Linear IgA bullous dermatosis–a fifty year experience of Warsaw Center of bullous diseases by Cezary Kowalewski, Katarzyna Wozniak

“…Our immunoelectron microscopic studies showed that the epitopes recognized by LABD sera are ultrastructurally localized in the lamina lucida. …”
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Biparatopic antibodies: therapeutic applications and prospects by David L. Niquille, Kyle M. Fitzgerald, Nimish Gera

“…Biparatopic antibodies (bpAbs) bind distinct, non-overlapping epitopes on an antigen. This unique binding mode enables new mechanisms of action beyond monospecific and bispecific antibodies (bsAbs) that can make bpAbs effective therapeutics for various indications, including oncology and infectious diseases. …”
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1.4 nm gold nanoparticle-antibody conjugates for in situ gold immunolabelling after transduction into living human cells by Groysbeck, Nadja, Haeberlé, Anne Marie, Ory, Stéphane, Hanss, Victor, Eltsov, Mikhael, Schultz, Patrick, Zuber, Guy

“…Their abilities to bind to and label their corresponding epitopes within living cells after cytosolic delivery by electroporation are documented here.…”
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Role of Adaptive Immunity in Alcoholic Liver Disease by Emanuele Albano

“…Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation. …”
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Developability considerations for bispecific and multispecific antibodies by Alaa Amash, Gesa Volkers, Patrick Farber, Daniel Griffin, K. Shawn Davison, Allison Goodman, Raffi Tonikian, Aaron Yamniuk, Bryan Barnhart, Tim Jacobs

“…Bispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to address previously difficult-to-treat or incurable diseases. …”
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A tailored lectin microarray for rapid glycan profiling of therapeutic monoclonal antibodies by Shen Luo, Baolin Zhang

“…These lectins have been specifically tailored to selectively bind to common N-glycan epitopes found in therapeutic IgG antibodies. By utilizing intact glycoprotein samples, our nine-lectin microarray provides a high-throughput platform for rapid glycan profiling, enabling comparative analysis of glycosylation patterns. …”
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Antibodies directed to antigens secreted by murine epithelioid macrophages modulate BCG-induced granulomata by Mario Mariano, Tania Aguiar, Celia R. W. Carneiro, Edilberto Postol, Venânclo A. F. Alves, Ricardo Ribeiro-dos-Santos

“…The immunoglobulin fraction of this antiserum reacted, by immunocytochemical methods, with epitopes in the cell membrane of macrophages adherent to coverslips subcutaneously implanted for 14 days; but not for 5 days. …”
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Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein by Pooja Gogia, Yiqing Xu

“…Studies on autoantigens on the platelets suggested epitopes to be located predominantly on the GP IIb/IIIa receptor or integrin αIIbβ3, though the trigger for the development of ITP is unclear. …”
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The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies by Randall J. Brezski, David M. Knight, Robert E. Jordan

“…Human anti-IgG hinge (HAH) autoantibodies constitute a class of immunoglobulins that recognize cryptic epitopes in the hinge region of antibodies exposed after proteolytic cleavage, but do not bind to the intact IgG counterpart. …”
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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery by Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton

“…These birds produce robust immune responses, consisting of antigen-specific antibodies targeting diverse epitopes with a range of affinities. Biophysical attributes are favorable, with good developability profiles and low predicted immunogenicity.…”
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Malaria: Factors affecting disease severity, immune evasion mechanisms, and reversal of immune inhibition to enhance vaccine efficacy. by Xin-Zhuan Su, Fangzheng Xu, Rachel V Stadler, Awet Alem Teklemichael, Jian Wu

“…Current vaccine research focuses on identifying conserved and protective epitopes, developing multivalent vaccines (including the whole parasite), and using more powerful adjuvants. …”
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Efficient reduction of β-lactoglobulin allergenicity in milk using Clostridium tyrobutyricum Z816 by Qianru Zhao, Yuwei Wang, Zhengming Zhu, Quanyu Zhao, Liying Zhu, Ling Jiang

