Exploring the impact of insufficient thermal ablation on hepatocellular carcinoma: NDST2 overexpression mechanism and its role in facilitating growth and invasion of residual cance... by Weijun Wan, Danxia Guo, Tong Kang, Jinshu Pang, Yunjing Pan, Jiamin Chen, Wei Liao, Yuji Chen, Peng Lin, Lipeng Li, Hong Yang, Yun He

“…This study aims to investigate the expression changes of NDST2 following ITA of HCC and its impact on residual cancer cells.Methods An in vitro model of heat stress-induced liver cancer was constructed to measure the expression of NDST2 using Quantitative Real-Time PCR and Western blotting experiments. The sequencing data from nude mice were used for validation. …”
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Decision-making under epistemic, strategic and institutional uncertainty during COVID-19: findings from a six-country empirical study by Clare Wenham, Alexandra L Phelan, Winifred Ukponu, Sumegha Asthana, Tahmina Shirin, Claire J Standley, Adachioma Chinonso Ihueze, Sanjana Mukherjee, Ibrahim B Gobir, Mohannad Al Nsour, JJ Woo, Mohammad Mushtuq Husain, Nevashan Govender, Roujia Lin, Sumit Asthana, Renee Vongai Mutare

“…Decision-making under institutional uncertainty involved using or adapting pre-existing experiences, structures and relationships and establishing new institutions and processes.Conclusions We contribute to the theory and practice of public health crisis decision-making by presenting a unified national-level applied decision-making framework for events involving uncertainty. …”
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Optimising Palm Olein-Based Betamethasone 17-Valerate Emulsions for Scalable Manufacturing and Stability by Thazin Win, Mohd. Rushdi Abu Bakar, Farahidah Mohamed, Muhammad Taher, Md. Zaidul I. Sarker

“…Methods: This research work established and optimised the manufacturing process parameters for the production of cream and lotion formulations containing betamethasone 17-valerate, utilising palm olein as the vehicle, with scale-up from lab-scale 5 kg batches to pilot-scale 80 kg batches. Design of experiments (DoE) where response surface methodology as well as three-level, two-factors (32) full factorial design were used to develop statistical models for representing the possible relationships between factors: homogenisation time and speed, and responses: particle size and phase separation. …”
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Non-contact tracking of shoulder bones using ultrasound and stereophotogrammetry by Ahmed Sewify, Ahmed Sewify, Maxence Lavaill, Maxence Lavaill, Dermot O’Rourke, Dermot O’Rourke, Maria Antico, Maria Antico, Peter Pivonka, Peter Pivonka, Davide Fontanarosa, Davide Fontanarosa, Saulo Martelli, Saulo Martelli

“…Ex-vivo, the CPD registration errors were (Humerus = 2 mm and Scapula = 13.9 mm) (Humerus = 7.2 mm and Scapula = 16.8 mm) and (Humerus = 14.28 mm and Scapula = 27.5 mm), for low, medium and high elevations respectively.ConclusionIn summary, we demonstrated the feasibility and accuracy of tracking shoulder bones with 3D US in a simulation and a cadaveric experiment. We discovered that CPD may be a more suitable registration method for the task than ICP. …”
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Assessment of the hypoglycemic effect of Cyanthillium cinereum (L.) H. Rob. and its dual impact on uterine contraction in gestational diabetic rats by Sasitorn Kerdsuknirund, Arreeya Kosinan, Panida Khunkaewla, Pakanit Kupittayanant, Pattama Tongdee, Porntip Nimkuntod, Susan Wray, Sajeera Kupittayanant

“…Histological analyses of maternal pancreatic and uterine tissues and uterine contractility studies using ex vivo muscle strip experiments were also performed. Results: CCE and metformin (MET) significantly reduced elevated blood glucose levels and improved the Islets of Langerhans area compared to the GDM group (P < 0.05). …”
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Performance of sulfur/steel slag composite matrix in removing nitrate from surface water with low-carbon content by PENG Xianchun, ZHENG Lili, LU Haoran, WANG Zhefeng, ZHU Zheng, LIANG Wenyan

