Nonlinear and Robust Control Strategy Based on Chemotherapy to Minimize the HIV Concentration in Blood Plasma by Ricardo Aguilar-López, Rigel Valentín Gómez-Acata, Gerardo Lara-Cisneros, Ricardo Femat

“…Numerical experiments show a satisfactory performance of the proposed methodology as a HIV therapy, in which the virion particles and the infected CD4+T cells are minimized and, as an interesting result, the drug dosage can be suspended, thus avoiding drug resistance from the virus. Finally, the proposed controller is compared to a standard sliding-mode and hyperbolic tangent controllers showing better performance.…”
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Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents by Ajani Olayinka O., Nlebemuo Martins T., Adekoya Joseph A., Ogunniran Kehinde O., Siyanbola Tolutope O., Ajanaku Christiana O.

“…Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. …”
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Let-7b-5p sensitizes breast cancer cells to doxorubicin through Aurora Kinase B. by Murat Kaya, Asmaa Abuaisha, Ilknur Suer, Selman Emiroglu, Semen Önder, Evren Onay Ucar, Mustafa Nuri Yenerel, Sukru Palanduz, Kivanc Cefle, Sukru Ozturk, Zeyneb Kurt

“…It has been shown in many cancers, including breast cancer, that aberrant expression of miRNAs may be associated with drug resistance. This study investigated the effect of let-7b-5p, detected by bioinformatics methods, on Dox resistance through the Aurora Kinase B (AURKB) gene. …”
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Targeting T-Cell Activation for Malaria Immunotherapy: Scoping Review by Balsa Nobility Gustifante, Shafia Khairani, Nisa Fauziah, Silvita Fitri Riswari, Afiat Berbudi

“…Malaria remains a critical global health issue due to high mortality rates, drug resistance, and low treatment efficacy. The genetic variability of <i>Plasmodium</i> proteins complicates the development of long-lasting immunity, as it impedes the human immune system’s ability to sustain effective responses. …”
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State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization by Cecilia Trucchi, Andrea Orsi, Cristiano Alicino, Laura Sticchi, Giancarlo Icardi, Filippo Ansaldi

“…However, the emergence of drug resistance and the suboptimal activity of DAAs therapies against diverse HCV genotypes have been observed, determining treatment failure and hampering an effective control of HCV spread worldwide. …”
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Veterinary Drug Residues in Food Products of Animal Origin and Their Public Health Consequences: A Review by Yeshambel Muluye Mesfin, Birhan Agmas Mitiku, Habtamu Tamrat Admasu

“…However, the rise of drug resistance has led to increased antibiotic consumption and resistance among microbes in the animal habitat. …”
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Macrophages in Tumor Microenvironments and the Progression of Tumors by Ning-Bo Hao, Mu-Han Lü, Ya-Han Fan, Ya-Ling Cao, Zhi-Ren Zhang, Shi-Ming Yang

“…This interaction leads to tumorigenesis, metastasis, and drug resistance. So mediating macrophage to resist tumors is considered to be potential therapy.…”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…Despite the availability of effective treatments like 5-fluorouracil (5-FU), pharmacological therapy for CRC still faces significant challenges, including drug resistance, toxicity, and limited specificity. Therefore, discovering new compounds remains critical to overcoming these barriers and expanding treatment options. …”
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Assessment of Prescribing Pattern of antibiotics by Dentists in Ardabil city Based on the International ATC/DDD System by Mehrnoosh Kaviani, Mouhamad Hassan Pourrashid, Saeedeh Galledar

“…Irrational use of these drugs can lead to unwanted drug side effects, such as drug resistance in addition to unnecessary costs. This research was conducted to determine the antibiotic prescription pattern by dentists of Ardabil City based on the international ATC/DDD system. …”
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Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer by Ziqiang Chen, Ting Yu, Yunhe Wang, Jiaxin Li, Bo Zhang, Liya Zhou

