant reviews using an ordinal regression approach based on evolutionary XGBoost by Dana A. Al-Qudah, Ala’ M. Al-Zoubi, Alexandra I. Cristea, Juan J. Merelo-Guervós, Pedro A. Castillo, Hossam Faris

“…Additionally, an automatic multi-language prediction approach for online restaurant reviews was proposed by combining the eXtreme gradient boosting (XGBoost) and particle swarm optimization (PSO) techniques for the ordinal regression of these reviews. …”
Get full text

Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia by Xin-Yu Li, Wen-Kai Yu, Jing-Hao Wu, Wen-Jun He, Yu-Nan Cheng, Kai Gao, Yi-Han Wei, Yu-Sheng Li

“…Through Protein–Protein Interaction (PPI) network analysis, Support Vector Machine-Recursive Feature Elimination (SVM-RFE) , and Extreme Gradient Boosting (XGBoost) machine learning, we identified Cytochrome P4501B1 (CYP1B1) and Electron Transfer Flavoprotein Alpha (ETFA) as key hub genes. …”
Get full text

Research Progress on Sugar Signaling during Fruit Development and Ripening by Libin WANG, Junpeng NIU, Guodong WANG, Yuhua XIE, Chen ZHANG, Zhifang YU, Bing XIE, Qiuqin ZHANG, Heyun ZHENG, Ruihong YUAN, Xinli GENG, Shaoling ZHANG

“…Sugar is extremely important for the growth and development of fruits, and it is also vital for the improvement of fruit quality. …”
Get full text

X-Ray/Radio Quasiperiodic Pulsations Associated with Plasmoids in Solar Flare Current Sheets by Pankaj Kumar, Judith T. Karpen, Joel T. Dahlin

“…Direct imaging of flare current sheets and the formation/ejection of multiple plasmoids in extreme-ultraviolet images, along with simultaneous X-ray and radio observations, offers significant insights into the mechanisms driving particle acceleration in solar flares. …”
Get full text

Active Moss Biomonitoring of Mercury in the Mine-Polluted Area of Abbadia San Salvatore (Mt. Amiata, Central Italy) by Federica Meloni, Sergio Calabrese, Orlando Vaselli, Francesco Capecchiacci, Francesco Ciani, Lorenzo Brusca, Sergio Bellomo, Walter D’Alessandro, Kyriaki Daskalopoulou, Stefania Venturi, Barbara Nisi, Daniele Rappuoli, Franco Tassi, Jacopo Cabassi

“…The results testified that the chosen biomonitoring technique was an extremely useful tool for understanding Hg transport and fate in a contaminated area.…”
Get full text

VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…In our study, we found targeting VSIG4+ TAMs by VSIG4 deficiency or blockade remarkably limited tumor growth and metastasis, especially those derived from anaplastic thyroid cancer (ATC) and pancreatic cancer, two extremely aggressive types. Moreover, the combination of VSIG4 blockade with a BRAF inhibitor synergistically enhanced anti-tumor activity in ATC-tumor bearing mice. …”
Get full text

Highly Adsorption-Photocatalytic Tablet-Shaped Graphite Oxide-TiO2 Composites for Handling Organic Dye Pollutants by Dwiprayogo Wibowo, Faizal Mustapa, Albi Fabian, Eza Fitaloka, Dedi Ardiansyah, Aryani Adami, Anwar Said, Jamal Mukaddas, Abriansyah Abriansyah

“…Furthermore, these tablets were molded using metal chips for extremely high adsorption photocatalysts towards organic dyes. …”
Get full text

Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report... by Yohei Ishiki, Atsuko Tamaki, Ken-ichiro Honma, Ken Yonaha, Takamitsu Yabiku, Taiki Teruya, Moriyuki Uehara, Yoshiro Nakayama, Rei Chinen, Tsugumi Uema, Sawako Nakachi, Shiki Okamoto, Hiroaki Masuzaki

“…Post-traumatic pituitary stalk transection syndrome (PSTS) is an extremely rare cause of combined pituitary hormone deficiency (CPHD), affecting approximately 9 per 100,000 cases of traumatic brain injury. …”
Get full text