“…Anaerobic bottle batch experiments were conducted to compare the denitrification performance of sulfur/steel slag and sulfur/limestone systems. …”
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The Aryl Hydrocarbon Receptor (AhR) Is a Novel Gene Involved in Proper Physiological Functions of Pancreatic β-Cells by Shuhd Bin Eshaq, Jalal Taneera, Shabana Anjum, Abdul Khader Mohammed, Mohammad H. Semreen, Karem H. Alzoubi, Mohamed Eladl, Yasser Bustanji, Eman Abu-Gharbieh, Waseem El-Huneidi

“…Additionally, functional experiments were conducted in INS-1 cells, a rat β-cell line, to elucidate the role of Ahr in β-cell biology. …”
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Grazing mortality as a controlling factor in the uncultured non-cyanobacterial diazotroph (Gamma A) around the Kuroshio region by T. Sato, T. Sato, T. Yamaguchi, K. Hidataka, S. Sogawa, T. Setou, T. Kodama, T. Kodama, T. Shiozaki, K. Takahashi

“…In this study, we investigated the diazotroph community structure using <i>nifH</i> amplicon sequencing and quantified the growth and microzooplankton grazing mortality rate of Gamma A using a combination of dilution experiments and quantitative polymerase chain reaction (PCR) in well-lit waters at the northern edge of the Kuroshio Current off the southern coast of Japan. …”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…Since one of the main effects of Wnt/β-catenin signaling is the modulation of target genes, in the present work we examined global transcriptional changes induced by short-term Wnt3a treatment (4 h) in primary cultures of rat hippocampal neurons. RNAseq experiments allowed the identification of 170 differentially expressed genes, including known Wnt/β-catenin target genes such as Notum, Axin2, and Lef1, as well as novel potential candidates Fam84a, Stk32a, and Itga9. …”
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Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study by Haiyu Wang, Guangying Cui, Ming Cheng, Tuerganaili Aji, Guotao Li, Xinjun Hu, Guangming Li, Shixi Zhang, Yanyang Zhang, Linqi Diao, Pan Li, Ling Wang, Yiqiang Yuan, Guowu Qian, Ruiqing Zhang, Xiaoli Jin, Juan Wang, Hong Luo, Donghua Zhang, Mingming Wang, Silin Li, Zhan Song, Mengzhao Yang, Guanyue Su, Ranran Sun, Junbiao Chang, Zujiang Yu, Zhigang Ren

“…Additionally, in vitro and in vivo experiments were used to evaluate the antitumor effects and safety of both drugs. …”
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Understanding the exodus: a 15-year retrospective cohort study on the pattern and determinants of migration among Nigerian doctors and dentists by Oghenebrume Wariri, Patience Toyin-Thomas, Itua C.G. Akhirevbulu, Oladapo Oladeinde, Oluchi Omogbai, Philippa Odika, John Osakue, Avwebo Ukueku, Efetobo Orikpete, Chinelo Iwegim, Efe E. Omoyibo, Jermaine Okpere, Uwaila Otakhoigbogie, Ekhosuehi T. Agho, Sunday C. Madubueze, Nnennaya C. Ugoji, Chukwunwike W. Ozegbe, Oti N. Aria, Paul Ikhurionan

“…Background Nigeria faces a critical shortage of healthcare professionals yet experiences a significant annual exodus of doctors and dentists. …”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…Transcriptomic sequencing and rescue experiments were used to investigate the molecular mechanism by which miR-203a-3p in EpiSC-EVs induces myofibroblast dedifferentiation. …”
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Utilizing Invasive <i>Pterygoplichthys pardalis</i> as a Sustainable Fish Meal Substitute and <i>Euphorbia hirta</i> Extract Supplement: Effects on Growth Performance, Organosomati... by Sontaya Sookying, Phanit Srisuttha, Vipada Rodprasert, Chanthima Chaodon, Wikit Phinrub, Nantaporn Sutthi, Paiboon Panase

