A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course and Pathogenesis by Isabella Bordi, Renato Umeton, Vito A. G. Ricigliano, Viviana Annibali, Rosella Mechelli, Giovanni Ristori, Francesca Grassi, Marco Salvetti, Alfonso Sutera

“…The model offers a new context to rethink key problems such as “missing heritability” and “hidden environmental structure” in the etiology of complex traits.…”
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PRMT5 Inhibitor EPZ015666 Decreases the Viability and Encystment of <i>Entamoeba invadens</i> by Rigoberto Ortiz-Hernández, Elmer Joel Millán-Casarrubias, Jeni Bolaños, Susana Munguía-Robledo, Carlos Vázquez-Calzada, Elisa Azuara-Licéaga, Jesús Valdés, Mario Alberto Rodríguez

“…<i>Entamoeba histolytica</i>, the etiologic agent of human amebiasis, has two stages in its life cycle, the trophozoite, which is the replicative form, and the cyst, corresponding to the infective phase. …”
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ZBP1 senses Brucella abortus DNA triggering type I interferon signaling pathway and unfolded protein response activation by Marco Túlio R. Gomes, Erika S. Guimarães, Erika S. Guimarães, Sergio C. Oliveira, Sergio C. Oliveira, Sergio C. Oliveira

“…Brucella abortus is the etiologic agent of brucellosis in livestock and humans, leading to significant economic losses and public health impact. …”
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Skin and Soft Tissue Infections in Patients with Solid Tumours by Diamantis P. Kofteridis, Antonios Valachis, Eirini Koutsounaki, Sofia Maraki, Eleni Mavrogeni, Foteini N. Economidou, Dimitra Dimopoulou, Kostas Kalbakis, Vassilis Georgoulias, George Samonis

“…Skin and soft tissue infections (SSTIs) in cancer patients represent a diagnostic challenge, as etiologic diagnosis is often missing, and clinical assessment of severity is difficult. …”
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The Effect of Ca and Mg Concentrations and Quantity and Their Correlation with Caries Intensity in School-Age Children by Milaim Sejdini, Kastriot Meqa, Nora Berisha, Ekrem Çitaku, Nora Aliu, Sokol Krasniqi, Sami Salihu

“…Besides the fundamental factors, saliva with its ingredient is one of the main etiologic factors of caries presence. In the development of dental caries, the relationship between demineralization and remineralization is influenced by the presence of saliva, which facilitates the transportation of ions, oral bacteria, and fermentable carbohydrates to the exposed surfaces of teeth. …”
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Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study by Guangming Dai, Yajuan Ran, Jiajia Wang, Xingru Chen, Junnan Peng, Xinglong Li, Huojin Deng, Min Xiao, Tao Zhu

“…Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is highly heterogeneous with a plethora of different etiologic factors and inflammatory presentations. COPD with higher blood eosinophil count is associated with increased readmission rates and better corticosteroid responses. …”
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In Silico Screening of Putative Corynebacterium pseudotuberculosis Antigens and Serological Diagnosis for Caseous Lymphadenitis in Sheep by Enzyme-Linked Immunosorbent Assay by Daniela Droppa-Almeida, Caroline de Santana Ferreira, Ioná Brito, Sibele Borsuk, Jorge Alberto López Rodríguez, Isabel Bezerra Lima-Verde, Francine Ferreira Padilha

“…Corynebacterium pseudotuberculosis is the etiologic agent of Caseous Lymphadenitis (CLA), a disease leading to severe damage in sheep and goats farming due to the lack of serological diagnosis, treatment, and effective prophylaxis. …”
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Isolation of Extended-Spectrum β-lactamase- (ESBL-) Producing Escherichia coli and Klebsiella pneumoniae from Patients with Community-Onset Urinary Tract Infections in Jimma Univer... by Mengistu Abayneh, Getnet Tesfaw, Alemseged Abdissa

“…A hospital-based cross-sectional study was conducted, and a total of 342 urine samples were cultured on MacConkey agar for the detection of etiologic agents. Double-disk synergy (DDS) methods were used for detection of ESBL-producing strains. …”
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Diagnostic Management and Surgical Treatment of Isolated Tricuspid Regurgitation by Arthur Cicupira Rodrigues de Assis, Gustavo Andre Boeing Boros, Lea Maria Macruz Ferreira Demarchi, Thiago Luis Scudeler, Paulo Cury Rezende

“…Primary tricuspid regurgitation in the absence of pulmonary hypertension and of unknown etiology is a very rare condition with scarce data about its diagnosis, treatment, and follow-up. …”
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Utility of Cand PCR in the Diagnosis of Vulvovaginal Candidiasis in Pregnant Women by Eduardo García-Salazar, Paola Betancourt-Cisneros, Xóchitl Ramírez-Magaña, Hugo Díaz-Huerta, Erick Martínez-Herrera, María Guadalupe Frías-De-León

