Polymer Design of Microwell Hydrogels Influences Epithelial–Mesenchymal Interactions During Human Bronchosphere Formation by Madeline K. Eiken, Justin E. Levine, Shinyeong Lee, Samantha Lukpat, Eleanor M. Plaster, Vikram Bala, Jason R. Spence, Claudia Loebel

“…Furthermore, both hydrogel type and cellular composition influence the amount and composition of deposited extracellular matrix within the microwells. This hydrogel fabrication platform provides an accessible in vitro culture platform for the formation and growth of bronchospheres which can be extended to the culture of other organoid systems.…”
Get full text

Comprehensive bioinformatic profiling of matrix metalloproteinases and their inhibitors: Expression and interaction patterns in head and neck cancer toward predictive biomarkers an... by Rishaba Byju, Sredha Sunil, Sabari Sadhasivan, Rajesh Parsanathan

“…Objective: Matrix metalloproteinases (MMPs) and Tissue inhibitors of metalloproteinases (TIMPs) are involved in the turnover of extracellular matrix (ECM) components. Overexpression of MMPs facilitates tumour progression by promoting ECM turnover, angiogenesis, and cell migration. …”
Get full text

High Sensitivity Method to Estimate Distribution of Hyaluronan Molecular Sizes in Small Biological Samples Using Gas-Phase Electrophoretic Mobility Molecular Analysis by Lan Do, Christen P. Dahl, Susanne Kerje, Peter Hansell, Stellan Mörner, Ulla Lindqvist, Anna Engström-Laurent, Göran Larsson, Urban Hellman

“…Up to now, it has been difficult to study the role of hyaluronan in diseases with pathological changes in the extracellular matrix where availability is low or tissue samples are small. …”
Get full text

Contribution of Glycosaminoglycans to the Microstructural Integrity of Fibrillar and Fiber Crimps in Tendons and Ligaments by Marco Franchi, Viviana De Pasquale, Désirée Martini, Marilisa Quaranta, Maria Macciocca, Alessio Dionisi, Vittoria Ottani

“…The biomechanical roles of both tendons and ligaments are fulfilled by the extracellular matrix of these tissues. In particular, tension is mainly transmitted and resisted by protein (collagen, elastin) fibers, whereas compression is opposed by water-soluble glycosaminoglycans (GAGs). …”
Get full text

Circ-PDE1C/miR-766-3p/SGTB axis regulates the IL-1β-induced apoptosis, inflammation and oxidative stress in human chondrocytes by Lixia Gao, Tao He, Qingkui Hu, Yan Ma

“…Downregulation of circ-PDE1C alleviated the IL-1β-induced cell apoptosis, inflammation, extracellular matrix degradation and oxidative stress. Circ-PDE1C could interact with miR-766-3p to serve as miRNA sponge. …”
Get full text

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways by Liang Zhu, Yanchi Bi, Ting Liang, Po Zhang, Xiao Xiao, Tengbo Yu

“…In vitro experiments showed GK effectively reverses oxidative stress damage from TBHP, inhibits inflammatory factor release, and protects Extracellular matrix (ECM) from degradation. These functions may be achieved via the NF-κB and MAPK signaling pathways. …”
Get full text

VASN knockout induces myocardial fibrosis in mice by downregulating non-collagen fibers and promoting inflammation by Junming Sun, Siwei Yin, Qiurui Li, Jun Zhang, Xiaoping Guo, Na Yu, Bing Hu, Yiqiang Ouyang, Qiaojuan Huang, Min He, Min He, Min He

“…Differential analysis of the genes showed that the extracellular matrix (ECM) genes (COL6A1, COL9A1, and FRAS1) had strong correlations while their expression levels were significantly reduced by qPCR, IHC-P, and Western blotting. …”
Get full text

Recent Development of Fibrous Hydrogels: Properties, Applications and Perspectives by Wen Luo, Liujiao Ren, Bin Hu, Huali Zhang, Zhe Yang, Lin Jin, Di Zhang

“…This article reviews the main advantages of FGs, including enhanced mechanical properties, high conductivity, high antimicrobial and anti‐inflammatory properties, stimulus responsiveness, and an extracellular matrix (ECM)‐like structure. It also discusses the influence of assembly methods, such as fiber cross‐linking, interfacial treatments of fibers with hydrogel matrices, and supramolecular assembly, on the diverse functionalities of FGs. …”
Get full text

A 3D Porous Gelatin-Alginate-Based-IPN Acts as an Efficient Promoter of Chondrogenesis from Human Adipose-Derived Stem Cells by Sorina Dinescu, Bianca Galateanu, Eugen Radu, Anca Hermenean, Adriana Lungu, Izabela Cristina Stancu, Dana Jianu, Tudorita Tumbar, Marieta Costache

