Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis by Chuanxin Liu, Xiaobin Huang, Jiao Kong, Xuejiao Li, Yuming Wang, Fangfang Zhang, Jiajia Duan

“…Western blot (WB) and RT-qPCR results showed significant upregulation of complement-pyroptosis pathway proteins (C5a, C5aR, NLRP3) and cGMP-PKG-autophagy pathway proteins (PKG, mTOR) in the PPT group (P < 0.05) (TEE1). In vitro cell experiments showed that PPT significantly reduced cell viability (P < 0.05) and increased the expression of proteins associated with pyroptosis and autophagy pathways, including ROS, NLRP3, PKG, and mTOR (P < 0.05) (TEE2). …”
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HSTC: hybrid traffic scheduling mechanism in time-sensitive networking by Changchuan YIN, Yanjue LI, Hailong ZHU, Xinxin HE, Wenxuan HAN

“…Results: To verify performance of core algorithm of HSTC mechanism, we built an experimental platform and compared performance of our mechanism with existing mechanisms from the perspectives of ST traffic bandwidth occupation, traffic scheduling priority, SR traffic mapping, injection slot selection, etc. In the experiment, the maximum transmission unit (MTU) of network was 1500B, the maximum buffer size of single queue in switch was 6MTU, and link rate was 1000 Mbit/s. …”
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Hesperidin enhances broiler growth performance by augmenting gastric acid secretion via the proton pump pathway by Yunfei Li, Mingyuan An, Shasha Wan, Yifan Li, Yusong Du, Yufei Zhao, Huimin Li, Qingzhen Zhong, Zewei Sun

“…A four-day nutrient utilization trial was conducted prior to the conclusion of the feeding experiment. Adoption of the total collection method, the collected droppings were weighed and dried at 65 °C. …”
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GravIS: mass anomaly products from satellite gravimetry by C. Dahle, E. Boergens, I. Sasgen, I. Sasgen, T. Döhne, S. Reißland, H. Dobslaw, V. Klemann, M. Murböck, M. Murböck, R. König, R. König, R. Dill, M. Sips, U. Sylla, A. Groh, M. Horwath, F. Flechtner, F. Flechtner

“…Satellite gravimetry, as realized with the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GRACE-FO) missions, is the only currently operative remote sensing technique that can track large-scale mass variations, making it a unique monitoring opportunity for various geoscientific disciplines. …”
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Effect of Simultaneous Use of Different Amounts of Biochar and Soil Application of Common Sulfur and Spraying of Nanosulfur on Yield and Yield Components and Some Phytochemical Cha... by Vahid Mohammadzadeh Kakhki, mohmmad Hossein Aminifard, Mohamad Behzad Amiri

“…Material and Methods To evaluate the combined application of ecological inputs, specifically biochar and sulfur nutritional treatments, on the medicinal plant savory (Satureja hortensis L.), a split-plot experiment based on a randomized complete block design (RCBD) with three replications was conducted over the 2020-2021 and 2021-2022 growing seasons at the Research Field of the University of Gonabad, Iran. …”
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Predicting Insemination Outcome in Holstein Dairy Cattle using Deep Learning by Mohammad Alishahi, Mahdi Ravakhah

“…We tuned the parameters and hyperparameters of each model and upon finalizing the optimal architectures for our models, we initiated training experiments by fitting the models to the prepared datasets.Results and Discussion: Our experimental findings reveal that the proposed LSTM model significantly improved prediction accuracy compared to the MLP and XGBoost models. …”
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The comparative studies of Borneo plant extracts to increases vaccine efficacy in tilapia, Oreochromis niloticus by Esti Handayani Hardi, Komsanah Sukarti, Maulina Agriandini, Irawan Wijaya Kusuma, Rudi Agung Nugroho

“…The same symptoms was found in ZZ+V at d14 challenge as much 11.11% and 42.86%. while, in the vaccine groups (V), after the challenge, tilapia were found fin rot and darkness color until the last experiment. The BP+V and SF+ZZ+V groups shown reducing the number of bacteria in the fish body after challenge test on d7, d14, and d 21. …”
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Screening 215 Lentil Genotypes under Salinity Stress During the Seedling Stage in Greenhouse Conditions by Ahmad Nezami, jafar Nabati, Mohammad Kafi, Elahe Boroumand Rezazadeh

“…Methods: This study was conducted in the research greenhouse of the Research Center for Plant Sciences, Ferdowsi University of Mashhad, in 2017. In this experiment, 215 lentil genotypes were studied using a completely randomized design with three replications under hydroponic conditions at 12 dS.m-1 sodium chloride salinity. …”
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Investigating the hatchability and nauplii biometry of Artemia franciscana in unconventional waters of Sistan region, Southeast Iran by Hashem Khandan Barani, Abdolali Rahdari, Narjes Sanchooli, Ali Khosravanizadeh

“…Water quality parameters including temperature, pH, salinity, ammonia, nitrate, nitrite, sulfate, hardness, Cl, Mg and Cu were recorded using standard methods during the experiment. All data obtained in this study were analyzed using One-Way ANOVA, followed by Tukey's test for any significant differences among the treatments. …”
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MSH-YOLOv8: Mushroom Small Object Detection Method with Scale Reconstruction and Fusion by YE Dapeng, JING Jun, ZHANG Zhide, LI Huihuang, WU Haoyu, XIE Limin

“…To further enhance training efficacy and convergence speed, the original loss function CIoU was replaced with wise-intersection over union (WIoU) Loss. Furthermore, experiments were conducted using mushrooms as the research subject on the open Fungi dataset. …”
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Editorial by Jörg Tremmel, Maria Lenk, Antony Mason, Markus Rutsche

