Examining the therapeutic potential and side effects of calcium channel blockers in mortality and morbidity of patients with stroke: A systematic review of pre-clinical and clinica... by Sevak Hatamian, Asad Abdi, Fatemeh Sadat Seyedi Asl, Armin Tafazolimoghadam, Arian Tavasol, Seyed Ali Mousavi Nejad, Reza Madadi, Zohre Tajabadi, Mina Dehghani, Najmeh Ahmadpoor, Mobina Fathi, Mohammadreza Hajiesmaeili, Navid Nooraei

“…Results: Among 56 selected studies, 33 were human studies, 23 were animal experiments, and one study was carried out both on animals and humans. …”
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CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment by Yu Wang, Haiyan Xu, Li Cai, Yang Sun, Liwei Wang, Ming Yue, Xiaofei Zhang, Yanling Wang, Shumin Li, Shengbai Xue, Jingyu Ma, Tiebo Mao, Weiyu Ge, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui

“…What’s more, RNAseq, qPCR, Western blotting, immunohistochemistry and multicolor flow cytometry experiments were used to explore the mechanism of how CREB3L1 worked in PDAC. …”
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<i>Cichorium intybus</i> L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress by Yanqin Luo, Xueyi Bei, Yiwen Zhang, Xinran Sun, Yongzhi Zhao, Fang Chen, Ruile Pan, Qi Chang, Qinghu He, Xinmin Liu, Ning Jiang

“…Seventy male C57BL/6N mice were adopted in the next part of the experiment and randomly divided into seven groups (Control, CUMS, Fluoxetine, MOO, CIO 25 mg/kg, and CIO 100 mg/kg) based on the sucrose preference index. …”
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EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis by Yang Chen, Shanshan Dong, Xin Zeng, Qing Xu, Mingwei Liang, Guangneng Liao, Lan Li, Bin Shen, Yanrong Lu, Haibo Si, Peifang Wei

“…Moreover, ER stress mediated the effects of EZH2, miR-142-3p, and HMGB1 on chondrocyte pyroptosis. In vivo experiments mechanistically validated the hierarchical regulatory relationship between EZH2, miR-142-3p, and HMGB1 and their effects on chondrocyte ER stress and pyroptosis. …”
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LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy f... by Yanjun Wang, Xin Zhang, Mengmeng Ren, Shu He, Hengjie Bie, Mengyang Duan, Zhiyuan Chen, Qiaowei Jia, Boyu Chi, Xiongkang Gan, Chengcheng Li, Yahong Fu, Hanxiao Zhou, Sheng Zhang, Qian Zhang, Fenghui An, Xiumei Chen, Enzhi Jia

“…Methods (1) Autophagy-related proteins including LC3, p62, Beclin1, ATG5, and ATG7 were immunohistochemical stained in coronary specimens; (2) The levels and function of autophagy in the HCAEC oxidative stress model were evaluated using western blot (WB), transmission electron microscopy (TEM), and mRFP-GFP-LC3 adenovirus transfection experiments; (3) The competing endogenous RNA (ceRNA) network of lncRNA LUCAT1/hsa-miR-6776-5p/LRRC25 axis was constructed and validated; (4) The expression levels of above autophagy-related RNAs in peripheral blood mononuclear cells (PBMCs) were verified by qPCR, and their diagnostic performance was subsequently analyzed using receiver operating characteristic (ROC) analysis. …”
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Optimizing fodder yield and quality through integrated organic nutrient amendments in multi-crop system by Santosh Onte, Santosh Onte, Vrushabh Vijay Fiskey, Manjunath S. Melavanki, Airadevi P. Angadi, Prasanna S. Pyati, Magan Singh, Dileep Kumar, Sanjivkumar Angadarao Kochewad, Sudhir Kumar, Hari Om, Vijendra Kumar Meena, Kamal Garg, Vetrivel Karunakaran, Manish Kanwat, Babu Lal Meena, Yogananda Shivalli Boregowda, Rahul Bellagi, K. Naveena, Sunil Chandersheker, Elisa Azura Azman, Sanjeev Kumar

“…Conducted during the period 2018 to 2021 using a randomized complete block design, the experiment encompassed seven treatments, each replicated three times. …”
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The role of OCO-3 XCO₂ retrievals in estimating global terrestrial net ecosystem exchanges by X. Wang, F. Jiang, F. Jiang, F. Jiang, H. Wang, Z. Zhang, M. Wu, J. Wang, W. He, W. Ju, W. Ju, J. M. Chen, J. M. Chen

