Optimizing plant density to improve the soil microenvironment and enhance crop productivity in cotton/cumin intercropping systems by Humei Zhang, Humei Zhang, Liwen Tian, Xianzhe Hao, Nannan Li, Xiaojuan Shi, Feng Shi, Yu Tian, Wenbo Wang, Honghai Luo

“…Through a two-year field experiment, the effects of cotton-cumin intercropping on the soil moisture, temperature, salt, respiration rate, weed density, cotton yield formation and intercropping advantages were studied.Results and discussionCompared with the CK treatment, the ID2 treatment decreased the water content in the 0–30 cm soil layer by 8.3%, increased the water consumption by 9.1%, increased the soil temperature by 0.5°C, and decreased the electrical conductivity of the 0–15 cm soil layer by 17.7%. …”
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Preparation and Anti-fatigue Function of Weizmannia coagulans BC99 Emergency Energy Bar by Haodan GUO, Ying WU, Yuqiong WEI, Li CAO, Zhouya BAI, Qiuxia FAN, Nan PENG, Shaobin GU

“…Methods: Taking sensory evaluation as the response value, the formulation of energy bar sandwich was optimized by a Box-Behnken design experiment. The contents of protein, fat, carbohydrate, moisture, ash, dietary fiber, and the composition of amino acid and fatty acid were analyzed. …”
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Salt tolerance evaluation and key salt-tolerant traits at germination stage of upland cotton by Mengjie An, Xinhui Huang, Yilei Long, Yin Wang, Yanping Tan, Zhen Qin, Xiantao Ai, Yan Wang

“…Therefore, in this study, 16 cotton samples with geographical representation were randomly selected from 308 cotton germplasms to determine the optimal 200 mmol·L-1 NaCl in cotton germination experiments. On this basis, the salt tolerance of 308 upland cotton varieties and the growth, ion distribution and transport of highly salt-tolerant and non salt-tolerant cotton germplasms were analyzed. …”
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Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch by Francisco J. Chorro, Francisco J. Chorro, Francisco J. Chorro, Luis Such-Miquel, Luis Such-Miquel, Samuel Cuñat, Oscar Arias-Mutis, Oscar Arias-Mutis, Patricia Genovés, Patricia Genovés, Manuel Zarzoso, Manuel Zarzoso, Antonio Alberola, Antonio Alberola, Luis Such-Belenguer, Luis Such-Belenguer, Irene Del Canto, Irene Del Canto

“…Under eleclazine perfusion, the VF activation patterns were less complex, and the arrhythmia stopped in 6 out of 11 experiments (55%; p < 0.05 vs. baseline).ConclusionEleclazine (GS6615) reduced the proarrhythmic electrophysiological changes induced by myocardial stretch and slowed and simplified activation patterns during VF in the experimental model used.…”
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Deflection of screen surface and spatial deformation law of screen apertures during 1 mm elastic screening by Haishen JIANG, Ran YANG, Runyu LIU, Shijie YU, Peng GUO, Miao PAN, Long HUANG, Chenlong DUAN

“…The influence of excitation parameters on the screening effect of 1 mm elastic screening was studied through screening experiments, and the optimal excitation parameters were determined. …”
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Identification of RAD51AP1 as a key gene in hepatitis B virus-associated hepatocellular carcinoma by Meiling Wan, Yonghong Wang, Xiaoling Liu, Yaling Li, Cunliang Deng, Changfeng Sun

“…Methods: HBV-associated HCC datasets (GSE19665, GSE121248, GSE55092, GSE94660, and TCGA-LIHC) acquired from public databases were mined to identify key driver genes by differentially expressed gene analysis, weighted gene co-expression network analysis (WGCNA), followed by protein-protein interaction network analysis, Lasso-Cox regression analysis, and randomforestSRC algorithm. Then, in vitro experiments including CCK-8 assay, wound healing, and Transwell assay were performed to explore the functions and mechanisms. …”
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High concentrations of polyethylene microplastics restrain the growth of Cinnamomum camphora seedling by reducing soil water holding capacity by Run Yang, Jinping Wang, Huanying Fang, Jinwen Xia, Guomin Huang, Rongzhen Huang, Hong Zhang, Liqin Zhu, Lichao Zhang, Jihong Yuan

