Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Eff... by Anastasia Latanova, Stefan Petkov, Yulia Kuzmenko, Athina Kilpeläinen, Alexander Ivanov, Olga Smirnova, Olga Krotova, Sergey Korolev, Jorma Hinkula, Vadim Karpov, Maria Isaguliants, Elizaveta Starodubova

“…Reverse transcriptase (RT) is a key enzyme in viral replication and susceptibility to ART and a crucial target of immunotherapy against drug-resistant HIV-1. RT induces oxidative stress which undermines the attempts to make it immunogenic. …”
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Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect by Coralia Cuadrado, Alex Mantilla, Luis Hidalgo, Diego Punina

“…Background: The rise of drug-resistant bacteria, including Staphylococcus aureus and Escherichia coli, presents a significant healthcare challenge. …”
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Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy by Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci

“…Protocadherin 19 (PCDH19) is an adhesion molecule involved in cell-cell interaction whose mutations cause a drug-resistant form of epilepsy, named PCDH19-Clustering Epilepsy (PCDH19-CE, MIM 300088). …”
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Coexistence of blaMIR-1 and blaNDM-1 resistance genes with a novel ST type in Enterobacter roggenkampii from a stool sample: A genome sequencing study by Qin Wang, Sayyed Salman, Ye Luo, XiaoMei Tong

“…Additionally, the genome harbours three antibiotic resistance genes and a newly discovered plasmid, pL3897_NDM, highlighting the need for surveillance of drug-resistant pathogens. Conclusions: The discovery of a new sequence type and the presence of an antibiotic resistance gene in E. roggenkampii L3897 underscores the need for ongoing genomic surveillance to effectively manage multidrug-resistant pathogens.…”
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Postpartum Tuberculosis: A Diagnostic and Therapeutic Challenge by Vijay Kodadhala, Alemeshet Gudeta, Aklilu Zerihun, Odene Lewis, Sohail Ahmed, Jhansi Gajjala, Alicia Thomas

“…Separation of mother and infant is only necessary when the mother has received treatment for less than 2 weeks, is sputum smear-positive, or has drug-resistant TB. This case highlights important aspects for management of TB during the postpartum period which has a higher morbidity. …”
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Isolation and characterization of a novel lytic phage K14-2 infecting diverse species of the genus Klebsiella and Raoultella by Seomin Kang, Jeong-Eun Han, Young-Sik Choi, In-Chul Jeong, Jin-Woo Bae, Jin-Woo Bae, Jin-Woo Bae

“…Multi-drug-resistant bacteria pose a significant global threat to public health, particularly among patients with critical nosocomial infection. …”
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Prediction model, risk factor score and ventilator-associated pneumonia: A two-stage case-control study by Hua Meng, Yuxin Shi, Kaming Xue, Di Liu, Xiongjing Cao, Yanyan Wu, Yunzhou Fan, Fang Gao, Ming Zhu, Lijuan Xiong

“…Results: LASSO, RF and XGBoost consistently revealed significant associations of length of stay before MV, MV time, surgery, tracheotomy, multiple drug resistant organism infection, C-reactive protein, PaO2, and APACHE II score with VAP. …”
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Utility of CB-NAAT in cutaneous tuberculosis: A prospective observational study by Parul Verma, Srishti Tripathi, Swastika Suvirya, Prakriti Shukla, Amita Jain, Atin Singhai, Urmila Singh, Nishant Verma

“…It can prove as a promising tool for early detection of cutaneous TB along with drug-resistant TB especially in the high endemic zones.…”
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Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy by Paulina Kinga Drobot, Aleksandra Banasik, Karolina Owsińska‐Schmidt, Marcin Wrzosek, Przemysław Podgórski

“…Diagnosis of TLE in dogs based on MRI volumetry in correlation with EEG examination, especially for dogs with drug‐resistant epilepsy, can influence the development of new therapeutic options, such as surgery.…”
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Toxicological assessment of citral and geraniol: Efflux pump inhibition in Staphylococcus aureus and invertebrate toxicity by Gildênia Alves de Araújo, Cícera Datiane de Morais Oliveira Tintino, Raimundo Luíz Silva Pereira, Isaac Moura Araújo, Cícera Laura Roque Paulo, João Arthur de Oliveira Borges, Ewerton Yago de Sousa Rodrigues, Ângella Eduarda da Silva, Francisco Assis Bezerra da Cunha, Zildene de Sousa Silveira, Nair Silva Macedo, Henrique Douglas Melo Coutinho, José Maria Barbosa Filho, Daniela Maria do Amaral Ferraz Navarro, Francisco Roberto de Azevedo, Saulo Relison Tintino

“…This study aimed to evaluate the antibacterial activity against multi-drug-resistant strains carrying efflux pumps and assess their toxicity on Drosophila melanogaster and Aedes aegypti models. …”
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Safety and Effectiveness of BPaL-Based Regimens to Treat Multidrug-Resistant TB: First Experience of an Italian Tuberculosis Referral Hospital by Gina Gualano, Maria Musso, Paola Mencarini, Silvia Mosti, Carlotta Cerva, Pietro Vittozzi, Antonio Mazzarelli, Angela Cannas, Assunta Navarra, Stefania Ianniello, Paolo Faccendini, Fabrizio Palmieri

