MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer by Xiaoyu He, Fu Gan, Yongjian Lin, Guoqing Liu, Yunhua Lin, Dongxu Chen

“…Enrichment analysis revealed that the differential genes (DEGs) between high and low group are involved in biological functions such as extracellular matrix and organization extracellular structure. …”
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MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models by Beatriz Aparecida Fioruci-Fontanelli, Luiz Gustavo A. Chuffa, Leonardo O. Mendes, Patricia Fernanda F. Pinheiro, Flávia Karina Delella, Cilmery S. Kurokawa, Sérgio Luis Felisbino, Francisco Eduardo Martinez

“…These important findings demonstrate that chronic ethanol intake impairs the physiological balance of the prostate extracellular matrix turnover, through downregulation of MMPs, which may contribute to the development of prostatic diseases. …”
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Evaluating the antifibrotic potential of naringenin, asiatic acid, and icariin using murine and human precision‐cut liver slices by Ke Luo, Yana Geng, Dorenda Oosterhuis, Vincent E. deMeijer, Peter Olinga

“…Abstract Liver fibrosis is an exaggerated wound healing response defined by the excessive accumulation of extracellular matrix. This study investigated the antifibrotic potential of naringenin (NRG), asiatic acid (AA), and icariin (ICA) using murine and human precision‐cut liver slices (PCLS). …”
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Redefining bladder cancer treatment: innovations in overcoming drug resistance and immune evasion by Peng Huang, Jie Wang, Zongze Yu, Jiaan Lu, Zhou Sun, Zhigui Chen

“…TME, comprising cancer-associated fibroblasts (CAFs), immunosuppressive cells, and different components of the extracellular matrix (ECM), orchestrates a setting that fosters tumor growth and immune evasion and confers resistance on any therapeutic regime that might be used. …”
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Pilot study: Initial investigation suggests differences in EMT-associated gene expression in breast tumor regions by Kylie L. King, Hamed Abdollahi, Zoe Dinkel, Alannah Akins, Homayoun Valafar, Heather Dunn

“…The development of breast cancer is highly associated with interactions between tumor cells and the extracellular matrix (ECM), and recent research suggests that cellular components of the ECM vary between racial groups. …”
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New therapies in pulmonary arterial hypertension: Recent insights by Giulia Guglielmi, Konstantinos Dimopoulos, S. John Wort

“…Current therapies primarily focus on pulmonary vasodilation; however, novel approaches that target the underlying pathophysiological mechanisms—such as TGF-β signalling, epigenetic alterations, growth factors, inflammation, and extracellular matrix remodelling—are promising alternatives for improving treatment outcomes. …”
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circ_0075048 silencing regulates LCP1 to improve IL-1β-induced chondrocyte injury by binding with miR-663b by Pin Zhang, Ru Pei, Quanhu Shen

“…Results The expression of circ_0075048 was up-regulated in IL-1β-induced chondrocytes. circ_0075048 silencing promoted the viability of and inhibited the apoptosis of and extracellular matrix (ECM) production of chondrocytes. circ_0075048 was found to be a sponge of miR-663b and LCP1 was found to be a target of miR-663b. circ_0075048 silencing increased miR-663b expression but decreased LCP1 expression levels in chondrocytes. …”
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Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts by Gayathri Vijayakumar, Anisha Latha, Aiswaria P. Anil, Yogini Surve, Aiswarya R, Bipin G. Nair, Indulekha CL. Pillai

“…TGF-β treated cardiac fibroblastss show enhanced cytokine expression, and inhibition of TLR4 signaling reduces the expression of cytokines, thereby reducing TGF-β targets such as extracellular matrix genes. Thus, our data demonstrate that TLR4 and other signaling molecules downstream of TLR4 are expressed in cardiac fibroblast, and inhibition of TLR4 modulates fibrotic changes in vitro.…”
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Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors by Gianna Dipalma, Angelo Michele Inchingolo, Valeria Colonna, Pierluigi Marotti, Claudio Carone, Laura Ferrante, Francesco Inchingolo, Andrea Palermo, Alessio Danilo Inchingolo

“…Conclusion: The findings of the reviewed studies underscore the potential of the CGF in enhancing bone regeneration through stimulating cell proliferation, angiogenesis, and extracellular matrix mineralization. Autologous materials have also demonstrated promising results due to their biocompatibility and capacity for seamless integration with natural bone tissue. …”
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Uniaxial Cyclic Tensile Stretching at 8% Strain Exclusively Promotes Tenogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells by Hui Yin Nam, Belinda Pingguan-Murphy, Azlina Amir Abbas, Azhar Mahmood Merican, Tunku Kamarul