“…In the current study, a 6-month pot experiment was conducted to investigate the inhibitory effect of soil polyethylene microplastics (PE-MPs) (average size of 6.5 µm) with increasing concentrations (0, 0.1 %, 0.5 %, 1 %, and 2 % w/w) on the growth of Cinnamomum camphora seedlings. …”
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Growth, fat metabolism and hepatic health in largemouth bass fed varying fat-level diets by Digen Qin, Jiale Chen, Junxiong Li, Zhiyou Liu, Weibin Huang, Yuanzhi Yang, Jing Zhang, Beiping Tan, Xiaohui Dong

“…This 60-day experiment investigated the influences of growth, fat metabolism and hepatic health of largemouth bass (Micropterus salmoides) fed varying fat diets. 225 fish (34 ± 0.04 g) were divided into three groups and fed diets with fat levels of 10 % (Low-fat diet, LFD), 14 % (Medium-fat diet, MFD) and 18 % (High-fat diet, HFD), respectively. …”
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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

“…Conclusions In vitro and in vivo experiments verified that H. pylori SlyD enhances TPT1 stability through hnRNPK, leading to OCT1-mediated transcriptional activation of CDX2 and the initiation of the GIM process. …”
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Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity by Roel A. van der Heijden, Martine C. Morrison, Fareeba Sheedfar, Petra Mulder, Marijke Schreurs, Pascal P. H. Hommelberg, Marten H. Hofker, Casper Schalkwijk, Robert Kleemann, Uwe J. F. Tietge, Debby P. Y. Koonen, Peter Heeringa

“…Energy substrate utilization was determined by indirect calorimetry in a subset of mice following the dietary switch and at the end of the experiment. Blood samples were collected at baseline and at 3 days and 4, 12, and 20 weeks after dietary switch and analyzed for systemic lipids and proinflammatory cytokines. …”
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Application of Biochar-Immobilized <i>Bacillus megaterium</i> for Enhancing Phosphorus Uptake and Growth in Rice by Keru Yu, Zhenyu Wang, Wenyan Yang, Shuai Li, Dongtao Wu, Hongtao Zheng, Zhengqian Ye, Shaona Yang, Dan Liu

“…Subsequently, rice pot experiments were conducted to investigate the response of soil microbial P mobilization and P uptake in rice to fertilizer inputs. …”
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Evaluation of musculoskeletal complaints, treatment approaches, and patient perceptions in family medicine clinics in a tertiary center in Jordan: a cross-sectional study by Moh’d S. Dawod, Mohammad N. Alswerki, Ahmad F. Alelaumi, Jehad Feras AlSamhori, Rana J. Rahhal, Lina Khraisat, Eman Mohammad Arabas, Hussein M. Bdair, Reem M. Alhyari, Mohammad Shahin, Mohammad Abu Hilal, Alaa Y. Akel, Aws Khanfar

“…Conclusion Our study reveals notable gender-based differences in musculoskeletal complaints and treatment experiences in a Jordanian tertiary setting. Females reported higher rates of low back and hip pain, more frequent referrals, and lower quality of life, while males experienced greater occupational strain, work-related injuries, and disability.…”
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Qualitative evaluation of the Rehabilitation Exercise and psycholoGical support After COVID-19 InfectioN (REGAIN) randomised controlled trial (RCT): ‘you are not alone’ by Gordon McGregor, Susanne Finnegan, Martin Underwood, Joyce Yeung, James Mason, Peter Heine, Nigel Edwards, Julie Bruce, Kate Seers, Harbinder Kaur Sandhu, Helen Atherton, Sharisse Alleyne, Katie Booth, Ranjit Lall, Vivien P Nichols, Stuart Ennis, Scott McGuire, Rachel Potter, Jessica Smith, Chen Ji, Shilpa Patel, Henry Nwankwo, Kate Evans, Susie Hennings, Alastair Canaway, Grace Lobley, David Mcwilliams, Christina Jones, Emma Padfield, David Montgomery, Beatriz Lara, Becky Haley, Francesca Denton, Bartholomew Sheehan, Mariam Ratna, Elaine Fairbrother, Zoe Noakes, Bogdan Zutic, Lee Austin, Tom Forsyth, Anne Bush, Alan Bush, Patrick Sawdon, Jonathon Prosser, Lee Tompkins, Jonathon Guck, Danielle Hale, Juwairia Said, Georgie Ray, Rowena Williams, Gail Evans, Thillini Hettiarachchi, Abeesh Panicker

