Deep Brain Stimulation for Pantothenate Kinase-Associated Neurodegeneration by Pedro J. Garcia-Ruiz, Joaquin Ayerbe, Lydia Vela Desojo, Cici E. Feliz, Javier del Val Fernandez

“…Pallidal stimulation (GPi DBS) has been carried out in selected cases of PKAN with drug-resistant dystonia with variable results. We report a 30-month follow-up study of a 30-year-old woman with PKAN-related dystonia treated with GPi DBS. …”
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Genotypic and phenotypic characterization of antimicrobial resistance in Salmonella strains isolated from both No-Antibiotics-Ever (NAE) and conventional broiler complexes by Yagya Adhikari, Dianna V. Bourassa, Sabin Poudel, Matthew A. Bailey, Richard J. Buhr, Kenneth S. Macklin

“…In addition, the odds of ATR Salmonella detection were 7 times (1.37 – 43.45; 95 % CL) more likely in the isolates from NAE complex as compared to conventional broiler complex (p = 0.0233). Overall, drug-resistant Salmonella were present within and surroundings of poultry production and poultry product that could potentially contaminate the final raw product. …”
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Tuberculosis in the 1990s: From Bedside to Bench and Back by Frances B Jamieson, Pamela Chedore

“…In the United States, a similar trend emerged, such that in the early 1990s there was an increase in new cases of TB. Outbreaks of drug-resistant TB also occurred with devastating clinical impact. …”
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Model Prognosis Masa Pengobatan Pasien Tuberkulosis Dengan Metode C4.5 by Rusdah Rusdah, Brian Agni Bregastantyo

“…Apabila salah diagnosa terkait dosis obat maka akan meningkatkan faktor resiko kesehatan yaitu dimana proses pengobatan akan lebih memakan waktu dan lebih lama karena adanya kondisi Multi-Drug Resistant. Hal ini yang harus menjadi perhatian semua pihak agat tingkat kegagalan atas proses pengobatan pasien Tuberkulosis harus ditekan se minimal mungkin. …”
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Optimized methods for the targeted surveillance of extended-spectrum beta-lactamase-producing Escherichia coli in human stool by Sarah Gallichan, Sally Forrest, Esther Picton-Barlow, Claudia McKeown, Maria Moore, Eva Heinz, Nicholas A. Feasey, Joseph M. Lewis, Fabrice E. Graf

“…To do this, we need to understand how drug-resistant bacteria spread to take action to stop infection and transmission. …”
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Hybrid optimal control for HIV multi-drug therapies: A finite set control transcription approach by Divya Thakur, Belinda Marchand

“…An STI treatment strategy may be beneficial in lowering the risk of HIV mutating to drug-resistant strains, and could provide patients with respite from toxic side effects of HAART. …”
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Pharma TARP: A Troubled Asset Relief Program for Novel, Abandoned Projects in the Pharmaceutical Industry by Tamas Bartfai, Graham Vaughan Lees

“…Society has a real need for the drugs that are no longer going to be developed for, among others, drug-resistant epilepsy, neuropathic and cancer pain, type-2 diabetes, obesity, and schizophrenia. …”
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Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicot... by Markus Leitinger, Serena Broggi, Mathias Spendel, Gudrun Kalss, Ivan Petrović, Herbert Krainz, Fabio Rossini, Julia Höfler, Andreea Toma, Giorgi Kuchukhidze, Matthias Mauritz, Kai‐Nicolas Poppert, Bernardo Crespo‐Pimentel, Pilar Bosque‐Varela, Anna Pleyers, Patricia Ganger, Dieter Kotzot, Davor Lessel, Christoph J. Griessenauer, Eugen Trinka

“…We present a 20+ year‐old man with drug‐resistant epilepsy who underwent stereo‐EEG with 17 depth electrodes. …”
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Relationship between programmed cell death and targeted therapy for thyroid cancer in patients with a poor prognosis: an update by Yuejia Zhao, Simeng Zhao, Zhe Fan, Yongfu Zhao, Guangzhi Wang

