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241
Developmental Pathways Pervade Stem Cell Responses to Evolving Extracellular Matrices of 3D Bioprinted Microenvironments
Published 2018-01-01“…Developmental studies and 3D in vitro model systems show that the production and engagement of extracellular matrix (ECM) often precede stem cell differentiation. …”
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242
Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma
Published 2017-12-01“…Introduction : Despite recent diagnostic and therapeutic improvements, pancreas cancer remains one of the highly lethal cancers. The extracellular matrix (ECM) is a physiological barrier that limits the spread of cancer cells into surrounding tissues and distant organs. …”
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243
Complicated Sporadic Cardiac Myxomas: A Second Recurrence and Myxomatous Cerebral Aneurysms in One Patient
Published 2013-01-01“…The challenging reconstruction of the normal anatomy was achieved with the use of porcine extracellular matrix patches. A diagnostic cerebral angiogram was later performed, and the aneurysms will be monitored for growth and possible intervention.…”
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244
Sulfated and Phosphorylated Agarose as Biomaterials for a Biomimetic Paradigm for FGF-2 Release
Published 2024-12-01“…In vivo, heparin, a sulfated polysaccharide present in abundance in the extracellular matrix (ECM), has been shown to function as a local reservoir for FGF-2 by binding FGF-2 and other morphogens and it plays a role in the evolution of GF gradients. …”
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245
Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment
Published 2025-02-01“…The tumor microenvironment (TME), composed of tumor cells, stromal cells, extracellular matrix, surrounding blood vessels, and other signaling molecules, plays a pivotal role in the development of lung cancer. …”
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246
Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma
Published 2013-01-01“…One hallmark of cancer is the degradation of the extracellular matrix (ECM), which is caused by proteinases. …”
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247
Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells
Published 2014-01-01“…In cancer cells, TGF-β regulates MMPs expression, while MMPs, produced by either cancer cells or residents’ stroma cells, activate latent TGF-β in the extracellular matrix, together facilitating the enhancement of tumor progression. …”
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248
The success of the tumor immunotherapy: neutrophils from bench to beside
Published 2025-01-01“…They play double “edge-sward” by either supporting or suppressing the tumor growth, including driving angiogenesis, extracellular matrix remodeling to promote tumor growth, participating in antitumor adaptive immunity, or killing tumor cells directly to inhibit the tumor growth. …”
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249
Role of macrophage in intervertebral disc degeneration
Published 2025-01-01“…Macrophages construct the inflammatory microenvironment of the intervertebral disc and are involved in regulating intervertebral disc cell activities, extracellular matrix metabolism, intervertebral disc vascularization, and innervation, profoundly influencing the progression of disc degeneration. …”
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250
Molecular and pathological identification of ovine pulmonary adenomatosis at Mosul city abattoirs
Published 2025-01-01“…Histological analysis showed nodular tumor areas (proliferative pulmonary nodules) were composed of carcinomatous cells supplementary with an adequate amount of extracellular matrix, characteristic columnar and cuboidal metaplasia, as well as hyperplasia of pulmonary cells, especially the pneumocytes (type II), an epithelial cell (secretory types) in the pulmonary alveoli, Non-ciliated Clara cells as well as the epithelial lining of the terminal bronchioles. …”
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251
Ribitol and ribose treatments differentially affect metabolism of muscle tissue in FKRP mutant mice
Published 2025-01-01“…Abstract Dystroglycanopathy is characterized by reduced or lack of matriglycan, a cellular receptor for laminin as well as other extracellular matrix proteins. Recent studies have delineated the glycan chain structure of the matriglycan and the pathway with key components identified. …”
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252
Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer
Published 2021-01-01“…Tumor cells undergo invasion and metastasis through epithelial-to-mesenchymal cell transition (EMT) by activation of alterations in extracellular matrix (ECM) protein-encoding genes, enzymes responsible for the breakdown of ECM, and activation of genes that drive the transformation of the epithelial cell to the mesenchymal type. …”
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253
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing
Published 2025-02-01“…Overall, resting secretomes were defined by extracellular matrix (ECM) and pro-regenerative proteins, while licensed secretomes were enriched in chemotactic and immunomodulatory proteins. iMSC and UC.MSC secretomes contained proteins indicating proliferative potential and telomere maintenance, whereas adult tissue-derived secretomes contained fibrotic and ECM-related proteins. …”
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254
Hyaluronan and Collagen in Human Hypertrophic Cardiomyopathy: A Morphological Analysis
Published 2012-01-01“…The hypertrophic cardiomyopathy (HCM) disease process is not only limited to cardiomyocyte abnormalities but also engages the extracellular matrix. Hyaluronan (HA) and its receptor CD44 are involved in cellular growth and tissue proliferation but have so far been less studied in myocardial hypertrophy. …”
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255
Comparison of Wide Conjunctival Flap and Conjunctival Autografting Techniques in Pterygium Surgery
Published 2013-01-01“…A stromal overgrowth of fibroblast and blood vessels is accompanied by an inflammatory cell infiltrate and abnormal extracellular matrix accumulation. The surgical excision is the main treatment method of pterygium, but recurrence is the most common postoperative complication. …”
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256
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation
Published 2025-01-01“…Single-cell RNA seq unveils the heterogeneity and multipotency exhibited by epicardium-derived-cells and fetal-like epicardium. Meanwhile, extracellular matrix and growth factors secreted by epicardial organoid mimics the ecology of subepicardial space between the epicardium and cardiomyocytes. …”
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257
Turnover of Focal Adhesions and Cancer Cell Migration
Published 2012-01-01“…Cells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to the ECM is a key step in their migration through tissues. …”
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258
Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species
Published 2009-01-01“…Hyaluronidases degrade hyaluronic acid, a major polysaccharide of the extracellular matrix of tissues, and are considered important for virulence in a number of Gram-positive and -negative bacteria. …”
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259
KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer
Published 2024-01-01“…We identified two hub gene modules related to the immunoscore of OV and found that these genes in the modules were related to the extracellular matrix and viral infections. At the same time, we also discovered six hub genes related to the immunity of OV. …”
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260
Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan
Published 2016-01-01“…Perineuronal nets (PNNs) are lattice-like extracellular matrix structures composed of chondroitin sulfate proteoglycans (CSPGs). …”
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