Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata by Taiga Miyazaki, Shintaro Shimamura, Yohsuke Nagayoshi, Hironobu Nakayama, Akihiro Morita, Yutaka Tanaka, Yasuhiko Matsumoto, Tatsuo Inamine, Hiroshi Nishikawa, Nana Nakada, Makoto Sumiyoshi, Tatsuro Hirayama, Shigeru Kohno, Hiroshi Mukae

“…Exposure of C. glabrata cells to micafungin (an echinocandin) leads to the isolation of a mutant exhibiting resistance to echinocandin and azole antifungals. The drug-resistant phenotype is due to a non-synonymous mutation (R70H) in gene IPI1, which is involved in pre-rRNA processing. …”
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The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in <i>Pseudomonas aeruginosa</i> Have Changed in Northwestern Transylvania by Matei-Ștefan Dobrescu, Dan-Alexandru Țoc, Adrian-Gabriel Pană, Carmen Costache, Anca Butiuc-Keul

“…The results reveal a concerning increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) isolates over the two-year period. …”
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Post-TB sequelae in adolescent pulmonary TB survivors by C. Cesilia, F.R. Rinawan, P. Santoso, H.M. Nataprawira

“…OBJECTIVE: To compare the persistent clinical symptoms, chest X-ray (CXR), spirometry and echocardiography results in adolescent survivors of drug-susceptible (DS) and drug-resistant (DR) pulmonary TB (PTB). METHODS: This retrospective cohort study was conducted in 52 adolescent PTB survivors. …”
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The Dragon and the Tiger: Realties in the Control of Tuberculosis by P. Bhatter, A. Chatterjee, N. Mistry

“…Globally, India and China recorded the highest Multi-Drug Resistant TB (MDR) cases notified in 2010 (64000 and 63000, respectively). …”
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FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking by Sophia Vincoff, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, Pranam Chatterjee

“…FusOn-pLM uniquely predicts drug-resistant mutations, providing insights for therapeutic design that anticipates resistance mechanisms. …”
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Biological properties of Moringa oleifera: A systematic review of the last decade [version 2; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Background The growing incidence of chronic diseases such as cancer and the emergence of drug-resistant microorganisms constitute one of the greatest health challenges of the 21st century. …”
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A Case of Nasopharyngeal Mycobacteriosis with Bony Erosion of the External Skull Base by Kohei Matsuo, Satoshi Tanaka, Masayuki Sakata, Hiroki Takeda, Akihiro Nagata, Masashi Mori, Rie Ito, Yoshifumi Yamamoto, Kiyonobu Ueno, Atsuhiko Uno

“…Surgical intervention should also be considered for drug-resistant mycobacteriosis. We concluded that mycobacteriosis should also be considered apart from carcinoma even if CT shows a diffuse enhancing mucosal irregularity with bone destruction in the nasopharynx.…”
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Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option? by Daniele Fanale, Giuseppe Bronte, Francesco Passiglia, Valentina Calò, Marta Castiglia, Florinda Di Piazza, Nadia Barraco, Antonina Cangemi, Maria Teresa Catarella, Lavinia Insalaco, Angela Listì, Rossella Maragliano, Daniela Massihnia, Alessandro Perez, Francesca Toia, Giuseppe Cicero, Viviana Bazan

“…Clinical application of earlier microtubule inhibitors, however, unfortunately showed several limits, such as neurological and bone marrow toxicity and the emergence of drug-resistant tumor cells. Here we review several natural and synthetic microtubule-targeting agents, which showed antitumor activity and increased efficacy in comparison to traditional drugs in various preclinical and clinical studies. …”
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Botulinum Therapy for Pain Caused by Spasticity in Advanced Stages of Brain Tumor in Adolescents: A Case Report by Tomoo Mano, Toshiharu Murakami, Haruki Mori, Takashi Masuda

“…This report elucidates the management of drug-resistant pain attributed to an adolescent brain tumor using botulinum therapy. …”
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Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy by Sadhak Sengupta, Jaclyn Marrinan, Caroline Frishman, Prakash Sampath

