Constructing Tissue-Engineered Dressing Membranes with Adipose-Derived Stem Cells and Acellular Dermal Matrix for Diabetic Wound Healing: A Comparative Study of Hypoxia- or Normoxi... by Wen Zhou, Xin Zhao, Xin Shi, Can Chen, Yanpeng Cao, Jun Liu

“…In vivo results indicated that compared to the N-ADSCs/ADM membrane, the transplanted cells in the H-ADSCs/ADM membrane can survive longer at the chronic ulcer site, consequently improve angiogenesis, inhibit inflammation, and increase extracellular matrix remodeling, eventually accelerating DFU closure. …”
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Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosis by Wenqiang Yu, Jinfang Song, Shuangquan Chen, Jiayi Nie, Chujun Zhou, Jiamin Huang, Hua Liang

“…Furthermore, suppression of exosome production reduced collagen deposition, extracellular matrix protein accumulation, and MMT in FA nephropathy. …”
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Infusion therapy for chronic liver diseases by I. A. Kurkina, M. V. Mayevskaya, I. N. Tikhonov, V. N. Zozulya, V. I. Leschenko

“…It results activation of pericytes providing synthesis of extracellular matrix components that are involved in metabolism and regeneration of liver parenchyma cells. …”
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Biology and Biotechnology of Follicle Development by Gustavo Adolfo Palma, Martin Eduardo Argañaraz, Antonio Daniel Barrera, Daniela Rodler, Adrian Ángel Mutto, Fred Sinowatz

“…Cell-cell and cell-extracellular matrix interactions influence the production of growth factors in the different follicular compartments (oocyte, granulosa, and theca cells). …”
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Autophagy Mediates MMP-2 Expression in Glaucomatous Trabecular Meshwork Cells by Yan-Ling Xiao, Xiao-Rui Wang, Kejing Ye, Wan-Zhu Chen, Bing-Ru Zheng, Yi-Hong Huang, Yu-Yu Wu

“…Autophagy may be involved in the pathogenesis of POAG via regulating the expression of MMP-2 and, subsequently, the deposition of the extracellular matrix.…”
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Matrix Metalloproteinase 9 as Biomarker for Malignant Mammary Tumors in Dogs by Islam S Alani, Huda S Al Biaty

“…Matrix metallopeptidase 9 (MMP-9) plays a role in dismantling the extracellular matrix during normal bodily functions and diseases, including cancer. …”
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Consumption of a High-Fat Diet Alters Perineuronal Nets in the Prefrontal Cortex by P. M. Dingess, J. H. Harkness, M. Slaker, Z. Zhang, S. S. Wulff, B. A. Sorg, T. E. Brown

“…One structure of interest is the perineuronal net (PNN), a specialized extracellular matrix surrounding, primarily, parvalbumin-containing GABAergic interneurons. …”
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Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit by Christophe Laumonnerie, Maleelo Shamambo, Daniel R. Stabley, Tommy L. Lewis, Niraj Trivedi, Danielle Howell, David J. Solecki

“…Developing neurons and their progenitors must interpret various niche signals—such as morphogens, guidance molecules, extracellular matrix components, and adhesive cues—to navigate this region. …”
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A sterilization method for human decellularized vaginal matrices by Jayson Sueters, Leonie de Boer, Freek Groenman, Judith A. F. Huirne, Theo H. Smit, Sebastian A. J. Zaat

“…Sterilization efficacy was evaluated through controlled contamination with common vaginal microbes and sterility testing subsequent to each sterilization method. The extracellular matrix (ECM) structure was assessed via histological staining. …”
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The Antifibrosis Effects of Peroxisome Proliferator-Activated Receptor δ on Rat Corneal Wound Healing after Excimer Laser Keratectomy by Yun Gu, Xuan Li, Tiangeng He, Zhixin Jiang, Peng Hao, Xin Tang

“…Corneal stromal fibrosis characterized by myofibroblasts and abnormal extracellular matrix (ECM) is usually the result of inappropriate wound healing. …”
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Pioglitazone Attenuates Vascular Fibrosis in Spontaneously Hypertensive Rats by Dengfeng Gao, Ning Ning, Guanghua Hao, Xiaolin Niu

