Tuberculosis vaccines and therapeutic drug: challenges and future directions by Yajing An, Ruizi Ni, Li Zhuang, Ling Yang, Zhaoyang Ye, Linsheng Li, Seppo Parkkila, Ashok Aspatwar, Wenping Gong

“…Despite the deployment of the Bacille Calmette-Guérin (BCG) vaccine and available therapeutic agents, the escalation of drug-resistant Mycobacterium tuberculosis strains underscores the pressing need for more efficacious vaccines and treatments. …”
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Sustainable utilization of bovine adipose tissue derivatives as robust antimicrobial agents against Methicillin-resistant Staphylococcus aureus by Muhammed Abdelhameed Ismael Alcici, Salma Waheed Abdelhaleem, Karima Mogahed Fahim, Neveen Mohamed Saleh, Heba Saeed Farag

“…Hence, assessing new strategies for managing Multi-Drug Resistant (MDR) microorganisms is vital. In this study, the use of mechanically isolated mature adipose cells (MIMACs) and their lysate (Adipolysate) as a new sustainable antimicrobial agent was assessed against Methicillin-resistant Staphylococcus aureus (MRSA). …”
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Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes by Jianying Han, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Miaomiao Liu

“…Background: The increasing prevalence of drug-resistant tuberculosis (TB) underscores the urgent need for novel antimicrobial agents. …”
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Antifungal and Antibacterial Activity of Aqueous and Ethanolic Extracts of Different <i>Rosa rugosa</i> Parts by Žaneta Maželienė, Jolita Kirvaitienė, Kamilė Kaklauskienė, Rasa Volskienė, Asta Aleksandravičienė

“…With the rising incidence of drug-resistant pathogens, focus should be placed on biologically active compounds derived from plant species used in herbal medicine, as these compounds may provide a new source of antifungal and antibacterial activities. …”
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Data Mining Models in Prediction of Vancomycin-Intermediate <i>Staphylococcus aureus</i> in Methicillin-Resistant <i>S. aureus</i> (MRSA) Bacteremia Patients in a Clinical Care Set... by Wei-Chuan Chen, Jiun-Ling Wang, Chi-Chuan Chang, Yusen Eason Lin

“…Vancomycin-intermediate <i>Staphylococcus aureus</i> (VISA) is a multi-drug-resistant pathogen of significant clinical concern. …”
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Molecular Diagnosis of Periprosthetic Joint Infection by Quantitative RT-PCR of Bacterial 16S Ribosomal RNA by Mel S. Lee, Wen-Hsin Chang, Su-Chin Chen, Pang-Hsin Hsieh, Hsin-Nung Shih, Steve W. N. Ueng, Gwo-Bin Lee

“…Based on the promising clinical results, we were attempting to differentiate bacterial species or drug-resistant strains by using species-specific primers and to detect the persistence of bacteria during the interim period before the second stage reimplantation in a larger scale of clinical subjects.…”
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A social enterprise model for TB detection and treatment through the private sector in Pakistan by S. M. A. Zaidi, W. Z. Jamal, U. Ibrahim, S. Khowaja, A. J. Khan, J. Creswell

“…RESULTS: Overall 171,488 people were screened and 18,683 cases were notified, including 197 individuals with drug-resistant TB. Annual TB notifications in Karachi increased from 18,105 in 2014 to a maximum of 25,840 (40% increase). …”
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Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadru... by Steven J. Smith, Xue Zhi Zhao, Stephen H. Hughes, Terrence R. Burke

“…However, the delayed rollouts of these INSTIs in low- to middle-income countries during the COVID-19 pandemic combined with increased transmission of drug-resistant mutants worldwide are leading to an increase in INSTI resistance. …”
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Epidemiology and Genetic Diversity of Colistin Nonsusceptible Nosocomial Acinetobacter baumannii Strains from Russia for 2013-2014 by Eugene A. Sheck, Mikhail V. Edelstein, Marina V. Sukhorukova, Natali V. Ivanchik, Elena Yu. Skleenova, Andrey V. Dekhnich, Ilya S. Azizov, Roman S. Kozlov

“…One strain had the multidrug-resistant (MDR) phenotype, 6 isolates had extensively drug-resistant (XDR) phenotype, and 3 isolates had pandrug-resistant (PDR) phenotype. …”
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Yield of TB screening in prisons in Tajikistan by S. Moe, M. Asozoda, A. Aung, Z. Dusmatova, F. Akintore, E. Nshimiyimana, A. Zavqibekov, N. Sitali, W.K. Mulanda, T. Cullip, A. Sinha

