Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

“…However, with the growing awareness of AR and rising expectations for improvements in quality of life, these treatments have become associated with a higher incidence of side effects and an elevated risk of drug resistance. Furthermore, the development of AR is intricately associated with dysregulation of the immune system, yet the underlying pathogenetic mechanisms remain incompletely understood. …”
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Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics by Heng Wei, Yingying Hao, Jin Zhang, Yue Qi, Chong Feng, Chen Zhang

“…Gynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. …”
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Antifungal effect of Euphorbia prostrata ethyl acetate extract on Microsporum audounii-induced skin dysfunction diseases in male rats by Wuraola O. Familusi, Folashade O. Oyedeji, Jeffrey D. Musa

“…The search for medicinal plants as viable substitutes for antifungal drug development is crucial due to the increasing threat of multiple drug resistance in global health. However, some of these medicinal plants have become prominent candidates due to reported biological functions such as antimicrobial properties, especially when it comes to treating drug-resistant skin infections with no or little side effects. …”
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Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…Interestingly, curcumin also reduced mutp53 expression, suggesting that it could enhance the efficacy of other therapies, particularly in overcoming drug resistance mechanisms associated with mutp53. For instance, in this study, we show that curcumin sensitized SW480 cells to SET7/9 inhibition by sinefungin, further supporting its potential as a combinatorial therapeutic agent. …”
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Diffusion Smart-seq3 of breast cancer spheroids to explore spatial tumor biology and test evolutionary principles of tumor heterogeneity by Antony Cougnoux, Loay Mahmoud, Per A. Johnsson, Alper Eroglu, Louise Gsell, Jakob Rosenbauer, Rickard Sandberg, Jean Hausser

“…Smart-seq3D can offer a cost-efficient approach to explore how cells adapt their transcriptome to different micro-environments, reveal spatial determinants of drug resistance and could serve to characterize spatial interactions between cancer and stromal/immune cells in 3D co-cultures.…”
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Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants by Yanru Long, Houhui Shi, Jiatian Ye, Xiaorong Qi

“…Oxidative stress can cause oxidative damage, promote the development of ovarian cancer, and even result in drug resistance. Therefore, studying oxidative stress in ovarian cancer is important for the prevention and treatment of ovarian cancer. …”
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Antimicrobial Characterization of Erythorbyl Laurate for Practical Applications in Food and Cosmetics by Jin-Woo Kim, Hyunjong Yu, Kyung-Min Park, Pahn-Shick Chang

“…In a multipassage resistance selection study, it was observed minimum inhibitory concentrations of EL against S. aureus were not increased over 20 passages, indicating EL might not develop drug resistance of bacteria. This study suggests EL has a potential to be applied as the multifunctional additive in food and cosmetics.…”
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The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer by Guomin Gu, Chunling Liu, Yan Yang, Yan Zhao, Xiaodan Zhu, Gang Sun

“…KRAS-G12C, KRAS-G12V, and KRAS-G12D mutations may enhance NSCLC drug resistance through immunosuppression.…”
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Identification and Validation of a Potential Stemness-Associated Biomarker in Hepatocellular Carcinoma by Yangyang Zhang, Ruike Zhang, Lingxiu Zeng, Haizhou Wang, Ruyi Peng, Meng Zhang, Hailin Zhang, Zhenwei Yang, Liping Gao, Meng Wang, Jing Liu

“…Cancer stem cells (CSCs) are typically related to metastasis, recurrence, and drug resistance in malignant tumors. However, the biomarker and mechanism of CSCs need further exploration. …”
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Frequency and antibiotic resistance pattern of Salmonella spp. isolated from traditional dairies and raw milks collected in Yazd province, Iran by Raziyeh Barzegar-Bafrouei, Bahador Hajimohammadi, Hengameh Zandi, Gilda Eslami, Hossein Fallahzadeh

“…Conclusion: According to our results there has been a rise in multiple drug resistance and contamination rate in traditional dairy products in Yazd province. …”
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A Review on the Role of Human Solute Carriers Transporters in Cancer by Md. Shafiul Hossen, Mohammed Shafin Ul Islam, Mohammad Yasin, Mohammed Ibrahim, Abhijit Das

