Danlian-Tongmai formula improves diabetic vascular calcification by regulating CCN3/NOTCH signal axis to inhibit inflammatory reaction by Wenting Wang, Yiwen Li, Mengmeng Zhu, Qian Xu, Jing Cui, Yanfei Liu, Yanfei Liu, Yue Liu

“…Molecular docking and molecular dynamics simulation demonstrated strong binding interactions between DLTM metabolites and key molecules within the CCN3/NOTCH pathway, including NOTCH1, DLL1, DLL4, hes1, and hey1. In vivo experiments confirmed that DLTM could upregulate CCN3, inhibit the activation of NOTCH signaling ligands DLL1 and downstream transcription factors hes1 and hey1, and reduce the release of inflammatory cytokines IL6, IL1β, and TNFα.ConclusionDLTM alleviates DVC by regulating the CCN3/NOTCH signaling axis to inhibit inflammatory responses. …”
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The process of nitrogen-adaptation root endophytic bacterial rather than phosphorus-adaptation fungal subcommunities construction unveiled the tomato yield improvement under long-t... by Xiaoxia Li, Xiaoxia Li, Xiaoxia Li, Muhammad Awais, Muhammad Awais, Muhammad Awais, Shuang Wang, Shuang Wang, Shuang Wang, Shuang Wang, Zhu Zhang, Zhu Zhang, Zhu Zhang, Shuning Zhao, Shuning Zhao, Shuning Zhao, Yufeng Liu, Yufeng Liu, Yufeng Liu, Zhouping Sun, Zhouping Sun, Zhouping Sun, Hongdan Fu, Hongdan Fu, Hongdan Fu, Tianlai Li, Tianlai Li, Tianlai Li

“…We studied the 26th year of a field experiment conducted in a greenhouse with varying levels of nitrogen and phosphorus (CKP0, CKP1, CNP0, CNP1, ONP0, and ONP1) to assess the composition of tomato root endophytes and their impact on yield. …”
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“Equity” in genomic health policies: a review of policies in the international arena by Prabhathi Basnayake Ralalage, Prabhathi Basnayake Ralalage, Tala Mitchell, Claire Zammit, Gareth Baynam, Gareth Baynam, Emma Kowal, Libby Masey, Julie McGaughran, Tiffany Boughtwood, Misty Jenkins, Gregory Pratt, Angeline Ferdinand

“…Recommendations for countries, irrespective of their economic and social contexts, include conducting regular policy reviews to accommodate the advances in genomics field and inclusion of specific mechanisms to achieve equity in genomic health. Insights and experiences in achieving healthcare equity in HICs and LMICs can offer valuable lessons for each other.…”
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Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…In this work, we hypothesized that RGZ exerts a PPARγ–dependent regulation of blood pressure through modulation of angiotensin-converting enzyme (ACE)-type 2 (ACE2)/angiotensin-(1-7)/angiotensin II type-2 receptor (AT2R) axis in an experimental model of high blood pressure. We carried on experiments in normotensive (Sham) and aortic coarctation (AoCo)-induced hypertensive male Wistar rats. …”
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Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis by Xuejie Gao, Qilin Feng, Qikai Zhang, Yifei Zhang, Chaolu Hu, Li Zhang, Hui Zhang, Guanli Wang, Ke Hu, Mengmeng Ma, Zhuning Wang, Yujie Liu, Dong An, Hongfei Yi, Yu Peng, Xiaosong Wu, Gege Chen, Xinyan Jia, Haiyan Cai, Jumei Shi

“…To investigate the biological functions of ENO1 in MM and the underlying molecular mechanisms involved, we conducted the following experiment: construction of a subcutaneous graft tumor model, co-immunoprecipitation, western blot, quantitative real-time polymerase chain reaction, immunohistochemistry, flow cytometry, and cell functional assays. …”
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Composite microbial agent improves cotton yield and resource use efficiency under mild salt stress by optimizing plant resource allocation by Xiao Zhao, Panpan Guo, Xiong Wu, Meng Zhu, Shaozhong Kang, Taisheng Du, Jian Kang, Jinliang Chen, Ling Tong, Risheng Ding, Wanli Xu, Guangmu Tang