“…Deletion of O6-methylguanine-DNA-methyltransferase (MGMT) activity, a DNA repair enzyme, by temozolomide has been determined to be the cause of lymphopenia. Drug-resistant mutation of the MGMT protein has been shown to render chemoprotection against TMZ. …”
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Biological properties of Moringa oleifera: A systematic review of the last decade [version 1; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Background The growing incidence of chronic diseases such as cancer and the emergence of drug-resistant microorganisms constitute one of the greatest health challenges of the 21st century. …”
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Levofloxacin Use in Patients with Suspected Tuberculosis in a Community Hospital, Thailand: A Pilot Study by Thanawat Khongyot, Sawitree Laopaiboonkun, Throngpon Kawpradid, Kannuwat Jitkamrop, Tawee Chanphakphoom, Suriyon Uitrakul

“…The results from this study indicated high usage of levofloxacin despite no evidence of drug-resistant TB or negative AFB results in a community hospital in Thailand. …”
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Medical Device-Associated Candida Infections in a Rural Tertiary Care Teaching Hospital of India by Sachin C. Deorukhkar, Santosh Saini

“…As Candida medical device-associated infection is highly drug resistant and can lead to serious life-threatening complications, there is a need of continuous surveillance of these infections to initiate preventive and corrective measures. …”
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Trends and Progress on Antibiotic-Resistant Mycobacterium tuberculosis and Genes in relation to Human Immunodeficiency Virus by N. G. Mbewana Ntshanka, T. A. M. Msagati

“…Numerous cases of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) have been announced immensely worldwide. …”
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Updating the Antimicrobial Resistance Pattern among Critical Priority Pathogens in the Intensive Care Unit in Northern Iran Post COVID-19 Pandemic by Golnar Rahimzadeh, Nadia Ghezljai, Shaghayegh Rezai, Raha Rezai, Mohammad Reza Navaiefar, Mohammad Sadegh Rezai, Masoud Moradi, Mostafa Shakeri

“…Background: During the COVID-19 pandemic, the widespread and indiscriminate prescription of antibiotics led to a significant increase in antibiotic resistance and the emergence of multi-drug-resistant (MDR) strains. This study aims to evaluate the prevalence of antibiotic resistance in MDR Gram-negative isolates in the intensive care unit (ICU) of northern hospitals in Iran following the COVID-19 pandemic. …”
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Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance by Andrew S. Bray, Christopher A. Broberg, Andrew W. Hudson, Weisheng Wu, Ravinder K. Nagpal, Maidul Islam, Juan D. Valencia-Bacca, Fawaz Shahid, Giovanna E. Hernandez, Noah A. Nutter, Kimberly A. Walker, Emma F. Bennett, Taylor M. Young, Andrew J. Barnes, David A. Ornelles, Virginia L. Miller, M. Ammar Zafar

“…Klebsiella pneumoniae, a problematic, often drug-resistant nosocomial pathogen, can colonize the GI tract asymptomatically, serving as an infection reservoir. …”
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Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species by Alexander Dumbai Joe, Runze Liu, Xiao Luo, Ruqiya Syed, Farhan Aslam, Zhenying Luo, Zhitian Zheng

“…We emphasize the importance of continued research and integrating different approaches to monitoring and managing drug-resistant Fusarium spp. populations. Integrating current inventions to inform strategies for sustainable disease control practices, and increase plant health, and yield will contribute to ongoing global efforts to achieve food and nutritional sustainability for the world's rapidly growing population while ensuring the effectiveness of the fungicidal product.…”
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Commitment, partnerships and operational research: three priorities for 11 EMR countries to achieve TB elimination by M. van den Boom, K. Bennani, G. B. Migliori, L. D’Ambrosio, R. Centis, A. Parvez Sayed, H. Y. Atta, Y. Hutin

“…RESULTS: Implementation was sufficient (≥74%) for 5 of 8 domains, highest for TB infection management, TB preventive treatment, laboratory service, drug management, drug-resistant TB and TB-HIV collaboration (89%, 83% and 78%, respectively). …”
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Direct-Acting Antivirals for the Treatment of Chronic Hepatitis C: Open Issues and Future Perspectives by Hee Bok Chae, Seon Mee Park, Sei Jin Youn

“…Combined drug regimens are necessary to prevent the emergence of drug-resistant HCV. Many promising DAA candidates have been identified. …”
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Control of <i>Vibrio parahaemolyticus</i> in Seafood Using the Combination of Lytic Phages and Citric Acid by Xiaoshuang Zheng, Lu Gao, Lei Yuan, Caowei Chen, Zhenquan Yang

“…Genome sequencing of the five phages showed a total genome length of 76,153–144,768 bp. No virulent or drug-resistant genes were detected in the five phages. …”
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