Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening mo... by Virginia Marugan-Hernandez, Javier Regidor-Cerrillo, Luis Ortega-Mora, Sara Arias-Maroto, Kelsilandia Aguiar-Martins

“…Anticoccidial activities of novel compounds is currently evaluated by expensive experiments that involve large numbers of chickens. …”
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Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma by Ziyi Zhou, Lanlan Yang, Yuan Fang, Rongzhong Xu, Xi Wang, Yuli Wang, Zhihong Fang

“…In addition, single-cell analysis displayed the cell types, the subcellular localization of prognostic genes, and the cellular interaction to reveal the potential molecular communication mechanism of anoikis resistance. Finally, in vitro experiments confirmed the critical role of CRABP2 in STAD. …”
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Influence of Cord Parameters on the Load Characteristics of Airbags by Yu-Ru Li, Shou-Ne Xiao, Jun-Ke Xie, Tao Zhu, Bing Yang, Guang-Wu Yang, Shi-De Xiao

“…First, uniaxial tension and compression experiments with airbag under different initial pressures were carried out to analyse the effects of the initial pressure and working height on the mechanical properties of the airbag. …”
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A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method by Yuki Kobayashi, Honoka Hashizume, Sotaro Takiguchi, Jiajue Ji, Ryuji Kawano, Keiichiro Koiwai, Haru Yamamoto, Mohamed Elbadawy, Tsutomu Omatsu, Amira Abugomaa, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki

“…These techniques have recently been used to reproduce the structure and function of organs in vitro and are expected to be promising alternatives for animal experiments in the future. In the present study, we designed and fabricated an organ-on-a-chip system for mounting organoids from mammary tumor-affected cats (FMT organoids) and normal intestinal organoids from mice (MI organoids) and perfused them with anti-cancer drugs. …”
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Time Series Classification of Raw Voice Waveforms for Parkinson's Disease Detection Using Generative Adversarial Network-Driven Data Augmentation by Marta Rey-Paredes, Carlos J. Perez, Alfonso Mateos-Caballero

“…For the PD detection task, deep learning models such as ResNet, LSTM-FCN, InceptionTime, and CDIL-CNN are used. The experiments were performed using the speech task of sustained vowel /a/ in the PC-GITA database, which contains the recordings of healthy and PD subjects. …”
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Water Model Study on Alloy Melting and Mixing in RH Refining Process by XU Zhibo, CHEN Chao, WANG Jia, LI Yihong, CAO Ruiyun, ZHAO Yansong, XUE Liqiang, FAN Jinping

“…[Methods] The transport process and mixing phenomenon of NaCl saturated solution or NaCl particles in water model of RH were studied by water model experiment and numerical simulation. The salt spheres made by KCl solution were used to simulate the heavy alloy, and the motion and mixing process after entering RH from the top of vacuum chamber in the water model was studied. …”
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Research Note: Establishment of vector system harboring duck RNA polymerase I promoter for avian influenza virus by Yunyueng Jang, Yoon-Gi Baek, Yu-Na Lee, Ra Mi Cha, Yun-Chan Choi, Min-Ji Park, Youn-Jeong Lee, Eun-Kyoung Lee

“…Furthermore, HPAI viruses were successfully rescued in DF-1 cells, a result that had not been achieved in previous experiments. In conclusion, our novel RG system harboring duck RNA pol I offers an additional tool for researching influenza viruses and may facilitate the development of vaccines for poultry.…”
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Modified CD15/CD16-CLL1 inhibitory CAR-T cells for mitigating granulocytopenia toxicities in the treatment of acute myeloid leukemia by Rui Zhang, Yifan Zhao, Xiao Chai, Yingshuai Wang, Mohan Zhao, Shujing Guo, Yu Zhang, Mingfeng Zhao

“…Furthermore, their functionality has been effectively validated through both in vitro and in vivo experiments. In conclusion, we have successfully engineered innovative CD16-CLL1 iCAR-T cells, which preserves the cytotoxicity against tumor cells while preventing elimination of neutrophils, thereby significantly reducing the incidence of granulocytopenia during CAR-T therapy. …”
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Effect of Ileal Transposition (IT) on Angiopoietin-Like Protein-8 (ANGPTL8) and Pentraxin (PTX3) Plasma Level in Sprague-Dawley Rats Fed High-Fat Diet (HFD) by Tomasz Sawczyn, Dominika Stygar, Katarzyna Nabrdalik, Michał Kukla, Oliwia Masri, Łukasz Magrowski, Wojciech Karcz, Jerzy Jochem

“…The effects of the IT procedure in this experiment are ambiguous and do not provide a clear answer as to whether or not they are beneficial.…”
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Simulation of interferometric imaging with EISCAT_3D for fine-scale in-beam incoherent scatter spectra measurements by D. Huyghebaert, D. Huyghebaert, B. Gustavsson, J. Vierinen, A. Kvammen, M. Zettergren, J. Swoboda, I. Virtanen, S. M. Hatch, K. M. Laundal

“…Furthermore, with more development, it can be used to test experimental setups and to design experiments for EISCAT_3D by investigating the needed integration time for various SNSDRs, beam patterns, and ionospheric conditions.…”
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Predictive modeling and optimization of noise emissions in a palm oil methyl ester-fueled diesel engine using response surface methodology and artificial neural network integrated... by J.M. Zikri, M.S.M. Sani, M.F.F.A. Rashid, J. Muriban, G.S. Prayogo

“…The outcomes of the experiments were contrasted with the forecasts produced by the RSM and ANN-GA models, emphasizing the goal of reducing error percentages. …”
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Hot deformation physical mechanisms and a unified constitutive model of a solid solution Ti55511 alloy deformed in the two-phase region by Huijie Zhang, Y.C. Lin, Gang Su, Yongfu Xie, Wei Qiu, Ningfu Zeng, Song Zhang, Guicheng Wu

