Ribosomal Protein L40e Fused With a Ubiquitin Moiety Is Essential for the Vegetative Growth, Morphological Homeostasis, Cell Cycle Progression, and Pathogenicity of Cryptococcus ne... by Jingyu Zhao, Jingyu Zhao, Yali Yang, Yali Yang, Yibin Fan, Jiu Yi, Chao Zhang, Zhongkai Gu, Weihua Pan, Julin Gu, Wanqing Liao, Wei Fang

“…Ubiquitin is a highly conserved protein required for various fundamental cellular processes in eukaryotes. Herein, we first report the contribution of the ubiquitin fusion protein Ubi1 (a ubiquitin monomer fused with the ribosome protein L40e, Rpl40e) in the growth and pathogenicity of Cryptococcus neoformans. …”
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Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci) by Alberto Guevara-Flores, Irene P. del Arenal, Guillermo Mendoza-Hernández, Juan Pablo Pardo, Oscar Flores-Herrera, Juan L. Rendón

“…Apparent Km values were 0.87  ±  0.04  μM, 41  ±  6  μM and 19  ±  10  μM for thioredoxin, GSSG and NADPH, respectively. Thioredoxin from eukaryotic sources was accepted as substrate. The enzyme reduced H2O2 in a NADPH-dependent manner, although with low catalytic efficiency. …”
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Double trouble: two retrotransposons triggered a cascade of invasions in Drosophila species within the last 50 years by Almorò Scarpa, Riccardo Pianezza, Hannah R. Gellert, Anna Haider, Bernard Y. Kim, Eric C. Lai, Robert Kofler, Sarah Signor

“…Abstract Horizontal transfer of genetic material in eukaryotes has rarely been documented over short evolutionary timescales. …”
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Identification and characterization of the COPII vesicle‐forming GTPase Sar1 in Chlamydomonas by Kin Pan Chung, Daniel Frieboese, Florent Waltz, Benjamin D. Engel, Ralph Bock

“…Abstract Eukaryotic cells are highly compartmentalized, requiring elaborate transport mechanisms to facilitate the movement of proteins between membrane‐bound compartments. …”
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Taxonomic and functional diversity of protists in saline and hypersaline lakes in southern Western Siberia, a region strongly affected by climate change by Elena A. Gerasimova, Alexander S. Balkin, Vladimir Y. Kataev, Ekaterina S. Filonchikova, Yulia V. Mindolina, Denis V. Tikhonenkov

“…Lakes in southern West Siberia, including saline and hypersaline waterbodies within endorheic basins, remain unexplored in terms of the biodiversity of the microbial eukaryotes inhabiting them. In this study, we investigated the taxonomic and functional diversity of planktonic protist communities in saline and hypersaline lakes (22–220‰) in southern Western Siberia through Illumina 18S rDNA amplicon sequencing. …”
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Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)]4 by Bruno Pagano, Iolanda Fotticchia, Stefano De Tito, Carlo A. Mattia, Luciano Mayol, Ettore Novellino, Antonio Randazzo, Concetta Giancola

“…Quadruplex-prone sequences are found in many regions of human genome and in the telomeres of all eukaryotic organisms. Since small molecules that target G-quadruplexes have been found to be effective telomerase inhibitors, the identification of new specific ligands for G-quadruplexes is emerging as a promising approach to develop new anticancer drugs. …”
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MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis by Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li, Christian Speck

“…Abstract The eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. …”
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PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response by Ling Cheng, Ian Meliala, Yidi Kong, Jingyuan Chen, Christopher G Proud, Mikael Björklund

“…Depletion of PEBP1 impaired mitochondrial ISR activation by reducing eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and subsequent ISR gene expression, which was independent of PEBP1’s role in inhibiting the RAF/MEK/ERK pathway. …”
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The study of the regulatory region of the Drosophila melanogaster Notch gene by new methods of directed genome editing by O. V. Andreyenkov, E. I. Volkova, N. G. Andreyenkova, S. A. Demakov

“…The Notch gene plays a key role in the development of organs and tissues of neuroectodermic origin, including the nervous system. In eukaryotic organisms, the Notch pathway is involved in cell fate determination. …”
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The Ivermectin Related Compound Moxidectin Can Target Apicomplexan Importin α and Limit Growth of Malarial Parasites by Sujata B. Walunj, Geetanjali Mishra, Kylie M. Wagstaff, Swati Patankar, David A. Jans

“…Signal-dependent transport into and out of the nucleus mediated by members of the importin (IMP) superfamily is crucial for eukaryotic function, with inhibitors targeting IMPα being of key interest as anti-infectious agents, including against the apicomplexan <i>Plasmodium</i> species and <i>Toxoplasma gondii</i>, causative agents of malaria and toxoplasmosis, respectively. …”
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Development of new SSR markers for homoeologous WFZP loci based on the study of structure and location of microsatellites in gene-rich regions of chromosomes 2AS , 2BS, 2DS by O. B. Dobrovolskaya, C. Pont, Yu. L. Orlov, J. Salse

