Transcriptomic and behavioral studies reveal that glutamate receptors are involved in depressive-like behavior in adult olive flounder Paralichthys olivaceus by Liangfang Liu, Tangsong Feng, Mengmeng Shi, Huafeng Zou, Weiqun Lu

“…In this study, using adult group (AG) and juvenile group (JG) flounder as a model, we compared the locomotor activity of AG and JG flounder, and analyzed the transcriptomic expression profiles in the spinal cord by RNA-seq methods. The behavioral experiment showed that AG flounder displayed lower locomotor activity. …”
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Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…Moreover, in vivo xenograft experiments showed that circ_0044516 downregulation reduced tumor growth. …”
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Plant Growth and Nutritional Quality Attributes of Basella alba Applied with Variable Rates of Nitrogen Fertilizer at Different Planting Dates under Canadian Maritime Climatic Cond... by Nishchitha Hemmige Natesh, Mercy O. Ijenyo, Samuel Kwaku Asiedu, H. P. Vasantha Rupasinghe, Lord Abbey

“…Nitrogen (N) fertilization at critical planting time is important to optimize productivity and reduce nitrate accumulation in edible portions of green leafy vegetable plants. A field experiment was performed to determine the effects of variations in N rate and planting time on plant growth, yield, and nutritional quality attributes of Basella alba under Atlantic maritime climatic conditions. …”
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Severe neonatal hypotonia due to SLC30A5 variant affecting function of ZnT5 zinc transporter by Vadim Dolgin, Pauline Chabosseau, Jacob Bistritzer, Iris Noyman, Orna Staretz‐Chacham, Ohad Wormser, Noam Hadar, Marina Eskin‐Schwartz, Bibi Kanengisser‐Pines, Ginat Narkis, Ramy Abramsky, Eilon Shany, Guy A. Rutter, Kyla Marks, Ohad S. Birk

“…Combining homozygosity mapping and exome sequencing studies of consanguineous Bedouin kindred, as well as transfection experiments and zinc monitoring in HEK293 cells, we demonstrate that a bi‐allelic in‐frame 3bp deletion variant in SLC30A5, deleting isoleucine within the highly conserved cation efflux domain of the encoded ZnT5, results in lower cytosolic zinc concentrations, causing a syndrome of severe non‐progressive neonatal axial and limb hypotonia with high‐arched palate and respiratory failure. …”
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Effect of Flowering Shading on Grain Yield and Quality of Durum Wheat in a Mediterranean Environment by Giancarlo Pagnani, Alfredo Lorenzo, Nausicaa Occhipinti, Lisa Antonucci, Sara D’Egidio, Fabio Stagnari, Michele Pisante

“…<i>Durum</i>) is increasingly constrained by abiotic factors, such as spring/summer heat stress and drought, as well as reductions in solar radiation. Field experiments were conducted in Mosciano Sant’Angelo, Italy, over two cropping seasons (2016–2017 and 2017–2018) to evaluate the effects of photosynthetically active radiation (PAR) availability and nitrogen (N) fertilization on durum wheat. …”
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Construction of complex three-dimensional vascularized liver tissue model in vitro based on a biphasic cell-laden embedding medium by Weikang Lv, Haoran Yu, Abdellah Aazmi, Tuya Naren, Wanli Cheng, Mengfei Yu, Zhen Wang, Xiaobin Xu, Huayong Yang, Liang Ma

“…Using the in situ endothelialization method, we constructed complex vascular structures and ensured close adhesion between hepatocytes and endothelial cells. In vitro experiments demonstrated that the vascularized liver tissue model exhibited enhanced protein synthesis and metabolic function compared to mixed liver tissue. …”
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Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy by Chen Ding, Jiange Wang, Jie Wang, Jiqiang Niu, Zhikai Xiahou, Zhou Sun, Zhenzhen Zhao, Dongyang Zeng

