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161
The Role of Hyaluronan in Innate Defense Responses of the Intestine
Published 2015-01-01“…Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. …”
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162
Principles of Medical Biochemistry /
Published 2017Table of Contents: “…Introduction to biomolecules -- Introduction to protein structure -- Oxygen-binding proteins : hemoglobin and myoglobin -- Enzymatic reactions -- Coenzymes -- DNA, RNA, and protein synthesis -- The human genome -- Protein targeting and proteostasis -- Introduction to genetic diseases -- Viruses -- DNA technology -- Biological membranes -- The cytoskeleton -- The extracellular matrix -- Extracellular messengers -- Intracellular messengers -- Plasma proteins -- Defense mechanisms -- Cellular growth control and cancer -- Digestive enzymes -- Introduction to metabolic pathways -- Glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation -- Oxygen deficiency and oxygen toxicity -- Carbohydrate metabolism -- The metabolism of fatty acids and triglycerides -- The metabolism of membrane lipids -- Lipid transport -- Amino acid metabolism -- Metabolism of iron and heme -- The metabolism of purines and pyrimidines -- Micronutrients -- Integration of metabolism.…”
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163
Combined Effects of Estrogen and Mechanical Loading on Anterior Cruciate Ligament Fibroblast Biosynthesis
Published 2005-01-01“…In a recent study, our group demonstrated a negative combined effect of estrogen and mechanical loading on the gene expression of major extracellular matrix component molecules in ACL fibroblasts.…”
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164
Sitagliptin and the Blood-Retina Barrier: Effects on Retinal Endothelial Cells Manifested Only after Prolonged Exposure
Published 2020-01-01“…Because both associated proteins are important for adhesion of iBREC to the extracellular matrix, the observed low CI might be caused by weakened attachment of the cells. …”
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165
Progress in Study of Low-Intensity Pulsed Ultrasound Acting on Inflammation-Related Signaling Pathways in Knee Osteoarthritis
Published 2023-10-01“…They appear in multiple pathogenic signaling pathways of KOA, regulate the intracellular activity of KOA and play an important role in pathological processes such as chondrocyte destruction, extracellular matrix reduction, abnormal cartilage remodeling, subchondral ossification, and synovial inflammation. …”
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166
The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics
Published 2025-02-01“…RNA sequencing revealed dex’s impact on cell adhesion and extracellular matrix signalling in TN cells and on DNA replication in ER + cells. …”
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167
Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer
Published 2025-02-01“…The nanoparticle PH20/CCM@PMCS could penetrate the extracellular matrix of tumor tissues and target both cancer cells and CAFs. …”
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168
Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery
Published 2021-01-01“…In conclusion, we identified a distinct set of DEGs in association with extracellular matrix and cancer cell activities to contrast CP and CPR. …”
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169
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Published 2016-01-01“…Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. …”
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170
Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
Published 2017-01-01“…Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. …”
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171
Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
Published 2023-01-01“…It is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ECM), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. …”
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172
Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
Published 2015-01-01“…Through digestion of the extracellular matrix and cleavage of bioactive proteins, a huge diversity of roles have been revealed for the MMPs in IBD, where they have been shown to regulate epithelial barrier function, immune response, angiogenesis, fibrosis, and wound healing. …”
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173
SOX9: a key transcriptional regulator in organ fibrosis
Published 2025-02-01“…Many disorders are associated with the process of fibrosis; moreover, fibrosis is a common symptom of chronic inflammatory diseases, characterized by the accumulation of excessive components in the extracellular matrix through different signaling pathways. …”
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174
Variations to the Nanotube Surface for Bone Regeneration
Published 2013-01-01“…A particularly fascinating area of research involves the study of nanostructured surfaces, which are believed to enhance osteogenic behavior, possibly due to the mimicry of components of the extracellular matrix of bone. There is a growing body of data that emphasizes the promise of the titanium oxide (TiO2) nanotube architecture as an advanced orthopedic implant material. …”
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175
Leukocytes: The Double-Edged Sword in Fibrosis
Published 2015-01-01“…Skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components, accompanied by the accumulation of a vast number of myofibroblasts. …”
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176
The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats
Published 2024-12-01“…Cardiomyocytes represent the contractile units of the myocardium, while the maintenance and renewal of the extracellular matrix is a function of fibroblasts. The extracellular matrix provides structural support and mechanical signals for resident cells, and stores biologically active signaling molecules. …”
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177
Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain
Published 2019-01-01“…Clinically dosed etoricoxib, that is, a highly selective COX-2 inhibition, did not have substantial effects on hPDL fibroblast-mediated periodontal inflammation, extracellular matrix remodeling, RANK-L/OPG expression, and osteoclastogenesis during simulated orthodontic compressive strain.…”
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178
Angiogenesis and Its Therapeutic Opportunities
Published 2013-01-01“…The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia) and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies). …”
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179
The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs
Published 2022-01-01“…During aging and disease progression, the extracellular matrix (ECM) undergoes structural changes in which elastin and collagens serve an essential role. …”
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180
Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
Published 2017-01-01“…Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance. …”
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