“…Beyond asking people what their preferred birth year would be in the context of such a thought experiment, it is possible to compare the attractiveness of actual birth years (and thus epochs in which to lead one’s life) from official statistics. …”
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Investigating and Completing Khanlari’s Theory on Metrical Units by Abbas Jahed Jah

“…Therefore, when Khanlari encounters a monosyllabic unit at the end of a meter, he experiences confusion and difficulty.Incomplete Set of Trisyllabic Units: Khanlari’s prosody contains six trisyllabic units, which is insufficient for representing all trisyllabic units in Persian prosody, missing a unit with the syllable pattern of two longs and one short (- - U). …”
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A Study on the Genotype × Environment Interaction in Promising Advanced Genotypes of Soybean using Graphical GGE-biplot Analysis by Bahram Masoudi, Amir Gholizadeh, Parastoo Majidian, Ebrahim Hezarjaribi, Nasrin Razmi, Farnaz Shariati

“…The genotype × environment interaction is a major challenge in the study of quantitative characters because it reduces yield stability in different environments and complicates the interpretation of genetic experiments, making predictions difficult. Therefore, it is crucial to know the type and nature of the interaction effect and reach the verities that have the least role in creating interaction effects. …”
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Retrieving the atmospheric concentrations of carbon dioxide and methane from the European Copernicus CO2M satellite mission using artificial neural networks by M. Reuter, M. Hilker, S. Noël, A. Di Noia, M. Weimer, O. Schneising, M. Buchwitz, H. Bovensmann, J. P. Burrows, H. Bösch, R. Lang

“…Since CO2M will not be launched until 2026, our study exploits simulated measurements over land surfaces from a comprehensive observing system simulation experiment (OSSE) that includes realistic meteorology, aerosols, surface bidirectional reflectance distribution function (BRDF), solar-induced chlorophyll fluorescence (SIF), and CO<span class="inline-formula">₂</span> and CH<span class="inline-formula">₄</span> concentrations. …”
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The Effect of Corona Dormancy on the Physiological Stress and Main Nutritional Components in the Transport of Trachinotus ovatus During Survival by Siwei LIU, Jiamei ZHONG, Xiuping FAN, Xiaoming QIN, Jian SHEN, Wenqi XU

“…The optimal treatment conditions of pulsed DC corona dormancy were optimized by using the dormancy rate, dormancy time, 72 h survival rate and survival time as evaluation indexes through single factor and orthogonal experiments, and the biochemical parameters of serum, brain tissue, muscle and liver are determined indexes of oxidative stress, metabolism, and basic nutrients. …”
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Benchmarking data-driven inversion methods for the estimation of local CO₂ emissions from synthetic satellite images of XCO₂ and NO₂ by D. Santaren, J. Hakkarainen, G. Kuhlmann, E. Koene, F. Chevallier, I. Ialongo, H. Lindqvist, J. Nurmela, J. Tamminen, L. Amorós, D. Brunner, G. Broquet

“…This exercise is based on pseudo-data experiments with simulations of synthetic <i>true</i> emissions, meteorological and concentration fields, and CO2M observations across a domain of 750 km <span class="inline-formula">×</span> 650 km, centered on eastern Germany, over 1 year. …”
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Effect of Sucrose Spray on some Phytochemical Characteristics of Stevia (Stevia rebaudiana Bertoni) under Field Conditions by Vahid Akbarpour, Hossein Aruei, Kambiz Mashayekhi, Majid Azizi Arani, Mohammad Ali Bahmanyar

“…Methods: This factorial experiment was carried out based on a randomized complete block design (RCBD) with four replications at Sari Agricultural Sciences and Natural Resources University from 2014 to 2015. …”
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Effects of rumen fluid transplantation on the fecal flora of yaks by Man Zhang, Man Zhang, Man Zhang, Yan Li, Yumin Li, Yumin Li, Yumin Li, Chenxu Cheng, Chenxu Cheng, Chenxu Cheng, Shatuo Chai, Shatuo Chai, Shatuo Chai, Yingkui Yang, Yingkui Yang, Yingkui Yang, Xun Wang, Xun Wang, Xun Wang, Shuxiang Wang, Shuxiang Wang, Shuxiang Wang

“…After this, yak feed intake was recorded daily; yaks were weighed on days 1, 30, and 60 of the formal trial; and yak feces were collected directly from the ground on days 1, 4, 7, 14, 30, and 60 to compare the microbial composition of the feces using 16S rRNA sequencing data.ResultsThe results showed that rumen fluid transplantation significantly increased the alpha diversity of fecal microflora (P &lt; 0.05), and on day 30 of the experiment, both the operational taxonomic unit (OTU) and Shannon index were significantly higher in the RT group than the CON group (P &lt; 0.05). …”
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A randomized trial of blended first aid education for the public

“…First aid educators are increasingly experimenting with blending learning modalities, combining asynchronous internet based (e-learning) and traditional instructor led (face-to-face). …”
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The Role of Iranians in Istanbul in Publishing and Distributing Modernist and Constitutionalist Texts by Mohammad Hossein Sadeghi, Hassan Hazrati

“…During their stay in the Ottoman Empire, these individuals engaged with various segments of the Ottoman society, including reformist politicians and constitutionalist intellectuals, and over forty years, played a pivotal role in exchanging experiences of reform and constitutionalism between Iranians and the Ottomans. …”
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