“…Microsatellites, or simple sequence repeats (SSRs), are ubiquitous in genomes of eukaryotes, including plant genomes. The structure and location of SSR loci determine their potential as molecular genetic markers and may have impact on the potential function of microsatellites in important biological processes. …”
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Retrotransposon-Based Genetic Diversity of <i>Rhodiola rosea</i> L. (Crassulaceae) from Kazakhstan Altai by Oxana Khapilina, Ainur Turzhanova, Moldir Zhumagul, Damelya Tagimanova, Olesya Raiser, Serik Kubentayev, Vladislav Shevtsov, Maria Hohn

“…Mobile genetic elements and other interspersed repeats, which are major components of eukaryotic genomes, serve as effective tools for studying plant biodiversity and variability. …”
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Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles by Seyyed Sam Mehdi Hosseininasab, Rasoul Ebrahimi, Shirin Yaghoobpoor, Kiarash Kazemi, Yaser Khakpour, Ramtin Hajibeygi, Ashraf Mohamadkhani, Mobina Fathi, Kimia Vakili, Arian Tavasol, Zohreh Tutunchian, Tara Fazel, Mohammad Fathi, Mohammadreza Hajiesmaeili

“…Various viruses such as Herpes simplex virus 1 (HSV-1), Epstein–Barr virus (EBV), Cytomegalovirus (CMV), influenza viruses, and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), as well as bacteria such as Chlamydia pneumoniae (CP), Helicobacter pylori (HP), Porphyromonas gingivalis (P. gingivalis), Spirochetes and eukaryotic unicellular parasites (e.g., Toxoplasma gondii), have been linked to AD due to their ability to activate the immune system, induce inflammation and increase oxidative stress, thereby leading to cognitive decline and AD. …”
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Soft Lithography and Minimally Human Invasive Technique for Rapid Screening of Oral Biofilm Formation on New Microfabricated Dental Material Surfaces by Marta Alvarez-Escobar, Sidónio C. Freitas, Derek Hansford, Fernando J. Monteiro, Alejandro Pelaez-Vargas

“…Wide information is available about cell/biomaterial interactions using eukaryotic and prokaryotic cells on surfaces of dental materials with different topographies, but studies using human being are still limited. …”
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Poly(A)-DG: A deep-learning-based domain generalization method to identify cross-species Poly(A) signal without prior knowledge from target species. by Yumin Zheng, Haohan Wang, Yang Zhang, Xin Gao, Eric P Xing, Min Xu

“…In eukaryotes, polyadenylation (poly(A)) is an essential process during mRNA maturation. …”
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Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM by Agalya Periasamy, Pamela Ornelas, Thomas Bausewein, Naomi Mitchell, Jiamin Zhao, Leonie M. Quinn, Werner Kuehlbrandt, Jacqueline M. Gulbis

“…The new structure provides an opportunity to pinpoint general features that differentiate the TOM structures of higher and unicellular eukaryotes. While the quaternary fold of the assembly is retained, local nuances of structural elements implicated in precursor import are indicative of subtle evolutionary change.…”
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Non-negligible Occurrence of Errors in Gender Description in Public Data Sets by Jong Hwan Kim, Jong-Luyl Park, Seon-Young Kim

“…We also analyzed 1,819 samples produced using the Affymetrix U133Plus2 array using several gender-specific genes (X (inactive)-specific transcript [XIST], eukaryotic translation initiation factor 1A, Y-linked [EIF1AY], and DEAD [Asp-Glu-Ala-Asp] box polypeptide 3, Y-linked [DDDX3Y]) and found that 40 samples from 3 datasets were erroneously described. …”
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Mitochondria of transformed cell as a target of antitumor influence by E. M. Frantsiyants, I. V. Neskubina, E. A. Sheiko

“…Mitochondria are intracellular organelles in eukaryotic cells that participate in bioenergy metabolism and cell homeostasis, including ATP generation through electron transport and oxidative phosphorylation in combination with oxidation of metabolites by the tricarboxylic acid cycle and fatty acid catabolism via β-oxidation. the production of reactive oxygen species, as well as the initiation and implementation of apoptosis. …”
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Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer by Marco Ragusa, Cristina Barbagallo, Duilia Brex, Angela Caponnetto, Matilde Cirnigliaro, Rosalia Battaglia, Davide Barbagallo, Cinzia Di Pietro, Michele Purrello

“…Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. …”
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A gene expression atlas of Nicotiana tabacum across various tissues at transcript resolution by Shizhou Yu, Jufen Wan, Jufen Wan, Tenghang Xu, Tenghang Xu, Jie Zhang, Linggai Cao, Jie Liu, Hongfeng Liu, Xueliang Ren, Zhixiao Yang

“…This mechanism is widespread in eukaryotes and plays a crucial role in development, environmental adaptation, and stress resistance. …”
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