“…To validate our hypothesis, we conducted an experiment using two cotton varieties: Xinluzao 72 (G1) and Zhongmiansuo 49 (G2); two microbial treatments: without STC-PGPR (B1) and with STC-PGPR (B2); and three salinity levels: 0, 4, and 8 g NaCl kg−1 soil (S1, S2, S3). …”
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Satisfaction and Preferences for Infusion Therapies in Advanced Parkinson’s Disease—Patient Perspective by Julia Węgrzynek-Gallina, Tomasz Chmiela, Michał Borończyk, Aleksandra Buczek, Patrycja Hudzińska, Hubert Bigajski, Damian Waksmundzki, Justyna Gawryluk, Joanna Siuda

“…A telephone survey conducted between June and July 2024 evaluated the experiences of patients with LCIG and CSAI. The Parkinson’s Disease Questionnaire (PDQ-8) and the Stress Scale for Family Caregivers (BSFC-s) were applied. …”
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Preparation, Structural Characterization and Antioxidant Activity of Extracellular Nanovesicles from Hericium erinaceus by Xueli YANG, Ben NIU, Hangjun CHEN, Weijie WU, Guannan WANG, Xiangjun FANG, Honglei MU, Haiyan GAO

“…Conclusion: It showed that HEDENVs had certain antioxidant activity in various antioxidant experiment.…”
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People’s knowledge, attitudes, and conflicts with carnivores in central hills, Sri Lanka by Ashan Thudugala, Hem Bahadur Katuwal, Nalindra Laxman, Vishwa Dushmantha, Ravindi Menikrama, Harsha Dissanayake, Chameera Dilshan, Ru-Chuan He, Rui-Chang Quan

“…Our goal was to explore people's knowledge—specifically their ability to identify carnivore species and understand environmental laws—alongside their attitudes and experiences with human-carnivore conflicts. We found that 99 % of the respondents identified at least one of the 12 carnivore species shown during the interview. …”
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Modeling soil respiration in summer maize cropland based on hyperspectral imagery and machine learning by Fanchao Zeng, Fanchao Zeng, Jinwei Sun, Huihui Zhang, Lizhen Yang, Xiaoxue Zhao, Jing Zhao, Xiaodong Bo, Yuxin Cao, Fuqi Yao, Fenghui Yuan, Fenghui Yuan

“…However, it remains uncertain whether hyperspectral remote sensing can provide an accurate and efficient method for estimating SR rate in croplands, particularly across different maize growth stages of under varying drought conditions.MethodsIn the study, we investigated the potential of combining hyperspectral remote sensing data with machine learning model (ML) to quantify SR rate in croplands. A drought field experiment was conducted, and SR and hyperspectral imagery were collected during four maize growth stages: Jointing Stage (JS), Tasseling Stage (TS), Flowering Stage (FS), and Grain Filling Stage (GFS). …”
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Metal Powder Production by Atomization of Free-Falling Melt Streams Using Pulsed Gaseous Shock and Detonation Waves by Sergey M. Frolov, Vladislav S. Ivanov, Viktor S. Aksenov, Igor O. Shamshin, Fedor S. Frolov, Alan E. Zangiev, Tatiana I. Eyvazova, Vera Ya. Popkova, Maksim V. Grishin, Andrey K. Gatin, Tatiana V. Dudareva

“…In general, the preliminary experiments show that the proposed method for the production of finely dispersed metal powders demonstrates potential in terms of powder characteristics.…”
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Repurposing of propane oxidative-dehydrogenation catalysts to deoxygenation of vegetable oils for green diesel production by S. Lucantonio, G. Di Vito Nolfi, C. Courson, K. Gallucci, A. Di Giuliano, L. Rossi

“…DO tests on NiCoMo and ZnCoMo were performed according to an unreplicated 23 factorial Design of Experiment (DoE) with three replications at center point. …”
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Understanding stakeholder views of the use of digital therapeutic interventions within children and young people’s mental health services by Brioney Gee, Brioney Gee, Tim Clarke, Tim Clarke, Jess Garner, Bonnie Teague, Bonnie Teague, Georgianna Coote, Aoife Dunne, Rachel McGuire, Andrew Laphan, Manjul Rathee, Jon Wilson, Jon Wilson

