Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma by Dirk Hose, Seemun Ray, Sina Rößler, Ulrich Thormann, Reinhard Schnettler, Kim de Veirman, Thaqif El Khassawna, Christian Heiss, Anne Hild, Daniel Zahner, Francisca Alagboso, Anja Henss, Susanne Beck, Martina Emde-Rajaratnam, Jürgen Burhenne, Juliane Bamberger, Eline Menu, Elke de Bruyne, Michael Gelinsky, Marian Kampschulte, Marcus Rohnke, Sabine Wenisch, Karin Vanderkerken, Thomas Hanke, Anja Seckinger, Volker Alt

“…Locally applicable biomaterials could stabilize and foster healing of bone defects, simultaneously delivering anti-cancer compounds at systemically intolerable concentrations, overcoming drug resistance. Methods We developed silica-collagen xerogels (sicXer) and bortezomib-releasing silica-collagen xerogels (boXer) for local treatment of osteolytic bone disease and MRD. …”
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Antimicrobial resistance (AMR) and spread of New Delhi Metallo-β-Lactamase (NDM) in Italy: A call for policymakers by Gabriella Nucera

“…Low-quality medicines, wrong prescriptions and poor infection prevention and control, as well as lack of government commitment and poor surveillance are also hindering the control of antimicrobial drug resistance [1, 3]. As AMR undermines the achievement of the UN’s Sustainable Development Goals, the World Health Organization (WHO) called for a coordinated action among all countries worldwide, giving a special role to their governments [2, 4]. …”

Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence by Michele Ramos Valente, Lucas Martins Alcântara, Deborah Santos Cintra, Susana Ruiz Mendoza, Elisa Gonçalves Medeiros, Kamilla Xavier Gomes, Leandro Honorato, Marcos de Abreu Almeida, Carmen Baur Vieira, Joshua Daniel Nosanchuk, Diana Bridon da Graça Sgarbi, Marcia Ribeiro Pinto, Leonardo Nimrichter, Allan Jefferson Guimarães

“…In this work, we precisely characterize the interactions of C. auris with the free-living amoeba Acanthamoeba castellanii and how these protozoa may alter the fungal behavior in terms of virulence, thermotolerance, biofilm formation capacity, and drug resistance. It may be essential to understand the various interactions C. auris could perform in the environment, directly impacting the outcome of human infections under the One Health approach.…”
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Spatial variations in the microbiota: comparative analysis of microbial composition and predicted functions across different intestinal segments and feces in donkeys by Yanwei Wang, Yanwei Wang, Yanwei Wang, Tong Hu, Tong Hu, Kaixuan Liang, Kaixuan Liang, Shinuo Li, Shinuo Li, Qiyue Zhang, Qiyue Zhang, Qiyue Zhang, Wenqiang Li, Honglei Qu, Honglei Qu, Boying Dong, Haihua Zhang, Qiugang Ma, Qiugang Ma, Ru Jia, Shimeng Huang, Shimeng Huang

“…A PICRUSt2 functional prediction analysis indicated that carbohydrate metabolism, prokaryotic cellular communities, antimicrobial drug resistance, immune diseases, membrane transport, signal transduction, and transcription exhibited significant differences among the different intestinal segments. …”
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Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experien... by Alex Durand Nka, Yagai Bouba, Wilfried Rooker Tsapi Lontsi, Davy-Hyacinte Gouissi Anguechia, Georges Teto, Aude christelle Ka’e, Ezechiel Ngoufack Jagni Semengue, Collins Ambe Chenwi, Désiré Takou, Lum Forgwei, Tatiana Anim-Keng Tekoh, Aurelie Minelle Kengni Ngueko, Bernadette Bomgning Fokou, Jeremiah Efakika Gabisa, Michel Carlos Tommo Tchouaket, Willy Leroi TognaPabo, Derrick Tambe Ayuk Ngwese, Jacky Njiki Bikoi, Daniele Armenia, Vittorio Colizzi, Marcel Yotebieng, Nicaise Ndembi, Maria-Mercedes Santoro, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Alexis Ndjolo, Joseph Fokam

“…We analyzed 1170 HIV-1 sequences from patients failing first-, second-, and third-line ART using the CIRCB Antiviral Resistance Evaluation (CIRCB-CARE) database. Drug resistance mutations (DRMs) were interpreted using Stanford HIVdb.v9, and covariation patterns between M184V and major NRTI/NNRTI DRMs were assessed. …”
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Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

“…It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition of the cystine-glutamate antiporter, system Xc–, induces ferroptosis. …”
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Genetic Analysis of Sodium Channel Genes in Pediatric Epilepsy Patients of Pakistan by Aqsa Ashfaq, Tayyaba Saleem, Nadeem Sheikh, Hafsa Maqbool

“…Although antiepileptic drugs work for the majority of epileptic patients, these drugs do not work for some of the patients, subjecting them to drug-resistant epilepsy (DRE). Voltage-gated sodium channels act as targets for a number of antiepileptic drugs, and the genes encoding these channels can play a crucial role in developing drug-resistant epilepsy. …”
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Efficacy of carbonyl cyanide-3-chlorophenylhydrazone in combination with antibiotics against Mycobacterium abscessus by Jifang Zheng, Qiang Liu, Haoran Wang, Fengmin Huo, Junnan Jia, Hairong Huang, Suting Chen