“…The tenogenic, osteogenic, adipogenic, and chondrogenic differentiation potential of hMSCs were evaluated using biochemical assays, extracellular matrix expressions, and selected mesenchyme gene expression markers; and were compared to primary tenocytes. …”
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Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages by Haoran Yu, Chengbiao Ding, Zhongyao Hu, Qi Liu, Xuesong Gu, Junyan He, Yiqun Yan, Shenrui Yu, Lin Gao, Wendan Cheng, Zhengwei Wu, Juehua Jing

“…The direct benefits of this improved microenvironment include enhanced chondrocyte viability, inhibition of apoptosis, and reduced degradation of the extracellular matrix. In vivo studies in rats showed that BIA inhibited M1 macrophage infiltration in the synovium, upregulated the proportion of M2 macrophages, alleviated cartilage degeneration, and delayed OA progression. …”
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CRYβB2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line by Amr A. Waly, London Harper, Jodie M. Fleming, Lindsey M. Costantini

“…RNA sequencing analysis indicated that CRYβB2 overexpression modulated cell-cell adhesion and extracellular matrix organization pathways, which are critical to invasion of cancer cells. …”
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Integrative analysis of transcriptome and metabolome profiling uncovers underlying mechanisms of the enhancement of the synthesis of biofilm in Sporobolomyces pararoseus NGR under... by Dandan Wang, Nan Zeng, Chunji Li, Chunwang Li, Yunjiao Wang, Bin Chen, Jiajia Long, Ning Zhang, Bingxue Li

“…When S. pararoseus NGR was cultured under pH 4.7, the colony morphology was wrinkled, the cells were wrapped by a large amount of extracellular matrix, and the hydrophobicity and anti-oxidative stress ability were significantly improved, and the yield of intracellular carotenoids was significantly increased. …”
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Mesothelial cell responses to acute appendicitis or small bowel obstruction reactive ascites: Insights into immunoregulation of abdominal adhesion. by Melissa A Hausburg, Kaysie L Banton, Christopher D Cassidy, Robert M Madayag, Carlos H Palacio, Jason S Williams, Raphael Bar-Or, Rebecca J Ryznar, David Bar-Or

“…Select rA caused MCs to form clusters of fibroblastic cells, extracellular matrix fibers (FIB), and secretion of GCX. …”
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A chitosan/acellular matrix-based neural graft carrying mesenchymal stem cells to promote peripheral nerve repair by Zhifa Zhang, Molin Li, Gang Cheng, Peng Wang, Chunhui Zhou, Yang Liu, Xiaofeng Duan, Jing Wang, Fang Xie, Yaqiong Zhu, Jianning Zhang

“…Results In vitro, acellular MTs retained the intrinsic extracellular matrix and improved the narrow microstructure of acellular nerves, thereby enhancing cell functionality. …”
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Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway by Chunxue Li, Rongrong Zhang, Yating Zhan, Jianjian Zheng

“…Liver fibrosis, which results from chronic liver injury due to factors such as chronic alcohol consumption, hepatitis virus infections, and immune attacks, is marked by excessive deposition of extracellular matrix (ECM). Resveratrol (Res), a polyphenol phytoalexin, has been demonstrated to show anti-inflammatory, antioxidative, antiproliferative, and chemopreventive activities. …”
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IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A by Xiuxia Wang, Yating Yang, Xianyu Zhou, Shun Yu, Xusong Luo, Lin Lu, Zhen Gao, Jun Yang

“…Moreover, keloid SPOCD1 deficiency attenuates KFs progression and extracellular matrix (ECM) deposition. Reducing IFNγ and SPOCD1 simultaneously can increase the positive rate of reactive oxygen species (ROS) and promote mitochondrial shrinkage. …”
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Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach by Ahmed M. Almehdi, Doha H. Aboubaker, Rania Hamdy, Ali El-Keblawy

“…The physiological characteristics of the highly selective blood-brain barrier and the electrostatic charge of the nanoporous extracellular matrix have long placed restrictions on the treatment of brain disorders. …”
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Biomaterials used in regeneration of salivary gland in three-dimensional culture system -a systematic review by M. Harinisubasri, Divya Bose, Dineshkumar Thayalan, Rajkumar Krishnan, Rameshkumar Annasamy

“…Biomaterials like hyaluronic acid-based, fibrin, Polyethylene glycol, Decellularized extracellular matrix hydro-gels, egg white-based scaffolds, and silk fibroin scaffolds have been tried. …”
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Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction by Andrea Ciavattini, Jacopo Di Giuseppe, Piergiorgio Stortoni, Nina Montik, Stefano R. Giannubilo, Pietro Litta, Md. Soriful Islam, Andrea L. Tranquilli, Fernando M. Reis, Pasquapina Ciarmela

“…To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. …”
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