“…Results: C1 ABCA8+ fibroblasts demonstrated heightened proliferative activity, underscoring their pivotal role in fostering tumor growth and metastasis via intricate signaling pathways. In vitro experiments verified that the T transcription factor NFAT5 of C1 ABCA8+ fibroblasts subpopulation was knocked down in LNCaP clone FGC and 22Rv1 cell lines, which was closely related to the proliferation of PC. …”
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Improvement in soil properties and soil water content due to the application of rice husk biochar and straw compost in tropical upland by Junita Barus, Rr Ernawati Rr Ernawati, Nila Wardani, Yulia Pujiharti, Nandari Suretno, Slameto Slameto

“…This study examined the effect of the application of rice husk biochar and straw compost on several soil properties and yields of rice and soybeans in tropical upland. Method  Field experiments were carried out with two applications of rice husk biochar and straw compost on upland rice and soybean cultivation, respectively. …”
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Mechanism of the blood-brain barrier modulation by cadherin peptides by Elinaz Farokhi, Ahmed L. Alaofi, Vivitri D. Prasasty, Filia Stephanie, Marlyn D. Laksitorini, Krzysztof Kuczera, Teruna J. Siahaan

“…The binding properties of ADTC5, ADTC7, and ADTC9 to the extracellular-1 (EC1) domain of E-cadherin were evaluated using chemical shift perturbation (CSP) method in the two dimensional (2D) 1H-15N-heteronuclear single quantum coherence (HSQC) nuclear magnetic resonance (NMR) spectroscopy. Molecular docking experiments were used to determine the binding sites of these peptides to the EC1 domain of E-cadherin. …”
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Research on a traditional Chinese medicine case-based question-answering system integrating large language models and knowledge graphs by Yuchen Duan, Qingqing Zhou, Yu Li, Chi Qin, Ziyang Wang, Hongxing Kan, Hongxing Kan, Jili Hu, Jili Hu

“…IntroductionTraditional Chinese Medicine (TCM) case records encapsulate vast clinical experiences and theoretical insights, holding significant research and practical value. …”
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Roles of core nosZ denitrifiers in enhancing denitrification activity under long-term rice straw retention by Shijie Zhang, Shijie Zhang, Mengyao Hou, Mengyao Hou, Bing Li, Bing Li, Panfeng Guan, Panfeng Guan, Qing Chi, Qing Chi, Hao Sun, Hao Sun, Hangbo Xu, Hangbo Xu, Dongjie Cui, Dongjie Cui, Yupan Zhu, Yupan Zhu

“…This study coupled field and incubation experiments to explore the characteristics of soil denitrification activity, soil and standing water physicochemical properties, and the abundance, community diversity, and co-occurrence network of nosZ denitrifiers, based on a paddy field implementing 10-year straw retention under a rice–wheat rotation system. …”
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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

“…Nanopore RNA sequencing, RIP assay, IP‐MS, MeRIP‐qPCR, PAR‐CLIP and luciferase reporter experiments showed that Hnrnpa1 induced Mettl3 post‐transcriptional splicing to inhibit m6A‐dependent Pbx1 and E2F1 degradation, thereby increasing Runx1, Ccne1, Cdk2 and Ccnb2 expression to promote CM DACCA. …”
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Laboratory-scale biogas production from vegetable juice waste using an IC reactor by Boualy Vongvisith, Chengyue Liang, Changmei Wang, Fang Yin, Kai Wu, Bin Yang, Jing Liu, Hong Yang, Wudi Zhang

“… This investigation aimed to assess the performance of an internal circulation (IC) reactor in converting vegetable juice waste (VJW) into biogas and evaluating its methane content. The experiment involved collecting different types of leafy vegetable waste from a market in Chenggong County, Yunnan Province. …”
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Application of human-in-the-loop hybrid augmented intelligence approach in security inspection system by Ying Huang, Ying Huang, XiaoKan Wang, XiaoKan Wang, Yong Zhang, Yong Zhang, Li Chen, Li Chen, HongJi Zhang

