Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country by Narayan Prasad Parajuli, Govardhan Joshi, Bashu Dev Pardhe, Jyotsna Shakya, Anjeela Bhetwal, Shreena Shakya, Roshan Pandit, Sumesh Shreekhanda Shrestha, Puspa Raj Khanal

“…In MDR strains, the third-generation cephalosporins have been used for the treatment, but, unfortunately, emerging reports of enzyme mediated β-lactam resistance among Shigella isolates from various parts of the world have greatly compromised the therapy of pediatric dysentery. In Nepal, drug resistant strains of Shigella spp. have been reported, but MDR and extended spectrum β-lactamase (ESBL) producing strains were previously unknown. …”
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Dynamical Models of Tuberculosis and Their Applications by Carlos Castillo-Chavez, Baojun Song

“…., TB co-infection with HIV/AIDS, drug-resistant TB, responsesof the immune system, impacts of demography, the role of publictransportation systems, and the impact of contact patterns. …”
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Recent advances in the biosynthesis of polysaccharide-based antimicrobial glycoconjugate vaccines by Yuhui Wang, Yuhui Wang, Yuhui Wang, Yuhui Wang, Haodi Liu, Haodi Liu, Haodi Liu, Haodi Liu, Baoying Wang, Baoying Wang, Baoying Wang, Baoying Wang, Gülzire Gheyret, Jingliang Qin, Hanlin Wang, Hanlin Wang, Hanlin Wang, Hanlin Wang, Yuhan Di, Yuhan Di, Yuhan Di, Yuhan Di, Yanling Wang, Juan Wang, Haining Tan, Haining Tan, Haining Tan, Haining Tan

“…Glycoconjugate vaccines are a vital category of effective and safe commercial vaccines that have significantly reduced the global prevalence of drug-resistant bacterial infections. These vaccines are synthesized by covalently linking bacterial polysaccharide antigens to a carrier protein. …”
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Overlapping Clinical Manifestations of Multisystem Inflammatory Syndrome in Children with Other Endemic Diseases of Pakistan: A Case Report by Anam Zafar, Sughra Wahid, Asad Ullah, Hassan Mumtaz

“…The authors present the case of an 8-year-old who presented with non-specific febrile illness which was managed as extensively drug-resistant typhoid with meropenem. The patient developed abdominal pain and hypotension during the hospital stay. …”
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Role of the Kidneys in Resistant Hypertension by Z. Khawaja, C. S. Wilcox

“…Since inappropriate renal salt retention underlies most cases of drug-resistant hypertension, the therapeutic focus should be on improving salt depleting therapy by assessing and, if necessary, reducing dietary salt intake, optimizing diuretic therapy, and adding a mineralocorticoid antagonist if there are no contraindications.…”
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Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly by Hong Chin Wee, Ru Shing Ng, Loke Meng Ong

“…Background: The prevalence of multidrug-resistant and extensively drug-resistant pathogens has led to increased reliance on broad-spectrum antimicrobials, such as tigecycline. …”
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Disruption of biological membranes by hydrophobic molecules: a way to inhibit bacterial growth by Alejandra Gabriela Valdez-Lara, Ángela M. Jaramillo-Granada, Daniel Ortega-Zambrano, Eristeo García-Marquez, Jorge Alberto García-Fajardo, H. Mercado-Uribe, J. C. Ruiz-Suárez

“…These findings may have useful implications in the global effort to discover new ways to effectively combat the growing threat of drug-resistant pathogens, especially in skin infections.…”
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Developing a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria by Junze Ma, Zheng Lu

“…The pervasive and often indiscriminate use of antibiotics has accelerated the emergence of drug-resistant bacterial strains, thus presenting an acute threat to global public health. …”
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Harnessing Bacillus Species for Antibiotic Discovery: A Review by Daniel Tunde Abbey, Aisha Tajudeen Oganija, Onyibo Leonard Ebube, Dim Emmanuel Ifeanyi

“…Bacillus species with antibiotics producing potentials can be applied in combatting the threat posed by antibiotic-resistant pathogens as well as multi-drug-resistant pathogens. …”
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Emergency Combination of Four Drugs for Bloodstream Infection Caused by Carbapenem-Resistant Enterobacteriaceae in Severe Agranulocytosis Patients with Hematologic Malignancies aft... by Xiaofan Li, Yaqun Hong, Xianling Chen, Ping Chen, Nainong Li

“…Bloodstream infection (BSI) caused by multidrug-resistant (MDR) bacteria or extensively drug-resistant (XDR) bacteria is a global threat. However, an effective treatment regimen is still controversial and inadequate due to the rapid deterioration caused by the bacteria. …”
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MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis by Vishesh Khanna, Gohar Eslami, Rochelle Reyes, Robert Diep, Sebastian Fernandez-Pol, Henning Stehr, Carlos Jose Suarez, Harlan Pinto, James M. Ford, Tian Yi Zhang, Christopher T. Chen

