Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier by Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto

“…DR promotes epithelial-mesenchymal transition and cancer cell invasion through CAF-mediated extracellular matrix remodeling and signaling pathways such as transforming growth factor-beta. …”
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Research progress on early intervention of postoperative scar by SHEN Si, LI Zhouna, JIN Zhehu

“…Following surgical procedures, dysregulation of the inflammatory response, abnormal mechanical forces surrounding the wound, and hypoxia within the scar tissue may lead to an overproliferation of fibroblasts in postoperative scars, resulting in excessive deposition of extracellular matrix and ultimately developing pathological scars. …”
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Agent-based modeling for the tumor microenvironment (TME) by Hasitha N. Weerasinghe, Pamela M. Burrage, Dan V. Nicolau Jr., Kevin Burrage

“…This work applies an agent-based model to investigate the effect of intra-tumoral communication on tumor progression, plasticity, and invasion, with results suggesting that cell-cell and cell-extracellular matrix (ECM) interactions affect tumor cell behavior. …”
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Wallerian degeneration: From mechanism to disease to imaging by Ruiqi Tian, Yingying Zhou, Yuan Ren, Yisen Zhang, Wei Tang

“…However, with the wide application of transgenic mice in experiments, the latest studies have found that the mechanism of WD is related to axonal degeneration, myelin clearance and extracellular matrix. This review summarizes the discovery and research progress of WD and discusses the mechanism of WD from the perspective of molecular biology. …”
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Protein-Mediated Interactions of Pancreatic Islet Cells by Paolo Meda

“…Also, other proteins (integrins) provide communication of the different islet cell types with the materials that form the islet basal laminae and extracellular matrix. Here, we review what is known about these proteins and their signaling in pancreatic β-cells, with particular emphasis on the signaling provided by Cx36, given that this is the integral membrane protein involved in cell-to-cell communication, which has so far been mostly investigated for effects on beta cell functions.…”
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Fungal Biofilm Resistance by Gordon Ramage, Ranjith Rajendran, Leighann Sherry, Craig Williams

“…This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. …”
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Features of pancreatic parenchyma fibrosis in the comorbid course of chronic pancreatitis and chronic obstructive pulmonary disease by I.V. Dudka, O.S. Khukhlina, T.V. Dudka, O.Y. Hryniuk, V.O. Pavliuk

“…The study also used data from a clinical blood analysis, a biochemical study of the content of markers of the syndrome of deviation of the pancreas enzymes in the blood, the content of elastase-1 in feces, ultrasonographic examination of abdominal organs, changes in the carbohydrate-pro­tein components of the extracellular matrix, the state of collagenolytic activity of the blood plasma. …”
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Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis by Abu Tayab Moin, Md. Asad Ullah, Jannatul Ferdous Nipa, Mohammad Sheikh Farider Rahman, Afsana Emran, Md. Minhazul Islam, Swapnil Das, Tawsif Al Arian, Mohammad Mahfuz Enam Elahi, Mukta Akter, Umme Sadea Rahman, Arnab Halder, Shoaib Saikat, Mohammad Jakir Hosen

“…These genes exhibited distinct expression patterns across tissues and were associated with pathways such as extracellular matrix organization, collagen fibril formation, and cell adhesion. …”
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Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration by Kaishun Xia, Jian Zhu, Jianming Hua, Zhe Gong, Chao Yu, Xiaopeng Zhou, Jingkai Wang, Xianpeng Huang, Wei Yu, Liming Li, Jianqing Gao, Qixin Chen, Fangcai Li, Chengzhen Liang

“…Histology and immunohistochemistry results indicated that the NP cells as well as their extracellular matrix were partially restored. Conclusions. …”
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The Role of GABAergic Inhibition in Ocular Dominance Plasticity by J. Alexander Heimel, Daniëlle van Versendaal, Christiaan N. Levelt

