3-MA attenuates collagen-induced arthritis in vivo via anti-inflammatory effect and autophagy inhibition by Chong Feng, Zi-rou Wang, Chen-yu Li, Xiang-yu Zhang, Xin-xing Wang

“…However, present clinical drugs have various disadvantages such as poor bioavailability and short biological half-life and drug resistance, or adverse effects. A recent study showed autophagy modulation may be a novel strategy in the treatment of RA. 3-Methylademine (3-MA), is the most widely used autophagy inhibitor, which blocks autophagy at the initiation and maturation stages. …”
Get full text

Risk factors of multidrug resistant tuberculosis among patients with tuberculosis at selected multidrug resistance treatment initiative centres in southern Ethiopia: a case-control... by Fantahun Admassu, Ermias Abera, Addisalem Gizachew, Tagesse Sedoro, Taye Gari

“…In order to reduce the burden of drug resistance, strategies of controlling MDR-TB in the study area should emphasise on enhancing public health education and reducing treatment interruptions of patients with TB and drug-resistant TB.…”
Get full text

Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 by Mark A Wainberg, Ronald Rooke, Michel Tremblay, XuGuang Li, Michael A Parniak, Qing Gao, Xiao-Jian Yao, Chris Tsoukas, JSG Montaner, M Fanning, J Ruedy

“…In certain instances, such drug-resistant viral isolates have been obtained from patients with clinical acquired immune deficiency syndrome (AIDS), while in others, isolation of drug-resistant strains has been achieved in the case of HIV seropositive, asymptomatic subjects. …”
Get full text

G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells by Chiao-Chun Liao, Yuqing Long, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Chia-Hwa Lee

“…Abstract Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. …”
Get full text

Investigating the Expression of c-Myc and BIRC5 in TRAIL and PBOX-15 treated Metastatic Prostate Cancer Cells by Corinne Kai Leng Chew, Hannah O'Toole, Daniela M Zisterer, Seema M. Nathwani, Jade K. Pollock

“…A novel microtubule-targeting agent, PBOX-15 is known to exhibit anti-tumour activity in cancer cell lines including those with multi-drug resistance. Previous studies demonstrated that PBOX-15 is capable in sensitising cancer cells to TRAIL-mediated cell death by upregulation of death receptors and downregulation of related oncogenes. …”
Get full text

YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…However, its application to epidermal growth factor receptor (EGFR)-mutant NSCLC patients is confronted with drug resistance. This study aimed to clarify the potential role of Yes1-associated transcriptional regulator (YAP1) in ICIs treatment for EGFR-mutant NSCLC population. …”
Get full text

Identification of CβS and ODC antimony resistance markers in anthroponotic cutaneous leishmaniasis field isolates by gene expression profiling by Farzaneh Zarrinkar, Iraj Sharifi, Razieh Tavakoli Oliaee, Ali Afgar, Elaheh Molaakbari, Mehdi Bamorovat, Zahra Babaei, Ebrahim Eskandari, Ehsan Salarkia, Marzieh Asadi

“…Alternative drugs or combination therapy and monitoring drug resistance to prevent the spread of resistant isolates are proper strategies to control the disease.…”
Get full text

The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro by Yakubu Jibira, Elizabeth Cudjoe, Frederick M. Tei-Maya, Benjamin Ayensu, Linda E. Amoah

“…Background. Drug resistance in malaria is a global problem, with reports of Plasmodium parasites resistant to the current first-line antimalarial drug, artemisinin, expanding from Southeast Asia to Africa. …”
Get full text

Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Further studies remain needed to address the issues of drug resistance and adverse events pertaining to such therapies for GC. …”
Get full text

Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTEN by Yuan Zeng, Haoran Jiang, Zhoufeng Chen, Jun Xu, Xiangting Zhang, Weimin Cai, Xianjie Zeng, Peipei Ma, Rong lin, Huilin Yu, Yuanhang He, Huiya Ying, Ruoru Zhou, Xiao Wu, Fujun Yu

“…Abstract FOLFOX (5-fluorouracil, oxaliplatin, folinic acid) is a standard treatment for hepatocellular carcinoma, but its efficacy is often limited by drug resistance, the underlying mechanisms of which remain unclear. …”
Get full text

Construction of cuproptosis-related genes risk model predicts the prognosis of Uterine Corpus Endometrial Carcinoma by Yanfang Huang, Guoxian Luo, Xiujie Sheng, Jianqi Li

“…These genes were associated with key signaling pathways, including the TCA cycle, Pyruvate metabolism, Glycolysis/Gluconeogenesis, and Platinum drug resistance. The LASSO regression and Nomogram models demonstrated robust predictive performance for UCEC prognosis, identifying CDKN2A, GLS, and PPAT as critical prognostic genes. …”
Get full text

