-
1021
Advances in chromosomal microarray analysis: Transforming neurology and neurosurgery
Published 2025-01-01“…In epilepsy, CMA helps identify genetic causes of drug-resistant seizures, enabling more targeted therapies and reducing adverse reactions. …”
Get full text
Article -
1022
The Global Challenge of <i>Campylobacter</i>: Antimicrobial Resistance and Emerging Intervention Strategies
Published 2025-01-01“…Resistance to fluoroquinolones, macrolides, and tetracyclines complicates treatment and increases the risk of severe infections. Drug-resistant <i>Campylobacter</i> is transmitted to humans via contaminated food, water, and direct contact with animals, highlighting its zoonotic potential. …”
Get full text
Article -
1023
Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi
Published 2025-06-01“…The study concluded that compounds 1615 and 1553 hold significant potential as lead molecules for developing new treatments against drug-resistant S. Typhi infections. This study illustrates how computational techniques, such as MD simulations and pharmacophore modeling, can speed up drug discovery, especially in the fight against antibiotic resistance.…”
Get full text
Article -
1024
Chemotherapeutic hormesis induced by the tumor microenvironment in refractory ovarian cancer
Published 2025-01-01“…Our findings indicate that NOS3 ovarian cancer cells, particularly drug-resistant variants, exhibit enhanced proliferation when exposed to low concentrations of these drugs. …”
Get full text
Article -
1025
Exploring post-rehabilitation plasticity with intra-cerebral recordings on anomic profiles
Published 2025-01-01“…BackgroundPatients with drug-resistant epilepsy involving the language network often exhibit anomic profiles in daily life due to difficulties with lexical selection processes. …”
Get full text
Article -
1026
Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA
Published 2023-04-01“…These results indicate that aptamer‐guided nano‐zinc carriers may be a potent carrier for the precise treatment of drug‐resistant tumors.…”
Get full text
Article -
1027
Biosynthesis of ZnO nanoparticles using banana peel pectin for antibacterial and photocatalytic applications
Published 2025-04-01“…Moreover, the p-ZnO NPs exhibited a significant bactericidal effect against drug-resistant gram-positive Staphylococcus aureus but were ineffective against gram-negative Escherichia coli.…”
Get full text
Article -
1028
The applications and mechanisms of Rosmarinus officinalis L. in the management of different wounds and UV-irradiated skin
Published 2025-01-01“…Wound healing is a complicated process involving interdependent stages, which may be impaired and delayed by infections with multi-drug resistant pathogens. Current medical strategies for wound healing, especially the treatment of non-healing wounds, exert limited therapeutic effects, thus become a dramatic challenge for modern medicine. …”
Get full text
Article -
1029
Impact of discontinuation of cephazolin prophylaxis on the incidence of postoperative adverse events in cataract surgery
Published 2025-01-01“…The routine use of systemic antimicrobial agents for preventing surgical site infections lacks strong evidence and may increase the risk of drug-resistant bacteria and adverse events. This study examined the impact of discontinuing cefazolin (CEZ) administration during the perioperative period of cataract surgery on the incidence of postoperative adverse events and medical costs. …”
Get full text
Article -
1030
Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host strain, and antibiotic pairing
Published 2025-02-01“…Supported by this interaction, here we explore the potential use of combined temperate phage and antibiotic against the multi-drug-resistant pathogen, Pseudomonas aeruginosa. In all, thirty-nine temperate phages were isolated from clinical strains, and a subset was screened for synergy with six antibiotics (ciprofloxacin, levofloxacin, meropenem, piperacillin, tobramycin, and polymyxin B), using checkerboard assays. …”
Get full text
Article -
1031
Evaluating Antimicrobial Effectiveness of Gold Nanoparticles against Streptococcus oralis
Published 2023-01-01“…Biofilm includes many microorganisms that causes the periodontal diseases. The increased drugs resistance against the infectious diseases is a major issue owing to excessive using of a broad spectrum of antibiotics. …”
Get full text
Article -
1032
KLF5 promotes esophageal squamous cell carcinoma radioresistance by targeting the Keap1-Nrf2 pathway
Published 2025-02-01“…KLF5 expression is upregulated in drug-resistant ESCC cells. Overexpression of KLF5 significantly increased cell viability and attenuated cellular responses to radiation. …”
Get full text
Article -
1033
Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport
Published 2025-02-01“…Abstract Plasmodium vivax is the most widespread malaria parasite affecting humans, and its eradication is challenging due to the spread of drug-resistant parasites and their ability to remain in liver as a dormant stage. …”
Get full text
Article -
1034
The effect of the nisin-based pharmaceutical formulation used in the treatment plan for cows with subclinical mastitis on the milk microbiota
Published 2024-09-01“…The research revealed presence of multi-drug resistant coliform bacteria, Streptococcus dysgalactiae, Aerococcus viridans, Staphylococcus aureus strains. …”
Get full text
Article -
1035
Mutant Prevention Concentration of Ciprofloxacin against Klebsiella pneumoniae Clinical Isolates: An Ideal Prognosticator in Treating Multidrug-Resistant Strains
Published 2019-01-01“…Estimation of the MPC in the case of multidrug-resistant isolates in the clinical setup may help in treating these drug-resistant strains.…”
Get full text
Article -
1036
Assessment of microbial diversity and antimicrobial resistance in raw camel milk: Genomic and phenotypic analysis of Kharai and Kutchi breeds of Gujarat, India
Published 2025-03-01“…Through phenotypic antimicrobial resistance analysis using the disc diffusion method, a significant number of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacterial isolates were identified. …”
Get full text
Article -
1037
Clinical Specimens are the Pool of Multidrug- resistant Pseudomonas aeruginosa Harbouring oprL and toxA Virulence Genes: Findings from a Tertiary Hospital of Nepal
Published 2021-01-01“…The multidrug- or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa carrying some virulence genes has become a global public health threat. …”
Get full text
Article -
1038
Antimicrobial and Antibiofilm Activity of 4-Benzylidene-2-methyl-oxazoline-5-one against Pathogen Bacteria
Published 2024-02-01“…Therefore, the discovery of new antimicrobial agents is crucial in controlling the spread of infections caused by drug-resistant bacteria. This study focuses on the synthesis of oxazoline and investigates the antimicrobial and anti-biofilm properties of this compound named 4-benzylidene-2-methyl-oxazoline-5-one. …”
Get full text
Article -
1039
Detection of OmpA and blaPER-1 Genes and Biofilm Formation in Acinetobacter baumannii Clinical Isolates
Published 2025-01-01“…Background: Multi-drug-resistant Acinetobacter baumannii (MDR A. baumannii) infections are an ongoing problem in many hospitals, particularly in intensive care units. …”
Get full text
Article -
1040
Intrahospital dissemination of multidrug-resistant Acinetobacter baumannii at a teaching hospital in Northeast of Mexico
Published 2025-03-01“…Summary: Background: Acinetobacter baumannii is an opportunistic drug-resistant Gram-negative coccobacillus associated with nosocomial infections, representing a worldwide public health problem. …”
Get full text
Article