“…Gastric cancer remains a leading cause of cancer-related mortality worldwide, with advanced stages presenting significant challenges due to metastasis and drug resistance. Traditional Chinese Medicine (TCM) offers a promising complementary approach characterized by holistic treatment principles and minimal side effects. …”
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High Level Aminoglycoside Resistance and Distribution of Aminoglycoside Resistant Genes among Clinical Isolates of Enterococcus Species in Chennai, India by Elango Padmasini, R. Padmaraj, S. Srivani Ramesh

“…Enterococci are nosocomial pathogen with multiple-drug resistance by intrinsic and extrinsic mechanisms. …”
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Obtaining a pancreatic cancer cell line stably expressing doxycycline-dependent endonuclease Cas9 by A.K. Nurgalieva, V.S. Skripova, L.F. Minigulova, R.G. Kiyamova

“…Early diagnosis of the disease is limited and antitumor therapy has low efficacy, because pancreatic cancer shows multiple drug resistance. It is still unclear how pancreatic tumor cells become resistant to chemotherapy and understanding of the resistance mechanisms and identification of their regulating genes is necessary to develop a new and more efficient pancreatic cancer therapy. …”
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PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing by Patricia E. Almeida, Alan Brito Carneiro, Adriana R. Silva, Patricia T. Bozza

“…Tuberculosis continues to be a global health threat, with drug resistance and HIV coinfection presenting challenges for its control. …”
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Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

“…Traditional treatments, including surgery, chemotherapy, and radiation, face limitations such as drug resistance, metastasis, and severe side effects. …”
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Pangenome Analysis of Helicobacter pylori Isolates from Selected Areas of Africa Indicated Diverse Antibiotic Resistance and Virulence Genes by Biigba Yakubu, Edwin Moses Appiah, Andrews Frimpong Adu

“…The challenge facing Helicobacter pylori (H. pylori) infection management in some parts of Africa is the evolution of drug-resistant species, the lack of gold standard in diagnostic methods, and the ineffectiveness of current vaccines against the bacteria. …”
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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease by Zhu J, Zhang Z, Chu Y, Xie Z, Zeng D, Jin L, Li L

“…However, in clinical practice, targeted ferroptosis therapy for kidney diseases faces obstacles such as poor drug solubility, low drug resistance, and imprecise targeting. With the rapid development of nanomaterials in the medical field, new opportunities have emerged for the precise regulation of ferroptosis in the treatment of kidney diseases. …”
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Phylogenetic Aspects of Antibiotic Resistance and Biofilm Formation of P. aeruginosa Isolated from Clinical Samples by Maryam Motevasel, Masoud Haghkhah, Negar Azimzadeh

“…Biofilm production and drug resistance phenomenon play a critical role in P. aeruginosa infections. …”
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Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6 by Deng Pan, Kehe Chen, Ping Chen, Yu Liu, Yingying Wu, Jingning Huang

“…Given its important regulatory role in cancer biology, we wondered whether SNHG7 is involved in drug resistance to anlotinib (ATB) in CRC. To answer this, we quantified the expression of SNHG7 by quantitative real-time PCR. …”
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Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection by Daniela Proverbio, Eva Spada, Giada Bagnagatti De Giorgi, Roberta Perego

“…In view of the low number of antileishmanial drugs available and the fact that some of these are used in human as well as veterinary medicine, it is of paramount importance that drug resistance is monitored and documented.…”
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Comprehensive Analysis of Gene Signatures of m6ARNA Methylation Regulators in Lung Adenocarcinoma and Development of a Risk Scoring System by Chundi Gao, Huayao Li, Wenzhe Ma, Qiming Zhang, Cun Liu, Lijuan Liu, Jing Zhuang, Changgang Sun

“…The recent application of targeted immunotherapy has greatly improved the clinical outcomes of patients with lung adenocarcinoma (LUAD), but drug resistance continues to emerge, and to evaluate and to improve patient prognosis are arduous. …”
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