RETRACTED: The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model by Yukihiro Hiramatsu, Koichiro Suzuki, Takashi Nishida, Naoki Onoda, Takashi Satoh, Shizuo Akira, Masahito Ikawa, Hiroko Ikeda, Junzo Kamei, Sandra Derouiche, Makoto Tominaga, Yasuhiko Horiguchi

“…This disease is characterized by severe and uncontrollable coughing, which imposes a significant burden on patients. However, its etiological agent and the mechanism are totally unknown because of a lack of versatile animal models that reproduce the cough. …”
Get full text

The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis by Luiza-Roxana Dorobantu-Lungu, Viviana Dinca, Andrei Gegiu, Dan Spataru, Andreea Toma, Luminita Welt, Mihaela Florentina Badea, Constantin Caruntu, Cristian Scheau, Ilinca Savulescu-Fiedler

“…<b>Background:</b> The purpose of this article is to overview the clinical significance of left supraclavicular adenopathy and review the etiology of inferior vena cava (IVC) thrombosis, starting from a presentation of a rare case of renal cell carcinoma (RCCs) with Xp11.2 translocation involving TFE3 gene fusion. …”
Get full text

Microbial dynamics of acute pancreatitis: integrating culture, sequencing, and bile impact on bacterial populations and gaseous metabolites by Agnieszka Chmielarczyk, Edyta Golińska, Anna Tomusiak-Plebanek, Natalia Żeber-Lubecka, Natalia Żeber-Lubecka, Maria Kulecka, Maria Kulecka, Antoni Szczepanik, Katarzyna Jedlińska, Krzysztof Mech, Konrad Szaciłowski, Agata Kuziak, Agata Pietrzyk, Magdalena Strus

“…Moreover, NGS verified the presence of the Fusobacteriota phylum and Fusobacteriaceae family only in rectal swabs, which may indicate a link between this type of bacteria and the etiology of diverticulitis. We observed that Escherichia coli 33 isolated from stool exhibited active gaseous metabolite production (mainly hydrogen).ConclusionsThe abundant production of hydrogen may substantially impact enzymatic processes, inducing specific alterations in disulfide bonds and trypsin inactivation. …”
Get full text

Association of HIVEP3 Gene and Lnc RNA with Femoral Neck Bone Mineral Content and Hip Geometry by Genome-Wide Association Analysis in Chinese People by Weiwei Hu, Jinwei He, Luyue Qi, Chun Wang, Hua Yue, Jiemei Gu, Hao Zhang, Yi Wang, Zhenlin Zhang

“…These results provide important information for us to further understand the etiology and genetic pathogenesis of osteoporosis. …”
Get full text

Peripheral Nerve Blocks Are Associated With Decreased Early Medical Complications, Dislocations, and Opioid Consumption Following Total Hip Arthroplasty by Brian P. McCormick, MD, Sean B. Sequeira, MD, Mark D. Hasenauer, MD, Robert P. McKinstry, MD, Frank R. Ebert, MD, Henry R. Boucher, MD

“…Methods: Opioid-naive patients who received PNBs on the same day as undergoing THA for degenerative etiologies were identified from a large national database and matched 1:5 to a control cohort using propensity scoring. …”
Get full text

Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis by Noelia Marquez Pete, Cristina Perez Ramirez, Maria del Mar Maldonado Montoro, Fernando Martinez Martinez, Fernando Fernández-Llimos, Antonio Sánchez Pozo, María del Carmen Ramirez Tortosa, Alberto Jiménez Morales

“…Introduction Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration of the joints, leading to severe pain and functional disability. …”
Get full text

An investigation of a hemophilia A female with heterozygous intron 22 inversion and skewed X chromosome inactivation by Xiaoyan Tan, Yi Yang, Xia Wu, Jing Zhu, Teng Wang, Huihui Jiang, Shu Chen, Shifeng Lou

“…Molecular genetic examinations, karyotype analysis, X-chromosome inactivation testing, and targeted bioinformatic analysis were used to identify potential genetic etiologies.ResultsThe proband exhibited a severe bleeding phenotype and was found to be a heterozygous carrier of an intron 22 inversion (Inv22) with a normal chromosomal karyotype. …”
Get full text

Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis by Shuji Kanmura, Akihito Tanaka, Kazuki Yutsudou, Kosuke Kuwazuru, Fukiko Komaki, Yuga Komaki, Hiromichi Iwaya, Shiho Arima, Fumisato Sasaki, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido

“…Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. …”
Get full text

Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2 by Brett A. Clementz, Ishanu Chattopadhyay, S. Kristian Hill, Jennifer E. McDowell, Sarah K. Keedy, David A. Parker, Rebekah L. Trotti, Elena I. Ivleva, Matcheri S. Keshavan, Elliot S. Gershon, Godfrey D. Pearlson, Carol A. Tamminga, Robert D. Gibbons

“…Conclusions: This low-burden algorithm using clinical and cognitive measures achieved high classification accuracy and can support Biotype-specific etiological and treatment investigations in clinical and research environments. …”
Get full text