“…<b>Background/Objectives</b>: Tuberculosis (TB) is preventable and curable, but multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) pose significant challenges worldwide due to the limited treatment options, lengths of therapies, and high rates of treatment failure. …”
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Bacteria-Inspired Synthesis of Silver-Doped Zinc Oxide Nanocomposites: A Novel Synergistic Approach in Controlling Biofilm and Quorum-Sensing-Regulated Virulence Factors in <i>Pseu... by Abirami Karthikeyan, Manoj Kumar Thirugnanasambantham, Fazlurrahman Khan, Arun Kumar Mani

“…Multidrug-resistant <i>Pseudomonas aeruginosa</i> infections pose a critical challenge to healthcare systems, particularly in nosocomial settings. This drug-resistant bacterium forms biofilms and produces an array of virulent factors regulated by quorum sensing. …”
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Monitoring the Spread of Multidrug-Resistant <i>Escherichia coli</i> Throughout the Broiler Production Cycle by Victor Dellevedove Cruz, Danilo Henrique Rabaçal Alves, Jamile Kellen de Souza, Maísa Fabiana Menck-Costa, Bruno Henrique Dias de Oliva, Ana Angelita Sampaio Baptista, Alexandre Oba, Fabrizio Matté, Kácio Emílio Borges Baierle, Sérgio Paulo Dejato da Rocha, Kelly Cristina Tagliari de Brito, Benito Guimarães de Brito, Gerson Nakazato, Marcio Costa, Renata Katsuko Takayama Kobayashi

“…The extensive use of antimicrobials in broiler production is changing the bird microbiota, fostering drug-resistant bacteria, and complicating therapeutic interventions, making the problem of multidrug resistance global. …”
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Neonatal Intensive Care Unit Apocalypse—Rise of the World Health Organization Priority Pathogens by Apurva Kawdiya, Swati Bhalse, Gaurav Mogra, Kewal K Arora

“…Conclusion: Burden of drug-resistant organisms in NICU is increasing at an alarming rate. …”
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Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Denis Dekugmen Yar

“…Artemether-lumefantrine (AL) is a highly effective and commonly used Artemisinin-based Combination Therapy (ACT) for treating uncomplicated malaria caused by Plasmodium falciparum, including drug-resistant strains. However, ineffective regulatory systems in resource-limited settings can lead to the infiltration of poor-quality and counterfeit antimalarial medicines into the pharmaceutical supply chain, causing treatment failures, prolonged illness, and disease progression. …”
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Isolation and Evaluation of Clinically Important Acinetobacter Baumannii From Intensive Care Unit Samples by Mohamed Mowfik Sehree, Hanaa N. Abdullah, Amani M. Jasim

“…The current findings suggest that automated Vitek 2 system is the most common method to accurately detect the isolates and evaluate multi-drug resistant A. baumannii among patients. …”
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Ventilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review by Harinivaas Shanmugavel Geetha, Yi Xiang Teo, Sharmitha Ravichandran, Amos Lal

“…This pattern is attributed to the elevated incidence of drug-resistant infections and the delayed initiation of antimicrobial treatment. …”
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Glycemic Profile and Clinical Treatment in Patients with Diabetes Mellitus-Tuberculosis: An Update Scoping Review by Rissaadah S, Nursiswati N, Pahria T

“…Severe hyperglycemia in patients with DM-TB is associated with an increased risk of TB treatment failure, a long recovery time, and the likelihood of developing multi-drug-resistant tuberculosis (MDR-TB). In addition, patients with DM-TB who did not start TB treatment were more likely to have poorer glycemic control than patients with DM-TB who underwent active TB treatment.Conclusion: Patients with DM-TB, such as MDR-TB, are at a higher risk of poor glycemic control, treatment failure, and clinical severity. …”
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Safety and Efficacy of Cryoballoon Ablation of Atrial Fibrillation in relation to the Patients’ Age: Results from a Large Real-World Multicenter Observational Project by Luigi Sciarra, Saverio Iacopino, Giuseppe Arena, Claudio Tondo, Paolo Pieragnoli, Giulio Molon, Massimiliano Manfrin, Antonio Curnis, Antonio Dello Russo, Giovanni Rovaris, Giuseppe Stabile, Leonardo Calò, Gabriele Boscolo, Roberto Verlato

“…Methods. 2,534 patients underwent pulmonary vein isolation (PVI) by way of CBA for paroxysmal or persistent drug-resistant and symptomatic AF. The population was divided into age quartiles for evaluation, including (1) <53 years, (2) ≥53 and <61 years, (3) ≥61 and <67 years, and (4) ≥67 years. …”
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Allogenic faecal microbiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial... by Ivana Cibulkova, Veronika Rehorova, Hana Soukupova, Petr Waldauf, Monika Cahova, Jan Manak, Martin Matejovic, Frantisek Duska

“…In addition, animal experiments and observational data suggest other benefits such as reduced colonization with multi-drug resistant bacteria and improved gut barrier and immune function. …”
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