“…The results show that when only the OCO-3 XCO<span class="inline-formula">₂</span> is assimilated (Exp_OCO3), the estimated global land sink is significantly lower than that from the OCO-2 experiment (Exp_OCO2). The estimate from the joint assimilation of OCO-3 and OCO-2 (Exp_OCO3&amp;2) is comparable on a global scale to that of Exp_OCO2. …”
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RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study by Yanju Li, Xu Yang, Feiqing Wang, Feiqing Wang, Jianing Zhao, Chike Zhang, Dan Wu, Bo Yang, Rui Gao, Peng Zhao, Yun Zan, Min Su, Zhixu He, Yang Liu, Yang Liu, Yang Liu, Jishi Wang, Dongxin Tang

“…The latter showed that five core targets of the PI3K/AKT signaling pathway could bind to quercetin, among which EGFR, IL-6, and MYC showed strong docking, and the diosgenin ligand could bind to VEGFA. Cell experiments showed that asparagus, through the PI3K/AKT/NF-κB pathway, inhibited the proliferation and migration of MM cells, and caused retardation and apoptosis of MM cells in the G0/G1 phase.Discussion: In this study, the anti-cancer activity of asparagus against MM was demonstrated using network pharmacology, and potential pharmacological mechanisms were inferred using in vitro experimental data.…”
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Micro-nano aerated subsurface drip irrigation and biochar promote photosynthesis, dry matter accumulation and yield of cucumbers in greenhouse by Zan Ouyang, Jie Zhang, Xueli Liang, Hui Wang, Zhenfeng Yang, Rong Tang, Qihua Yu, Yong Zhang

“…Compared to CK, in the two-season experiment, the average soil aeration porosity (SAP) increased by 0.53–44.00 %, the soil oxygen content (SO) increased by 0.47–31.80 %, the net photosynthetic rate (Pn) increased by 1.91–50.78 %, the dry matter accumulation increased by 10.53–69.19 %, the yield increased by 1.72–44.23 %, and the water use efficiency (WUE) improved by 0.42–76.57 %. …”
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Productivity of water and heat resources and cotton yield response to cropping pattern and planting density in cotton fields in arid area by Zhenlin Dong, Sumei Wan, Yunzhen Ma, Jinbin Wang, Lu Feng, Yunlong Zhai, Tiantian Li, Zhengjun Cui, Jian Wang, Beifang Yang, Ze Yang, Zhan Zhao, Fei Yan, Shiwu Xiong, Yabing Li, Guodong Chen

“…To test this, a two-year field experiment (2022–2023) employed a split-plot design with two main planting patterns (four rows per film and six rows per film) and three planting densities (low, medium, and high) as subplots. …”
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Effects of nitrogen fertilizer basal-to-top-dressing ratios on maize straw decomposition, soil carbon and nitrogen, and bacterial community structure in different soil textures on... by Jingyu Li, Jingyu Li, Xiaonan Yang, Rui Hou, Yujie Ma, Yanqun Wang, Yang Ma, Wenchao Zhen, Yuanyuan Huang, Xin Fu, Zhengping Peng, Zhengping Peng, Mingxin Men

“…In a wheat–maize rotation system, field experiments were conducted over 2 years in loam and clay loam soils with five fertilizer (N) application treatments (i.e., no N fertilizer (N0) and N fertilizer basal-to-top-dressing ratios of 3:7 (N3:7), 4:6 (N4:6), 5:5 (N5:5), and 6:4 (N6:4)) to investigate the dynamics of maize straw decomposition, changes in soil organic carbon (SOC) and total nitrogen (TN) concentrations, soil bacterial diversity and abundance, and their interactions. …”
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Best evidence summary for nutritional management of cancer patients with chyle leaks following surgery by Jie Zhou, Wentao Huang, Ya Hu, Fen Liu, Man Xu, Xiaoping Chen, Mingzhu Xin, Huiming Lu, Xia Zheng

“…This search included guidelines, evidence summaries, expert consensus, clinical decision-making, recommended practices, systematic evaluations or Meta-analyses, randomized controlled trials (RCTs), and class experiments. The search timeframe was from the library's establishment to June 2024. …”
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Flood susceptibility mapping based on watershed geomorphometric characteristics and land use/land cover on a small island by B.H. Narendra, O. Setiawan, R.A. Hasan, C.A. Siregar, , Pratiwi, N. Sari, A. Sukmana, I.W.S. Dharmawan, R. Nandini