“…Thus, SLC transporters become a potential therapeutic target that plays a crucial role in drug resistance, tumor microenvironment regulation, and modulation of immune response. …”
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Determination of salmonella spp. presence and antibiotic resistance in egg and egg products by Hilal Keskinoğlu, Göknur Terzi Gülel

“…The results showed that 11/11 (100%) of Salmonella spp. from three sample showed multi-drug resistance against three or more antibiotic agents.…”
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TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies by Wolfgang Eberhardt, Usman Nasrullah, Josef Pfeilschifter

“…A growing body of evidence has highlighted the multifaceted role of tripartite motif 25 (TRIM25) in controlling different aspects of tumorigenesis, including chemotherapeutic drug resistance. Accordingly, overexpression of TRIM25 is observed in many tumors and frequently correlates with a poor patient survival. …”
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Advances in Spiky Antibacterial Materials: From Bioinspired Design to Application by Zijun Zhang, Limei Qian, Nan Zhang, Xinyue Wang, Yunshen Fu, Guanbin Gao, Taolei Sun

“…Bacterial infections, particularly those caused by drug‐resistant bacteria, pose a significant threat to human life and health safety. …”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Abstract Genotype-informed anticancer therapies such as BRAF inhibitors can show remarkable clinical efficacy in BRAF-mutant melanoma; however, drug resistance poses a major hurdle to successful cancer treatment. …”
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Insight into the Burden of Antimicrobial Resistance among Bacterial Pathogens Isolated from Patients Admitted in ICUs of a Tertiary Care Hospital in India by Garima Gautam, Shweta Satija, Ravinder Kaur, Anil Kumar, Divakar Sharma, Megh Singh Dhakad

“…The aim of the study was to determine the bacteriological profiles and their drug resistance pattern among different infections in ICU patients of a tertiary care hospital. …”
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Biofilm Formation and blaOXA Genes Detection Among Acinetobacter baumannii from Clinical Isolates in a Tertiary Care Kirtipur Hospital, Nepal by Upasana Ghimire, Rupesh Kandel, Mary Neupane, Sanjit Shrestha, Sudeep K C, Santosh Khanal, Dev Raj Joshi

“…This study was carried to associate the biofilm formation with the drug resistance pattern of A. baumannii and to detect blaOXA-23, blaOXA-24, and blaOXA-51 from carbapenem resistance isolates. (2) Methods: Among different clinical samples, a total of 19 Acinetobacter spp. were identified with conventional microbiological procedures. …”
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Mycobacterium tuberculosis Lineage Distribution Using Whole-Genome Sequencing and Bedaquiline, Clofazimine, and Linezolid Phenotypic Profiles among Rifampicin-Resistant Isolates fr... by Andriansjah Rukmana, Cynthia Gozali, Linda Erlina

“…New anti-TB drugs from groups A and B, such as bedaquiline, clofazimine, and linezolid, have been shown to be effective in curing drug resistance in TB patients, and Indonesia is already using these drugs to treat patients. …”
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The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance by Kavitha EZHILARASU, Anand KASIRANJAN, Shanmuga PRIYA, Anand KAMARAJ

“…Drug development projects face significant obstacles because of the rapid rise in antimicrobial drug resistance in the world healthcare system and the introduction of multidrug-resistant (MDR) strains. …”
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Comparative Quality Evaluation of Selected Brands of Cefuroxime Axetil Tablets Marketed in the Greater Accra Region of Ghana by Christina Osei-Asare, Esther Eshun Oppong, Frederick William Akuffo Owusu, John Antwi Apenteng, Yvonne Ochesinda Alatu, Robert Sarpong

“…The ever-growing commercialization of poor-quality and substandard medicines, especially anti-infectives characterized by inadequate postmarket surveillance by stakeholders remains a major global health challenge, particularly in developing countries, where antibiotic drug resistance and its repercussions on human health remain dominant. …”
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