“…Framework and thematic analysis were used to analyse the findings.Setting England and Wales, UK.Participants Adults discharged from National Health Service (NHS) hospitals at least 3 months previously after COVID-19, with ongoing physical and/or mental health sequelae.Results Twenty intervention participants, 20 control participants and five practitioners were interviewed.The themes from the group support sessions were: (1) you are not alone; (2) sharing experiences and addressing worries; (3) gaining new perspectives; (4) hope for progression; (5) peer support and bonding; (6) integration of facilitation skills; (7) modified activity pacing and goal setting, and (8) giving participants structure. …”
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Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model by Xing Tu, Zixing Zou, Jiahui Li, Simiao Zeng, Zhengchao Luo, Gen Li, Yuanxu Gao, Kang Zhang, Jing Ni

“…Subsequently, these target candidates were validated using molecular simulations (molecular docking, absorption, distribution, metabolism, excretion, and toxicity [ADMET] prediction, and molecular dynamics simulations) and biological experiments (Western blotting and fluorescence staining) in vitro and in vivo. …”
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Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies by Lindiwe Khumbuzile Zuma, Ofentse Jacob Pooe, Nonduduzo Hlengiwe Mabaso, John Alake, Vincent A. Obakachi, Sinethemba Yakobi, Nothando Gasa, Rajshekhar Karpoormath, Mthokozisi Simelane

“…Parasite inhibition studies confirmed potent antimalarial activity against the P. falciparum NF54 strains, with BA and IMA showing IC50 values of 1.27 µg/ml and 1.03 µg/ml against the asexual stage of P. falciparum, respectively. FTIR experiments confirmed interactions between the compounds and the secondary structure of the proteins. …”
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Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults by Yuankang Zhu, Zhenlin Yang, Yuhao Chen, Lingzi Qian, Changning Hao, Liangshi Hao, Boshen Yang, Junli Duan

“…Recent data from animal experiments have proved its potential cardiovascular toxicity. …”
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Single-cell RNA sequencing and immune microenvironment analysis reveal PLOD2-driven malignant transformation in cervical cancer by Zhiheng Lin, Fengxin Wang, Renwu Yin, Shengnan Li, Yuquan Bai, Baofang Zhang, Chenlin Sui, Hengjie Cao, Dune Su, Lianwei Xu, Honghong Wang

“…A NNMT CAEPCs Risk Score (NCRS) model was developed, revealing a correlation between elevated NCRS scores and adverse patient outcomes characterized by immune evasion. In vitro experiments validated that the prognostic gene PLOD2 significantly enhances proliferation, migration, and invasion of cervical cancer cells.ConclusionThis investigation delineated eight cell types and five subpopulations of malignant EPCs in cervical cancer, establishing the C1 NNMT+ CAEPCs as a crucial therapeutic target. …”
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DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure by Wenwu Tang, Wenwu Tang, Zhixin Wang, Xinzhu Yuan, Liping Chen, Haiyang Guo, Zhirui Qi, Ying Zhang, Xisheng Xie

“…We constructed a ceRNA regulatory network, and found that 4 hub genes (TYMS, CDCA2 and DEPDC1B) might be regulated by 4 miRNAs (hsa-miR-1297, hsa-miR-4465, hsa-miR-27a-3p, hsa-miR-129-5p) and 21 lncRNAs (such as HCP5, CAS5, MEG3, HCG18). 24 small molecule drugs were predicted based on TYMS through DrugBank website. Finally, qRT-PCR experiments showed that the expression trend of biomarkers was consistent with the results of transcriptome sequencing.DiscussionOverall, our results reveal the molecular mechanism of HF in patients with MHD and provide insights into potential diagnostic markers and therapeutic targets.…”
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The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…In elderly persons (61–80 years old compared to practically healthy people at 40–60 years of age), we revealed increased cystatin C levels both in serum and intraocular fluid. In an experiment on C57Bl/6J mice, cystatin C concentration was significantly higher in brain tissue than in the liver and spleen: an indication of an important function of this cysteine protease inhibitor in the brain. …”
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Rehydrated corn grain silage with wet brewery residue and different inoculants by E. L. L. Lelis, V. B. Tavares, R. M. A. Teixeira, B. G. C. Homem, C. H. Nogueira, J. M. Silva

“… The objective was to evaluate the effects of including different proportions of Wet Brewery Residue (WBR) using inoculants on rehydrated ground corn silage quality. The experiment was conducted in a completely randomized design in a 4 x 3 factorial scheme with four replications. …”
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