A novel imatinib analogue inhibitor of chronic myeloid leukaemia: design, synthesis and characterization—explanation of its folded conformation by Rodolfo Moreno-Fuquen, Juan F. Avellaneda-Tamayo, Kevin Arango-Daraviña, Javier Ellena, Alan R. Kennedy

“…However, the development of drug resistance and adverse side effects necessitate the exploration of alternative therapeutic agents. …”
Get full text

An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice. by Paromita Bag, Durbadal Ojha, Hemanta Mukherjee, Umesh Chandra Halder, Supriya Mondal, Nidhi S Chandra, Suman Nandi, Ashoke Sharon, Mamta Chawla Sarkar, Sekhar Chakrabarti, Debprasad Chattopadhyay

“…Till date no effective vaccine is available, while the existing therapy frequently yielded drug resistance, toxicity and treatment failure. Thus, there is a pressing need for non-nucleotide antiviral agent from traditional source. …”
Get full text

African animal trypanocide resistance: A systematic review and meta-analysis by Keneth, Iceland Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…Clinical studies also showed evidence of multi-drug resistance on DA and ISM (RR = 1.01, 95% CI: 0.71–1.43; I2 = 46%, P = 0.16). …”
Get full text

Herbal based nanoparticles as a possible and potential treatment of cancer: a review by Roshan Yadav, Himmat Singh Chawra, Gaurav Dubey, Md Sabir Alam, Vikram Kumar, Pragya Sharma, Navneet Kumar Upadhayay, Tejpal Yadav

“…These drugs may damage quickly dividing healthy tissues, structural anomalies, bodily toxicity, long-term side effects, tumor cell drug resistance, and psychiatric disturbances. Researchers are developing nanoscale medicines using natural medications like Malva sylvestris and Curcumin to lower concentrations and improve target specificity. …”
Get full text

Extended spectrum betalactamase and Carbapenemase producing gram negative bacteria from healthcare workers gowns at Debre Berhan Comprehensive Specialized Hospital, Ethiopia by Sisay Gebrish Sharew, Daniel Gebretsadik Weldehanna, Demissew Shenkute Gebreyes, Tsegahun Asfaw Abebe, Agumas Shibabaw

“…The overall multi-drug resistance (MDR) rate was 65 (55.6%). Of the 117 isolates, 17(14.5%) and 12(10.3%) were ESBL and carbapenemase producers respectively. …”
Get full text

HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib by Yingai Zhang, Yuting Zhang, Shuai Zhou, Mujeeb Ur Rehman, Fankai Lin, Jianquan Zhang, Hailong Zhou

“…Interference with HTR1D gene expression demonstrated its role in promoting HCC proliferation, migration, and drug resistance through the PI3K/Akt pathway. These findings were validated in a mouse model. …”
Get full text

Cloning, expression, and purification of fusion antigens MPT83 and ESAT6 from the local strain of Mycobacterium tuberculosis in Escherichia coli as a seed vaccine candidate against... by Rusdina Bte Ladju, Ahyar Ahmad, Abdul Karim, Rugaiyah Arfah, Rosana Agus, Najdah Hidayah, Muhammad Nasrum Massi, Astutiati Nurhasanah, Harningsih Karim, Irda Handayani

“…Eradicating tuberculosis (TB) globally is increasingly challenging with the growing number of drug-resistant Mycobacterium tuberculosis (M. tuberculosis) strains. …”
Get full text

A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance by Muhammad Redzwan S. Rashid Ali, Uma Parameswaran, Timothy William, Elspeth Bird, Christopher S. Wilkes, Wai Khew Lee, Tsin Wen Yeo, Nicholas M. Anstey, Anna P. Ralph

“…Among 15 inpatients with suspected TB, 2 had multidrug resistant TB (one extensively drug resistant), 2 had INH-R, and 4 had NTM. Conclusions. …”
Get full text

RAGE and its ligands in breast cancer progression and metastasis by Madalina Coser, Bogdan Mihai Neamtu, Bogdan Mihai Neamtu, Bogdan Pop, Bogdan Pop, Calin Remus Cipaian, Calin Remus Cipaian, Maria Crisan, Maria Crisan

“…We conducted a meta-analysis to assess the relationship between the RAGE rs1800624 polymorphism and breast cancer risk using fixed-effect or random-effect models to calculate odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs).ResultsRAGE upon activation by its ligands enhances downstream signaling pathways, contributing to breast cancer cells migration, growth, angiogenesis, metastasis, and drug resistance. In addition, studies have shown that RAGE and its ligands influence the way breast cancer cells interact with immune cells present in the tumor microenvironment (macrophages, fibroblasts), thus regulating it to promote tumor growth and metastasis.ConclusionBreast cancers with a high expression of RAGE are associated with poor prognosis. …”
Get full text