“…Moreover, we find that after exposure to prochondrogenic conditions a key transcription factor known to induce chondrogenesis, namely, Sox9, is highly expressed in our hADSCs/G-A-PAA bioconstruct, along with cartilage specific markers such as collagen type II, CEP68, and COMP extracellular matrix (ECM) components. These data suggest that our G-A-PAA structural properties and formulation might enable hADSCs conversion towards functional chondrocytes. …”
Get full text

The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering by Hongru Li, Zhiping Qi, Shuang Zheng, Yuxin Chang, Weijian Kong, Chuan Fu, Ziyuan Yu, Xiaoyu Yang, Su Pan

“…Hydrogels are used as extracellular matrix mimics. Although various materials are able to form hydrogels, hyaluronic acid and its derivatives are prominently used. …”
Get full text

ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-κB signaling pathway by Shuo Zhou, Yuhang Yang, Feiyu Qi, Wanliang Sun, Dengyong Zhang, Zheng Lu, Yongliang Chen

“…A Disintegrin and Metalloprotease Domain-like Protein Decysin-1 (ADAMDEC1) can promote the development and metastasis in various tumors by degrading the extracellular matrix. However, its regulatory mechanism in CCA remains unclear. …”
Get full text

Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps by Venera Cristina Dinescu, Liviu Martin, Marius Bica, Ramona Constantina Vasile, Andrei Gresita, Marius Bunescu, Mihai Andrei Ruscu, Madalina Aldea, Alexandra Daniela Rotaru-Zavaleanu

“…Their ability to mimic the extracellular matrix facilitates localized drug delivery, anti-adhesion barrier formation, and tissue regeneration. …”
Get full text

Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceutic... by Lujain Bader Eddin, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Samer N. Goyal, Shreesh Ojha

“…Cardiac fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly collagen in the cardiac interstitium. …”
Get full text

Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases by Cheng-Cheng Deng, Xue-Yan Xu, Yan Zhang, Long-Can Liu, Xuan Wang, Jun-Yi Chen, Liu-Yi Yao, Ding-Heng Zhu, Bin Yang

“…BackgroundFibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix components. The immune cells are postulated to exert a pivotal role in the development of fibrotic skin disease. …”
Get full text

PAI-1: An Integrator of Cell Signaling and Migration by Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins

“…Cellular migration, over simple surfaces or through complex stromal barriers, requires coordination between detachment/re-adhesion cycles, involving structural components of the extracellular matrix and their surface-binding elements (integrins), and the precise regulation of the pericellular proteolytic microenvironment. …”
Get full text

Extracellular MMP-9-Based Assessment of Ocular Surface Inflammation in Patients with Primary Open-Angle Glaucoma by Anna Zaleska-Żmijewska, Ewa Strzemecka, Zbigniew M. Wawrzyniak, Jacek P. Szaflik

“…Objective assessment of dry eye disease (DED) severity and ocular inflammation using the InflammaDry® test for extracellular matrix metalloproteinase-9 (MMP-9) and the impact of antiglaucoma eye drops in people with primary open-angle glaucoma (POAG). …”
Get full text

Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…In this review, we summarized and analyzed a wide spectrum of PTMs of proteins involved in all regulatory mechanisms that drive tumorigenesis, genetic instability, epigenetic reprogramming, all events of the metastatic cascade, cytoskeleton and extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, and metabolism rewiring as the most important hallmarks of cancer. …”
Get full text

Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammation by Parto Babaniamansour, Diego Jacho, Agustin Rabino, Rafael Garcia-Mata, Eda Yildirim-Ayan

“…M1 macrophages exposed to 3% mechanical strain exhibited upregulated pro-inflammatory responses, including increased pro-inflammatory gene expression and enhanced proteolytic activity within the extracellular matrix. TRPV4 inhibition partially mitigated this inflammation. …”
Get full text

Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…These mechanisms include the expression of various surface molecules that mediate adhesion, motility, and phagocytosis of host cells, as well as the secretion of proteases and other factors that degrade host extracellular matrix and modulate host immune response. However, there are still many unanswered questions regarding the complex interactions between the amoeba and its host, which limit the development of effective diagnostic and therapeutic strategies. …”
Get full text

Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes by D. Lattuada, R. Gualtierotti, K. Crotta, P. Seneci, F. Ingegnoli, C. Corradini, R. Viganò, O. Marelli, C. Casnici

“…Fibroblast-like synoviocytes (FLSs) are apoptosis-resistant and contribute to the pathogenesis of RA by producing cytokines and proteolytic enzymes, which degrade the extracellular matrix. We evaluated the proapoptotic and anti-inflammatory activity of the small molecule Smac127 on RA-FLSs cultured in synovial fluid (SF), in order to reproduce the physiopathological environmental characteristic of RA joints. …”
Get full text