Higher Trace Elements and Lower Fatty Acids Levels in Erythrocytes as Predictors of Preeclampsia by Ruth Widhiati Raharjo Putri, Damar Prasmusinto, Noroyono Wibowo, Rima Irwinda, Yuditiya Purwosunu, Yudianto Budi Saroyo

“…However, predictors of preeclampsia need to be observed to add more focus on the etiology and prevention of preeclampsia. The imbalances of trace elements and fatty acids play an important role in preeclampsia. …”
Get full text

Vesicoureteral Reflux in Children with Accidental Diagnosis of Unilateral Small Size Kidney by Mohsen Mohammadi, Khadijeh Ebrahimi, Soraya Khafri, Maryam Nikpour, Hadi Sorkhi

“…This suggests that VUR may constitute a significant etiological factor in the development of small-size kidneys. …”
Get full text

Novel nonsense mutation in gene CHRNA2 identified by whole-genome sequencing in infant with epilepsy disorder: A case report by Sultan Makhmetov, Kamila Temirkhanova, Saule Rakhimova, Nazerke Satvaldina, Ruslan Kalendar, Ulan Kozhamkulov, Aidos Bolatov, Mirgul Bayanova, Assiya Bazenova, Lyazzat Nazarova, Ainur Akilzhanova, Ulykbek Kairov

“…Our results revealed an identification of a novel mutation in a 2-year-old male patient who suffered from recurrent epileptic seizures of unknown etiology. The detected variant is heterozygous and located in gene CHRNA2 (chr8:27321348, NM_000742, c.612G > A, p.Trp204∗) in exon 6. …”
Get full text

Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)—Two-Year Follow-Up Study by Leila Yazdanpanah, Hajieh Shahbazian, Iraj Nazari, Hamid Reza Arti, Fatemeh Ahmadi, Seyed Ehsan Mohammadianinejad, Bahman Cheraghian, Saeed Hesam

“…These findings provide support for a multifactorial etiology for DFU.…”
Get full text

Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia by Xiaoqian Ma, Nana Feng, Lena Palaniyappan, Luolong Cao, Zixin Gu, Jujiao Kang, Liu Yuan, Lijun Ouyang, Yujue Wang, Chunwang Li, Ke Jin, Xiaogang Chen, Jianfeng Feng, Ying He, Qiang Luo

“…The stratified association between the striatum and stress highlights the differential vulnerability to stress, contributing to the complexity of the gene-by-environment etiology of schizophrenia.…”
Get full text

Modified Trochanteric Flip Osteotomy in Varus Intertrochanteric Osteotomy for Treatment of Legg–Calvé–Perthes Disease by Andrea Laufer, Carina Antfang, Georg Gosheger, Adrien Frommer, Gregor Toporowski, Henning Tretow, Robert Roedl, Bjoern Vogt

“…<b>Background/Objectives</b>: Legg–Calvé–Perthes disease (LCPD) presents challenges in treatment due to its varied course and unclear etiology. This study aimed to evaluate the efficacy of combining proximal femoral varus osteotomy (PFVO) with a modified trochanteric flip osteotomy to address biomechanical consequences and improve hip abductor muscle strength. …”
Get full text

The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis by Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

“…We conclude that the E3L.GK+/− mouse is a promising novel diet-inducible disease model for investigation of the etiology and evaluation of drug treatment on diabetic atherosclerosis.…”
Get full text

Relationship of serum irisin levels, physical activity, and metabolic syndrome biomarkers in obese individuals with low-calorie intake and non-obese individuals with high-calorie i... by Jalal Hejazi, Bijan Ghobadian, Nasrin Ghasemi, Hossein Sadeh, Nasim Abedimanesh, Mehran Rahimlou

“…Abstract Background Despite all the advances in our knowledge regarding obesity, our understanding of its etiology is still far from complete. This study aimed to evaluate the association of serum irisin levels with physical activity and some of the metabolic syndrome-related biomarkers among obese people with low-calorie intake and non-obese people with high-calorie intake. …”
Get full text

A Genome-Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients by Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen

“…Among the 9 confirmed lncRNAs, lncRNA MSTRG.128697 and lncRNA MSTRG.128958 were novel and human-specific; however, further validation is required. lncRNA MSTRG.63013 has orthologous sequences in the mouse genome and was identified as a key node for etiology and pathophysiology in animal studies, which will help understand the epigenetic mechanisms of T1D complications.…”
Get full text

HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC by Chiao-Ling Li, Chia-Lang Hsu, You-Yu Lin, Ming-Chih Ho, Rey-Heng Hu, Sheng-Tai Tzeng, Ya-Chun Wang, Yasuhito Tanaka, Pei-Jer Chen, Shiou-Hwei Yeh

“…These insights are crucial for understanding viral etiology-specific carcinogenesis and guiding surveillance policies for HBCV-HCC post-antiviral therapy.…”
Get full text

Diagnostics and treatment of exocrine pancreatic insufficiency: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…To present the modern concept of etiology and pathogenesis of exocrine pancreatic insufficiency to general practitioners as well as with the established approach to diagnostics and treatment of this syndrome. …”
Get full text