“…Cand PCR showed low sensitivity for detecting <i>Candida</i> spp. directly from vaginal swabs, but it was useful for identifying the etiologic agent and reducing the time to obtain the result, which is usually at least 48 h.…”
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The value of metagenomic next-generation sequencing in the diagnosis of fever of unknown origin by Lan Min Lai, Qing-gen Chen, Yang Liu, Rui Zhao, Mei Ling Cao, Lei Yuan

“…Little is known about the clinical impact of mNGS in the etiological diagnosis of FUO. This study focuses on the value of mNGS in the etiologic diagnosis of FUO by diagnostic performance, further clarifying the value of mNGS in clinical management. …”
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Tailored BEST Exercise Protocol in Heart Failure Rehabilitation by Kevin Triangto, Basuni Radi, Bambang Budi Siswanto, Tresia Fransiska Ulianna Tambunan, Teuku Heriansyah, Alida Rosita Harahap, Aria Kekalih, Ade Meidian Ambari, Bambang Dwiputra, Dwita Rian Desandri, Hajime Katsukawa, Anwar Santoso

“…This study evaluated the protocol's effects on HFrEF patients and classified responses based on VO2max changes.   Methods In this etiologic study with prospective cohort design, all participants underwent a three-month cardiac rehabilitation program using the BEST Exercise Protocol. …”
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Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile by Luz María Medrano, Carlos Taxonera, Cristina González-Artacho, Virginia Pascual, María Gómez-García, Manuel Barreiro-de Acosta, José L. Pérez-Calle, Fernando Bermejo, Antonio López-Sanromán, Dolores Martín Arranz, Javier P. Gisbert, Juan Luis Mendoza, Javier Martín, Concepción Núñez, Elena Urcelay

“…The expression profile of five genes (S100A8-S100A9, G0S2, TNFAIP6, and IL11) reportedly predicted response to IFX and we aimed at investigating their etiologic role through genetic association analysis. …”
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Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Tric... by Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu

“…ABSTRACT Trichomonas vaginalis is the etiologic agent of trichomoniasis, one of the most common non-viral sexually transmitted infections globally. …”
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Doença de chagas e seus vetores: Conhecer para prevenir! by Flavia dos Santos, Jairo Torres Magalhães-Junior, Ianei de Oliveira Carneiro, Ellenise Elsa Emidio Bicalho, Maurício dos Santos Conceição, Carlos Roberto Franke

“…Abstract: This qualitative, descriptive study reports the experience in extension activities developed by students, technicians and professors of the Veterinary Medicine course at the Federal University of West Bahia (UFOB) as a result of a larger project of teaching, research and extension with the population from the Santo Inácio district, Gentio do Ouro, Bahia, an endemic region for Trypanosoma cruzi, the etiologic agent of Chagas disease (CD). In the district, two extension activities were carried out, with the participation of 21.9% (56/255) and 30.6% (78/255) of the population. …”
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Disease burden of biliary tract cancer in 204 countries and territories, 1990–2021: A comprehensive demographic analysis of the Global Burden of Disease Study 2021 by Xuheng Sun, Jiangmei Liu, Wei Zhang, Yijun Wang, Yan Jiang, Lijun Wang, Yixin Zou, Yuxuan Xiao, Yongbing Xiang, Maolan Li, Maigeng Zhou, Yingbin Liu, Sihan Zhou, Xiuyuan Hao

“…This study provided a comprehensive comparison of differences in the burden of disease across populations and over time, and further presented evidence concerning the formulation of prevention and control policies and etiologic studies for BTCs and proposed logical hypotheses to investigate.…”
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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

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Impact of Population Stratification on Family-Based Association in an Admixed Population by T. B. Mersha, L. Ding, H. He, E. S. Alexander, X. Zhang, B. G. Kurowski, V. Pilipenko, L. Kottyan, L. J. Martin, D. W. Fardo

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The potential of urinary miR-200c-3p as a biomarker of fluorosis in rats by Ailin Li, Jian Wang, Xinyue Meng, Xu Ma, Ying Liu, Hanying Li, Zhe Mo, Rui Zhang, Lei Wu, Shirui Yan, Paula Fiorella Chacon Campoverde, Gazala Zafar, Yongzheng Ma, Wenjun Que, Zhe Li, Tuo Wang, Korto Fatti Tarnue, Junrui Pei

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Clinical Characteristics and Management of Hypercalcemic Crisis in 155 Patients: A Single Center Retrospective Study by Yuqing Qu, Yang Liu, Xianling Wang, Qinghua Guo, Jin Du, Yu Pei, Jianming Ba, Weijun Gu, Jingtao Dou, Zhaohui Lv, Yiming Mu

“…The general data, clinical manifestations, etiology, photographic examination, emergency treatment, etiological treatment, and prognosis were analysed. …”
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