“…RESULTS: A total of 7,223 screenings were conducted, identifying 31 TB cases, including 17 drug-susceptible TB cases, eight drug-resistant TB cases, and six clinically diagnosed cases. …”
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Impact of post-traumatic stress disorder on epileptogenic networks: a functional connectivity study by Lisa-Dounia Soncin, Sara Simula, Nicolas Hemmer, Hélène Mourre, Marie Arthuis, Julia Makhalova, Christian Benar, Sylvane Faure, Fabrice Bartolomei

“…Abstract Post-traumatic stress disorder (PTSD) is more common in patients with drug-resistant epilepsy. Some of these patients experience PTSD due to early psychotraumatic events. …”
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Increasing Trend of Resistance to Penicillin, Tetracycline, and Fluoroquinolone Resistance in Neisseria gonorrhoeae from Pakistan (1992–2009) by Kauser Jabeen, Summiya Nizamuddin, Seema Irfan, Erum Khan, Faisal Malik, Afia Zafar

“…Emergence and spread of drug resistant Neisseria gonorrhoeae is global concern. …”
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Isolation of Acinetobacter in patients admitted to Intensive Care Units by Midiela López López, Juan Rafael Zerquera Rodriguez, Midiala Iglesias López, Yanet Rodríguez Zulueta

“…More than 80% of the isolations were resistant to most β-lactam antibiotics and it was found a high percentage of multi-drug and pan-drug resistant strains (41,6% and 48,1% respectively).…”
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Boosting the human antiviral response in conjunction with natural plant products by Rashmi Srivastava, Neeraj Kumar Dubey, Megha Sharma, Harsha Kharkwal, Rajesh Bajpai, Rakesh Srivastava

“…The increasing prevalence of viral infections and the emergence of drug-resistant or mutant strains necessitate the exploration of novel antiviral strategies. …”
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MicroRNA-3145 as a potential therapeutic target for hepatitis B virus: inhibition of viral replication via downregulation of HBS and HBX by Amrizal Muchtar, Amrizal Muchtar, Daichi Onomura, Daichi Onomura, Dan Ding, Dan Ding, Hironori Nishitsuji, Kunitada Shimotohno, Shunpei Okada, Keiji Ueda, Koichi Watashi, Takaji Wakita, Kei Iida, Kei Iida, Hironori Yoshiyama, Hisashi Iizasa

“…Current treatments for hepatitis B virus (HBV), such as interferons and nucleic acid analogs, have limitations due to side effects like depression and the development of drug-resistant mutants, highlighting the need for new therapeutic approaches. …”
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Inactivation of antibiotic resistant bacteria by nitrogen-doped carbon quantum dots through spontaneous generation of intracellular and extracellular reactive oxygen species by Weibo Xia, Zixia Wu, Bingying Hou, Zhang Cheng, Dechuang Bi, Luya Chen, Wei Chen, Heyang Yuan, Leo H. Koole, Lei Qi

“…In in vivo studies, the N-CQDs were more efficient in treating drug-resistant bacterial keratitis and reducing corneal damage compared to the common antibiotic levofloxacin. …”
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Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates by Jersley D. Chirawurah, Felix Ansah, Samuel Blankson, Bridget Adikah, Silas Nkansah Yeboah, Lucas Amenga-Etego, Gordon A. Awandare, Yaw Aniweh

“…Furthermore, these results may support the identification of new antimalarial agents that are effective against drug-resistant malaria parasites.…”
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Profil Bakteri Patogen dan Kepekaannya pada Pasien Ventilator Associated Pneumonia dengan Infeksi COVID- 19 di Rumah Sakit UKRIDA¬ by Jeremy Christopher, Ade Dharmawan, Donna Mesina Pasaribu, Nicolas Layanto

“…The emergence of multi-drug resistant (MDR) bacteria during the pandemic presents a challenge due to limited antibiotic options. …”
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Toward <i>Mycobacterium tuberculosis</i> Virulence Inhibition: Beyond Cell Wall by Maria S. Kotliarova, Mikhail S. Shumkov, Anna V. Goncharenko

“…The development of medicines that act on new targets will expand treatment options for tuberculosis caused by multidrug-resistant or extensively drug-resistant Mtb. Therefore, the development of drugs that target virulence factors is an attractive strategy. …”
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Characterization of a Novel Tc-Carbonyl Complex as a Functional Probe of P-Glycoprotein Transport Activity by Mary Dyszlewski, Helen M. Blake, Julie L. Dahlheimer, Christina M. Pica, David Piwnica-Worms

“…Tc-CO-MIBI showed 60-fold higher accumulation in drug-sensitive KB 3–1 cells compared to colchicine-selected drug-resistant KB 8-5 cells. In KB 8-5 cells, tracer enhancement was observed with the potent MDR modulator LY335979 (EC 50 = 62 nM). …”
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