“…The hydrolyzed peptides were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and analyzed by molecular modeling, which indicated that C. tyrobutyricum Z816 could effectively degrade the antigenic epitopes of β-LG. Finally, the concentration and digestibility of β-LG in actual samples was quantified using enzyme-linked immunosorbent assay (ELISA) and gastrointestinal digestion simulation experiments. …”
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Rational engineering of minimally immunogenic nucleases for gene therapy by Rumya Raghavan, Mirco J. Friedrich, Indigo King, Samuel Chau-Duy-Tam Vo, Daniel Strebinger, Blake Lash, Michael Kilian, Michael Platten, Rhiannon K. Macrae, Yifan Song, Lucas Nivon, Feng Zhang

“…Through MHC-associated peptide proteomics (MAPPs) analysis, we identify putative immunogenic epitopes on each nuclease. Using computational modeling, we rationally design these proteins to evade the immune response. …”
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Cow milk αs1-casein induces allergic responses in a mouse model of atopy by Guangyu Wang, Xiaofeng Yu, Yanjun Cong, Linfeng Li

“…We had identified αs1-casein and its epitopes in previous studies. The present study aimed to evaluate the allergic mechanism of αs1-casein in a BALB/c mouse model. …”
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Prediction of IL4 Inducing Peptides by Sandeep Kumar Dhanda, Sudheer Gupta, Pooja Vir, G. P. S. Raghava

“…It was also observed that IL4 inducing and noninducing epitopes differ in compositional and motif pattern. …”
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Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets by Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

“…Presence of sialyl Lewis x epitopes on PSGL-1 was crucial for its interaction with SSL5. …”
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Identification of Allergenic Tropomyosins with Known and Unknown Sequences in Seafood Products by Marta Godlewska, Piotr Minkiewicz, Małgorzata Darewicz, Anna Iwaniak

“…Some peptides from the boiled samples contained entire linear epitopes. The prediction of tropomyosin cleavage sites failed in the case of fried products. …”
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MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies by Olubukola M. Abiona, Nianshuang Wang, Sarah R. Leist, Alexandra Schäfer, Adam S. Cockrell, Lingshu Wang, Sandhya Bangaru, Laura Stevens, Rachel L. Graham, Jacob F. Kocher, Yaroslav Tsybovsky, Masaru Kanekiyo, Azad Kumar, Kaitlyn M. Morabito, Osnat Rosen, Wei Shi, Anne Werner, Yi Zhang, Cynthia Ziwawo, Christian K.O. Dzuvor, Charis Palandjian, Connor Eastman, Hannah R. Matthews, Jeswin Joseph, James D. Chappell, Wing-Pui Kong, John R. Mascola, Andrew B. Ward, Mark R. Denison, Ralph Baric, Jason S. McLellan, Barney S. Graham, Kizzmekia S. Corbett-Helaire

“…Summary: The COVID-19 pandemic underscores the need to prepare for future emerging coronavriuses (CoVs) by understanding the principles behind effective CoV vaccine design such as protective immunity and antibody responses. To study which epitopes and subdomains contribute to in vivo protection, we utilized the prefusion-stabilized spike protein of MERS-CoV, MERS S-2P, as a vaccine immunogen. …”
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Recombinant Pvs48/45 antigen expressed in E. coli generates antibodies that block malaria transmission in Anopheles albimanus mosquitoes. by Myriam Arévalo-Herrera, Andrés F Vallejo, Kelly Rubiano, Yezid Solarte, Catherin Marin, Angélica Castellanos, Nora Céspedes, Sócrates Herrera

“…Results indicate the presence of reactive epitopes in the Pvs48/45 recombinant product that induce antibodies with TB activity. …”
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Humatch - fast, gene-specific joint humanisation of antibody heavy and light chains by Lewis Chinery, Jeliazko R. Jeliazkov, Charlotte M. Deane

“…Humatch’s optimization toward specific genes and good VH/VL pairing increases the chances that final designs will be stable and express well and reduces the chances of immunogenic epitopes forming between the two chains. Humatch’s training data and source code are provided open-source.…”
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