“…Many molecular and cellular events have been identified that drive this developmental process, including signaling through BDNF and IGF-1, transcriptional control by OTX2, maturation of the extracellular matrix, and GABA-regulated inhibitory synapse formation. …”
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From heparan glycobiology to stem cell therapy: a historical perspective by Victor Nurcombe

“…We discuss the importance of key experiments that revealed the important functions of heparan sugars in the extracellular matrix (ECM), such as the Gospodarowicz revolution for cell culture, the Edgar dose-response shift induced by ECM, and the Moscatelli migration experiment. …”
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Conservation Law Analysis in Numerical Schema for a Tumor Angiogenesis PDE System by Pasquale De Luca, Livia Marcellino

“…Here, we provide a conservation properties analysis in a tumor angiogenesis model describing the evolution of endothelial cells, proteases, inhibitors, and extracellular matrix. The adopted approach introduces a numerical framework that combines spatial and time discretization techniques. …”
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Regulators of Actin Dynamics in Gastrointestinal Tract Tumors by Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald

“…Actin-nucleating and actin-depolymerizing (ANFs/ADFs) and nucleation-promoting factors (NPFs) regulate cytoskeletal dynamics at the leading edge of migrating cells, thereby modulating cell shape; these proteins facilitate cellular movement and mediate degradation of the surrounding extracellular matrix by secretion of lytic proteases, thus eliminating barriers for tumor cell invasion. …”
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N-Acetylglucosamine Functions in Cell Signaling by James B. Konopka

“…It is a key component of bacterial cell wall peptidoglycan, fungal cell wall chitin, and the extracellular matrix of animal cells. Interestingly, recent studies have also identified new roles for GlcNAc in cell signaling. …”
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Non-invasive of liver fibrosis diagnostics: the role of serum markers by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…Investigations in the field of fibrogenesis processes made possible quantitative estimation of liver fibrosis by non-invasive tests based both on assessment of peripheral blood levels of substances, directly involved in various stages of extracellular matrix synthesis and disintegration, and on the routine laboratory tests reflecting activity of inflammation, degree of disorder of synthetic liver function and fibrosis progression.Conclusion. …”
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Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies by Marie-Noëlle Giraud, Anne Géraldine Guex, Hendrik T. Tevaearai

“…The tissue engineering approach thus constitutes an attractive alternative since it provides the opportunity to deliver a large number of cells that are already organized in an extracellular matrix. Recent laboratory reports confirmed the interest of this approach and already encouraged a few groups to investigate it in clinical studies. …”
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Metalloproteinase Inhibitors: Status and Scope from Marine Organisms by Noel Vinay Thomas, Se-Kwon Kim

“…Metalloproteinases, especially, matrix metalloproteinases (MMPs) are a class of structurally similar enzymes that contribute to the extracellular matrix degradation and play major role in normal and pathological tissue remodeling. …”
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Aldosterone and Its Blockade: A Cardiovascular and Renal Perspective by V. Lahera, V. Cachofeiro, G. Balfagon, J.L. Rodicio

“…A pathophysiological action of aldosterone involves development of extracellular matrix and fibrosis, inflammation, stimulation of reactive oxygen species production, endothelial dysfunction, cell growth and proliferation. …”
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Sugar Antennae for Guidance Signals: Syndecans and Glypicans Integrate Directional Cues for Navigating Neurons by Christa Rhiner, Michael O. Hengartner

“…Recently, heparan sulfate proteoglycans (HSPGs), which are present on the cell surface of neurons and in the extracellular matrix through which neurons and axons migrate, have been found to play a role in regulating cell migration and axon guidance. …”
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The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair by Shebin Tharakan, Michael Hadjiargyrou, Azhar Ilyas

“…Collagen, a primary constituent of the extracellular matrix (ECM) in musculoskeletal tissues, is one of the most widely used materials for gel-based scaffolds in rotator cuff repair, but other ECM-based and synthetic-based composite scaffolds have also been utilized. …”
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