“…Her pancytopenia was associated with 20 distinct pathogenic TP53 mutations in peripheral blood and bone marrow not present in drug-resistant tumor tissue. Plasma TP53 mutations were similarly detected among 4 other patients treated at our institution, with the number of mutations correlating strongly with duration of treatment. …”
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YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates by Inés Bouzón-Arnáiz, Mukul Rawat, Rachael Coyle, Lionel Brice Feufack-Donfack, Malen Ea, Agnes Orban, Jean Popovici, Lucía Román-Álamo, Antonino Nicolò Fallica, Bárbara Domínguez-Asenjo, Javier Moreno, Elsa M. Arce, Ana Mallo-Abreu, Diego Muñoz-Torrero, Marcus C. S. Lee, Xavier Fernàndez-Busquets

“…Using single-dose and ramping methods, assays were done to select Plasmodium falciparum parasites resistant to YAT2150 concentrations ranging from 3× to 0.25× the in vitro IC50 of the compound (in the two-digit nM range) and performed a cross-resistance assessment in P. falciparum lines harboring mutations that make them resistant to a variety of antimalarial drugs. Resistant parasites did not emerge in vitro after 60 days of incubation, which postulates YAT2150 as an ‘irresistible’ antimalarial. …”
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Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry by Md. Ashrafuzzaman, Mamudul Hasan Razu, Nazmir-Nur Showva, Tohmina Afroze Bondhon, Md. Moniruzzaman, Sad Al Rezwan Rahman, Md. Raisul Islam Rabby, Fatema Akter, Mala Khan

“…These biomolecules are antimicrobial and antibacterial, enabling them to be drug resistant. This review is aimed at explaining the biomolecules identified in the horseshoe crab’s hemolymph and their application scopes in the pharmaceutical and biotechnology sectors.…”
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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

“…However, cancer cells also utilize DNA-based strategies, often perceived as slow, irreversible changes like point mutations or drug-resistant clone selection. Extrachromosomal DNA (ecDNA), in contrast, represents a rapid, reversible, and predictable DNA alteration critical for cancer’s adaptive response.MethodsIn this study, we developed a novel post-processing pipeline for automated detection and quantification of ecDNA in metaphase Fluorescence in situ Hybridization (FISH) images, leveraging the Microscopy Image Analyzer (MIA) tool. …”
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Prevalence and Antibiotic Resistance Pattern of Salmonella Isolated from Caecal Contents of Exotic Chicken in Debre Zeit and Modjo, Ethiopia by Destaw Asfaw Ali, Belege Tadesse, Aragaw Ebabu

“…Further studies are needed to describe the risk factors associated with the emergence of drug-resistant Salmonella in chicken.…”
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Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species by Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodríguez

“…The limitations of current therapies and the emergence of drug-resistant parasites underscore the need for new treatments that could harness the host immune response. …”
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Toxicity of Ulva lactuca and green fabricated silver nanoparticles against mosquito vectors and their impact on the genomic DNA of the dengue vector Aedes aegypti by Al Thabiani Aziz

“…The antimicrobial activity of both the extract and green synthesised nanomaterials showed prominent activity against pathogenic drug resistant bacteria. Our results contribute to further development of eco‐friendly insecticides with lower cost of preparation. …”
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The Detection of Fosfomycin-Modifying Enzymes (fos) in Uropathogenic Enterobacterale, Azerbaijan, Iran by Aidin Lalezadeh, Pardis Ghotaslou, Reza Ghotaslou

“…Multidrug resistant (MDR) and XDR (extensively drug-resistant) Enterobacteriaceae in UTIs have increased in the world. …”
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High incidence of Escherichia coli resistance to colistin from chicken farms in Kathmandu Valley by Kipa Tamrakar, Avina Lama, Binita Dhakal, Luna Adhikari, Megha Shrestha, Jeena Amatya

“… Overusing antimicrobial growth promoters in poultry farming plays a significant role in spreading drug-resistant Escherichia coli. The widespread practice of colistin for any purpose in chickens can potentially disseminate resistant genes from the environment to humans, posing an undeniable threat to livestock and public health. …”
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Anti-Biofilm Agents to Overcome <i>Pseudomonas aeruginosa</i> Antibiotic Resistance by Marie Hanot, Elodie Lohou, Pascal Sonnet

“…In addition to the emerging prevalence of multi-drug resistant (MDR) strains, the bacterium also possesses a wide variety of virulence traits that worsen the course of the infections. …”
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