“…The study utilized six dietary treatments: a control diet (0% PPM, no EHE) and five experimental diets with varying PPM levels (0%+, 25%+, 50%+, 75%+, and 100%+), each fortified with 300 mg/kg EHE. The experiment spanned 90 days. The analysis revealed that PPM exhibited superior amino acid profiles compared to CFM, both in quality and quantity, while CFM demonstrated higher fatty acid content. …”
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Pyroxsulam Resistance in <i>Apera spica-venti</i>: An Emerging Challenge in Crop Protection by Soham Bhattacharya, Madhab Kumar Sen, Katerina Hamouzová, Pavlína Košnarová, Rohit Bharati, Julio Menendez, Josef Soukup

“…This study reports a biotype of <i>A. spica-venti</i> resistant to pyroxsulam, with cross and multiple resistance to iodosulfuron, propoxycarbazone, pinoxaden, and chlortoluron. Dose–response experiments revealed high resistance of both R1 and R2 biotypes to pyroxsulam, with resistance factors (RF) of 6.69 and 141.65, respectively. …”
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Predictive method for poultry carcass visceral dimensions using 3D point cloud and Genetic Algorithm-based wavelet neural network by Zhengwei Zhu, Yan Chen, Lu Cai, Jinzhou Yang, Ke Wen, Jingjing Bao, Zhigang Hu, Dandan Fu

“…Finally, in order to verify the generalizability of the method, generalizability experiments were conducted on different breeds of poultry, which proved that the method of this study had superior generalizability ability. …”
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Multiple Episodes of Remote Brightenings Driven by a Coronal Extreme-ultraviolet Jet on the Sun by Chao Zhang, Zhenghua Huang, Hengyuan Wei, Youqian Qi, Mijie Shi, Hui Fu, Xiuhui Zuo, Weixin Liu, Mingzhe Sun, Ming Xiong, Lidong Xia

“…We attribute the second peak of RB directly to this hot flow, which our numerical experiments suggest is the result of a slow shock wave. …”
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Use of Relay Method for Enhancing Comb Construction by <i>Apis cerana cerana</i> Utilizing <i>Apis mellifera ligustica</i> by Shunhua Yang, Shanglun Ge, Yiqiu Liu, Danyin Zhou, Xueyang Gong, Kun Dong

“…The present study aimed to accelerate comb construction in CHB colonies using IHBs. In the experiment, IHB colonies, each with approximately 42,000 adult workers, required over four hours to construct a semi-drawn comb on CHB wax foundations. …”
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An AI recognition method for children's clinical operative pain by skin potential (SP) signal by Mingxuan Huang, Cangcang Fu, Linbo Chui, Jiadong He, Xiaozhi Wang, Jikui Luo, Bin Wu, Yonggang Chen, Shaohua Hu, Jihua Zhu, Yubo Li

“…By combining pain monitoring with SP signals and ML, subjective pain experiences are transformed into quantifiable data, achieving high accuracy and real-time measurement capabilities. …”
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Development of a neural network for diagnosing the risk of depression according to the experimental data of the stop signal paradigm by M. O. Zelenskih, A. E. Saprygin, S. S. Tamozhnikov, P. D. Rudych, D. A. Lebedkin, A.  N. Savostyanov

“…An architecture was developed and a system was implemented for testing motor control indicators in humans, then it was tested in real experiments. A comparison of neural network technologies and methods of mathematical statistics was carried out. …”
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Multielement Principal Component Analysis and Origin Traceability of Rice Based on ICP-MS/MS by Yan Wang, Xiaoxuan Yuan, Linan Liu, Junmei Ma, Sufang Fan, Yan Zhang, Qiang Li

“…In this experiment, inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) was used to determine the content of 30 elements in rice from six places of production and to explore the relationship between the multielement content in rice and the producing area. …”
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