“…Study 2 involved eight focus groups with children and young people’s clinicians, service managers, commissioners, and policy leads (n=28), exploring participants’ views and experiences of implementing and sustaining digital therapeutic interventions. …”
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Response surface methodology for the design of malachite green dye removal by γ-Fe2O3 dispersed on reduced graphene oxide sheets by Liu Zhu, Anam Sana, Muhammad Tariq Qamar, Ali Bahadur, Guocong Liu, Mohammad Aslam, Ammar Zidan, İsmail Seçkin Çardaklı, Shahid Iqbal, Sajid Mahmood, Muhammad Saad, Khalid M. Alotaibi

“…The adsorbent’s surface charge (pHPZC = ~ 7.1) was also estimated using the salt addition technique. To minimize experiments and optimize adsorption parameters for the removal of MG by the nanocomposite at 25 °C, central composite design (CCD) using response surface methodology (RSM) was used. …”
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Enhanced expression of ten‐eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P‐glycoprotein expression by Chuanxu Wang, Hua Ye, Lei Zhang, Yayu Cheng, Shifeng Xu, Ping Zhang, Zijie Zhang, Jimin Bai, Fangkang Meng, Lin Zhong, Guangjun Shi, Hao Li

“…And then, the possible effect of TET1 on the expression of P‐gp was examined by western blot analysis. Xenograft tumor experiment was conducted to confirm the association between TET1 and P‐gp expression under gemcitabine chemoresistance. …”
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Application of fractal model in the Jurassic tight sandstone reservoirs of central Junggar Basin as constrained by mercury ejection curves by Hongkang Zhao, Xiangchun Chang, Tianchen Ge, Zhiping Zeng, Junjian Zhang, Daiqi Ming, Runye Han

“…The high-pressure mercury intrusion (HPMI) experiment is widely used to assess the pore architecture of tight sandstone reservoirs. …”
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Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease by Femke C. C. van Rhijn-Brouwer, Bas W. M. van Balkom, Diana A. Papazova, Diënty H. M. Hazenbrink, Anke J. Meijer, Isaac Brete, Vidalmar Briceno, Arjan D. van Zuilen, Raechel J. Toorop, Joost O. Fledderus, Hendrik Gremmels, Marianne C. Verhaar

“…Passage 3 BM MSCs and BM MSC-conditioned medium (CM) were used for experiments. EVs were isolated from CM by differential ultracentrifugation. …”
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A Cause Analysis of the High-Content Nitrogen and Low-Content Hydrocarbon in Shale Gas: A Case Study of the Early Cambrian in Xiuwu Basin, Yangtze Region by Yizhou Huang, Kun Zhang, Zhenxue Jiang, Yan Song, Shu Jiang, Chengzao Jia, Weiwei Liu, Ming Wen, Xuelian Xie, Tianlin Liu, Xin Li, Xin Wang, Xiaoxue Liu, Ye Zhang, Ling Tang

“…This study focused on the lower Cambrian shale in Xiuwu Basin, Lower Yangtze Region, with emphasis on the well Jiangye-1, using gas component analysis, stable nitrogen isotope analysis, overburden permeability tests in parallel and perpendicular directions, and FIB-HIM experiments, also combining with core description, outcrop observation, and seismic interpretation to explore the causes of the high-content nitrogen and low-content hydrocarbon in the lower Cambrian shale gas. …”
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Mechanistic study on the mitigation of cadmium accumulation in Ligusticum sinense cv. Chuanxiong through plant growth-promoting rhizobacteria Arthrobacter sp. CX-2 by Shu-qi Niu, Ting Li, Lin Liu, Xiu-wen Bao, Xing-mao Yang, Hao-ran Song, Yang Li, Jing Bai, Li-ying He, Qing-he Wang, Si-jing Liu, Jin-lin Guo

“…Chuanxiong were not affected by the addition of CX-2, which was confirmed through cell experiments. For rhizosphere soil, CX-2 significantly decreased the exchangeable Cd content by 36.84 % and enhanced the availability of nutrients. …”
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Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota by Ling Lv, Mireguli Maimaitiming, Jichen Yang, Shuli Xia, Xin Li, Pingyuan Wang, Zhiqing Liu, Chang-Yun Wang

“…The antibiotic-mediated microbiota depletion experiments demonstrated that the gut microbiota primarily contributed to barrier function protection, with little impact on inflammatory factor levels during the MR2938 treatment. …”
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