“…These strategies play complementary roles in bolstering the decision-making process’s overall performance. Comparative experiments on a dataset from a specific security inspection site confirmed the hybrid method’s effectiveness, drawing several conclusions. …”
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A Spray Foliar Containing <i>Methylobacterium symbioticum</i> Did Not Increase Nitrogen Concentration in Leaves or Olive Yield Across Three Rainfed Olive Orchards by Manuel Ângelo Rodrigues, João Ilídio Lopes, Sandra Martins, Cátia Brito, Carlos Manuel Correia, Margarida Arrobas

“…In two orchards managed according to European Union (EU) integrated production rules, the experiment was organized as a factorial design with inoculant (applied at two levels, yes and no) and N fertilization (applied to the soil at three levels, 0, 40, and 80 kg ha⁻¹ of N). …”
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Mapping ground deformation in the northern Yangtze River estuary using improved MT-InSAR based on ICA and non-stationary analysis by Zhijie Zhang, Songbo Wu, Guoqiang Shi, Xiaoli Ding, Chaoying Zhao, Bochen Zhang, Liang Chen, Zhong Lu

“…In this paper, we introduce a novel approach that designs a non-stationarity test for independent component analysis (ICA) to effectively separate the APS and deformation phase components in MT-InSAR applications. Through simulated experiments, the proposed method demonstrated a 50% improvement in deformation accuracy and can effectively track deformation progression. …”
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Genetic analysis and heterosis breeding of seed yield and yieldattributing traits in Indian mustard (Brassica juncea (L.) Czern & Coss.) by Sanghamitra Rout, Suvendu Kumar Roy, Rupsanatan Mandal, Saurav Singla, Mehdi Rahimi, Bijaya Sur, Naderla Umamaheswar, Moumita Chakraborty, Lakshmi Hijam, Sahanob Nath, Manoj Kanti Debnath, Tulsi Saran Ghimiray

“…Abstract This study aimed to assess the genetic basis and combining ability of 10 morphological traits in Indian mustard. The experiment involved eight parent lines and 28 crosses derived from a half-diallel mating design. …”
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Cancer Cell‐Derived Exosomal miR‐500a‐3p Modulates Hepatic Stellate Cell Activation and the Immunosuppressive Microenvironment by Yu Zhang, Xin Li, Huiyan Chen, Jiawei Li, Xiaohuan Guo, Yilin Fang, Linjie Chen, Kaiqiang Li, Yi Zhang, Fei Kong, Aodong Chen, Jianxin Lyu, Wei Zhang, Zhen Wang

“…Subsequently, the role of miR‐500a‐3p transported by HCC exosomes in hepatic stellate cell (HSC) activation, hepatoma growth and invasion, and immune cell differentiation is determined by in vitro and in vivo experiments. In clinical tissues, miR‐500a‐3p is significantly enriched in HCC and cirrhosis tissues, and co‐expression of the immune marker CD4 or PD‐L1 significantly correlates with low survival rates in patients. …”
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Beyond COVID-19, the case for collecting, analysing and using sex-disaggregated data and gendered data to inform outbreak response: a scoping review by Simone E Carter, Shirin Heidari, Leah Zilversmit Pao, Marie-Amelie Degail, Marie Meudec, McKinzie Gales, Emelie Love Yonally Phillips, Christine Dubray, Clara Rodriguez Ribas Elizalde, M Ruby Siddiqui

“…These disparities encompassed a wide range of risk factors for disease, vulnerability, access to and use of services, health-seeking behaviour, healthcare options, as well as experiences in healthcare settings and health and social outcomes and consequences.Conclusion Significant gender-evidence gaps remain in outbreak response. …”
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Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of oste... by Angela M. Mickle, Jared J. Tanner, Udell Holmes, III, Ahmed Rashid, Olivier Barolette, Brittany Addison, Nicola Sambuco, Cynthia Garvan, Song Lai, Christoph Seubert, Siegfried Schmidt, Roland Staud, Jeffrey C. Edberg, David Redden, Burel R. Goodin, Catherine C. Price, Roger B. Fillingim, Kimberly T. Sibille

“…Dispositional traits serve as the biological interface for life experiences. Objectives:. We investigate group differences based on dispositional traits and poverty status, specific to (1) pain intensity and functional limitations and (2) biological measures, a clinical composite and brain age. …”
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