“…In this work, the flow behaviors and microstructure evolution of a solid solution Ti55511 alloy deformed in the two-phase region are investigated by hot compression experiments. Subsequently, The spheroidization mechanisms of α phases and the refinement mechanism of β matrix are analyzed. …”
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Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6 by Huan Yi, Yan-zhao Su, Rong Lin, Xiang-qin Zheng, Diling Pan, Dan-mei Lin, Xiang Gao, Rong Zhang

“…Increased RIPK4 expression in OC markedly correlated with a worse overall survival than lower RIPK4 expression levels (hazard rate (HR) 1.5 (1.45–1.87); P=0.001). In functional experiments, RIPK4 downregulation significantly inhibited metastatic behaviours in OC cells. …”
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Dimorphos’s Material Properties and Estimates of Crater Size from the DART Impact by Angela M. Stickle, Kathryn M. Kumamoto, Dawn M. Graninger, Mallory E. DeCoster, Wendy K. Caldwell, Jason M. Pearl, J. Michael Owen, Olivier Barnouin, Gareth S. Collins, R. Terik Daly, Isabel Herreros, Jens Ormö, Jessica Sunshine, Carolyn M. Ernst, Toshi Hirabayashi, Simone Marchi, Laura Parro, Harrison Agrusa, Megan Bruck Syal, Nancy L. Chabot, Andy F. Cheng, Thomas M. Davison, Elisabetta Dotto, Eugene G. Fahenstock, Fabio Ferrari, Martin Jutzi, Alice Lucchetti, Robert Luther, Nilanjan Mitra, Maurizio Pajola, Sabina Raducan, KT Ramesh, Andrew S. Rivkin, Alessandro Rossi, Paul Sánchez, Stephen R. Schwartz, Stefania Soldini, Jordan K. Steckloff, Filippo Tusberti, Kai Wünnemann, Yun Zhang

“…Hera’s measurement of crater size in combination with measurement of Dimorphos’s mass will allow us to assess our simulations and provide the information needed to make the DART impact experiment both the first test of a planetary defense mitigation mission and the first full-scale planetary defense simulation validation exercise.…”
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Interplanetary Influence on Thermospheric Mass Density: Insights From Deep Learning Analyses by Wenbo Li, Libo Liu, Yiding Chen, Yi‐Jia Zhou, Huijun Le, Ruilong Zhang

“…We explore the TMD features under different solar‐terrestrial environmental conditions and discuss the effects of various inputs by comparing the DL simulation results with satellite observations from Gravity Recovery and Climate Experiment‐A and Swarm‐A, as well as the simulation results from Jacchia‐Bowman 2008, Naval Research Laboratory Mass Spectrometer Incoherent Scatter radar model 2.1, and Drag Temperature Model 2013. …”
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Leakage of Octyl(Phenyl)--Di-Isobutylcarbamoylmethylphosphine Oxide from a Macroporous Silica-Based Chelating Polymeric Adsorption Material and its Recovery by Some Selected Porous... by Anyun Zhang, Yuezhou Wei, Harutaka Hoshi, Mikio Kumagai, Yoshikazu Koma

“…The corresponding elution volumes and the amounts of CMPO leaking were 8700.9 BV/g and 239.3 mg/g at 25°C and 11 842.9 BV/g and 359.4 mg/g at 50°C, respectively. The adsorption experiment showed that a polymer-based porous material, SEPABEADS® SP-825, was capable of recovering CMPO effectively from 0.01 M HNO 3 . …”
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LMF-Net: A Learnable Multimodal Fusion Network for Semantic Segmentation of Remote Sensing Data by Jihao Li, Wenkai Zhang, Weihang Zhang, Ruixue Zhou, Chongyang Li, Boyuan Tong, Xian Sun, Kun Fu

“…They are able to dynamically adjust the collaborative relationships of different modal embeddings and features in a learnable approach, respectively. Experiments on two well-established benchmark datasets reveal that our LMF-Net possesses superior segmentation behavior and strong generalization capability. …”
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MGScoliosis: Multi-grained scoliosis detection with joint ordinal regression from natural image by Xiaojia Zhu, Rui Chen, Zhiwen Shao, Ming Zhang, Yuhu Dai, Wenzhi Zhang, Chuandong Lang

“…The feature learning and the ordinal regression is put into an end-to-end framework, in which the two tasks of scoliosis severity level estimation and scoliosis angle level estimation are jointly learned and can contribute to each other. Extensive experiments demonstrate that our approach outperforms state-of-the-art methods as well as human performance, which provides a promising and economical solution to wide-range scoliosis screening. …”
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DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma by Ze Qian, Yifan Jiang, Yacong Wang, Yu Li, Lin Zhang, Xiaofeng Xu, Diyu Chen

“…Through in vivo and in vitro experiments, we confirmed that cg08618068 was methylated in HCC. …”
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Leverage of lysozyme dietary supplementation on gut health, hematological, antioxidant, and immune parameters in different plumage-colors Japanese quails by Ibrahim A. Elkhaiat, Seham El-Kassas, Safaa E Abdo, Karima El-Naggar, Haitham K. Shalaby, Reyad Y. Nofal, Mayada R. Farag, Mahmoud M. Azzam, Antonia Lestingi

“…Two forms of LZ; extracted from egg white (natural LZ (NLZ)), and the commercial LZ (CLZ) were included in this experiment. For each quail variety, 240 birds were randomly allocated into four groups with four replicates per group. …”
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