“…Lombok, a small tropical island, experiences severe flooding almost yearly. Flood susceptibility mapping is important to determine the priority watershed in implementing flood mitigation action, including improving the spatial planning in watershed management. …”
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Production of giant gourami Osphronemus goramy Lac. juvenile with different rate of water exchange by Tatag Budiardi, Rona Albrettico Nemanita Ginting, Yani Hadiroseyani

“…The results of this experiment showed that 125% daily water exchange improved the production performance of giant gourami juvenile cultured at a density of 20 fish/L. …”
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Utilization of fish bone charcoal in feed on growth and physiological responses of catfish fry Clarias gariepinus by Rizqiyatul Fardila Putri, Mia Setiawati, Dedi Jusadi, Julie Ekasari

“… This study aimed to assess the impact of charcoal inclusion in feed on the physiological responses and growth of catfish. The experiment employed a completely randomized design (CRD) with five treatments and four replicates. …”
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Blending of Slow-Release N Fertilizer and Urea Improve Rainfed Maize Yield and Nitrogen Use Efficiency While Reducing Apparent N Losses by Jinjin Guo, Hanran Yang, Yong Yuan, Pengzhou Yin, Nv Zhang, Zhizhao Lin, Qichang Ma, Qiliang Yang, Xiaogang Liu, Haidong Wang, Fucang Zhang

“…The purpose of this study was to improve N use efficiency (NUE) and minimize N loss by optimizing the rate and type of N fertilizer application while maintaining a high yield of maize. A two-year field experiment with U (urea), S (slow-release N fertilizer), and SU (blending of S and U) under four N application levels (N1: 90 kg ha⁻¹, N2: 120 kg ha⁻¹, N3: 180 kg ha⁻¹, N4: 240 kg ha⁻¹) was conducted to investigate their effects on ammonia (NH₃) volatilization, residual soil nitrate N (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mi mathvariant="normal">N</mi><mi mathvariant="normal">O</mi></mrow><mrow><mn>3</mn></mrow><mrow><mo>−</mo></mrow></msubsup><mo>-</mo><mi mathvariant="normal">N</mi></mrow></semantics></math></inline-formula>), yield, NUE, apparent N losses of rainfed maize. …”
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Hurricane Effects on a Shallow Lake Ecosystem and Its Response to a Controlled Manipulation of Water Level by Karl E. Havens, Kang-Ren Jin, Andrew J. Rodusky, Bruce Sharfstein, Mark A. Brady, Therese L. East, Nenad Iricanin, R. Thomas James, Matthew C. Harwell, Alan D. Steinman

“…We treated this operation as a whole ecosystem experiment, and assessed ecological responses using data from an existing network of water quality and submerged plant monitoring sites. …”
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Jiangu Granules Regulates Endoplasmic Reticulum Stress-Induced Apoptosis in UMR-106 Cells by Modulating the PERK/eIF2α/ATF4/CHOP Pathway by CHEN Sainan, ZHOU Fen, HUANG Yunmei, LIN Yanping

“…Additionally, mRNA transcription level and protein expression of ERS related markers GRP78, PERK, eIf2α, ATF4, and CHOP were detected using qPCR and Western blot methods.ResultsIn comparison to the 0 μmol/L group, it was found that 0.03 μmol/L of GSK2606414 had no impact on cell viability after 12 hours of intervention in UMR-106 cells, and this concentration was chosen for subsequent experiments. Compared with the NC group, the H₂O₂ group showed a significant increase in ROS content (<italic>P</italic>&lt;0.01). …”
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进口大豆储存期间品质变化研究 Quality changes of imported soybeans during storage by 郑有涛，曾剑豪，孙玉萍，陈伟，杨亚，仇长璐，符文志 " ZHENG Youtao, ZENG Jianhao, SUN Yuping, CHEN Wei, YANG Ya, QIU Changlu, FU Wenzhi"

“…The American soybeans with moisture content of 10.85%, crude fat acidity of 0.80 mgKOH/g, and percent of heat-damaged kernel of 0.27% had a crude fat acidity of 2.25 mgKOH/g after being stored for 77 d in an accelerated simulated experiment at 40 ℃, and even at 45 ℃, the crude fat acidity was only 3.05 mgKOH/g, which still met the suitable storage requirements for high oil soybeans. …”
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Precision Target Spraying System Integrated with Remote Deep Learning Recognition Model for Cabbage Plant Centers by ZHANG Hui, HU Jun, SHI Hang, LIU Changxi, WU Miao

“…The findings of this research will offer valuable experiences and guidance for the implementation of agricultural robots in the precise application of pesticides, with a particular emphasis on parameter selection and system optimization.…”
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