“…Masson’s trichrome staining for collagen III and real-time RT-PCR analysis of collagen I, III and fibronectin mRNA indicated that pioglitazone significantly inhibited extracellular matrix production in the aorta. Compared with Wistar Kyoto rats, SHRs showed significantly increased vascular CTGF expression. …”
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Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases by Nausicaa Clemente, Davide Raineri, Giuseppe Cappellano, Elena Boggio, Francesco Favero, Maria Felicia Soluri, Chiara Dianzani, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

“…This is in part ascribable to the fact that OPN is a complex molecule with several posttranslational modifications and it may act as either an immobilized protein of the extracellular matrix or a soluble cytokine or an intracytoplasmic molecule by binding to a wide variety of molecules including crystals of calcium phosphate, several cell surface receptors, and intracytoplasmic molecules. …”
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Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing by Jianghong Huang, Jun Zhang, Jianyi Xiong, Shuqing Sun, Jiang Xia, Lei Yang, Yujie Liang

“…Wound healing and regeneration are a dynamic and complex process that requires a collaborative effort between growth factors, epidermal cells, dermal cells, extracellular matrix, and vessels local to the wound area. …”
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Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration by Chun-Sheng Li, Yan Xu, Juan Li, Shu-Hao Qin, Shao-Wen Huang, Xue-Mei Chen, Yi Luo, Cheng-Tao Gao, Jian-Hui Xiao

“…For example, natural and synthetic polymer hydrogel scaffolds can effectively mimic the microenvironment of the natural extracellular matrix; exhibit high cytocompatibility, biocompatibility, and biodegradability; and have attracted increasing attention in bone and cartilage tissue engineering and regeneration medicine. …”
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Osteoblastic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells on P3HT Thin Polymer Film by Paola Campione, Maria Giovanna Rizzo, Luana Vittoria Bauso, Ileana Ielo, Grazia Maria Lucia Messina, Giovanna Calabrese

“…Different biomaterials have attracted great interest in BTE applications, including the poly(3-hexylthiofene) (P3HT) conductive polymer, whose primary advantage is its capability to provide a native extracellular matrix-like environment. Based on this evidence, in this study, we evaluated the biological response of human adipose-derived mesenchymal stem cells cultured on P3HT thin polymer film for 14 days. …”
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The oral microbiota: new insight into intracranial aneurysms by Wentao Gong, Hairong Yu, Wei You, Zhen Chen, Yu Wang, Chao Liu, Youxiang Li, Sheng Guan

“…Chronic inflammatory states induced by oral pathogens contribute to extracellular matrix degradation, impaired vascular remodeling, and an increased susceptibility to IA rupture.Conclusions The findings highlight the importance of maintaining oral microbiota homeostasis as a potential therapeutic target for preventing IAs. …”
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Effect of Tumor Necrosis Factor Family Member LIGHT (TNFSF14) on the Activation of Basophils and Eosinophils Interacting with Bronchial Epithelial Cells by Huai Na Qiu, Chun Kwok Wong, Jie Dong, Christopher Wai-Kei Lam, Zhe Cai

“…Allergic asthma can cause airway structural remodeling, involving the accumulation of extracellular matrix and thickening of smooth muscle. Tumor necrosis factor (TNF) family ligand LIGHT (TNFSF14) is a cytokine that binds herpesvirus entry mediator (HVEM)/TNFRSF14 and lymphotoxin β receptor (LTβR). …”
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Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis by Gamal Shiha, Ahmed Nabil, Ahmed Lotfy, Reham Soliman, Ayman A. Hassan, Islam S. Ali, Doaa F. Gad, Faten Zahran

“…Liver fibrosis is the excessive extracellular matrix accumulation of proteins, such as collagen, which follows the chronic liver diseases. …”
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Cathepsin G, a Neutrophil Protease, Induces Compact Cell-Cell Adhesion in MCF-7 Human Breast Cancer Cells by Tomoya Kudo, Hideaki Kigoshi, Takashi Hagiwara, Takahisa Takino, Masatoshi Yamazaki, Satoru Yui

“…Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between cells or the extracellular matrix. Here, we demonstrate that cathepsin G induces cell-cell adhesion of MCF-7 human breast cancer cells resulting from the contact inhibition of cell movement on fibronectin but not on type IV collagen. …”
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The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability by Tiewei Li, Xiaojuan Li, Yichuan Feng, Geng Dong, Yuewu Wang, Junmei Yang

“…Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability. …”
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