“…We also provide an outlook on future treatments for drug-resistant thyroid cancer, poorly differentiated thyroid cancer, and iodine-refractory thyroid cancer, aiming to accurately identify targets and offer effective targeted therapeutic strategies.…”
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Cytogenetic Evolution of Human Ovarian Cell Lines Associated with Chemoresistance and Loss of Tumorigenicity by Stéphanie Struski, Martine Doco‐Fenzy, Michael Koehler, Ilse Chudoba, Francis Levy, Linda Masson, Nicole Michel, Evelyne Ulrich, Nadine Gruson, Jean Bénard, Gérard Potron, Pascale Cornillet‐Lefebvre

“…Multicolor FISH (Multiplex‐FISH and Spectral Karyotype) and conventional FISH are also used to elucidate the karyotype of parental cell line. The drug‐resistant subcell lines displayed many chromosomal abnormalities suggesting the implication of different pathways leading to a multidrug resistance phenotype. …”
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Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. by Zhihao Chen, Qiyuan Jin, Jinqi Zhong, Zonggang Xie, Qi Chen, Liubing Li, Jijie Li, Chenhao Zhao, Junfeng Wang, Xiaoying Tang, Mingxiao Han, Ru Li, Ziyuan Li, Zelei Tong, Min Wang, Hong Du, Haifang Zhang

“…Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging. …”
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The role of gene copy number variation in antimicrobial resistance in human fungal pathogens by Adarsh Jay, David F. Jordan, Aleeza Gerstein, Christian R. Landry

“…Abstract Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms. …”
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Urinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy by Mahmood Almosuli, Anna Kirtava, Archil Chkhotua, Lia Tsveniashvili, Nina Chanishvili, Sumaiya Safia Irfan, Emily Ng, Hope McIntyre, Adam J. Hockenberry, Robyn P. Araujo, Weidong Zhou, Ngoc Vuong, Barbara Birkaya, Lance Liotta, Alessandra Luchini

“…Abstract Despite much promise in overcoming drug-resistant infections, clinical studies of bacteriophage antibacterial therapy have failed to show durable effectiveness. …”
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A Flexible, Implantable, Bioelectronic Electroporation Device for Targeted Ablation of Seizure Foci in the Mouse Brain by Rita Matta, Zsofia Balogh-Lantos, Zoltan Fekete, Martin Baca, Attila Kaszas, David Moreau, Rodney Philip O’Connor

“…The primary method of treatment for patients suffering from drug-resistant focal-onset epilepsy is resective surgery, which adversely impacts neurocognitive function. …”
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The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis by Nazar Trotsko, Agnieszka Głogowska, Barbara Kaproń, Katarzyna Kozieł, Ewa Augustynowicz-Kopeć, Agata Paneth

“…The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. …”
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The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro by Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy

“…ABSTRACT Due to the increase in the number of drug-resistant Candida albicans strains, new antifungal compounds with limited potential for the development of resistance are urgently needed. …”
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World antimicrobial resistance (AMR) awareness week by Mohammad Mehdi Feizabadi

“…The health policy makers try to find the right solutions for combating the drug-resistant superbugs but they should not ignore Microbiology principles. …”
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Potential Synergies of β-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health by Franco Cavaleri, Emran Bashar

“…The low-carbohydrate high-fat diet (LCHFD), also known as the ketogenic diet, has cycled in and out of popularity for decades as a therapeutic program to treat metabolic syndrome, weight mismanagement, and drug-resistant disorders as complex as epilepsy, cancer, dementia, and depression. …”
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Psychiatric presentation in Rasmussen’s encephalitis by Prashant Maravi, Suneel Singh Kushwaha, Riya Gangwal, Dheerendra Mishra, Nimisha Mishra

“…Rasmussen’s encephalitis (RE) is a rare neurological disorder characterized by drug-resistant focal epilepsy, progressive hemiplegia, and cognitive decline. …”
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The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies by Mary E. George, Tonisha T. Gaitor, David B. Cluck, Andrés F. Henao-Martínez, Nicholas R. Sells, Daniel B. Chastain

“…These factors may expand the geographic range of pathogenic fungi, exposing populations to novel, potentially more virulent, or drug-resistant strains. Simultaneously, human factors such as declining immunity, aging populations, and increased use of immunosuppressive therapies are enhancing host susceptibility. …”
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