Desmoplasia in Pancreatic Cancer. Can We Fight It? by E. E. Merika, K. N. Syrigos, M. W. Saif

“…Herein we discuss such new developments to fight the desmoplastic reaction, including inhibitors of the epidermal growth factor, fibroblast growth factor, the hedgehog pathway, as well as new molecular targets like CD40 agonist and its effects on T cells, extracellular matrix modifying enzymes such as LOXL2 inhibitor and novel tumour penetrating peptides for delivery of drugs.…”
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Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications by E. Russo, M. Caprnda, P. Kruzliak, P. G. Conaldi, C. V. Borlongan, G. La Rocca

“…In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. …”
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morphoHeart: A quantitative tool for integrated 3D morphometric analyses of heart and ECM during embryonic development. by Juliana Sánchez-Posada, Christopher J Derrick, Emily S Noël

“…Previous studies have associated regional expansion of extracellular matrix (ECM) space with tissue morphogenesis during development. …”
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Skin Acute Wound Healing: A Comprehensive Review by Luis Cañedo-Dorantes, Mara Cañedo-Ayala

“…This review provides present day information regarding the status of the participant cells, extracellular matrix, cytokines, chemokines, and growth factors, as well as their interactions with the microenvironment during the wound healing process.…”
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Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease by Hiromi Fujioka, Yusuke Dairyo, Kei-ichiro Yasunaga, Kazuo Emoto

“…This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. …”
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Cytokines as Therapeutic Targets for the Gastrointestinal Manifestations of Scleroderma by Jennifer M Raoul, Monica Verma, Ernest Tan, Theresa C Peterson

“…Cytokines are the soluble mediators of immune activation, altered fibroblast proliferation and extracellular matrix accumulation in SSc and thereby provide important therapeutic targets. …”
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Lysyl oxidase inhibitors in colorectal cancer progression by Muxian Liu, Jie Wang, Meihong Liu

“…The lysine oxidase (LOX) family, consisting of LOX and LOX-like-1–4 (LOXL1–LOXL4), catalyses the cross-linking reaction of collagen and elastin in the extracellular matrix (ECM). Numerous studies have demonstrated that LOX family members are dysregulated in a variety of cancers, including colorectal cancer (CRC), and play a key role in cancer cell migration, proliferation, invasion and metastasis. …”
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Impacts of Hyaluronan on Extracellular Vesicle Production and Signaling by Melanie A. Simpson

“…The goal of this review is to present a comprehensive summary of the research on HA and its related receptors and enzymes in extracellular vesicle biogenesis and the cellular responses to vesicles bearing these extracellular matrix modulators. When present in extracellular vesicles, HA is assumed to be on the outside of the vesicle and is sometimes found associated with CD44 or the HAS enzyme itself. …”
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The Role of Inflammation in the Pathogenesis of Osteoarthritis by Yoke Yue Chow, Kok-Yong Chin

“…Subsequently, collagenase like matrix metalloproteinases-13 (MMP-13) will degrade the extracellular matrix. As a result, anatomical and physiological functions of the joint are altered. …”
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Secreted LGALS3BP facilitates distant metastasis of breast cancer by Seung-Su Kim, Issac Park, Jeesoo Kim, Na-Lee Ka, Ga Young Lim, Mi-Ye Park, Sewon Hwang, Ji-Eun Kim, So Yeon Park, Jong-Seo Kim, Hyun-Woo Rhee, Mi-Ock Lee

“…Secreted LGALS3BP in the TAMR secretome helped BC cells adhere to the extracellular matrix and promoted the tube formation of human umbilical vein endothelial cells. …”
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IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis by Li H, Liang X, Ma J, Liu Q, Lin Y, Tang J, Ren Z, Liang Z

“…By intersecting the biological pathways influenced by IL-8, alongside those affected by IL-2, IL12p70, or IL-7, we found that these latter cytokines antagonized the mediation effects of IL-8 via regulating critical pathways such as neutrophil degranulation, extracellular matrix organization and asparagine N-linked glycosylation.Conclusion: Infection-induced fever may improve breast cancer prognosis through IL-8 downregulation and the mediation mechanisms may be involved in neutrophil degranulation, extracellular matrix organization and asparagine N-linked glycosylation. …”
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Improved porosity promotes reendothelialization and smooth muscle remodeling in decellularized tissue-engineered vascular grafts by Tun Wang, Sheng Liao, Peng Lu, Zhenyu He, Siyuan Cheng, Tianjian Wang, Zibo Cheng, Yangyang An, Mo Wang, Chang Shu

“…This study demonstrates that porous dTEVGs promote reendothelization, smooth muscle remodeling and extracellular matrix regeneration while retaining a stable graft structure, enhancing durability and puncture resistance in hemodialysis.…”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…Novel pharmacological interventions targeting metabolism, calcium homeostasis, oxidative stress, extracellular matrix remodeling, endothelial function, and inflammation are needed to address RVF effectively. …”
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ1 is a member of a large growth factor family including activins/inhibins and bone morphogenic proteins (BMPs) that have a potent growth regulatory and immunomodulatory functions in normal skin homeostasis, regulation of epidermal stem cells, extracellular matrix production, angiogenesis, and inflammation. …”
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Structural model of a bacterial focal adhesion complex by Christian Cambillau, Tâm Mignot

“…Abstract Cell movement on surfaces relies on focal adhesion complexes (FAs), which connect cytoskeletal motors to the extracellular matrix to produce traction forces. The soil bacterium Myxococcus xanthus uses a bacterial FA (bFA), for surface movement and predation. …”
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Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma by Alex-Adrian Salagean, Cezara-Anca-Denisa Moldovan, Mark Slevin

“…Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilisation of ultra-high molecular weight HA—originally identified as a mechanism for maintaining longevity in the naked mole-rat—as both a protective and extracellular matrix-optimizing colloidal scaffold, and a means to deliver therapy in resected brain tumours. …”
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Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling by Jiechen Wang, Fengyuan Guo, Guangjin Chen, Jiwei Sun, Qingming Tang, Lili Chen

“…The bone extracellular matrix (ECM) contains organic and mineral constituents. …”
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CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms by Raanan Greenman, Chris J. Weston

“…Regardless of the affected organ, fibrosis shares the following common hallmarks: the recruitment of immune cells, fibroblast activation/proliferation, and excessive extracellular matrix deposition. Chemokines play a pivotal role in initiating and advancing these fibrotic processes. …”
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Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

“…HIF-1α-mediated tumor hypoxia drives angiogenesis, immune suppression, and extracellular matrix remodeling, creating an environment that promotes tumor progression and resistance to immunotherapies. …”
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Neuroprotection Caused by Hyperoxia Preconditioning in Animal Stroke Models by Mohammad Reza Bigdeli

“…I clearly establish that the cerebrovascular, extracellular matrix, plasma membrane, endoplasmic reticulum, mitochondrial, and lysosomal reactions are critical in neuroprotection induced by HO in focal ischemia. …”
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