From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies by Dong Xie, Linglin Sun, Manxiang Wu, Qiang Li

“…Regarding treatment, INMs play a key role in advanced strategies such as immunotherapy, magnetic hyperthermia, and synergistic combination therapy, which effectively overcome tumor-induced drug resistance and reduce systemic toxicity. The integration of INMs with artificial intelligence (AI) and radiomics further expands its capabilities for precise tumor identification, and treatment optimization, and amplifies treatment monitoring. …”
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Panoptosis – new frontier in research in head neck cancer by Shrikant B. Mali

“…Numerous studies have demonstrated that PANoptosis can successfully stop cancer cells from growing, proliferating, and developing drug resistance, changing the focus of targeted anticancer therapy.…”
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Genetic Analysis of CYP2C9 with Reference to Drug Response in Epilepsy Patients of Pakistan by Hafsa Maqbool, Tayyaba Saleem, Nadeem Sheikh, Aqsa Ashfaq

“…The current study included 337 individuals including 100 control subjects, 110 drug-resistant subjects, and 127 drug responders. Genomic DNA was isolated from blood, and amplification of rs1799853 (430C > T) and rs1057910 was carried out by polymerase chain reaction. …”
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Probiotics to Prevent the Need for, and Augment the Use of, Antibiotics by Gregor Reid

“…The timing of resurgent interest in this ancient field coincides with the need to augment or replace antibiotics whose side effects are unwelcome and whose efficacy is diminishing due to drug resistance. Evidence that probiotic strains can act as adjuncts to antibiotic therapy by reducing adverse effects, improving antibiotic function and enhancing mucosal immunity is mounting. …”
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Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i> by Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

“…The development of new therapeutic strategies based on inhibiting essential viral enzymes or viral–host protein interactions is problematic due to the fast mutation rate and rapid emergence of drug resistance. This study focuses on the NS2B-NS3 protease as a promising target for antiviral drug development. …”
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Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…., reduced relapse disease frequency); (iii) duration response (i.e., decreased drug resistance). Eventually, multidisciplinary approaches are still requested (e.g., genomics for personalized medicine, nanomedicine to overcome low free-drug bioavailability and targeting, systematic search of “melanoma stem cells” to enhance the prognosis and develop more valuable theranostics). …”
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Molecular mechanisms of mTOR-mediated cisplatin response in tumor cells by Amirhosein Maharati, Yasamin Rajabloo, Meysam Moghbeli

“…PI3K/Akt/mTOR axis functions as a key modulator of drug resistance and unfavorable prognosis in different cancers. …”
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Predictive Assessment of the Antiviral Properties of Imperata cylindrica against SARS-CoV-2 by Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu

“…The existing therapeutic alternatives have presented various setbacks such as low potency, poor pharmacokinetic profiles, and drug resistance. The need for alternative therapeutic options cannot be overemphasized. …”
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Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects by Zhipeng Cao, Sadia Quazi, Sakshi Arora, Laura D. Osellame, Ingrid J. Burvenich, Peter W. Janes, Andrew M. Scott

“…Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance. Notably, cancer-associated fibroblasts (CAFs) have emerged as one of the primary contributors in shaping TME, creating a favourable environment for cancer development. …”
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In silico evaluation, characterization, and in vitro anticancer activity of curcumin–nimbin loaded nanoformulation in HCT-116 cell lines by Arumugam Madeswaran, Selvam Tamilazhagan, Sellappan Mohan

“…Chemotherapy medications are often limited in use due to issues like drug resistance, P-glycoprotein efflux, and relapse of chemotherapy. …”
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Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity by Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Laura Hurtado-Navarro, Laura Hurtado-Navarro

“…This process has been shown to potentially drive tumour progression, drug resistance, and cancer recurrence. In this review, we explore the potential mechanisms that govern cancer cell fusion, the molecular mediators involved, the metastatic characteristics acquired by fusion-derived hybrids, and their clinical significance in human cancer. …”
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Nucleoside analogues in treatment of liver cirrhosis as an outcome of chronic hepatitis B by I. G. Bakulin

“…Its antiviral effect limited basically by development of drug resistance of a virus as a result of mutant strains development. …”
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Gambaran Tingkat Kepatuhan Pengobatan Pasien TB Paru by Endang Martini, Rika Sarfika, Siti Yuliharni

“… Adherence to tuberculosis (TB) treatment is crucial for achieving cure and preventing drug resistance. Low adherence can lead to treatment failure and increase the risk of infection transmission. …”
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Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells by Mairim Alexandra Solis, Ying-Hui Chen, Tzyy Yue Wong, Vanessa Zaiatz Bittencourt, Yen-Cheng Lin, Lynn L. H. Huang

“…This highly viscous polysaccharide is not only a lubricator, but also a significant regulator of cellular behaviors during embryogenesis, morphogenesis, migration, proliferation, and drug resistance in many cell types, including stem cells. …”
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Animal-derived therapeutic alternatives for candidiasis treatment by Manuela Gómez-Gaviria, Joaquín O. Chávez-Santiago, José A. Martínez-Álvarez, Héctor M. Mora-Montes

“…Recently, an increase in the isolation frequency of species different from Candida albicans has been observed, and some of them are characterized by the ability to develop resistance to antifungal drugs, which could be related to the misuse of these agents and biological attributes that allow drug resistance. Thus, the search for new therapeutic options to expand the alternatives to control candidiasis and other fungal infections is a priority. …”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…The upregulation of FBXW7 inhibited the stemness and reduced the tumorigenicity and drug resistance of HCC cells. Mechanistically, proteins binding to FBXW7 were identified by coimmunoprecipitation and protein colocalization assays. …”
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Real-world studies of crizotinib in patients with ROS1-positive non-small-cell lung cancer: experience from China by Hua Zhong, Jun Lu, Mengzhao Wang, Baohui Han

“…As one of the leading countries of real-world research on crizotinib, China has contributed significantly to data on standardization of the therapeutic use of crizotinib, including its clinical treatment patterns, the timing and duration of treatment and drug resistance monitoring and management.…”

Rat Sarcoma Virus Family Genes in Acute Myeloid Leukemia: Pathogenetic and Clinical Implications by Shaimaa Khattab, Adriatik Berisha, Natalia Baran, Pier Paolo Piccaluga

“…The frequency of <i>RAS</i> mutations increases in the context of AMLs’ chemoresistance; thus, novel anti-RAS strategies to overcome drug resistance and improve patients’ therapy responses and overall survival are the need of the hour. …”
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Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule. by Tingting Wang, Huaizhi Yang, Qiushuang Sheng, Ying Ding, Jian Zhang, Feng Chen, Jianfeng Wang, Lei Song, Xuming Deng

“…Hypervirulent Klebsiella pneumoniae (hvKP) poses an alarming threat in clinical settings and global public health owing to its high pathogenicity, epidemic success and rapid development of drug resistance, especially the emergence of carbapenem-resistant lineages (CR-hvKP). …”
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Shionone Relieves Urinary Tract Infections by Removing Bacteria from Bladder Epithelial Cells by Hao Yin, Jiaoli Zhu, Yi Jiang, Yijing Mao, Chenquan Tang, Hui Cao, Yufang Huang, Huijun Zhu, Jianping Luo, Qingjiang Jin, Qinglei Jin, Yi Xue, Xin Wang

“…In recent years, drug resistance of Escherichia coli (E. coli) has increased significantly. …”
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