“…These insights not only advance our understanding of antimicrobial synergy but also hold promise for the development of more effective treatment regimens against drug-resistant M. abscessus infections.…”
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Resistance Rates of Mycobacterium tuberculosis Complex Isolates to Primary Anti-tuberculosis Drugs: A 5-Year Retrospective Study by Sondos A. A. Ibnouf, Fatma Esenkaya Taşbent

“…The absence of multi-drug resistant and extensively drug-resistant tuberculosis in our study indicates that the tuberculosis surveillance program implemented in our region was successful.…”
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Evaluation of Non-HIV-Related, Drug-Sensitive Cluster Outbreaks of Tuberculosis with PCR-based DNA Fingerprinting by JM FitzGerald, WA Black, D Kunimoto

“…OBJECTIVES: To characterize two cluster outbreaks of tuberculosis by DNA fingerprinting and to evaluate the possibility of their association with human immunodeficiency virus (HIV) infection and multiple drug-resistant Mycobacterium tuberculosis.…”
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Application of green silver nano-particles as anti-bacterial and photo-catalytic degradation of azo dye in wastewater by Zainab Haider Ali, Lubna Abdulazeem, Wurood Alwan Kadhim¹, Mazin H. Kzar³, Osamah J. Al-sareji

“…Subsequently, the disc diffusion method assessed their anti-bacterial efficacy against multi-drug resistant (MDR) bacteria and their ability to degrade Azo dye (Methyl Red) in wastewater. …”
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Occipital Nerve Blockade for the Treatment of Occipital Neuralgia-Like Acute Postcraniotomy Headache: A Retrospective Study by Shaoheng Wang, Xueye Han, Chunmei Zhao, Fang Luo

“…Forty-one patients, who developed drug-resistant ON-APCH after elective craniotomy and received ONB with lidocaine for diagnoses, were included in this study, all of whom were treated using dexamethasone and lidocaine. …”
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Clinical Outcome with Oral Linezolid and Rifampin Following Recurrent Methicillin-Resistant Staphylococcus aureus Bacteremia Despite Prolonged Vancomycin Treatment by Jon-David Schwalm, Philippe El-Helou, Christine H Lee

“…Drug-resistant Gram-positive bacteria, especially Staphylococcus aureus, are emerging as the predominant organisms involved in both nosocomial and community-acquired infections. …”
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Missed rifampicin and isoniazid resistance by commercial molecular assays by L Richards, F Ismail, J Nel, S V Omar

“… Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. …”
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ClpB chaperone as a promising target for antimicrobial therapy: A narrative review by Sachini J. Udari, Sayoka Shamodhi, Rumesh M. Nelumdeniya, Udayana Ranatunga, Nimesha N. Senadeera, Chathuranga B. Ranaweera

“…Infections caused by ESKAPE pathogens are particularly challenging due to their resistance to broad-spectrum antibiotics and biofilm formation, posing a significant global health threat as they are often multidrug-resistant, extensively drug-resistant, and pan-drug-resistant. Given its absence in human cells and its essential role in bacterial survival under stress, ClpB is a promising target for antimicrobial therapy. …”
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Decoding the WHO Global Tuberculosis Report 2024: A Critical Analysis of Global and Chinese Key Data by Zhi Chen, Tao Wang, Jingli Du, Lin Sun, Guirong Wang, Ruizi Ni, Yajing An, Xueting Fan, Yufeng Li, Rui Guo, Lirong Mao, Wei Jing, Ke Shi, Jing Cheng, Qinglan Wang, Wenjuan Nie, Haican Liu, Jianqin Liang, Wenping Gong

“…This paper provides an in-depth interpretation of the report, analyzes global TB trends, updates the status of drug-resistant TB, discusses the intersection between TB and HIV, and summarizes the implications of the pandemic on TB control efforts. …”
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Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence by Suneel Kumar Garg, Omender Singh, Deven Juneja, Niraj Tyagi, Amandeep Singh Khurana, Amit Qamra, Salman Motlekar, Hanmant Barkate

“…Polymyxin B has resurged in recent years as a last resort therapy for Gram-negative multidrug-resistant (MDR) and extremely drug resistant (XDR) infections. Understanding newer evidence on polymyxin B is necessary to guide clinical decision making. …”
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HOXB8 mediates resistance to cetuximab in colorectal cancer cells through activation of the STAT3 pathway by Yunan Liang, Han Lin, Zongsheng Jiang, Qi Zhao, Ri Cui, Shaotang Li

“…By comparing drug-sensitive cell lines (SW48) with drug-resistant cell lines (HCT116, CACO2), we discovered that HOXB8 was substantially expressed in cetuximab-resistant cell lines, and furthermore, in drug-resistant cell lines (HCT116, CACO2), HOXB8 knockdown increased the cytotoxicity of cetuximab via blocking the signal transducer and activator of transcription 3 (STAT3) signaling pathway. …”
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Immunohistochemical analysis revealed that INPP4B expression was significantly higher in drug resistant pancreatic cancer tissues compared to non-drug resistant tissues, and lower in normal tissues than in both cancerous tissue types. …”
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In vitro evaluation of the antibacterial effects of monomer components of Pithecellobium clypearia against aquatic pathogens and synergy with enrofloxacin by Wenhao Wu, Jiahao Zhang, Xiaoyin He, Wei Li, Chun Liu, Biao Jiang, Youlu Su

“…These compounds demonstrate greater efficacy against the multi-drug resistant Aeromonas schubertii strain WL23R compared to the sensitive A. schubertii strain WL23S, indicating their potential in combating antibiotic resistance. …”
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